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| 1 | Photoactivated CRY1 and phyB Interact Directly with AUX/IAA Proteins to Inhibit Auxin Signaling in Arabidopsis显示文摘光是在 Arabidopsis 通过蓝色和调停 cryptochrome 的 red/far-red 光光敏电阻器和调停 phytochrome 的小径禁止胚轴房间延伸的关键环境暗示。相反,作为枢轴的内长的植物激素,植物生长素通过 AUX/IAA 蛋白质(AUX/IAAs ) 的植物生长素受体 TIR1/AFBs-mediated 降级支持胚轴延伸。然而,位于发信号的光和植物生长素的对抗相互作用下面的分子的机制仍然保持不清楚。这里,我们报导光禁止由 cryptochrome 的蓝、红的轻依赖者的相互作用通过 AUX/IAAs 的稳定发信号的植物生长素 1 (CRY1 ) 并且有 AUX/IAAs 的 phytochrome B 分别地。有 AUX/IAAs 的 CRY1 的蓝被触发光的相互作用与 AUX/IAAs 禁止 TIR1 的协会,导致这些蛋白质的导致植物生长素的降级的压抑。我们的结果显示光敏电阻器下游地直接作为一样与植物生长素受体分享 AUX/IAAs 表明部件。我们建议由光敏电阻器和植物生长素受体的 AUX/IAA 蛋白质稳定性的那条对抗规定允许植物平衡光和植物生长素信号优化他们的生长。 | Feng Xu Shengbo He Jingyi Zhang Zhilei Mao Wenxiu Wang Ting Li Jie Hua Shasha Du Pengbo Xu Ling Li Hongli Lian Hong-Quan Yang | 2018 | Molecular Plant2018，11，4： | 24 |
| 2 | Experimental investigation of railway train-induced vibrations of surrounding ground and a nearby multi-story building显示文摘In this paper, a field experiment was carried out to study train-induced environmental vibrations. During the field experiment, velocity responses were measured at different locations of a six-story masonry structure near the Beijing-Guangzhou Railway and along a small road adjacent to the building. The results show that the velocity response levels of the environmental ground and the building floors increase with train speed, and attenuate with the distance to the railway track. Heavier freight trains induce greater vibrations than lighter passenger trains. In the multi-story building, the lateral velocity levels increase monotonically with floor elevation, while the vertical ones increase with floor elevation in a fluctuating manner. The indoor floor vibrations are much lower than the outdoor ground vibrations. The lateral vibration of the building along the direction of weak structural stiffness is greater than along the direction with stronger stiffness. A larger room produces greater floor vibrations than the staircase at the same elevation, and the vibration at the center of a room is greater than at its corner. The vibrations of the building were compared with the Federal Transportation Railroad Administration (FTA) criteria for acceptable ground-borne vibrations expressed in terms of rms velocity levels in decibels. The results show that the train-induced building vibrations are serious, and some exceed the allowance given in relevant criterion. | Xia He Chen Jianguo Wei Pengbo Xia Chaoyi G. De Roeck G. Degrande | 2009 | Earthquake Engineering and Engineering Vibration2009，8，1： | 13 |
| 3 | Photoexcited CRYPTOCHROME 1 Interacts Directly with G-Protein 13 Subunit AGB1 to Regulate the DNA-Binding Activity of HY5 and Photomorphogenesis in Arabidopsis显示文摘 | Hongli Lian Pengbo Xu Shengbo He Jun Wu Jian Pan Wenxiu Wang Feng Xu Sheng Wang Junsong Pan Jirong Huang Hong-Quan Yang | 2018 | Molecular Plant2018，11，10： | 10 |
| 4 | LSECtin on tumor-associated macrophages enhances breast cancer sternness via interaction with its receptor BTN3A3显示文摘Macrophages have bee n suggested to con tribute to con structing a cancer stem cell(CSC)niche.However,whether and how macrophages regulate the activity of CSCs through juxtacrine signaling are poorly understood.Here we report LSECtin,a transmembrane protein highly expressed on tumor-associated macrophages(TAMs),enhances sternness of breast cancer cells(BCCs).We identified BTN3A3,a B7 family member with previously unknown functions as the receptor for LSECtin on BCCs responsible for stemness-promoting effect of LSECtin.In mice bearing human tumor xenografts,either macrophage-specific ablation of LSECtin or silencing of BTN3A3 in BCCs decreased CSC frequency and tumor growth.Admixture of LSECtin-positive macrophages increased the tumorigenic activity of BCCs dependent on BTN3A3.Disruption of the LSECtin-BTN3A3 axis with BTN3A3-Fc or anti-BTN3A3 mAb has a therapeutic effect on breast cancer.These findings define a juxtacrine signaling mechanism by which TAMs promote cancer stemness.Targeting this axis in the CSC niche may provide potential therapies to breast cancer. | Di Liu Qian Lu Xing Wang Jun Wang Ning Lu Zefei Jiang Xiaopeng Hao Jianbin Li Jing Liu Pengbo Cao Guilin Peng Yuandong Tao Dianyuan Zhao Fuchu He Li Tang | 2019 | Cell Research2019，29，5： | 8 |
| 5 | Neuronal effects of SP600125 pretreatment in a rat model of cerebral ischemia/reperfusion injury Inhibited down-regulation of DNA repair protein显示文摘BACKGROUND: Recent studies have shown that the selective inhibitor of c-Jun N-terminal kinases(JNKs) signaling pathway, SP600125, exhibits neuronal protective effects in a rat model of brainischemia/reperfusion.OBJECTIVE: To determine the mechanisms of neuroprotective effects of SP600125 in a rat modelof brain ischemia/reperfusion, and determine the role of the JNK signaling pathway inSP600125-induced effects.DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at theAnimal Experiment Center, Medical School of Xi'an Jiaotong University from June 2007 toSeptember 2008.MATERIALS: SP600125 was provided by Biosource, USA; rabbit anti-phospho-JNK(Thr183/Tyr185) polyclonal antibody from Cell Signaling Technology, USA; rabbit anti-X-ray repaircross-complementing protein 1 (XRCC1) and anti-Ku70 polyclonal antibodies from Santa CruzBiotechnology, USA; and TUNEL kit from Beijing Huamei Biology, China.METHODS: A total of 108 male, 4-month-old, Sprague Dawley rats were randomly assigned to threegroups, with 36 rats per group. The sham operation group and ischemia/reperfusion group (I/Rgroup) were intracerebroventricularly injected with 10 μL 1% DMSO. The SP600125-treated group(pre-SP group) was given 10 μL SP600125 (3 μg/μL). Thirty minutes later, brain ischemia wasinduced in the I/R and pre-SP groups using the four-vessel occlusion method. Specifically, wholebrain ischemia was induced for 6 minutes, and the clips were released to restore carotid artery bloodflow. Rats from each group were observed at 2, 6, 12, 24, 48, and 72 hours, with 6 rats for each timepoint. The sham operation group was treated with the same surgical exposure procedures, withexception of occlusion of the carotid artery.MAIN OUTCOME MEASURES: Hematoxylin-eosin staining was used to observe neuronal survivalin the hippocampal CA1 region, TUNEL was used to detect apoptosis in the hippocampal CA1region, and immunohistochemistry was used to detect expression of phospho-JNK, XRCC1, andKu70.RESULTS: Following brain ischemia/reperfusion, neuronal survival significantly decreased, and thenumber of apoptotic cells significantly increased (P < 0.01). Compared with the I/R group, neuronalsurvival significantly increased in the pre-SP group, and the number of apoptotic cells significantlydecreased (P < 0.01). Expression of phospho-JNK increased, and XRCC1 and Ku70 significantlydecreased (P < 0.05) following ischemia/reperfusion. Compared with the I/R group, expression ofphospho-JNK decreased, and XRCC1 and Ku70 significantly increased in the pre-SP group (P <0.05). Correlation analysis revealed an inverse correlation between phospho-JNK gray value andXRCC1 and Ku70 gray values in the hippocampal CA1 region (r = -0.983, -0.953, P < 0.01).CONCLUSION: SP600125 treatment decreased apoptosis induced by global brainischemia/reperfusion in the rat hippocampal CA1 region. Results suggested that the neuroprotectiveeffects were due to inhibited phosphorylation of JNK and reduced down-regulation of XRCC1 andKu70. | Ning Wang Rongliang Xue Fengzhen Yao Jiaxuan He Jianrui Lu Pengbo Zhang Gang Wu | 2009 | Neural Regeneration Research2009，4，12： | 1 |
| 6 | Carbon nanodots enhanced performance of Cs_(0.15)FA_(0.85)PbI_(3) perovskite solar cells显示文摘A high-quality hybrid Cs_(0.15)FA_(0.85)PbI_(3) thin film is deposited through doping of carbon nanodots(CNDs)into perovskite precursor solution.The corresponding inverted planar perovskite solar cells(PSCs)of ITO/PTAA/Cs_(0.15)FA_(0.85)PbI_(3)/PC_(61)BM/BCP/Ag exhibit an improvement in efficiency from 17.36%to 20.06%,which could be attributed to the passivation of the defects at the crystallized perovskite thin film and enhanced perovskite phase uniformity.The results of electron trap density indicate that the addition of CNDs significantly reduces the defects density at the perovskite thin film and the recombination of charge carriers in transport process is minimized.These results demonstrate that low-cost CNDs are effective additives for passivating defects,further reducing charge carrier recombination and improving device efficiency. | Yu Gao Wenzhan Xu Fang He Pengbo Nie Qingdan Yang Zhichun Si Hong Meng Guodan Wei | 2021 | Nano Research2021，14，7： | 0 |
| 7 | Highly Emissive Luminogens in Both Solution and Aggregate States显示文摘Organic light-emitting materials have attracted considerable attention because of their promising applications in diverse areas.Most fluorophores emit brightly in either dilute solutions or aggregate states;the former generally suffer from aggregation-caused quenching problem,and the latter encounter intensity loss at low concentrations.Herein,we propose a new strategy to overcome these dilemmas by balancing the planar and distorted structures of terphenyl-based luminogens and obtain three luminogens,2PB-AC,2Me2PB-AC,and 2T2PB-AC,with bright emission in both solution and aggregate states.Among them,2PB-AC shows absolute photoluminescence quantum yields(ФPL)higher than 90%in both tetrahydrofuran solution(90.2%)and aggregate states(92.7%for powder and 95.3%for crystal).Thus,2PB-AC could be an efficient probe to realize dual-channel explosive detection in both solution and aggregate states.Moreover,it could be used to image live-cell lipid droplets at a wide range of concentrations.In addition,benefiting from its thermodynamically favorable intersystem crossing process,2Me2PB-AC could be doped in polymethyl methacrylate matrix to provide efficient room-temperature phosphorescence.Thus,this work provides a feasible strategy for the design of luminogens with highly efficient emission in both solution and aggregate states,greatly facilitating and broadening their practical applications. | Pengbo Han Guiquan Zhang Jia Wang Yejun Yao Yanping Qiu He Xu Anjun Qin Ben Zhong Tang | 2023 | CCS Chemistry2023，5，7： | 0 |
| 8 | Target Motion Compensation by Means of Adjustable Beam Slow-extraction: simulation显示文摘 | He Pengbo Li Qiang Dai Zhongying Liu Xinguo | 2011 | IMP & HIRFL Annual Report2011，，1： | 0 |
| 9 | 3-41 Bio-audiovisual Feedback Breathing Guidance Technique for Synchrotron-based Ion Beam Delivery显示文摘Based on the periodic synchrotron-based beam delivery,a bio-audiovisual feedback breathing guidance technique has been developed to mitigate the interplay between target motion and dynamic beam delivery for ion beam therapy,in which variable beam extraction and generation of individualized breathing guidance curve are two key factors.Shown in Fig.1 is the schematic diagram of the breathing guidance technique.Through the simulations with 15 healthy volunteers for the breathing guidance technique,we found not only the treatment efficiency of synchrotron-based pulsed ion beam could be increased effectively,but also the residual movement of respiration during gating window could be reduced. | Li Qiang He Pengbo Liu Xinguo Dai Zhongying Ma Yuanyuan Shen Guosheng Yan Yuanlin Huang Qiyan Fu Tingyan | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 10 | 3-42 Fast Calibration of EBT Films in Scanned Ion Therapy显示文摘In the quality assurance of photon and ion beam radiotherapy with EBT films, the dose response curves of thesefilms should previously be calibrated. The traditional calibration method is to cut a big piece of EBT film intomany small ones, which are separately irradiated with different doses. Then these small EBT films are digitizedwith a commercial flatbed color scanner to get the net optical density (netOD) values, which are fitted against thedoses. In this work, we present a fast calibration method of EBT films in scanned ion radiotherapy. | Liu Xinguo Li Qiang Dai Zhongying He Pengbo Huang Qiyan Yan Yuanlin | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 11 | 3-44 Monte Carlo Simulation Study on Optimizing the Active Beam Delivery System at HIRFL显示文摘To obtain carbon ion beam suitable for the active spot scanning beam delivery system at the Heavy Ion ResearchFacility in Lanzhou (HIRFL), the Monte Carlo (MC) program SHIELD-HIT12A was used to study the influencesof beam delivery distance and structure period of mini ridge filter on full width at the half maximum (FWHM) ofbeam spot and dose flatness at the iso-center of the treatment room. | Yan Yuanlin Liu Xingguo Dai Zhongying Ma Yuanyuan Huang Qiyan He Pengbo Shen Guosheng Fu Tingyan Li Qiang | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 12 | 重离子放射治疗中视听反馈引导模式下体表和体内运动相互关系显示文摘Based on the audio-visual biofeedback(BFB)method for respiratory-gated radiotherapy of synchrotron-based pulsed heavy-ion beam delivery with tracking of external abdominal wall motion[1;2],this study evaluated the feasibility of the respiratory guidance method on thoracic and abdominal cancer patients,and the internal/external respiratory motion consistency under respiratory guidance maneuvers due to its interactive intervention in free breathing(FB). | He Pengbo Li Qiang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 13 | Drainage pattern recognition method considering local basin shape based on graph neural network显示文摘Drainage pattern recognition is crucial for geospatial understanding and hydrologic modelling.Currently,drainage pattern recognition methods employ geometric measures of overall and local features of river networks but lack measures of river basin unit shape features,so that potential correlations between river segments are usually ignored,resulting in poor drainage pattern recognition results.In order to overcome this problem,this paper proposes a supervised graph neural network method that considers the local basin unit shape of river networks.First,based on the overall hierarchy of the river networks,the confluence angle of river segments and the shape of river basin units,multiple drainage pattern classification features are extracted.Then,typical drainage pattern samples from the multi-scale NSDI and USGS databases are used to complete the training,validation and testing steps.Experimental results show that the drainage pattern indexes proposed can describe the characteristics of different drainage patterns.The method can effectively sample the adjacent river segments,flexibly transfer the associated pattern features among river segment neighbours,and aggregate the deeper characteristics of the river networks,thus improving the drainage pattern recognition accuracy relative to other methods and reliably distinguishing different drainage patterns. | Wenning Wang Haowen Yan Xiaomin Lu Yi He Tao Liu Wende Li Pengbo Li Fang Xu | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 14 | TEPC壁效应对重离子束微计量学能谱的影响显示文摘Tissue equivalent proportional counter(TEPC)[1;2]is widely used for microdosimetric measurements of heavy ion beams,which provide basic data for calculating relative biological effectiveness(RBE).To study the influence of TEPC wall on microdosimetric spectra of heavy ion beams,an ideal TEPC combined with Monte Carlo(MC)simulations was introduced to accurately calculate the microdosimetric spectra at different water equivalent depths of carbon ion beams.Three setups used in Gate-based[3]Monte Carlo simulations are shown in Fig.1,namely the ideal TEPC,general TEPC and the TEPC wall as a water layer with a fixed water equivalent thickness respectively. | Dai Tianyuan Liu Xinguo Dai Zhongying He Pengbo Shen Guosheng Ma Yuanyuan Zhang Hui Meng Qianqian Zhang Xiaofang Chen Weiqiang Li Qiang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 15 | HIMM-WW碳离子束治疗相对生物学效应的微计量学验证显示文摘Heavy Ion Medical Machine in Wuwei(HIMM-WW)has already been built.The new facility,with four therapy terminals,can provide carbon-ion beams with energy ranging from 120 to 400 MeV/u.For HIMM-WW,a LETbased approach is adopted to calculate RBE.Considering the successful application of microdosimetric kinetic model(MKM)and plentiful therapeutic experience in Japan for clinical Carbon-ion therapy,the purpose of this study is to verify the RBE value used in HIMM-WW with microdosimetric approach. | Dai Tianyuan Liu Xinguo Dai Zhongying He Pengbo Shen Guosheng Ma Yuanyuan Zhang Hui Meng Qianqian Zhang Xiaofang Chen Weiqiang Li Qiang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 16 | 基于蒙特卡罗模拟的重离子精确笔形束模拟研究显示文摘An accurate kernel model is of vital importance for pencil-beam dose algorithm in charged particle therapy using precise spot-scanning beam delivery,in which an accurate depiction of the low dose envelope is especially crucial.Although the dose level of the low dose envelope is under 3 or 4 orders of magnitude to the dose in the beam axis,the superimposed effect cannot be neglected.In many primary versions of treatment planning system(TPS)for proton or carbon ion therapy,two-dimension single Gaussian model is used to calculate the lateral dose distribution of pencil beam in medium[1��3].However,it was found that the single Gaussian model does not depict adequately the dose contributed from secondary particles especially for low dose envelope. | Zhang Hui Dai Zhongying Liu Xinguo Chen Weiqiang Ma Yuanyuan He Pengbo Dai Tianyuan Shen Guosheng Yuan Ping Li Qiang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 17 | 二重高斯-逻辑斯蒂模型的计量计算精确性验证显示文摘The accuracy of dose calculation is of vital importance in treatment planning system(TPS).Taking the low dose envelope of carbon-ion pencil beam into consideration,a novel model,called as double Gaussian-logistic model,has been proposed to depict the lateral dose distribution of carbon-ion pencil beam in our previous work,where the accuracy of the model was preliminarily verified using both single-spot beam and superposed fields in various cases for carbon-ion pencil beam[1].In this work,virtual spherical target volumes of different sizes in water tank were adopted to testify the superiority of the double Gaussian-logistic modelto the single,double and triple Gaussian models for carbon ion beam further.Based on Monte Carlo(MC)simulation and dose optimization-oriented iterative least square method,comparisons of the dose distributions between the MC simulations and calculations using the single。 | Zhang Hui Dai Tianyuan Liu Xinguo Chen Weiqiang Ma Yuanyuan He Pengbo Shen Guosheng Yuan Ping Dai Zhongying Li Qiang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 18 | A DAC-CLGD-Danet network based method for defaced image segmentation显示文摘Based on the problems of high noise,lower contrast,and complex features in defaced images and the low accuracy of existing defaced image segmentation techniques,this paper proposes a defaced image segmentation algorithm based on DAC-CLGD-Danet.Firstly,a CBDNet asymmetric blind denoising network is used for noise-containing defaced images,and natural and synthetic images are trained together to model the image noise and enhance the denoising ability of natural noise.Secondly,Danet is used as the base network.A Dense Atrous Convolution module(DAC)is added to the dual attention mechanism module to extend the perceptual domain of deep convolution,reduce image feature loss,and enhance the representation of global information and edge features of defaced images;Cross-Level Gating Decoder module(CLGD)is introduced to lighten the segmentation network,enhance image context aggregation,and produce accurate semantic segmentation.The experimental results demonstrated that the method in this paper has a significant effect on the HRF dataset and Cityscapes dataset,with a significant improvement compared with FCN,UNet,and SETR models,with Intersection over Union(IoU)improved by 9.81%and Mean Intersection over Union(mIoU)improved by 3.01%compared with UNet. | Pengbo Li Gang Li Yibin He Ling Zhang Yuanjin Sun Fayun Guo | 2022 | Intelligent and Converged Networks2022，3，3： | 0 |
| 19 | Study on Particle Dose Distributions in Carbon-ion Pencil Beam显示文摘In heavy ion radiotherapy,secondary particles impact not only on physical dose but also on biological effective dose due to different radiation qualities contributed from different secondary particles.Therefore,it is necessary to comprehend the constitutions of carbon-ion pencil beam along its penetration. | Zhang Hui Li Qiang Liu Xinguo Dai Zhongying Chen Weiqiang Ma Yuanyuan He Pengbo Shen Guosheng Dai Tianyuan | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 20 | A Logistic Nanodosimetry Model to Predict the Relative Biological Effectiveness in Ion-Beam Therapy显示文摘Althoughl physical characteristics of ion beam are well understood,the complex relative biological effectiveness(RBE)prevents it from playing its all the potential clinical advantages.To better predict the RBE in ion-beam therapy,a novel logistic nanodosimetry model(LNDM)based on the ion cluster size distributions on nanoscale was established. | Dai Tianyuan Liu Xinguo Dai Zhongying He Pengbo Shen Guosheng Ma Yuanyuan Zhang Hui Meng Qianqian Zhang Xiaofang Chen Weiqiang Li Qiang | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
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