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| 1 | Recurrence after endoscopic piecemeal mucosal resection for large sessile colorectal polyps显示文摘AIM: To evaluate the safety and outcomes of endoscopic piecemeal mucosal resection (EPMR) for large sessile colorectal polyps. METHODS: The patients enrolled in this study were 47 patients with 50 large sessile polyps (diameter, 2 cm or greater) who underwent EPMR using a submucosal saline injection technique between December 2002 and October 2005. All medical records, including characteristics of the patients and polyps, complications, and recurrences, were retrospectively reviewed. The first follow-up endoscopic examination was performed at 3-6 mo after initial endoscopic resection, and the second at 12 mo postEPMR. Subsequent surveillance colonoscopic examinations were individualized, taking risk factors into account. RESULTS: The patients were 23 men and 24 women,with a mean age of 60 years. Mean polyp size was 30.1 mm. Of 50 polyps identified, 34 (68%) were benign and 16 (32%) were malignant. There were 6 (12%) cases with EPMR-related bleeding: 5 intra-procedural and 1 early post-procedural bleeding. All bleeding episodes were managed by endoscopic clipping or argon beam coagulation. There were no perforations. Recurrence was identified in 5 cases (12.2%): 4 local recurrences detected at 3 mo post-EPMR and 1 local recurrence detected at 14 mo post-EPMR. The recurrence rate after EPMR was 3.1% for benign polyps and 33.3% for malignant polyps (P < 0.05). Median follow-up time was 37 mo. CONCLUSION: EPMR is safe, but should be applied carefully in malignant polyps. Close follow-up endoscopic examinations are necessary for early detection of recurrence. | Guh Jung Seo Dae Kyung Sohn Kyung Su Han Chang Won Hong Byung Chang Kim Ji Won Park Hyo Seong Choi Hee Jin Chang Jae Hwan Oh | 2010 | World Journal of Gastroenterology2010，16，22： | 17 |
| 2 | Effect of Nucleases on the Cellular Internalization of Fluorescent Labeled DNA-Functionalized Single-Walled Carbon Nanotubes显示文摘Nuclease effects on the cell internalization of single-walled carbon nanotubes(SWNTs)functionalized with fluorescent-labeled DNA in serum containing cell growth media were examined.When Cy3-labeled DNA-functionalized SWNT conjugates(Cy3DNA-SWNTs)were incubated with HeLa cells in a fatal bovine serum(FBS)medium,a high fl uorescence intensity was obtained from the cells,indicative for the high level inclusion of Cy3DNA-SWNTs.However,the fluorescence intensity was remarkably reduced if Cy3DNA-SWNTs were incubated with cells in the FBS-free medium.Further systematic control experiments revealed that Cy3 dye molecules were released from Cy3DNA-SWNT conjugates by nuclease,and the free Cy3 dyes penetrate into HeLa cell with high efficiency.Although the actual amounts of SWNTs internalized in the cells were almost identical for both cells incubated in the FBS-present and FBS-absent media according to the Raman measurements,one should be cautious to determine the degree of SWNT internalization based on the fl uorescence intensities especially when the coloring dye molecules were linked to oligonucleotides in nuclease containing media. | Hye Kyung Moon Chan Il Chang Dong-Ki Lee Hee Cheul Choi | 2008 | Nano Research2008，1，4： | 7 |
| 3 | Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis显示文摘AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic diverticulitis.METHODS:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ACD.RESULTS:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan. | Jeong Ah Hwang Sun Moon Kim Hyun Jung Song Yu Mi Lee Kyung Min Moon Chang Gi Moon Hoon Sup Koo Kyung Ho Song Yong Seok Kim Tae Hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk Chung | 2013 | World Journal of Gastroenterology2013，19，40： | 6 |
| 4 | Open versus laparoscopic surgery for mid or low rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): short-term outcomes of an open-label randomised controlled trial显示文摘 | Sung-Bum Kang Ji Won Park Seung-Yong Jeong Byung Ho Nam Hyo Seong Choi Duck-Woo Kim Seok-Byung Lim Taek-Gu Lee Dae Yong Kim Jae-Sung Kim Hee Jin Chang Hye-Seung Lee Sun Young Kim Kyung Hae Jung Yong Sang Hong Jee Hyun Kim Dae Kyung Sohn Dae-Hyun Kim Jae H | 2010 | Lancet Oncology2010，，7： | 5 |
| 5 | Correlation of fatty liver and abdominal fat distribution using a simple fat computed tomography protocol显示文摘AIM: To evaluate the relationship between hepatic fat infiltration and abdominal fat volume by using computed tomography (CT).METHODS: Three hundred and six patients who visited our obesity clinic between November 2007 and April 2008 underwent fat protocol CT scans.The age range of the patients was 19 to 79 years and the mean age was 49 years.The male to female ratio was 116:190.Liver and spleen attenuation measurements were taken with three regions of interests (ROIs) from the liver and two ROIs from the spleen.Hepatic attenuation indices (HAIs) were measured as follows: (1) hepatic parenchymal attenuation (CTLP);(2) liver to spleen attenuation ratio (LS ratio);and (3) difference between hepatic and splenic attenuation (LSdif).Abdominal fat volume was measured using a 3 mm slice CT scan starting at the level of the umbilicus and was automatically calculated by a workstation.Abdominal fat was classified into total fat (TF),visceral fat (VF),and subcutaneous fat (SF).We used a bivariate correlation method to assess the relationship between the three HAIs and TF,VF,and SF.RESULTS: There were significant negative correlations between CTLP,LS ratio,and LSdif with TF,VF,and SF,respectively.The CTLP showed a strong negative correlation with TF and VF (r = -0.415 and -0.434,respectively,P < 0.001).The correlation between CTLP and SF was less significant (r = -0.313,P < 0.001).CONCLUSION: Fatty infiltration of the liver was correlated with amount of abdominal fat and VF was more strongly associated with fatty liver than SF. | Seonah Jang Chang Hee Lee Kyung Mook Choi Jongmee Lee Jae Woong Choi Kyeong Ah Kim Cheol Min Park | 2011 | World Journal of Gastroenterology2011，17，28： | 5 |
| 6 | Clinical impact of atypical endoscopic features in rectal neuroendocrine tumors显示文摘AIM: To validate the association between atypical endoscopic features and lymph node metastasis(LNM).METHODS: A total of 247 patients with rectal neuroendocrine tumors(NETs) were analyzed. Endoscopic images were reviewed independently by two endoscopists, each of whom classified tumors by sized and endoscopic features, such as shape, color, and surface change(kappa coefficient 0.76 for inter-observer agreement). All of patients underwent computed tomography scans of abdomen and pelvis for evaluation of LNM. Univariate and multivariate analyses were performed to identify the factors associated with LNM. Additionally, the association between endoscopic atypical features and immunohistochemical staining of tumors was analyzed.RESULTS: Of 247 patients, 156(63.2%) were male and 15(6.1%) were showed positive for LNM. On univariate analysis, tumor size(P < 0.001), shape(P < 0.001), color(P < 0.001) and surface changes(P < 0.001) were significantly associated with LNM. On multivariate analysis, tumor size(OR = 11.53, 95%CI: 2.51-52.93, P = 0.002) and atypical surface(OR = 27.44, 95%CI: 5.96-126.34, P < 0.001) changes were independent risk factors for LNM. The likelihood of atypical endoscopic features increased as tumor size increased. Atypical endoscopic features were associated with LNM in rectal NETs < 10 mm(P = 0.005) and 10-19 mm(P = 0.041) in diameter. Immunohistochemical staining showed that the rate of atypical endoscopic features was higher in non L-cell tumors.CONCLUSION: Atypical endoscopic features as well as tumor size are predictive factors of LNM in patients with rectal NETs. | Jong Hee Hyun Seong Dae Lee Eui Gon Youk Jae Bum Lee Enu-Jung Lee Hee Jin Chang Dae Kyung Sohn | 2015 | World Journal of Gastroenterology2015，21，47： | 3 |
| 7 | Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial显示文摘 | Seung-Yong Jeong Ji Won Park Byung Ho Nam Sohee Kim Sung-Bum Kang Seok-Byung Lim Hyo Seong Choi Duck-Woo Kim Hee Jin Chang Dae Yong Kim Kyung Hae Jung Tae-You Kim Gyeong Hoon Kang Eui Kyu Chie Sun Young Kim Dae Kyung Sohn Dae-Hyun Kim Jae-Sung Kim Hye Seu | 2014 | Lancet Oncology2014，，7： | 3 |
| 8 | K2Ti6O13 Nanoparticle-Loaded Porous rGO Crumples for Supercapacitors显示文摘One-dimensional alkali metal titanates containing potassium,sodium,and lithium are of great concern owing to their high ion mobility and high specific surface area.When those titanates are combined with conductive materials such as graphene,carbon nanotube,and carbon nanofiber,they are able to be employed as efficient electrode materials for supercapacitors.Potassium hexa-titanate(K2Ti6O13,KTO),in particular,has shown superior electrochemical properties compared to other alkali metal titanates because of their large lattice parameters induced by the large radius of potassium ions.Here,we present porous rGO crumples(PGC)decorated with KTO nanoparticles(NPs)for application to supercapacitors.The KTO NP/PGC composites were synthesized by aerosol spray pyrolysis and post-heat treatment.KTO NPs less than 10 nm in diameter were loaded onto PGCs ranging from 3 to 5μm.Enhanced porous structure of the composites was obtained by the activation of rGO by adding an excessive amount of KOH to the composites.The KTO NP/PGC composite electrodes fabricated at the GO/KOH/TiO2 ratio of 1:3:0.25 showed the highest performance(275 F g−1)in capacitance with different KOH concentrations and cycling stability(83%)after 2000 cycles at a current density of 1 A g−1. | Chongmin Lee Sun Kyung Kim Hankwon Chang Hee Dong Jang | 2020 | Nano-Micro Letters2020，12，1： | 3 |
| 9 | Association Between Markers of Glucose Metabolism and Risk for Colorectal Adenoma显示文摘 | Sanjay Rampal Moon Hee Yang Jidong Sung Hee Jung Son Yoon-Ho Choi Jun Haeng Lee Young-Ho Kim Dong Kyung Chang Poong-Lyul Rhee Jong Chul Rhee Eliseo Guallar Juhee Cho | 2014 | Gastroenterology2014，，： | 2 |
| 10 | 健康男性的胰岛素抵抗指数、肥胖、血清PSA水平间的关系显示文摘本研究旨在确定血清PSA水平低于4ngmL^-1的健康男性的胰岛素抵抗指数、肥胖和血清前列腺特异性抗原(PSA)水平之间的关系。调查对象为韩国水力原子力株式会社的11827名健康男性职员,在2003年1月到2008年12月间接受了体检,体检项目包括空腹血糖水平、空腹胰岛素水平和血清PSA水平。用稳态模式评估法(HOMA;[空腹血糖水平×空腹胰岛素水平]/22.5)和定量胰岛素敏感性检验指数(QUICKI;1/[10g(空腹胰岛素水平)+log(空腹血糖水平)])测定胰岛素抵抗指数。协方差分析(ANOVA)和Duncan’s多重比较试验显示,随着用HOMA和OuICKI测定的胰岛素抵抗指数四分位的上升,年龄标化体重指数(BMI)也显著增加(P〈0.001)。多变量线性回归分析表明,相对于血清PSA水平,年龄、BMI、以及用HOMA或QUICKI测得的胰岛素抵抗指数都是显著的独立变量(P〈0.001)。本研究说明胰岛素抵抗指数和BMI都是血清PSA水平的独立变量,在健康男性体内,两者都与血清PSA水平呈负相关,两者之间呈正相关。 | June Hyun Han Yong Taec Lee Kyung Won Kwak Seung Hyun Ahn In Ho Chang Soon Chul Myung Seung Young Oh Yong-Seong Lee Wonyong Kim Young-Woo Jin Tae-In Choi Sook Hee Sung | 2010 | Asian Journal of Andrology2010，12，3： | 2 |
| 11 | Pathologic Nodal Classification Is the Most Discriminating Prognostic Factor for Disease-Free Survival in Rectal Cancer Patients Treated With Preoperative Chemoradiotherapy and Curative Resection显示文摘 | Tae Hyun Kim Hee Jin Chang Dae Yong Kim Kyung Hae Jung Yong Sang Hong Sun Young Kim Ji Won Park Jae Hwan Oh Seok-Byung Lim Hyo Seong Choi Seung-Yong Jeong | 2010 | International Journal of Radiation Oncology, Biology, Physics2010，，4： | 2 |
| 12 | Diagnosis of gastric epithelial neoplasia:Dilemma for Korean pathologists显示文摘The histopathological diagnosis of gastric mucosal biopsy and endoscopic mucosal resection/endoscopic submucosal dissection specimens is important,but the diagnostic criteria,terminology,and grading system are not the same in the East and West.A structurally invasive focus is necessary to diagnose carcinoma for most Western pathologists,but Japanese pathologists make a diagnosis of cancer based on severe dysplastic cytologic atypia irrespective of the presence of invasion.Although the Vienna classification was introduced to reduce diagnostic discrepancies,it has been difficult to adopt due to different concepts for gastric epithelial neoplastic lesions.Korean pathologists experience much difficulty making a diagnosis because we are influenced by Japanese pathologists as well as Western medicine.Japan is geographically close to Korea,and academic exchanges are active.Additionally,Korean doctors are familiar with Western style medical terminology.As a result,the terminology,definitions,and diagnostic criteria for gastric intraepithelial neoplasia are very heterogeneous in Korea.To solve this problem,the Gastrointestinal Pathology Study Group of the Korean Society of Pathologists has made an effort and has suggested guidelines for differential diagnosis:(1) a diagnosis of carcinoma is based on invasion;(2) the most important characteristic of low grade dysplasia is the architectural pattern such as regular distribution of crypts without severe branching,budding,or marked glandular crowding;(3) if nuclear pseudostratification occupies more than the basal half of the cryptal cells in three or more adjacent crypts,the lesion is considered high grade dysplasia;(4) if severe cytologic atypia is present,careful inspection for invasive foci is necessary,because the risk for invasion is very high;and(5) other structural or nuclear atypia should be evaluated to make a final decision such as cribriform pattern,papillae,ridges,vesicular nuclei,high nuclear/cytoplasmic ratio,loss of nuclear polarity,thick and irregular nuclear membrane,and nucleoli. | Joon Mee Kim Mee-Yon Cho Jin Hee Sohn Dae Young Kang Cheol Keun Park Woo Ho Kim So-Young Jin Kyoung Mee Kim Hee Kyung Chang Eunsil Yu Eun Sun Jung Mee Soo Chang Jong Eun Joo Mee Joo Youn Wha Kim Do Youn Park Yun Kyung Kang Sun Hoo Park Hye Seung Han Young Bae Kim Ho Sung Park Yang Seok Chae Kye Won Kwon Hee Jin Chang The Gastrointestinal Pathology Study Group of Korean Society of Pathologists | 2011 | World Journal of Gastroenterology2011，17，21： | 2 |
| 13 | Association of colorectal adenoma with components of metabolic syndrome显示文摘 | Byung Kim Aesun Shin Chang Hong Dae Sohn Kyung Han Kum Ryu Bum Park Ji Nam Ji Park Hee Chang Hyo Choi Jeongseon Kim Jae Oh | 2012 | Cancer Causes & Control2012，，5： | 2 |
| 14 | Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment显示文摘 | Jae‐Hyun Park Sang Won Seo Changsoo Kim Geon Ha Kim Hyun Jin Noh Sung Tae Kim Ki‐Chang Kwak Uicheul Yoon Jong Min Lee Jong Weon Lee Ji Soo Shin Chi Hun Kim Young Noh Hanna Cho Hee Jin Kim Cindy W. Yoon Seung Jun Oh Jae Seung Kim Yearn Seong Choe Kyung‐Han | 2013 | Ann Neurol2013，，5： | 1 |
| 15 | 胃的 Neuroendocrine 癌: 一份案例报告显示文摘 Neuroendocrine carcinoma(NEC)is a rare tumor,comprising<1%of stomach cancers.A 55-year-old woman was referred to our hospital with biopsy-proven gastric cancer.A shallow ulcerative lesion was detected in the lesser curvature of the lower body.It was suspected to be early gastric cancerⅡA+ⅡC type.Thus,endoscopic submucosal dissection was performed.She was subsequently diagnosed with NEC,which is aggressive and carries a poor prognosis.We conducted a radical resection and a laparoscopic-assisted distal gastrectomy.The tumor had infiltrated the subserosal layer and6/42 lymph nodes were involved.The mitotic index was16/10 high power fields and the Ki-67 labeling index was 26%-50%.The final diagnosis of NEC was made according to the World health Organization 2010 criteria.She was suspected of having jumping metastasis to the proximal margin.The patient was treated with an oral anticancer drug(5-flurouracil based drug)for2 years.The patient has been followed up for 3 years without recurrence. | Sang hyun Kang Kwang hee Kim Sang hyuk Seo Min Sung An Tae Kwun ha ha Kyung Park Ki Beom Bae Chang Soo Choi Sang hun Oh Young Kil Choi | 2014 | World Journal of Gastrointestinal Surgery2014，6，4： | 1 |
| 16 | TOP1 and 2,polysaccharides from Taraxacum officinale,attenuate CCl4-induced hepatic damage through the modulation of NF-κB and its regulatory mediators显示文摘 | Chung Mu Park Hyun Joo Youn Hee Kyung Chang | 2010 | Food Chem Toxicol2010，48，5： | 1 |
| 17 | Learning curves for laparoscopic sigmoidectomy used to manage curable sigmoid colon cancer: single-institute, three-surgeon experience显示文摘 | Dong Hyun Choi Woon Kyung Jeong Sang-Woo Lim Tae Sung Chung Jung-In Park Seok-Byung Lim Hyo Seong Choi Byung-Ho Nam Hee Jin Chang Seung-Yong Jeong | 2009 | Surgical Endoscopy2009，，3： | 1 |
| 18 | Clinical outcomes of palliative self‐expanding metallic stents in patients with malignant colorectal obstruction显示文摘 | Byung ChangKIM Kyung SuHAN Chang WonHONG Dae KyungSOHN Ji WonPARK Sung ChanPARK Sun YoungKIM Ji YeonBAEK Hyo SeongCHOI Hee JinCHANG Dae YongKIM Jae HwanOH | 2012 | Journal of Digestive Diseases2012，，5： | 1 |
| 19 | Enhanced photocatalytic property of nanoporous TiO 2 /SiO 2 micro-particles prepared by aerosol assisted co-assembly of nanoparticles显示文摘 | Sun Kyung Kim Hankwon Chang KuK Cho Dae Sup Kil Sung Wook Cho Hee Dong Jang Jeong-Woo Choi Jinhoon Choi | 2011 | Materials Letters2011，，21： | 1 |
| 20 | Clinical Parameters Predicting Pathologic Tumor Response After Preoperative Chemoradiotherapy for Rectal Cancer显示文摘 | Sang Min Yoon Dae Yong Kim Tae Hyun Kim Kyung Hae Jung Hee Jin Chang Woong Sub Koom Seok-Byung Lim Hyo Seong Choi Seung-Yong Jeong Jae-Gahb Park | 2007 | International Journal of Radiation Oncology Biology Physics2007，，4： | 1 |
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