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| 1 | Biopathologic features and clinical significance of micrometatasis in the lymph node of early gastric cancer显示文摘AIM: To evaluate the biopathologic features and clinical significance of nodal micrometastasis(MI) in early gastric cancer(EGC).METHODS: Among 1022 EGC patients who underwent gastrectomy with lymphadenectomy of D1 + β or more from March 2001 to December 2005 at the Korean National Cancer Center, available nodal metastasis was found in 90 p T1N1 patients. Nodal metastasis was confirmed by immunohistochemistry(IHC) with cytokeratin and patients were classified into MI and macrometastasis(MA) groups based on the main tumor burden according to the 6th International Union Against Cancer/American Joint Committee on Cancer staging system; the main tumor burden with a diameter of greater than 0.2 mm but no greater than 2 mm as MI, and greater than 2 mm as MA of the representative metastatic node. Proliferative and apoptotic activities of the primary tumor and the nodal metastasis were measured by IHC with Ki-67 and terminal deoxynucleotidyl transferase d UTP nick end labeling, respectively. Biopathologic and clinical features of the patients were analyzed and compared between MI and MA groups. Patients with recurrence were compared with those without recurrence to identify risk factors for recurrence.RESULTS: Thirty-seven patients showed MI and the other 53 patients revealed MA in the lymph node; the incidence of patients with MI and MA was 41.1% and 58.9%. The main tumor burden was 0.9 and 4.6 mm in the representative metastatic node, respectively. Japanese N2 stations were more frequently involved in MA group(20.9%) than in MI group(10.3%) butthe difference was not statistically different(P = 0.338). Proliferative and apoptotic activities of MI were decreased than those of MA(26.7% vs 40.5%, P = 0.004 and 1.0% vs 3.0%, P < 0.001, respectively). However, nodal MI in the current study showed a relatively high proliferative activity and an equivalent apoptotic activity compared to other cancers in the previously published studies. Recurrence was observed in 6 patients during the mean follow up period of 87.6 ± 26.2 mo. The recurrence was significantly associated with the presence of MA(P = 0.041) and lymphovascular invasion of the primary tumor(P = 0.032).CONCLUSION: Lymphadenectomy of D1 + β or more might be necessary in patients with MI in sentinel node to prevent recurrence by clearing MI involving Japanese N2 station. | Min Jung Jo Ji Yeon Park Joon Seon Song Myeong-Cherl Kook Keun Won Ryu Soo-Jeong Cho Jun Ho Lee Byung-Ho Nam Eun Kyung Hong Il Ju Choi Young-Woo Kim | 2015 | World Journal of Gastroenterology2015，21，2： | 9 |
| 2 | Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis显示文摘AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic diverticulitis.METHODS:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ACD.RESULTS:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan. | Jeong Ah Hwang Sun Moon Kim Hyun Jung Song Yu Mi Lee Kyung Min Moon Chang Gi Moon Hoon Sup Koo Kyung Ho Song Yong Seok Kim Tae Hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk Chung | 2013 | World Journal of Gastroenterology2013，19，40： | 6 |
| 3 | Acute mediastinitis arising from pancreatic mediastinal fistula in recurrent pancreatitis显示文摘Acute mediastinitis is a fatal disease that usually originates from esophageal perforation and surgical infection.Rare cases of descending necrotizing mediastinitis can occur following oral cavity and pharynx infection or can be a complication of pancreatitis.The most common thoracic complications of pancreatic disease are reactive pleural effusion and pneumonia,while rare complications include thoracic conditions,such as pancreaticopleural fistula with massive pleural effusion or hemothorax and extension of pseudocyst into the mediastinum.There have been no reports of acute mediastinitis originating from pancreatitis in South Korea.In this report,we present the case of a 50-year-old female suffering from acute mediastinitis with pleural effusion arising from recurrent pancreatitis that improved after surgical intervention. | In Soo Choe Yong Seok Kim Tae Hee Lee Sun Moon Kim Kyung Ho Song Hoon Sup Koo Jung Ho Park Jin Sil Pyo Ji Yeong Kim In Seok Choi | 2014 | World Journal of Gastroenterology2014，20，40： | 6 |
| 4 | Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population显示文摘 | Hye‐Rim Song Hee Nam Kim Sun‐Seog Kweon Jin‐Su Choi Hyun Jeong Shim Sang Hee Cho Ik Joo Chung Young‐Kyu Park Soo Hyun Kim Yoo‐Duk Choi Kyung Woong Joo Min‐Ho Shin | 2013 | Mol Carcinog2013，，1： | 2 |
| 5 | A randomized phase II trial of S-1-oxaliplatin versus capecitabine–oxaliplatin in advanced gastric cancer显示文摘 | Gun Min Kim Hei-Cheul Jeung Sun Young Rha Hyo Song Kim Inkyung Jung Byung Ho Nam Kyung Hee Lee Hyun Cheol Chung | 2011 | European Journal of Cancer2011，，4： | 2 |
| 6 | Vasodilatory effects of ethanol extract of Radix Paeoniae Rubra and its mechanism of action in the rat aorta显示文摘 | Song Nan Jin Jin Fu Wen Ting Ting Wang Dae Gill Kang Ho Sub Lee Kyung Woo Cho | 2012 | Journal of Ethnopharmacology2012，，1： | 1 |
| 7 | Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study显示文摘 | Hyun Joo Jang Jung Han Kim Hun Ho Song Kyung Hee Woo Mi Kim Sea Hyub Kae Jin Lee Ji Wong Cho Jung Hun Kang Soon Il Lee Soo Jung Gong Jung Ae Lee Dae Young Zang | 2008 | Digestive Diseases and Sciences2008，，2： | 1 |
| 8 | Upstream regulation of matrix metalloproteinase by EMMPRIN; extracellular matrix metalloproteinase inducer in advanced atherosclerotic plaque显示文摘 | Young Won Yoon Hyuck Moon Kwon Ki-Chul Hwang Eui-Young Choi Bum-kee Hong Dongsoo Kim Hyun-Seung Kim Sang Ho Cho Kyung Soon Song Giuseppe Sangiorgi | 2004 | Atherosclerosis2004，，1： | 1 |
| 9 | Morbidity and mortality after non‐curative gastrectomy for gastric cancer in elderly patients显示文摘 | Jung Ho Shim Kyung Jai Ko Han Mo Yoo Seong Il Oh Dong Jin Jeon Hae Myung Jeon Cho Hyun Park Kyo Young Song | 2012 | J Surg Oncol2012，，6： | 1 |
| 10 | Endoscopic sphincterotomy plus large-balloon dilation versus endoscopic sphincterotomy for removal of bile-duct stones <ce:link locator='fx1'/>显示文摘 | Jeung Ho Heo Dae Hwan Kang Hyo Jin Jung Dae Sik Kwon Jin Kwang An Bo Suk Kim Kyung Duk Suh Sang Yong Lee Joo Ho Lee Gwang Ha Kim Tae Oh Kim Jeong Heo Geun Am Song Mong Cho | 2007 | Gastrointestinal Endoscopy2007，，4： | 1 |
| 11 | The effect of type of organic phase solvents on the particle size of poly( d,l -lactide-co-glycolide) nanoparticles显示文摘 | Ki Chang Song Ho Seok Lee Il Yeop Choung Kyung In Cho Yangkyu Ahn Eun Jung Choi | 2005 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2005，，1： | 1 |
| 12 | TP53 codon 72 polymorphism associated with prognosis in patients with advanced gastric cancer treated with paclitaxel and cisplatin显示文摘 | Jong Gwang Kim Sang Kyun Sohn Yee Soo Chae Hong Suk Song Ki-Young Kwon Young Rok Do Min Kyoung Kim Kyung Hee Lee Myung Soo Hyun Won Sik Lee Chang-Hak Sohn Joo Seop Jung Gab Chul Kim Ho Young Chung Wansik Yu | 2009 | Cancer Chemotherapy and Pharmacology2009，，2： | 1 |
| 13 | Endoscopic sphincterotomy plus large-balloon dilation versus endoscopic sphincterotomy for removal of bile-duct stones <ce:link locator='fx1'/>显示文摘 | Jeung Ho Heo Dae Hwan Kang Hyo Jin Jung Dae Sik Kwon Jin Kwang An Bo Suk Kim Kyung Duk Suh Sang Yong Lee Joo Ho Lee Gwang Ha Kim Tae Oh Kim Jeong Heo Geun Am Song Mong Cho | 2007 | Gastrointestinal Endoscopy2007，，4： | 1 |
| 14 | Frequency of rebleeding events in obscure gastrointestinal bleeding with negative capsule endoscopy显示文摘 | Ji‐Beom Kim Byong Duk Ye Yelim Song Dong‐Hoon Yang Kee Wook Jung Kyung‐Jo Kim Jeong‐Sik Byeon Seung‐Jae Myung Suk‐Kyun Yang Jin‐Ho Kim | 2013 | J Gastroenterol Hepatol2013，，5： | 1 |
| 15 | Platelet microparticles induce angiogenesis in vitro 显示文摘 | Hyun Kyung Kim Kyung Soon Song Jun -Ho Chung | 2004 | Br J Haematol2004，124，3： | 1 |
| 16 | A randomized phase II trial of S-1-oxaliplatin versus capecitabine–oxaliplatin in advanced gastric cancer显示文摘 | Gun Min Kim Hei-Cheul Jeung Sun Young Rha Hyo Song Kim Inkyung Jung Byung Ho Nam Kyung Hee Lee Hyun Cheol Chung | 2011 | European Journal of Cancer2011，，4： | 1 |
| 17 | Anthocyanins from black soybean inhibit Helicobacter pylori ‐induced inflammation in human gastric epithelial AGS cells显示文摘 | Jung‐Min Kim Kyung‐Mi Kim En‐Hee Park Ji‐Hyun Seo Jae‐Young Song Sung‐Chul Shin Hyung‐Lyun Kang Woo‐Kon Lee Myung‐Je Cho Kwang‐Ho Rhee Hee‐Shang Youn Seung‐Chul Baik | 2013 | Microbiol Immunol2013，，5： | 1 |
| 18 | Amplification of fluorescence with packed beads to enhance the sensitivity of miniaturized detection in microfluidic chip显示文摘 | Kyeong-Sik Shin Sung Woo Lee Ki-Cheol Han Sang Kyung Kim Eun Kyung Yang Jung Ho Park Byeong-Kwon Ju Ji Yoon Kang Tae Song Kim | 2006 | Biosensors and Bioelectronics2006，，9： | 1 |
| 19 | Electrically configurable electroforming and bipolar resistive switching inPt/TiO<SUB>2</SUB>/Pt structures显示文摘 | Kyung Min Kim Gun Hwan Kim Seul Ji Song Jun Yeong Seok Min Hwan Lee Jeong Ho Yoon Cheol Seong Hwang | 2010 | Nanotechnology2010，，30： | 1 |
| 20 | Endoscopic removal of bile-duct stones by using a rotatable papillotome and a large-balloon dilator in patients with a Billroth II gastrectomy (with video)显示文摘 | Gwang Ha Kim Dae Hwan Kang Geun Am Song Jeong Heo Chan Ho Park Tae In Ha Kyung Yeob Kim Hye Jeong Lee Il Doo Kim Seong Ho Choi Chul Soo Song | 2008 | Gastrointestinal Endoscopy2008，，7： | 1 |
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