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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Detection of alcoholic liver disease显示文摘INTRODUCTIONAlcohol has been used in society over centuries and all over the world for its mood-lifting properties and taste. It is probably ,however ,the commonest drug of abuse world-wide and unfortunately causes considerable morbidity, mortality and social disruption .In 1990 the cost tl the USA was more than $ 100 billion and 100 000 lives.The relationship between alcohol and mankind is well documented from the earliest tines . | Harriet Gordon | 2001 | World Journal of Gastroenterology2001，7，3： | 13 |
| 3 | 从其他慢性疾病的研究证据看社区干预能否降低老年痴呆病的危险显示文摘目的用科学的证据支持老年痴呆病社区教育战略的开发。方法通过对国家健康优先领域的证据分析,提出慢性疾病社区干预的共性特点,并特别提出针对少数和弱势人群的干预策略。结果需要采取全方位干预策略,并通过周密的计划和评价来保证目标人群能获得足够的健康教育信息。结论应该进一步对降低老年痴呆病危险的干预策略进行深入研究。国际上各种证据一致表明,社区健康教育是现在采取的主要策略。 | Jocelyn Angus Jane Sims Susan Feldman Harriet Radermacher | 2008 | 中国全科医学2008，11，19： | 9 |
| 4 | 老年痴呆的负担以及通过社区干预降低老年痴呆的危险显示文摘本文讨论老年痴呆的病因学以及与其他疾病的关系,并讨论采用社区干预方法降低人群的老年痴呆危险。认为针对可治疗的并发症采取积极的诊断和社区教育策略,可以降低或延迟老年痴呆的发病,从而提高病人的生活质量和改善卫生资源的有效利用。 | Jane Sims Jocelyn Angus Susan Feldman Harriet Radermacher | 2008 | 中国全科医学2008，11，17： | 8 |
| 5 | Predicting and monitoring cancer treatment response with diffusion‐weighted MRI显示文摘 | Harriet C.Thoeny Brian D.Ross | 2010 | J Magn Reson Imaging2010，，1： | 3 |
| 6 | Cytokine mucosal expression in ulcerative colitis, the relationship between cytokine release and disease activity显示文摘 | Daniel S. Pearl Krina Shah Mark A. Whittaker Harriet Nitch-Smith James F. Brown Janis K. Shute Timothy M. Trebble | 2012 | Journal of Crohn’s and Colitis2012，，： | 3 |
| 7 | Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications显示文摘Autosomal dominant osteopetrosis type 2 (ADO2) is a high-density brittle bone disease characterized by bone pain,multiple fractures and skeletal-related events,including nerve compression syndrome and hematological failure.We demonstrated that in mice carrying the heterozygous Clcn7^G213R mutation,whose human mutant homolog CLCN7^G215R affects patients,the clinical impacts of ADO2 extend beyond the skeleton,affecting several other organs.The hallmark of the extra-skeletal alterations is a consistent perivascular fibrosis,associated with high numbers of macrophages and lymphoid infiltrates.Fragmented clinical information in a small cohort of patients confirms extra-skeletal alterations consistent with a systemic disease,in line with the observation that the CLCN7 gene is expressed in many organs.ADO2 mice also show anxiety and depression and their brains exhibit not only perivascular fibrosis but also β-amyloid accumulation and astrogliosis,suggesting the involvement of the nervous system in the pathogenesis of the ADO2 extra-skeletal alterations.Extra-skeletal organs share a similar cellular pathology,confirmed also in vitro in bone marrow mononuclear cells and osteoclasts,characterized by an impairment of the exit pathway of the Clcn7 protein product,ClC7,through the Golgi,with consequent reduced ClC7 expression in late endosomes and lysosomes,associated with high vesicular pH and accumulation of autophagosome markers.Finally,an experimental siRNA therapy,previously proven to counteract the bone phenotype,also improves the extra-skeletal alterations.These results could have important clinical implications,supporting the notion that a systematic evaluation of ADO2 patients for extra-skeletal symptoms could help improve their diagnosis,clinical management,and therapeutic options. | Antonio Maurizi Mattia Capulli Annabel Curle Rajvi Patel Argia Ucci Juliana Alves Cotes Harriet Oxford Shireen R. Lamandé John F. Bateman Nadia Rucci Anna Teti | 2019 | Bone Research2019，7，2： | 3 |
| 8 | 通过社会营销提高社区对公共健康问题的认识:怎样降低老年痴呆病的危险显示文摘降低老年痴呆危险的战略的一个突出特点,是让居民掌握老年痴呆早期发病的知识,并认识到通过降低风险能延缓因疾病导致的社会和经济成本。本研究探讨社会营销在社区教育战略中的效果,并分析其在降低老年痴呆危险中的作用。本文重点介绍通过大众传媒的社会营销在强化社区对公共卫生问题意识方面的效果。结论为应该在今后的公共卫生项目中使用社会营销技术,在降低老年痴呆危险的项目中,更应该在特定的目标人群中使用社会营销。 | Jocelyn Angus Jane Sims Susan Feldman Harriet Radermacher 杨辉 | 2010 | 中国全科医学2010，13，34： | 3 |
| 9 | Comparison of Intestinal Permeabilities Determined in Multiple in Vitro and in Situ Models: Relationship to Absorption in Humans显示文摘 | Barbra H. Stewart O. Helen Chan Rosalind H. Lu Eric L. Reyner Heidi L. Schmid Harriet W. Hamilton Bruce A. Steinbaugh Michael D. Taylor | 1995 | Pharmaceutical Research1995，，5： | 2 |
| 10 | Acute Severe Isovolemic Anemia Impairs Cognitive Function and Memory in Humans显示文摘 | Richard B. Weiskopf Joel H. Kramer Maurene Viele Mireille Neumann John R. Feiner Jessica J. Watson Harriet W. Hopf Pearl Toy | 2000 | Anesthesiology2000，，6： | 2 |
| 11 | Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway显示文摘 | Kusum K. Kharbanda Mark E. Mailliard Cheryl R. Baldwin Harriet C. Beckenhauer Michael F. Sorrell Dean J. Tuma | 2006 | Journal of Hepatology2006，，2： | 2 |
| 12 | Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: Protection by betaine显示文摘 | Kusum K. Kharbanda David D. Rogers Mark E. Mailliard Gerri L. Siford Anthony J. Barak Harriet C. Beckenhauer Michael F. Sorrell Dean J. Tuma | 2005 | Biochemical Pharmacology2005，，12： | 2 |
| 13 | Presence of Nosema ceranae in honeybees ( Apis mellifera ) in Uruguay显示文摘 | Ciro Invernizzi Carolina Abud Ivanna H. Tomasco Jorge Harriet Gustavo Ramallo Juan Campá Helena Katz Gabriela Gardiol Yamandú Mendoza | 2009 | Journal of Invertebrate Pathology2009，，2： | 2 |
| 14 | A new generation of HIV vaccines显示文摘 | Harriet L R | 2002 | Trends in Molecular Medicine2002，8，10： | 1 |
| 15 | Levofoxacin: areview of its antibacterial activity,pharmacokineties and therapeutic efficacy 显示文摘 | RICK D HARRIET MB | 2004 | Drugs2004，47，10： | 1 |
| 16 | Validity and eliability of Resource Utilization Groups(RUG-Ⅲ )in finnish long-term care facilities显示文摘 | Magnus AB Unto H Harriet U | 1999 | Scand J Public Health1999，27，： | 1 |
| 17 | miR-193b Regulates Mcl-1 in Melanoma显示文摘 | Jiamin Chen Xiao Zhang Cindy Lentz Marie Abi-Daoud Geneviève C. Paré Xiaolong Yang Harriet E. Feilotter Victor A. Tron | 2011 | The American Journal of Pathology2011，，5： | 1 |
| 18 | Proteolytic abilities of some Lactic acid bacteria in a model cheese system显示文摘 | Nana Y Farkye Sabry A Madkor Harriet G Atkins | 1995 | International Dairy Journal1995，5，7： | 1 |
| 19 | Preoperative Fasting:Knowledge and Perceptions显示文摘 | Patrice Baril Harriet Portman | 2007 | AORN2007，86，4： | 1 |
| 20 | Cusp gun TE21 second-harmonic Ka-band gyro-TWT amplifier显示文摘 | HARRIET S B MCDERMOTT D B GALLAGHER DA | 2002 | IEEE Trans Plasma Science2002，30，3： | 1 |
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