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| 1 | 3-N-butylphthalide improves neuronal morphology after chronic cerebral ischemia显示文摘3-N-butylphthalide is an effective drug for acute ischemic stroke. However, its effects on chronic cerebral ischemia-induced neuronal injury remain poorly understood. Therefore, this study ligated bilateral carotid arteries in 15-month-old rats to simulate chronic cerebral ischemia in aged humans. Aged rats were then intragastrically administered 3-n-butylphthalide. 3-N-butylphthalide administration improved the neuronal morphology in the cerebral cortex and hippocampus of rats with chronic cerebral ischemia, increased choline acetyltransferase activity, and decreased malondialdehyde and amyloid beta levels, and greatly improved cognitive function. These findings suggest that 3-n-butylphthalide alleviates oxidative stress caused by chronic cerebral ischemia, improves cholinergic function, and inhibits amyloid beta accumulation, thereby improving cerebral neuronal injury and cognitive deficits. | Wanhong Zhao Chao Luo Jue Wang Jian Gong Bin Li Yingxia Gong Jun Wang Hanqin Wang | 2014 | Neural Regeneration Research2014，9，7： | 43 |
| 2 | Impacts of climate variability and extremes on global net primary production in the first decade of the 21st century显示文摘许多研究估计了全球陆上的网的大小主要生产(NPP ) ,而是它的变化,空间地并且时间地,仍然保持不明确。由使用一个改进基于过程的陆上的生态系统模型( DLEM ,动态陆地生态系统模型),我们提供多重环境因素导致的全球陆上的 NPP 的估计并且在整个 第21 世纪的第一十年在生物群系和全球层次并且沿着纬度检验陆上的 NPP 的反应到气候可变性。模型模拟在 20002009 期间估计 54.6 Pg C 年 1 的平均全球陆上的 NPP,从 2002 ~ 56.4 Pg C 的干燥的年里的 52.8 Pg C 年 1 变化 2008 的湿年里的年 1 。在湿年里,与十的平均数相比的陆上的 NPP 的大增加在 Amazonia,非洲和澳大利亚是流行的。在干燥的年里,然而,我们与十的平均数相比在全球陆上的 NPP 发现了 3.2% 减小,首先由于在热带区域的有限潮湿供应。在全球水平,降水在陆上的 NPP 解释了约 63% 变化,当剩余的在温度和另外的环境因素被归因于变化时。降水是在低纬度的区域在陆上的 NPP 决定内部年度的变化的主要因素。在中间纬度、高纬度的区域,然而,温度可变性大部分控制了陆上的 NPP 的大小。我们的结果暗示温暖并且增加气候极端事件的那投射气候将改变大小和全球陆上的 NPP 的空间与时间的模式。 | PAN Shufen TIAN Hanqin DANGAL Shree R.S. OUYANG Zhiyun LU Chaoqun YANG Jia TAO Bo REN Wei BANGER Kamaljit YANG Qichun ZHANG Bowen | 2015 | Journal of Geographical Sciences2015，25，9： | 15 |
| 3 | Cropland redistribution to marginal lands undermines environmental sustainability显示文摘Cropland redistribution to marginal land has been reported worldwide;however,the resulting impacts on environmental sustainability have not been investigated sufficiently.Here we investigated the environmental impacts of cropland redistribution in China.As a result of urbanization-induced loss of high-quality croplands in south China(~8.5 t ha^(-1)),croplands expanded to marginal lands in northeast(~4.5 t ha^(-1)) and northwest China(~2.9 t ha^(-1)) during 1990-2015 to pursue food security.However,the reclamation in these low-yield and ecologically vulnerable zones considerably undermined local environmental sustainability,for example increasing wind erosion(+3.47%),irrigation water consumption(+34.42%),fertilizer use(+20.02%) and decreasing natural habitats(-3.11%).Forecasts show that further reclamation in marginal lands per current policies would exacerbate environmental costs by 2050.The future cropland security risk will be remarkably intensified because of the conflict between food production and environmental sustainability.Our research suggests that globally emerging reclamation of marginal lands should be restricted and crop yield boost should be encouraged for both food security and environmental benefits. | Wenhui Kuang Jiyuan Liu Hanqin Tian Hao Shi Jinwei Dong Changqing Song Xiaoyong Li Guoming Du Yali Hou Dengsheng Lu Wenfeng Chi Tao Pan Shuwen Zhang Rafiq Hamdi Zherui Yin Huimin Yan Changzhen Yan Shixin Wu Rendong Li Jiuchun Yang Yinyin Dou Wenbin Wu Liqiao Liang Bao Xiang Shiqi Yang | 2022 | National Science Review2022，9，1： | 13 |
| 4 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 5 | Data-driven estimates of global nitrous oxide emissions from croplands显示文摘Croplands are the single largest anthropogenic source of nitrous oxide(N2O) globally, yet their estimates remain difficult to verify when using Tier 1 and 3 methods of the Intergovernmental Panel on Climate Change(IPCC). Here, we re-evaluate global cropland-N2O emissions in 1961–2014, using N-rate-dependent emission factors(EFs) upscaled from 1206 field observations in 180 global distributed sites and high-resolution N inputs disaggregated from sub-national surveys covering 15593 administrative units. Our results confirm IPCC Tier 1 default EFs for upland crops in 1990–2014, but give a ~15% lower EF in 1961–1989 and a ~67% larger EF for paddy rice over the full period. Associated emissions(0.82 ±0.34 Tg N yr–1) are probably one-quarter lower than IPCC Tier 1 global inventories but close to Tier 3 estimates. The use of survey-based gridded N-input data contributes 58% of this emission reduction, the rest being explained by the use of observation-based non-linear EFs. We conclude that upscaling N2O emissions from site-level observations to global croplands provides a new benchmark for constraining IPCC Tier 1 and 3 methods. The detailed spatial distribution of emission data is expected to inform advancement towards more realistic and effective mitigation pathways. | Qihui Wang Feng Zhou Ziyin Shang Philippe Ciais Wilfried Winiwarter Robert B.Jackson Francesco N.Tubiello Greet Janssens-Maenhout Hanqin Tian Xiaoqing Cui Josep G.Canadell Shilong Piao Shu Tao | 2020 | National Science Review2020，7，2： | 7 |
| 6 | Global methane and nitrous oxide emissions from terrestrial ecosystems due to multiple environmental changes显示文摘Greenhouse gas(GHG)-induced climate change is among the most pressing sustainability challenges facing humanity today,posing serious risks for ecosystem health.Methane(CH_(4))and nitrous oxide(N_(2)O)are the two most important GHGs after carbon dioxide(CO_(2)),but their regional and global budgets are not well known.In this study,we applied a process-based coupled biogeochemical model to concurrently estimate the magnitude and spatial and temporal patterns of CH_(4)and N_(2)O fluxes as driven by multiple environmental changes,including climate variability,rising atmospheric CO_(2),increasing nitrogen deposition,tropospheric ozone pollution,land use change,and nitrogen fertilizer use.The estimated CH_(4)and N_(2)O emissions from global land ecosystems during 1981-2010 were 144.39±12.90 Tg C/yr(mean 62 SE;1 Tg=1012 g)and 12.52±0.74 Tg N/yr,respectively.Our simulations indicated a significant(P,0.01)annually increasing trend for CH_(4)(0.43±0.06 Tg C/yr)and N_(2)O(0.14±0.02 Tg N/yr)in the study period.CH_(4)and N_(2)O emissions increased significantly in most climatic zones and continents,especially in the tropical regions and Asia.The most rapid increase in CH_(4)emission was found in natural wetlands and rice fields due to increased rice cultivation area and climate warming.N_(2)O emission increased substantially in all the biome types and the largest increase occurred in upland crops due to increasing air temperature and nitrogen fertilizer use.Clearly,the three major GHGs(CH_(4),N_(2)O,and CO_(2))should be simultaneously considered when evaluating if a policy is effective to mitigate climate change. | Hanqin Tian Guangsheng Chen Chaoqun Lu Xiaofeng Xu Wei Ren Bowen Zhang Kamaljit Banger Bo Tao Shufen Pan Mingliang Liu Chi Zhang Lori Bruhwiler Steven Wofsy | 2015 | Ecosystem Health and Sustainability2015，1，1： | 7 |
| 7 | Global pattern and change of cropland soil organic carbon during 1901-2010: Roles of climate, atmospheric chemistry, land use and management显示文摘Soil organic carbon(SOC)in croplands is a key property of soil quality for ensuring food security and agricultural sustainability,and also plays a central role in the global carbon(C)budget.When managed sustainably,soils may play a critical role in mitigating climate change by sequestering C and decreasing greenhouse gas emissions into the atmosphere.However,the magnitude and spatio-temporal patterns of global cropland SOC are far from well constrained due to high land surface heterogeneity,complicated mechanisms,and multiple influencing factors.Here,we use a process-based agroecosystem model(DLEM-Ag)in combination with diverse spatially-explicit gridded environmental data to quantify the long-term trend of SOC storage in global cropland area during 1901-2010 and identify the relative impacts of climate change,elevated CO2,nitrogen deposition,land cover change,and land management practices such as nitrogen fertilizer use and irrigation.Model results show that the total SOC and SOC density in the 2000s increased by 125%and 48.8%,respectively,compared to the early 20th century.This SOC increase was primarily attributed to cropland expansion and nitrogen fertilizer use.Factorial analysis suggests that climate change reduced approximately 3.2%(or 2,166 Tg C)of the total SOC over the past 110 years.Our results indicate that croplands have a large potential to sequester C through implementing better land use management practices,which may partially offset SOC loss caused by climate change. | Wei Ren Kamaljit Banger Bo Tao Jia Yang Yawen Huang Hanqin Tian | 2020 | Geography and Sustainability2020，1，1： | 6 |
| 8 | THE GENETIC DIVERSITY OF GAOZHOU WILD RICE ANALYZED BY SSR显示文摘The genetic diversity of total 240 acces- sions of common wild rice coming from Gaozhou, Shaoguan, Zhanjiang, and other places in Guang- dong, and Jiangxi, Fujian, Yunnan provinces, etc. in China and South-eastern Asia was evaluated by us- ing 24 pairs of SSR primers. The results indicated that: (i) there were 17 polymorphic loci in 24 pairs of SSR primers, and the average percentage of poly- morphic loci was 69%; the average total number of alleles, the average number of alleles per locus and the average number of alleles per polymorphic loci were 51.1, 2.04 and 2.43, respectively; (ii) the aver- age gene diversity was 0.8447. There were remark- able differentiations among 5 populations of Gaozhou wild rice. All the above-mentioned genetic parame- ters indicated that Gaozhou wild rice of Pengshan Village (or Bei Toudong) of Zhenjiang Town should be a center of genetic differentiation and diversity of Gaozhou wild rice. Gaozhou wild rice is probably the largest center of genetic differentiation and diversity of common wild rice from Guangdong Province, South China and even the whole China. | LI Chen PAN Dajian MAO Xingxue TU Congyong ZHOU Hanqin FAN Zhilan LI Xiaofang | 2006 | Chinese Science Bulletin2006，51，5： | 5 |
| 9 | Climate change induced eutrophication of cold-water lake in an ecologically fragile nature reserve显示文摘Aquatic ecosystem sustainability around the globe is facing crucial challenges because of increasing anthropogenic and natural disturbances. In this study, the Tianchi Lake, a typical cold-water lake and a UNESCO/MAB(Man and Biosphere) nature reserve located in high latitude and elevation with the relatively low intensity of human activity was chosen as a system to examine the linkages between climate change and eutrophication. As a part of the UNESCO Bogda Man and Biosphere Reserve, Tianchi Lake has been well preserved for prevention from human intervention, but why has it been infected with eutrophication recent years? Our results show that climate change played a significant role in the eutrophication in the Tianchi Lake. Increased temperature, changed precipitation pattern and wind-induced hydrodynamic fluctuations in the summer season were suggested to make a major contribution to the accelerated eutrophication. The results also showed that the local temperature and precipitation changes were closely linked to the large-scale atmospheric circulation, which opens the door for the method to be applied in other regions without local climatic information. This study suggests that there is an urgent need to take into consideration of climate change adaptation into the conservation and management of cold-water lakes globally. | Xiaotian Lu Yonglong Lu Deliang Chen Chao Su Shuai Song Tieyu Wang Hanqin Tian Ruoyu Liang Meng Zhang Kifayatullah Khan | 2019 | Journal of Environmental Sciences2019，31，1： | 4 |
| 10 | Pattern and variation of C:N:P ratios in China’s soils: a synthesis of observational data显示文摘 | Hanqin Tian Guangsheng Chen Chi Zhang Jerry M. Melillo Charles A. S. Hall | 2010 | Biogeochemistry2010，，1： | 3 |
| 11 | Linking microbial community composition to farming pattern in selenium-enriched region:Potential role of microorganisms on Se geochemistry显示文摘Selenium(Se)is an essential micronutrient for lives.Indigenous microbial communities play an important role on Se geochemistry in soils.In this study,the microbial community composition and functions of 53 soil samples were investigated using high-throughput sequencing.Samples were divided into 3 groups with different farming types based on the measured geochemical parameters and microbial functional structures.Results indicated that putative Se related bacteria Bacillus,Dyella,Paenibacillus,Burkholderia and Brevibacillus were dominant in dryland plantation soils which were characterized with higher available Se and low contents of H_(2)O,total organic carbon(TOC),NH_(4)^(+) and NO_(2)^(-).In contrast,the putative denitrifier Pseudomonas dominated in flooded paddy soils with higher TOC,NO_(3)^(-) and organic Se,whereas genera Rhizobium,Nitrosospira,and Geobacter preferred woodland soils with higher oxidation-reduction potential(ORP),pH,NH_(4)^(+) and Fe.Farming patterns resulted in distinct geochemical parameters including moisture,pH,ORP,TOC,and contents of soluble Fe,NO_(2)^(-) and NH_(4)^(+),shaping the microbial communities,which in turn affected Se forms in soils.This study provides a valuable insight into understanding of Se biogeochemistry in soils and prospective strategy for Se-rich agriculture production. | Yanhong Wang Xinyan Shi Xianxin Huang Chunlei Huang Helin Wang Hanqin Yin Yixian Shao Ping Li | 2022 | Journal of Environmental Sciences2022，34，2： | 3 |
| 12 | The improved mechanical properties of Al matrix composites reinforced with oriented β-Si3N4 whisker显示文摘The β-Si3N4 whiskers (β-Si3N4w) reinforced A1 matrix com posites were first fabricated by hot pressing, then treated through hot extrusion. The microstructure characterization dem onstrated the preferred orientations of both β-Si3N4w and A1 grains in the as-extruded composites. It indicated th at β-Si3N4w were aligned along the extrusion direction and A1 grains exhibited a distinct <111>ai texture. The interface betw een β-Si3N4w and A1 was in a good bonding status without voids and reaction products. Effects of extrusion process on the mechanical properties of com posites were also investigated. The results indicated the extrusion process had a prom inent strengthening effect on the mechanical properties of composites. The maxim umyield strength and ultim ate tensile strength of com posites reached up to 170 and 289 MPa, respectively, accompanied by a 12.3% elongation at fracture w hen the w hisker fraction was 15 vol.%. This im provem ent was collectively attributed to the densification of composites, the strong interface, and the preferred orientation inside composites. The yield strength of the composites reinforced with 5 vol.%β-Si3N4w corresponded well w ith the theoretical value from different strengthening mechanisms. | Chenxu Zhang Yu-Ping Zeng Dongxu Yao Jinwei Yin Kaihui Zuo Yongfeng Xia Hanqin Liang | 2019 | Journal of Materials Science & Technology2019，35，7： | 2 |
| 13 | The preparation, characterization, and their photocatalytic activities of rare-earth-doped TiO2 nanoparticles 显示文摘 | Xu AnWu Gao Yuan Liu HanQin | 2002 | Journal of Catalysis2002，207，： | 2 |
| 14 | MicroRNA-29a modulates axon branching by targeting doublecortin in primary neurons显示文摘MicroRNAs (miRNAs ) 内长地被表示调整蛋白质表示的小、非编码的抄本。实质的证据建议 miRNAs 在中央神经系统被充实,在他们被假设在神经开发期间起枢轴的作用的地方。在现在的学习,我们在在不同发展阶段和发现 miR-29a 的服的外皮和马头鱼尾的怪兽在出生后的阶段戏剧性地增加了的老鼠分析了 miRNAs 表示。另外,我们提供了 miR-29a 在 vitro 并且在 vivo 在成熟神经原被充实的充分证据。进一步的调查证明 glutamate 受体的激活在主要神经原导致了内长的 miR-29a 水平。而且,我们证明 miR-29a 直接调整了它的目标蛋白质 Doublecortin (DCX ) 表示,它进一步调制的轴突在主要文化分叉。一起,我们的结果建议 miR-29a 在鼠标的 neuronal 开发起一个重要作用大脑。 | Hanqin Li Susu Mao Haitao Wang Ke Zen Chenyu Zhang Liang Li | 2014 | Protein & Cell2014，5，2： | 2 |
| 15 | Spatial and temporal patterns of China’s cropland during 1990–2000: An analysis based on Landsat TM data显示文摘 | Jiyuan Liu Mingliang Liu Hanqin Tian Dafang Zhuang Zengxiang Zhang Wen Zhang Xianming Tang Xiangzheng Deng | 2005 | Remote Sensing of Environment2005，，4： | 2 |
| 16 | Industrial land expansion in rural China threatens environmental securities显示文摘China’s rural industrialization has been a major driver for its rapid economic growth during the recent decades,but its myriad environmental risks are yet to be fully understood.Based on a comprehensive national land-use data set,our study shows that the area of China’s rural industrial land(RIL)quadrupled during 1990–2015,reaching 39338 km2 in 2015,comparable to urbanization in magnitude but with a much greater degree of landscape fragmentation which implies stronger ecological and environmental impacts.About 91%of the protected areas in the central China were within 50 km from rural industrial land,thus exposed to industrial disturbances.Accelerated rural industrial land expansion,particularly in regions under high geo-hazard risks,led to dramatically increased environmental risks,threatening the safety and health of both rural industrial workers and residents.Moreover,negative effects from rural industrial land expansion could partially offset the crop production growth in recent decades.The underprivileged rural population in the west bears a disproportionally large share of the increased environmental risks.China urgently needs to design and implement sustainable policies to restrict and reshape its rural industrialization.This study aims to inspire policy makers and researchers to rethink the current model of industrial expansion and improve rural industrial land planning,which is important for achieving the sustainable development goals of China. | Chi Zhang Wenhui Kuang Jianguo Wu Jiyuan Liu Hanqin Tian | 2021 | Frontiers of Environmental Science & Engineering2021，15，2： | 2 |
| 17 | An analysis of mainland Chinese visitors’motivations to visit Hong Kong 显示文摘 | Hanqin Z Q Lam T | 1999 | Tourism Management1999，20，5： | 1 |
| 18 | Service quality of travel agents:the case of travel agents in Hong Kong显示文摘 | Hanqin Qiu Zhang | 1999 | Tourism Management1999，20，： | 1 |
| 19 | Pattern and variation of C : N : P ratios in China ' s soil: A synthesis of observational data显示文摘 | Tian Hanqin Chen Guangsheng Zhang Chi | 2010 | Biogeo- chemistry2010，98，1： | 1 |
| 20 | Modified Smith predictor design for periodic disturbance rejection 显示文摘 | Zhou Hanqin Wang Qingguo Liu Min | 2007 | ISA Transactions2007，46，4： | 1 |
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