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| 1 | 曲马多治疗糖尿病性神经疼痛的双盲随机试验显示文摘目的 :本研究旨在评价曲马多治疗糖尿病性神经痛的有效性和安全性。背景 :糖尿病性神经痛是糖尿病患者的主要症状 ,其治疗和其他的末梢神经病变一样 ,不能令人满意。曲马多是作用于中枢的镇痛剂 ,用于治疗中到重度疼痛。方法 :多中心、门诊病例、随机、双盲、安慰剂做对照、设置平行组的研究 ,包括清洗期 (在此期间停用所有镇痛剂 )和一个为期 42天的双盲治疗期。总共有 1 31名患糖尿病性神经痛的患者按每日 4次接受了曲马多 (n =65)或看上去与曲马多相同的安慰剂胶囊治疗 (n =66)。 42天的治疗结束后或治疗中断后比较曲马多组和安慰剂组平均疼痛强度评分作出主要有效性分析 ;次要有效性分析为疼痛缓解率评分和根据日常活动和睡眠状况作出的对生活质量的评估。结果 :曲马多平均剂量为 2 1 0mg/天 ,治疗糖尿病性神经痛较安慰剂有显著疗效 (P≤ 0 .0 0 1 )。曲马多组患者生理(P =0 .0 2 )和社会功能 (P =0 .0 4 )的评分显著优于安慰剂组。未发现对睡眠有显著治疗作用。曲马多最常见的不良反应是恶心 ,便秘 ,头疼和嗜睡。结论 | Harati Y Gooch C Swenson M Green D Raskin P Donofrio P Cornblath D Sachdeo R Siu CO Kamin M | 2001 | 中国疼痛医学杂志2001，7，1： | 2 |
| 2 | Extracorporeal membrane oxygenation for acute respiratory distress syndrome in burn patients:a case series and literature update显示文摘Background:Acute respiratory distress syndrome(ARDS)has a reported incidence of 34–43%in ventilated burn patients and is associated with a mortality of 59%in the severe form.The use and experience with extracorporeal membrane oxygenation(ECMO)in burn patients developing ARDS are still limited.We present our results and discuss the significance of ECMO in treating burn patients.Methods:A retrospective analysis of burn patients treated with ECMO for ARDS between January 2017 and January 2019 was performed.Demographic,clinical,and outcome data were collected and analyzed.Results:Eight burn patients were treated at our institution with ECMO in the designated time period.Of these,all but one patient had inhalation injury,burn percentage of TBSA was 37±23%,ABSI score was 8.4±2,and R-Bauxscore was 98±21.Seven patients developed severe ARDS and one patient moderate ARDS according to the Berlin classification with a PaO_(2)/FiO_(2) ratio upon initiation of ECMO therapy of 62±22 mmHg.ECMO duration was 388±283 h.Three patients died from severe sepsis while five patients survived to hospital discharge.Conclusions:ECMO is a viable therapy option in burn patients developing severe ARDS and can contribute to survival rates similar to ECMO therapy in non-burn-associated severe ARDS.Consequently,patients with severe respiratory insufficiency with unsuccessful conventional treatment and suspected worsening should be transferred to burn units with the possibility of ECMO treatment to improve outcome. | Mehran Dadras Johannes M.Wagner Christoph Wallner Julika Huber Dirk Buchwald Justus Strauch Kamran Harati Nicolai Kapalschinski Björn Behr Marcus Lehnhardt | 2019 | Burns & Trauma2019，7，1： | 2 |
| 3 | Maintenance of the long-term effectiveness of tramadol in treatment of the pain of diabetic neuropathy显示文摘 | Gooch C Swenson M | 2000 | J Diabetes Complication2000，14，2： | 1 |
| 4 | Doubleblind randomized trial of tramal for the pain of diabetic neuropathy显示文摘 | Harati Y Gooch C Swenson M | 1998 | Neurology1998，50，： | 1 |
| 5 | Meta-analysis of microarray gene expression studies on intracranial aneurysms显示文摘 | Roder C Kasuya H Harati A | | 0，，： | 1 |
| 6 | Myeloneuropathic presentation of spinal epidural lipomatosis显示文摘 | Izadyar S Kwan JY Harati Y | 2006 | Journal of clinical neuromuscular disease2006，7，3： | 1 |
| 7 | Sympathetic skin response in diabetic neuropathy显示文摘 | Niakan E Harati Y | 1988 | Muscle Nerve1988，2，： | 1 |
| 8 | Diabetic neuropathies: unanswered questions 显示文摘 | Harati Y | 2007 | Neurol Clin2007，25，1： | 1 |
| 9 | Evaluating the incidence of cognitive disorder following off-pump coronary artery bypasses surgery and its predisposing factors显示文摘 | Joudi M Fathi M Harati H | 2014 | Anesth Pain Med2014，4，18： | 1 |
| 10 | Diabetic neuropathies : Unanswered questions 显示文摘 | Harati Y | 2007 | Neurol Clin2007，25，1： | 1 |
| 11 | Preparation of solid lipid nanoparticles using a membrane contactor显示文摘 | Charcosset C El- Harati A Fessi H | 2005 | J Control Release2005，108，1： | 1 |
| 12 | TRAIL and Taurolidine Enhance the Anticancer Activity of Doxorubicin, Trabectedin and Mafosfamide in HT 1080 Human Fibrosarcoma Ceils 显示文摘 | Harati K Chromik AM Bulut D | 2012 | Anticancer Res2012，32，7： | 1 |
| 13 | Effects of surface alloying on microstructure and wear be- havior of ductile iron surface-modi? ed with anickel-based alloy using shielded metal arc welding 显示文摘 | JESHVAGHANI R A HARATI E SHAMANIAN M | 2011 | Materials and Design2011，32，： | 1 |
| 14 | Prevalence of gestmional di- abetes melitus in southern Iran (Bandar Abbas City) 显示文摘 | Hadaegh F Tohidi M Harati H | 2005 | Endocr Pract2005，11，5： | 1 |
| 15 | Effect of vanadyl sulfate on fructose-induced insulin resistance rat显示文摘 | Harati M Ani M Messripour M | 2003 | Iranian Biomedical Journal2003，7，4： | 1 |
| 16 | Diabetes and the Nervous System显示文摘 | Harati Y | 1996 | Chronic Complications Diabetes1996，25，2： | 1 |
| 17 | Silent myocardial infarction and diabetic cardiovascular autonomic neuropathy显示文摘 | Niakan E Harati Y Rolak LA | | 0，，11： | 1 |
| 18 | Double-blind random- ized trial of tramadol for the treatment of the pain of diabetic neuropathy显示文摘 | Harati Y Gooch C Swenson M | 1998 | Neurology1998，50，6： | 1 |
| 19 | Sympathetic skin response in diabetic peripheral neuropathy显示文摘 | Niakan E Harati Y | 1988 | Muscle Nerve1988，11，3： | 1 |
| 20 | Maintenance of the long-term effectiveness of tramadol in treatment of the pain of diabetic neuropathy显示文摘 | Harati Y Gooch C Swenson M | 2000 | J Diabetes Complications2000，14，2： | 1 |
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