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| 1 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 2 | Comparison of etanereept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis 显示文摘 | van der Heijde D Klareskog L Rodriguez-Valverde V | 2006 | Arthrtis Rheum2006，54，4： | 1 |
| 3 | Nonsteroidal anti-inflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis:a randomized clinical trial显示文摘 | Wanders A Heijde D Landewe R | 2005 | Arthritis Rheum2005，，： | 1 |
| 4 | Efficacy and safety of adallmumab in patients with non-radiographic axial spondyloarthritis: results of a randomised placebo-controlled trial (ABILITY-1) 显示文摘 | SIEPER J VAN DER HEIJDE D DOUGADOS M | 2012 | Ann Rheum Dis2012，，： | 1 |
| 5 | Relative val- ue of erythrocyte sedimentation rate and C-reactive proteili in as-sessment of disease activity in ankylosing spondylitis显示文摘 | Spoorenberg A van der Heijde D de Klerk E | 1999 | J Rheu matol1999，26，： | 1 |
| 6 | Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis: a randomized, controlled trial 显示文摘 | Davis J C Van Der Heijde D Braun J | 2003 | Arthritis Rheum2003，48，11： | 1 |
| 7 | HLA-B27 positive patients differ from HLA-B27 negative patients in clinical presentation and imaging: results from the DESIH cohort of patients with recent onset axial spondyloarthritis显示文摘 | Chung HY Machado P van der Heijde D | 2011 | Ann Rheum Dis2011，70，11： | 1 |
| 8 | Recombinant human tumor necrosis factor receptor (etanercept)for treating ankylosing spondylitis:a randomized,controlled trial显示文摘 | Van Der Heijde D Braun J | 2003 | Arthritis Rheum2003，48，： | 1 |
| 9 | Recombinant human tumor necrosis factor receptor (etanercept) for treating ankylosing spondylitis:a randomized,controlled trial显示文摘 | Davis JC Jr Van Der Heijde D Braun J | 2003 | Arthritis Rheum2003，48，11： | 1 |
| 10 | Efficacy and safety of infliximab in patients with ankylosing spondylitis re- sults of a randomized, placebo - controlled trial(ASSERT) 显示文摘 | Vander Heijde D Dijkmans B Geusens P | 2005 | Arthritis Rheum2005，52，2： | 1 |
| 11 | TheAssessment of SpondyloArthritis International Societyclassification criteria for peripheral spondyloarthritis and forspondyloarthritis in general显示文摘 | Rudwaleit M van der Heijde D LandewéR | 2011 | Ann Rheum Dis2011，70，1： | 1 |
| 12 | Infliximab and methotrexate in the treatment of rheumatoid arthritis显示文摘 | Lipsky P E Van der Heijde D M St clair E W | 2000 | N Eng J Med2000，343，： | 1 |
| 13 | How to diagnose axial spondyloarthritis early显示文摘 | Rudwaleit M van der Heijde D Khan MA | 2004 | Ann Rheum Dis2004，63，5： | 1 |
| 14 | Higher disease activity leads to more structural damage in the spine in ankylosing spondylitis: 12-year longitudinal data from the OASIS cohort显示文摘 | RAMIRO S VAN DER HEIJDE D VAN TUBERGEN A | 2014 | Annals of the Rheumatic Diseases2014，73，8： | 1 |
| 15 | 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis显示文摘 | Van der Heijde D Sieper J Maksymowyeh WP | 2011 | Ann Rheum Dis2011，70，6： | 1 |
| 16 | Disease remission and sustained halting of radiographic progression with combination etanercept and methotrexate in patients with rheumatoid arthritis 显示文摘 | van der Heijde D Klareskog L Landewe R | 2007 | Arthritis Rheum2007，56，： | 1 |
| 17 | Undiferentiated spondyloarthritis: anosological missing link显示文摘 | van der Heijde D BarM HS Ramos - RemusC | 2005 | Arthritis Rheum2005，52，4： | 1 |
| 18 | Efficacy and safety of adalimumab in patients with ankylosing spondylitis: Results of a multicenter, randomized, double-blind, placebo-controlled trial显示文摘 | van der Heijde D Kivitz A Schiff M H | 2006 | Arthritis Rheum2006，54，7： | 1 |
| 19 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 20 | Infliximab and methotrexate in the treatment of rheumatoid arthritis显示文摘 | LIPSKY P E van der HEIJDE D M F M ST-CLAIR E W | 2000 | N Engl J Med2000，343，22： | 1 |
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