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| 1 | Washed microbiota transplantation vs.manual fecal microbiota transplantation:clinical findings,animal studies and in vitro screening显示文摘Fecal microbiota transplantation(FMT)by manual preparation has been applied to treat diseases for thousands of years.However,this method still endures safety risks and challenges the psychological endurance and acceptance of doctors,patients and donors.Population evidence showed the washed microbiota preparation with microfiltration based on an automatic purification system followed by repeated centrifugation plus suspension for three times significantly reduced FMT-related adverse events.This washing preparation makes delivering a precise dose of the enriched microbiota feasible,instead of using the weight of stool.Intraperitoneal injection in mice with the fecal microbiota supernatant obtained after repeated centrifugation plus suspension for three times induced less toxic reaction than that by the first centrifugation following the microfiltration.The toxic reactions that include death,the change in the level of peripheral white blood cells,and the proliferation of germinal center in secondary lymphoid follicles in spleen were noted.The metagenomic next-generation sequencing(NGS)indicated the increasing types and amount of viruses could be washed out during the washing process.Metabolomics analysis indicated metabolites with pro-inflammatory effects in the fecal microbiota supernatant such as leukotriene B4,corticosterone,and prostaglandin G2 could be removed by repeated washing.Near-infrared absorption spectroscopy could be served as a rapid detection method to control the quality of the washingprocess.In conclusion,this study for the first time provides evidence linking clinical findings and animal experiments to support that washed microbiota transplantation(WMT)is safer,more precise and more quality-controllable than the crude FMT by manual. | Ting Zhang Gaochen Lu Zhe Zhao Yafei Liu Quan Shen Pan Li Yaoyao Chen Haoran Yin Huiquan Wang Cicilia Marcella Bota Cui Lei Cheng Guozhong Ji Faming Zhang | 2020 | Protein & Cell2020，11，4： | 44 |
| 2 | Root microbiota shift in rice correlates with resident time in the field and developmental stage显示文摘Land plants in natural soil form intimate relationships with the diverse root bacterial microbiota. A growing body of evidence shows that these microbes are important for plant growth and health. Root microbiota composition has been widely studied in several model plants and crops; however, little is known about how root microbiota vary throughout the plant's life cycle under field conditions. We performed longitudinal dense sampling in field trials to track the time-series shift of the root microbiota from two representative rice cultivars in two separate locations in China. We found that the rice root microbiota varied dramatically during the vegetative stages and stabilized from the beginning of the reproductive stage, after which the root microbiota underwent relatively minor changes until rice ripening. Notably, both rice genotype and geographical location influenced the patterns of root microbiota shift that occurred during plant growth. The relative abundance of Deltaproteobacteria in roots significantly increased overtime throughout the entire life cycle of rice, while that of Betaproteobacteria, Firmicutes, and Gammaproteobacteria decreased. By a machine learning approach, we identified biomarker taxa and established a model to correlate root microbiota with rice resident time in the field(e.g., Nitrospira accumulated from 5 weeks/tillering in field-grown rice). Our work provides insights into the process of rice root microbiota establishment. | Jingying Zhang Na Zhang Yong-Xin Liu Xiaoning Zhang Bin Hu Yuan Qin Haoran Xu Hui Wang Xiaoxuan Guo Jingmei Qian Wei Wang Pengfan Zhang Tao Jin Chengcai Chu Yang Bai | 2018 | Science China(Life Sciences)2018，61，6： | 24 |
| 3 | High Temperature Strain Structures and Quartz C-Axis Fabrics from Mylonitic Rocks in the Ailaoshan-Red River Shear Zone,Yunnan,and Their Tectonic Implication显示文摘Ailaoshan 红的河(ASRR ) 砍地区是考虑了东方西藏的现在的构造框架的主要东南亚洲构造断绝之一。几座变形山岳沿着 shear 地区线性地是分布式的,例如从北方的 Xuelongshan, Diancangshan, Ailaoshan 和到南方的天 Nui 反对 Voi。他们为构造进化忍受证据的很多线东方在在不同构造舞台的不同外壳的层次西藏。争吵仍然沿着 ASRR 在有变态的变丑结构,微观结构和他们的关系上存在。在这,纸详细说明了微结构和 EBSD (电子 Backscattered 衍射) 从沿着 ASRR 的不同山岳的一些高度砍的花岗石的岩石的织物分析被进行。高温度结构和微观结构在 unsheared 片麻岩被保存,在微弱地砍的捕虏体或在高度砍的岩石(糜棱岩) 的一些部分。高温度石英 c 轴织物的几种类型显示出对称的模式或转变从对不均匀的模式对称。前者在在印第安人欧亚的构造相互作用的一个早阶段的地区性的弄短期间被归因于同轴的变丑,后者与从同轴的压缩的转变有关到在让侧面的 post-collisional ASRR 期间砍的 noncoaxial 砍。 | LIU Junlai TANG Yuan XIA Haoran GUO Qiang TRAN My Dung CAO Shuyun WU Hujun WU Wenbin ZHANG Zhaochong ZHAO Zhidan | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 12 |
| 4 | First observation of tropospheric nitrogen dioxide from the Environmental Trace Gases Monitoring Instrument onboard the GaoFen-5 satellite显示文摘The Environmental Trace Gases Monitoring Instrument(EMI)is the first Chinese satellite-borne UV–Vis spectrometer aiming to measure the distribution of atmospheric trace gases on a global scale.The EMI instrument onboard the GaoFen-5 satellite was launched on 9 May 2018.In this paper,we present the tropospheric nitrogen dioxide(NO2)vertical column density(VCD)retrieval algorithm dedicated to EMI measurement.We report the first successful retrieval of tropospheric NO_(2) VCD from the EMI instrument.Our retrieval improved the original EMI NO_(2) prototype algorithm by modifying the settings of the spectral fit and air mass factor calculations to account for the on-orbit instrumental performance changes.The retrieved EMI NO_(2) VCDs generally show good spatiotemporal agreement with the satellite-borne Ozone Monitoring Instrument and TROPOspheric Monitoring Instrument(correlation coefficient R of ~0.9,bias<50%).A comparison with ground-based MAX-DOAS(Multi-Axis Differential Optical Absorption Spectroscopy)observations also shows good correlation with an R of 0.82.The results indicate that the EMI NO_(2) retrieval algorithm derives reliable and precise results,and this algorithm can feasibly produce stable operational products that can contribute to global air pollution monitoring. | Chengxin Zhang Cheng Liu Ka Lok Chan Qihou Hu Haoran Liu Bo Li Chengzhi Xing Wei Tan Haijin Zhou Fuqi Si Jianguo Liu | 2020 | Light(Science & Applications)2020，9，1： | 11 |
| 5 | Effects of tourmaline on nitrogen removal performance and biofilm structures in the sequencing batch biofilm reactor显示文摘The effects of tourmaline on nitrogen removal performance and biofilm structures were comparatively investigated in two identical laboratory-scale sequencing batch biofilm reactors(SBBRs)(denoted SBBR1 and SBBR2) at different nitrogen loading rates(NLRs) varying from(0.24 ± 0.01) to(1.26 ± 0.02) g N/(L·day). SBBR1 was operated in parallel with SBBR2, but SBBR1 was filled with polyurethane foam loaded tourmaline(TPU) carriers and another(SBBR2) filled with polyurethane foam(PU) carriers. Results obtained from this study showed that the excellent and stable performance of SBBR1 was obtained. Ammonia nitrogen removal and total nitrogen removal were higher in SBBR1 than that in SBBR2 with increase of NLR. At an NLR of(0.24 ± 0.01) g N/(L·day), the majority of the spherical and elliptical bacteria were surrounded by the extracellular polymeric substance(EPS) and bacillus or filamentous bacteria in two SBBRs biofilms. When NLR increased to(1.26 ± 0.02) g N/(L·day), the clusters were more obvious in the SBBR1 biofilm than that in the SBBR2 biofilm. Bacteria in SBBR1 were inclined to synthesis more EPS, and the formed EPS could protect the bacteria from free ammonia(FA) under extreme condition NLR(1.26 ± 0.02) g N/(L·day). The results of polymerase chain reaction-denaturing gradient gel electrophoresis analysis showed that the microbial community similarity in SBBR2 decreased more obviously than that in SBBR1 with the increase of NLR, which the microbial community in SBBR1 was relatively stable. | Chong Tan Haoran Xu Di Cui Jinlong Zuo Junsheng Li Yubin Ji Shan Qiu Lin Yao Ying Chen Yingjie Liu | 2018 | Journal of Environmental Sciences2018，30，5： | 10 |
| 6 | Ni Flower/MXene-Melamine Foam Derived 3D Magnetic/Conductive Networks for Ultra-Efficient Microwave Absorption and Infrared Stealth显示文摘The development of multifunctional and efficient electromagnetic wave absorbing materials is a challenging research hotspot.Here,the magnetized Ni flower/MXene hybrids are successfully assembled on the surface of melamine foam(MF)through electrostatic self-assembly and dip-coating adsorption process,realizing the integration of microwave absorption,infrared stealth,and flame retardant.Remarkably,the Ni/MXene-MF achieves a minimum reflection loss(RLmin)of−62.7 dB with a corresponding effective absorption bandwidth(EAB)of 6.24 GHz at 2 mm and an EAB of 6.88 GHz at 1.8 mm.Strong electromagnetic wave absorption is attributed to the three-dimensional magnetic/conductive networks,which provided excellent impedance matching,dielectric loss,magnetic loss,interface polarization,and multiple attenuations.In addition,the Ni/MXene-MF endows low density,excellent heat insulation,infrared stealth,and flame-retardant functions.This work provided a new development strategy for the design of multifunctional and efficient electromagnetic wave absorbing materials. | Haoran Cheng Yamin Pan Xin Wang Chuntai Liu Changyu Shen Dirk W.Schubert Zhanhu Guo Xianhu Liu | 2022 | Nano-Micro Letters2022，14，4： | 7 |
| 7 | Development of ecohydrological assessment tool and its application显示文摘The development of Hydro-Informatic Modelling System (HIMS) provides an integrated platform for hydrological simulation. To extend the application of HIMS, an ecohydrological modeling system named ecohydrological assessment tool (EcoHAT) has been developed. Integrating parameter-management tools, RS (remote sensing) inversion tools, module-design tools and GIS analysis tools, the EcoHAT provides an integrated tool to simulate ecohydrological processes on regional scale, which develops a new method on sustainable use of water. EcoHAT has been applied to several case studies, such as, the Yellow River Basin, the acid deposition area in Guizhou province and the riparian catchment of Guanting reservoir in Beijing. Results prove that EcoHAT can efficiently simulate and analysis the ecohydrological processes on regional scale and provide technical support to integrated water resources management on basin scale. | LIU ChangMing YANG ShengTian WEN ZhiQun WANG XueLei WANG YuJuan LI Qian SHENG HaoRan | 2009 | Science China(Technological Sciences)2009，52，7： | 7 |
| 8 | Conversion between polarization states based on a metasurface显示文摘Transmission of an anisotropic metasurface is analyzed in a polar base relying on the Jones calculus, and polarization conversion from the spatial uniform polarization to the spatial nonuniform polarization is explored.Simple and compact polarization converters based on rectangular holes or cross holes etched in silver film are designed, and polarization conversions from the linear and circular polarization to the radial and azimuthal polarization are realized. Numerical simulations of three designed polarization converters consisting of rectangular holes equivalent to polarizers and quarter-and half-wave plates, exhibit the perfect polarization conversion.The experiment results consistent with the simulations verify theoretic predictions. This study is helpful for designing metasurface polarization converters and expanding the application of a metasurface in polarization manipulations. | SHUYUN TENG QI ZHANG HAN WANG LIXIA LIU HAORAN LV | 2019 | Photonics Research2019，7，3： | 7 |
| 9 | Reinforcement Learning-Based Joint Task Offloading and Migration Schemes Optimization in Mobility-Aware MEC Network显示文摘Intelligent edge computing carries out edge devices of the Internet of things(Io T) for data collection, calculation and intelligent analysis, so as to proceed data analysis nearby and make feedback timely. Because of the mobility of mobile equipments(MEs), if MEs move among the reach of the small cell networks(SCNs), the offloaded tasks cannot be returned to MEs successfully. As a result, migration incurs additional costs. In this paper, joint task offloading and migration schemes in mobility-aware Mobile Edge Computing(MEC) network based on Reinforcement Learning(RL) are proposed to obtain the maximum system revenue. Firstly, the joint optimization problems of maximizing the total revenue of MEs are put forward, in view of the mobility-aware MEs. Secondly, considering time-varying computation tasks and resource conditions, the mixed integer non-linear programming(MINLP) problem is described as a Markov Decision Process(MDP). Then we propose a novel reinforcement learning-based optimization framework to work out the problem, instead traditional methods. Finally, it is shown that the proposed schemes can obviously raise the total revenue of MEs by giving simulation results. | Dongyu Wang Xinqiao Tian Haoran Cui Zhaolin Liu | 2020 | China Communications2020，17，8： | 7 |
| 10 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 11 | Recent developments in luminescent nanoparticles for plant imaging and photosynthesis显示文摘Luminescent nanoparticles(upconversion nanoparticles,carbon dots,silicon nanoparticles and nanophosphors)have the advantages of tunable photoluminescence,good biocompatibility,low cytotoxicity and chemical/physical stability.Recently,the luminescent nanoparticles have been involved in the plant research for imaging plant phenotype and improving the photosynthesis efficiency.Luminescent nanoparticles are applied for the plant imaging in vivo and in vitro,while the plant photosynthesis is dependent on the specific light wavelength,providing the luminescent nanoparticles an opportunity to optimize the agriculture light.This review presents the recent developments of luminescent nanoparticles applied on the plant imaging and photosynthesis and discusses the trend for future research. | Riyue Dong Yanjuan Li Wei Li Haoran Zhang Yingliang Liu Li Ma Xiaojun Wang Bingfu Lei | 2019 | Journal of Rare Earths2019，37，9： | 5 |
| 12 | Emerging roles of transforming growth factor β signaling in wet age-related macular degeneration显示文摘Age-related macular degeneration (AMD) is one of the major causes of irreversible blindness among aging populations in developed countries and can be classified as dry or wet according to its progression.Wet AMD,which is characterized by angiogenesis on the choroidal membrane,is uncommonly seen but more severe.Controlling or completely inhibiting the factors that contribute to the progression of events that lead to angiogenesis may be an effective strategy for treating wet AMD.Emerging evidence has shown that transforming growth factor-β(TGF-β) signaling plays a significant role in the progression of wet AMD.In this review,we described the roles of and changes in TGF-β signaling in the development of AMD and discussed the mechanisms of the TGF-β superfamily in choroidal neovascularization (CNV) and wet AMD,including the modulation of angiogenesis-related factors,inflammation,vascular fibrosis,and immune responses,as well as cross-talk with other signaling pathways.These remarkable findings indicate that TGF-β signaling is a potential target for wet AMD treatment. | Kai Wang Haoran Li Ruipu Sun Chaxian Liu Yunfei Luo Shuhua Fu Ying Ying | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 5 |
| 13 | A Green Biocompatible Fabrication of Highly Porous Functional Ceramics with High Strength and Controllable Pore Structures显示文摘A green biocompatible foaming method utilizing natural coconut oil and cornstarch was developed to fabricate highly porous functional ceramics with controllable strengths and pore structures. The porosity of Al2O3 ceramics prepared via this method reached 79.6%–86.9% while these ceramics maintained high compressive strengths of 2.2–5.5 MPa. More importantly, porous Al2O3 ceramic with a pore size gradient was also readily fabricated by casting serial layers of foams that were set for different time periods.The potential applications of porous Al2O3 and HA ceramics fabricated by this green foaming method including scaffolds for oil cleaning and cell culture, respectively, were also demonstrated. | Changlu Xu Haoran Liu Huilin Yang Lei Yang | 2016 | Journal of Materials Science & Technology2016，32，8： | 4 |
| 14 | Three Tiaobu Feishen therapies protect human alveolar epithelial cells against cigarette smoking and tumor necrosis factor-mlear factor-kappa B pathwayα-induced inflamation by nuc显示文摘OBJECTIVE: To investigate the efficacy of Tiaobu Feishen formulae(TBFS), including Bufei Jianpi formula(BJF), Bufei Yishen formula(BYF), and Yiqi Zishen formula(YZF), on inflammatory response, protease-anti-protease imbalance and collagen deposition in rats.METHODS: In present work, we used an in vitro model of cigarette smoking extract(CSE)-and tumor necrosis factor-α(TNF-α)-induced A549 cellsto examine the efficacy of BJF, BYF and YZF on the production of inflammatory cytokines, including TNF-α and interleukin(IL)-8, IL-6, matrix metalloproteinases(MMP)-9, and IL-10 in CSE or TNF-ls. And their related transcripα-induced A549 celtion factors and signaling pathway were also analyzed.RESULTS: The results showed that BJF, BYF and YZF could significantly decrease the expression levels of the pro-inflammatory cytokines induced by CSE or TNF-α. Furthermore, BJF, BYF and YZF could suppress CSE-or TNF-α-induced activation of nuclear factor-kappa B(NF-κB) transcription factors and its corresponding pathways. Taken together, these data implied that BJF, BYF and YZF effectively inhibited CSE-or TNF-α-induced inflammatory response in alveolar epithelial cell, which was due to their inhibition effect on NF-κB pathways.CONCLUSION: Our findings suggest that the Tiaobu Feishen therapies may protect human alveolar epithelial cells against cigarette smoking and TNF-α-induced inflammation. NF-κB pathway may involve in the actions. | Chen Yulong Wu Yaosong Li Jiansheng Feng Suxiang Hao Lili Liu Xuefang Zheng Wanchun Dong Haoran Qin Yanqin Yin Sugai Zhao Peng | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 4 |
| 15 | An Examination of the Predictability of Tropical Cyclone Genesis in High-Resolution Coupled Models with Dynamically Downscaled Coupled Data Assimilation Initialization显示文摘Predicting tropical cyclone(TC)genesis is of great societal importance but scientifically challenging.It requires fineresolution coupled models that properly represent air−sea interactions in the atmospheric responses to local warm sea surface temperatures and feedbacks,with aid from coherent coupled initialization.This study uses three sets of highresolution regional coupled models(RCMs)covering the Asia−Pacific(AP)region initialized with local observations and dynamically downscaled coupled data assimilation to evaluate the predictability of TC genesis in the West Pacific.The APRCMs consist of three sets of high-resolution configurations of the Weather Research and Forecasting−Regional Ocean Model System(WRF-ROMS):27-km WRF with 9-km ROMS,and 9-km WRF with 3-km ROMS.In this study,a 9-km WRF with 9-km ROMS coupled model system is also used in a case test for the predictability of TC genesis.Since the local sea surface temperatures and wind shear conditions that favor TC formation are better resolved,the enhanced-resolution coupled model tends to improve the predictability of TC genesis,which could be further improved by improving planetary boundary layer physics,thus resolving better air−sea and air−land interactions. | Mingkui LI Shaoqing ZHANG Lixin WU Xiaopei LIN Ping CHANG Gohkan DANABASOGLU Zhiqiang WEI Xiaolin YU Huiqin HU Xiaohui MA Weiwei MA Haoran ZHAO Dongning JIA Xin LIU Kai MAO Youwei MA Yingjing JIANG Xue WANG Guangliang LIU Yuhu CHEN | 2020 | Advances in Atmospheric Sciences2020，37，9： | 4 |
| 16 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 17 | Optimization of the O_(3)/H_(2)O_(2) process with response surface methodology for pretreatment of mother liquor of gas field wastewater显示文摘The present study reports the use of the O_(3)/H_(2)O_(2) process in the pretreatment of the mother liquor of gas field wastewater(ML-GFW),obtained from the multi-effect distillation treatment of the gas field wastewater.The range of optimal operation conditions was obtained by single-factor experiments.Response surface methodology(RSM)based on the central composite design(CCD)was used for the optimization procedure.A regression model with Total organic carbon(TOC)removal efficiency as the response value was established(R^(2)=0.9865).The three key factors were arranged according to their significance as:pH>H_(2)O_(2) dosage>ozone flow rate.The model predicted that the best operation conditions could be obtained at a pH of 10.9,an ozone flow rate of 0.8 L/min,and H_(2)O_(2) dosage of 6.2 mL.The dosing ratio of ozone was calculated to be 9.84 mg O3/mg TOC.The maximum removal efficiency predicted was 75.9%,while the measured value was 72.3%.The relative deviation was found to be in an acceptable range.The ozone utilization and free radical quenching experiments showed that the addition of H_(2)O_(2) promoted the decomposition of ozone to produce hydroxyl radicals(·OH).This also improved the ozone utilization efficiency.Gas chromatography-mass spectrometry(GC-MS)analysis showed that most of the organic matters in ML-GFW were degraded,while some residuals needed further treatment.This study provided the data and the necessary technical supports for further research on the treatment of ML-GFW. | Haoran Feng Min Liu Wei Zeng Ying Chen | 2021 | Frontiers of Environmental Science & Engineering2021，15，4： | 3 |
| 18 | Bionic SERS chip with super-hydrophobic and plasmonic micro/nano dual structure显示文摘Natural surface-enhanced Raman spectroscopy(SERS) chips based on plants or insects have gained increased attention due to their facile characteristics and low costs. However, such chips remain a major challenge for practical application because of poor reproducibility and stability as well as unavoidable damage to the surface structure during coating metal and uncontrolled dehydration. By using a simple wrinkling method, we develop a new route to fabricate a low-cost bionic SERS chip for practical detection. Inspired by the taro leaf, we fabricate a SERS chip with a super-hydrophobic and plasmonic micro/nano dual structure, and its structure parameters can be optimized. Compared with the natural taro-leaf SERS chip, our artificial chip exhibits Raman signals with an order of magnitude higher sensitivity(~10^(-9)M) and enhancement factor(~10~7) under the illumination of weak laser radiation, demonstrating that our SERS chip has great potential in biological detection. The excellent performances of our bionic SERS chip are attributed to a synergy of optimized micro-wrinkle and nano-nest, which is verified by experiment and simulation. We believe our bionic chip could be a promising candidate in practical application due to its merits such as simple fabricating process, optimizable structure, low cost, excellent homogeneity, high sensitivity, and stability. | FENGYOU YANG HAORAN ZHANG HUIMIN FENG JIANJIE DONG CHUANG WANG QIAN LIU | 2018 | Photonics Research2018，6，2： | 3 |
| 19 | A flexible conductive hybrid elastomer for high-precision stress/strain and humidity detection显示文摘Flexible and environment-responsive materials are essential for a large number of applications from artificial skin to wearable devices. The present study develops a flexible, ultra-low cost conductive hybrid elastomer(CHE), which possesses high responsive capabilities to stress/strain and humidity. CHE was composed of polydimethylsiloxane(PDMS) and starch hydrogel(SH), enabling great elasticity(56 kPa),high conductivity(10^(-2)S/m) and high sensitivity to external stimuli(gauge factor of CHE under stress and strain are 0.71 and 2.22, respectively, and sensitivity to humidity is 1.2 × 10^(-6)S/m per RH%). These properties render CHE a promising candidate for artificial skin and wearable electronics applications of continuously monitoring environmental information. | Haoran Liu Zhenyi Zhang Jun Ge Xiao Lin Xinye Ni Huilin Yang Lei Yang | 2019 | Journal of Materials Science & Technology2019，35，1： | 2 |
| 20 | Microfluidic chips for the endothelial biomechanics and mechanobiology of the vascular system显示文摘Endothelial cells arranged on the vessel lumen are constantly stimulated by blood flow,blood pressure and pressureinduced cyclic stretch.These stimuli are sensed through mechanical sensory structures and converted into a series of functional responses through mechanotransduction pathways.The process will eventually affect vascular health.Therefore,there has been an urgent need to establish in vitro endothelial biomechanics and mechanobiology of models,which reproduce three-dimensional structure vascular system.In recent years,the rapid development in microfluidic technology makes it possible to replicate the key structural and functionally biomechanical characteristics of vessels.Here,we summarized the progress of microfluidic chips used for the investigation of endothelial biomechanics and mechanobiology of the vascular system.Firstly,we elucidated the contribution of shear stress and circumferential stress,to vascular physiology.Then,we reviewed some applications using microfluidic technology in angiogenesis and vasculogenesis,endothelial permeability and mechanotransduction,as well as the blood-brain barrier under these physical forces.Finally,we discussed the future obstacles in terms of the development and application of microfluidic vascular chips. | HAORAN SU KEXIN LI XIAO LIU JING DU LI WANG XIAOYAN DENG YUBO FAN | 2021 | BIOCELL2021，45，4： | 2 |
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