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| 1 | TGF-β signaling in cancer metastasis显示文摘转变生长因素(TGF )- 发信号的事件是众所周知的控制多样的进程和众多的回答例如房间增长,区别, apoptosis,和移植。在癌症的 TGF- 发信号戏上下文依赖者角色:在 pre 恶意的房间, TGF- 首先作为肿瘤 suppressor 工作,当在癌症的以后的阶段发信号的 TGF- 支持侵略和转移时。最近的研究也建议了在 TGF- 发信号和另外的发信号的小径之间的串音例如河马, Wnt, EGFR/RAS,和 PI3K/AKT 小径,可以实质地贡献我们 TGF- 发信号和癌症的当前的理解。由于 TGF- 的广阔效果, TGF- 和它的下游的发信号部件的封锁提供多重治疗学的机会。因此,为为众多的疾病表明治疗的 anti-TGF- 的眼界显得明亮并且将提供珍贵信息并且想在这药上分子的设计。在这评论,我们集中于最近的卓见进在可以贡献新奇指向癌症的治疗的发展的癌症转移发信号的 TGF- 的规定。 | Feng Xie Li Ling Hans van Dam Fangfang Zhou Long Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 36 |
| 2 | ;he regulation of TGF-β/SMAD signaling by protein deubiquitination显示文摘 | Juan Zhang Xiaofei Zhang Feng Xie Zhengkui Zhang Hans van Dam Long Zhang Fangfang Zhou | 2014 | Protein & Cell2014，5，7： | 27 |
| 3 | UBE20 negatively regulates TRAF6-mediated NF-kB activation by inhibiting TRAF6 polyubiquitination显示文摘 | Xiaofei Zhang Juan Zhang Long Zhang Hans van Dam Peter ten Dijke | 2013 | Cell Research2013，23，3： | 8 |
| 4 | Determination of polar organophosphorus pestieides in vegetables and fruits using liquid chromatography with tauden mass spectrometry: selection of extraction solvent 显示文摘 | Hans G J Mol Ruud C J van Dam Steijgcr O M | 2003 | Journal of Chromatorgraphy A2003，1015，12： | 1 |
| 5 | VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type Ⅰ receptor degradation显示文摘The transforming growth factor-β(TGF-β)family controls embryogenesis,stem cell differentiation,and tissue homeostasis.However,how post-translation modifications contribute to fine-tuning of TGF-βfamily signaling responses is not well understood.Inhibitory(I)-Smads can antagonize TGF-β/Smad signaling by recruiting Smurf E3 ubiquitin ligases to target the active TGF-βreceptor for proteasomal degradation.A proteomic interaction screen identified Vpr binding protein(VprBP)as novel binding partner of Smad7.Mis-expression studies revealed that VprBP negatively controls Smad2 phosphorylation,Smad2–Smad4 interaction,as well as TGF-βtarget gene expression.VprBP was found to promote Smad7–Smurf1–TβRI complex formation and induce proteasomal degradation of TGF-βtype I receptor(TβRI).Moreover,VprBP appears to stabilize Smurf1 by suppressing Smurf1 poly-ubiquitination.In multiple adult and mouse embryonic stem cells,depletion of VprBP promotes TGF-βor Activin-induced responses.In the mouse embryo VprBP expression negatively correlates with mesoderm marker expression,and VprBP attenuated mesoderm induction during zebrafish embryogenesis.Our findings thereby uncover a novel regulatory mechanism by which Smurf1 controls the TGF-βand Activin cascade and identify VprBP as a critical determinant of embryonic mesoderm induction. | Yihao Li Chao Cui Feng Xie Szymon Kietbasa Hailiang Mei Maarten van Dinther Hans van Dam Andreas Bauer Long Zhang Peterten Dijke | 2020 | Journal of Molecular Cell Biology2020，12，2： | 1 |
| 6 | Determination of daminozide in apple and apple leaves by liquid chromatography-mass spectrometry显示文摘 | Hans G J Mol Ruud C J Van Dam | 1999 | J Chromatogr A1999，833，： | 1 |
| 7 | 咖啡摄入与总死亡率和病因特异性死亡率的关系显示文摘含咖啡因与不含咖啡因的咖啡摄入与死亡风险的关系尚无定论。方法:研究人员纳入护士健康研究(Nurses'Health Study,NHS)中74 890名女性,NHS2中93 054名女性和卫生专业人员随访研究中的40 557名男性,探索其总的、含咖啡因和不含咖啡因的咖啡摄入与随后总死亡率、病因特异性死亡率的相关性。采用一个半定量食物摄入频率问卷评估基线咖啡摄入情况。 | 刘莉 叶鹏 Ding M Satija A Bhupathiraju SN Hu Y Sun Q Han J Lopez-Garcia E Willett W van Dam RM Hu FB | 2015 | 中华高血压杂志2015，23，10： | 0 |
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