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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Integrity of complex shape product by powder injection molding 显示文摘 | HENS K F LEE D LIN S T | 1991 | Powder Metallurgy International1991，23，1： | 1 |
| 3 | Anthraquinones in Rheum palmatum and Rumex dentatus (Polygonaceae),and phorbol esters in Jatropha curcas (Euphorbiaceae) with molluscicidal activity against the schistosome vector snails Oncomelania,Biomphalaria and Bulinus显示文摘 | LIU S Y SPORER F WINK M JOURDANE J HENNING R Li Y L RUPPEL A | 1997 | Trop Med Int Health1997，2，2： | 1 |
| 4 | Ten years of genetic fuzzy systems: Current framework and new trends 显示文摘 | Cordon O Gomide F Hen'era F | 2004 | Fuzzy Sets and Systems (S0615-0114)2004，141，1： | 1 |
| 5 | A model based on linguistic 2-Tuples for dealing with multigrannlar hierarchical linguistic contexts in multi-expert decision-making显示文摘 | Hen'era F Martinez L | 2001 | IEEE Transactions on Systems Man and Cybernetics Part B : Cybernetics2001，31，： | 1 |
| 6 | Temperature dependedinduction of salicylic acid and its conjugates during the resistance response to tobacco mosaic virus infection显示文摘 | Malamy J Henning J Klessing D F | 1992 | Plant Ce111992，，： | 1 |
| 7 | LFTs for automotive appli- cations显示文摘 | Henning F Ernst H Brussel R | 2005 | Reinforced plastics2005，49，2： | 1 |
| 8 | Prevalence of chlamycliae in boars and semen used for artificial insemination显示文摘 | Kauffold J Melzer F Henning K | 2006 | Theriogenology2006，65，9： | 1 |
| 9 | Liver-specific dene expression in cultured human hepmatopoietic stem cell显示文摘 | HENNING C F MICHAEL V L LOURDES C D | 2003 | Stem Cells2003，21，： | 1 |
| 10 | Following TRAIL' s path in the immune system显示文摘 | Christina F Uta S Henning W | 2009 | Immunology2009，127，8： | 1 |
| 11 | Gypenosides derived from Gynostemma pentaphyllum suppress NO synthesis in murine macrophanges by inhibiting iNOS enzymatic activity and attenuating NF-kappaB-medeated iNOS protein expression显示文摘 | Aktan F Henness S Roufogalis BD | 2003 | Nitric Oxide2003，8，4： | 1 |
| 12 | Power Metallurgy Pro-cessing ofThermal Management Materials for Microelectronic Ap-plications显示文摘 | German R M Hens K F Johnson J L | 1994 | International Journal of Power Metallurgy1994，30，2： | 1 |
| 13 | Temperature-dependence of salicylic acid and its conjugate during the resistance response to tobacco mosaic virus infection显示文摘 | Malamy J Henning J Klessing D F | 1992 | Plant Cell1992，4，2： | 1 |
| 14 | Harald,Experimental demonstration of free-space decoy-state quantum key distribution over 144km显示文摘 | Tobias S M Henning W Martin F | 2007 | Phys Rev Lett2007，98，01： | 1 |
| 15 | Measurement of salivary immunoglobulin A as an immunologic biomarker of job stress 显示文摘 | Henning GM Hurrell JJ Jr Baker F | 1992 | Scand J Work Environ Health1992，18，2： | 1 |
| 16 | Key issues in powder injec tion molding显示文摘 | Hens K F | 1991 | Ceramic Bulletin1991，70，8： | 1 |
| 17 | Intergrity of complex shape products by powder injection molding显示文摘 | Hens K F | 1991 | Int of P/M1991，23，1： | 1 |
| 18 | Powder metallurgy processing of thermal management materials for microelectronic applications 显示文摘 | German R M Hens K F - Johnson J L | 1994 | International Journal of Powder Metallurgy1994，30，2： | 1 |
| 19 | Temperature stable dielectric materials in system BaTiO3-Nb2O5-Co3O4显示文摘 | Hennings D F K Schreinemaher B S | 1994 | J Eur Ceram Soc1994，14，2： | 1 |
| 20 | Carbon in the universe显示文摘 | Henning T Salama F | 1998 | Science1998，282，12： | 1 |
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