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| 1 | Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment显示文摘Melanoma is the most aggressive form of skin cancer.Disrupted intracellular signaling pathways are responsible for melanoma's extraordinary resistance to current chemotherapeutic modalities. The pathophysiologic basis for resistance to both chemo- and radiation therapy is rooted in altered genetic and epigenetic mechanisms that, in turn, result in the impairing of cell death machinery and/or excessive activation of cell growth and survival-dependent pathways. Although most current melanoma therapies target mitochondrial dysregulation,there is increasing evidence that endoplasmic reticulum(ER) stress-associated pathways play a role in the potentiation,initiation and maintenance of cell death machinery and autophagy. This review focuses on the reliability of ER-associated pathways as therapeutic targets for melanoma treatment. | Mohamed Hassan Denis Selimovic Matthias Hannig Youssef Haikel Robert T Brodell Mossaad Megahed | 2015 | World Journal of Experimental Medicine2015，5，4： | 15 |
| 2 | 自蚀粘接剂对复合树脂微渗漏的影响显示文摘目的 :实验研究自蚀粘接剂、混合型复合树脂和流动树脂对微渗漏的影响。方法 :4 0颗人类离体磨牙 ,根据颊侧 (A)、近中侧 (B)和远中侧 (C)分成三大组。在釉牙骨质交界处制备成约 3× 2× 2 mm V类洞洞型。分别用自蚀粘接剂、混合型复合树脂和流动树脂修复 V类洞。所有牙齿着色后 ,在立体显微镜下观察微渗漏情况。结果 :微渗漏在壁处各组间差异无显著性 (P>0 .0 5 ) ,而在龈壁处流动树脂 (C组 )较混合型复合树脂存在较大的微渗漏 (P<0 .0 5 )。洞缘斜面组与无洞缘斜面组的微渗漏等级差异无显著性 (P>0 .0 5 )。结论 :自蚀粘接剂未能显著减少复合树脂的微渗漏。在修复 V类洞时 ,流动树脂较混合型树复合微渗漏大。 | 傅柏平 金光盛 HANNIG Matthias | 2002 | 浙江大学学报(医学版)2002，31，5： | 8 |
| 3 | Effect of anti-biofilm glass–ionomer cement on Streptococcus mutans biofilms显示文摘Dental restorative materials with antimicrobial properties can inhibit bacterial colonization, which may result in a reduction of caries at tooth-filling interaction zones. This study aimed to develop antibacterial glass–ionomer cements(GIC) containing a quaternary ammonium monomer(dimethylaminododecyl methacrylate, DMADDM), and to investigate their effect on material performance and antibacterial properties. Different mass fractions(0, 1.1% and 2.2%) of DMADDM were incorporated into the GIC. The flexure strength, surface charge density, surface roughness and fluoride release were tested. A Streptococcus mutans biofilm model was used. Exopolysaccharides(EPS) staining was used to analyze the inhibitory effect of DMADDM on the biofilm matrix. In addition, biofilm metabolic activity, lactic acid metabolism and the expression of glucosyltransferase genes gtf B, gtf C and gtf D were measured. GIC containing 1.1% and 2.2% DMADDM had flexural strengths matching those of the commercial control(P40.1). DMADDM was able to increase the surface charge density but reduced surface roughness(Po0.05). The incorporation of 1.1% and 2.2% DMADDM elevated the release of fluoride by the GIC in the first 2 days(Po0.05). The novel DMADDM-modified GIC significantly reduced biofilm metabolic activity(Po0.05) and decreased lactic acid production(Po0.05). The quantitative polymerase chain reaction(q PCR) results showed that the expression of gtf B, gtf C and gtf D decreased when mass fractions of DMADDM increased(Po0.05). EPS staining showed that both the bacteria and EPS in biofilm decreased in the DMADDM groups. The incorporation of DMADDM could modify the properties of GIC to influence the development of S. mutans biofilms. In this study, we investigated the interface properties of antibacterial materials for the first time. GIC containing DMADDM can improve material performance and antibacterial properties and may contribute to the better management of secondary caries. | Su-Ping Wang Yang Ge Xue-Dong Zhou Hockin HK Xu Michael D Weir Ke-Ke Zhang Hao-Hao Wang Matthias Hannig Stefan Rupf Qian Li Lei Cheng | 2016 | International Journal of Oral Science2016，8，2： | 5 |
| 4 | 空气喷磨和酸蚀与树脂突超微结构的关系显示文摘目的 体外评价 5种处理方法对树脂突超微结构的影响。方法 对照组 :对 1颗离体磨牙常规预防性树脂充填。其余 4颗磨牙用空气喷磨处理 ,分别用 5 0 μ和 2 7μ氧化铝微粒 ,酸处理其中 2颗磨牙。窝洞用复合树脂充填后 ,用 10 %盐酸溶解牙釉质 ,扫描电镜观测树脂突超微结构。结果 对照组呈典型蜂窝状结构。空气喷磨的树脂突呈不规则结构 ,结合酸蚀的树脂突表面更加粗糙。 | 傅柏平 Hannig M 吴求亮 Albers HK | 2000 | 现代口腔医学杂志2000，14，1： | 4 |
| 5 | 壁处与龈壁处的微渗漏的比较——湿润粘接技术修复V类洞洞型显示文摘目的:实验研究湿润粘接技术修复V类洞洞型时,壁处与龈壁处的微渗漏的比较.方法:48颗人离体磨牙根据颊、近中和远中面分别分成A、B、C三组,每组又随机分成4小组(n=12),洞型位于釉牙本质交界处.A1和A2组常规制备V类洞洞型;但A2制备洞缘斜面;A3、A4用空气喷磨技术制备V类洞洞型,但分别使用方法50μm和27μm氧化铝微粒.B、C各小组处理与相应A组相同.所有牙齿用0.5%亚甲基蓝着色.结果:所有标本在龈壁处存在严重的微渗漏(p<0.001). | 傅柏平 Hannig,M | 1999 | 口腔医学1999，19，2： | 3 |
| 6 | Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit显示文摘 | Robert W. Busby Alexander P. Bryant Wilmin P. Bartolini Etchell A. Cordero Gerhard Hannig Marco M. Kessler Shalina Mahajan-Miklos Christine M. Pierce Robert M. Solinga Li Jing Sun Jenny V. Tobin Caroline B. Kurtz Mark G. Currie | 2010 | European Journal of Pharmacology2010，，1： | 2 |
| 7 | Shift from denitrification to anammox after inflow events in the central Baltic Sea显示文摘 | Hannig M Lavik G Kuypers M M M | 2007 | Limnology and Oceanography2007，52，4： | 1 |
| 8 | Shift from denitrification to anammox after inflow events in the central Baltic Sea显示文摘 | Hannig M Lavik G Kuypers M | 2007 | Lim-nology and Oceanography2007，52，4： | 1 |
| 9 | Effect of air abrasion and resin composite on microleakage of Class V restorations bonded with self-etching primers 显示文摘 | Hannig M Fu B | 2001 | J Adhes Dent2001，3，3： | 1 |
| 10 | Three-dimensional,non-destructive visualization of vertical root fractures using flat panel volume detector computer tomography:an ex vivo in vitro case report显示文摘 | Hannig C Dullin C Hülsmann M | 2005 | Int Endod J2005，38，12： | 1 |
| 11 | Sinus floor elevation via hydraulic detachment and elevation of the Schneiderian membrane显示文摘 | Vitkov L Gellrich NC Hannig M | 2005 | Clin Oral Implants Res2005，16，5： | 1 |
| 12 | Effect of Carisolv solution on sound, demineralized and denatured dentin an ultrastructural investigation显示文摘 | Hannig M | 1999 | Clin Oral Investig1999，3，3： | 1 |
| 13 | A recurrent RNA-splicing mutation in the SEDL gene X-linked spondyloepiphyseal dysplasia tarda显示文摘 | Tiller GE Hannig VL Dozier D | 2001 | Am J Hum Genet2001，68，6： | 1 |
| 14 | Efficient Control Generation for Mapping Nested Loop Programs onto Processor Arrays显示文摘 | Dutta H Hannig F Ruckdeschel H | 2007 | Journal of Systems Architecture2007，53，5： | 1 |
| 15 | Biochemical analysis of the e IF2βγcomplex reveals a structural function for e IF2αin catalyzed nucleotide exchange显示文摘 | Nika J Rippel S Hannig E M | 2001 | J Biol Chem2001，276，2： | 1 |
| 16 | The protective nature of the salivary pelliele显示文摘 | Hannig M | 2002 | Int Dent J2002，52，： | 1 |
| 17 | Transmission electron microscopic study of vivo pellicle formation on dental restorative materials显示文摘 | Hannig M | 1997 | J Eu Oral Sci1997，105，： | 1 |
| 18 | Use of sequence variation in three highly variable regions of the mitochondrial DNA for the discrimination of allogeneic platelets显示文摘 | Warner JB Brain EJ Hannig H | 2006 | Transfusion2006，46，8： | 1 |
| 19 | Strategies for optimizing heterologous protein expression inEscherichia coli显示文摘 | Hannig G Makrides S C | 1998 | Trends Biotechnol1998，16，2： | 1 |
| 20 | Transmission electron microscopy of early plaque formation on dental materials in vivo显示文摘 | Hannig M | 1999 | Eur J Oral Sci1999，107，1： | 1 |
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