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| 1 | Diabetes and cardiac autonomic neuropathy: Clinical manifestations, cardiovascular consequences, diagnosis and treatment显示文摘Cardiac autonomic neuropathy(CAN) is a frequent chronic complication of diabetes mellitus with potentially life-threatening outcomes. CAN is caused by the impairment of the autonomic nerve fibers regulating heart rate, cardiac output, myocardial contractility, cardiac electrophysiology and blood vessel constriction anddilatation. It causes a wide range of cardiac disorders, including resting tachycardia, arrhythmias, intraoperative cardiovascular instability, asymptomatic myocardial ischemia and infarction and increased rate of mortality after myocardial infarction. Etiological factors associated with autonomic neuropathy include insufficient glycemic control, a longer period since the onset of diabetes, increased age, female sex and greater body mass index. The most commonly used methods for the diagnosis of CAN are based upon the assessment of heart rate variability(the physiological variation in the time interval between heartbeats), as it is one of the first findings in both clinically asymptomatic and symptomatic patients. Clinical symptoms associated with CAN generally occur late in the disease process and include early fatigue and exhaustion during exercise, orthostatic hypotension, dizziness, presyncope and syncope. Treatment is based on early diagnosis, life style changes, optimization of glycemic control and management of cardiovascular risk factors. Medical therapies, including aldose reductase inhibitors, angiotensin-converting enzyme inhibitors, prostoglandin analogs and alpha-lipoic acid, have been found to be effective in randomized controlled trials. The following article includes the epidemiology, clinical findings and cardiovascular consequences, diagnosis, and approaches to prevention and treatment of CAN. | Akif Serhat Balc?o?lu Haldun Müderriso?lu | 2015 | World Journal of Diabetes2015，6，1： | 22 |
| 2 | Coronary flow reserve is impaired in patients with slow coronary flow显示文摘 | Dogan Erdogan Mustafa Caliskan Hakan Gullu Alpay Turan Sezgin Aylin Yildirir Haldun Muderrisoglu | 2006 | Atherosclerosis2006，，1： | 2 |
| 3 | Application of scoring systems with point-of-care ultrasonography for bedside diagnosis of appendicitis显示文摘BACKGROUND: Appendicitis is a common disease requiring surgery. Bedside ultrasound(BUS) is a core technique for emergency medicine(EM). The Alvarado score is a well-studied diagnostic tool for appendicitis. This study aimed to investigate the relationship between patients' symptoms, Alvarado score and ultrasound(US) findings, as performed by emergency physicians(EPs) and radiologists, of patients with suspected appendicitis.METHODS: Three EM specialists underwent the BUS course and core course for appendicitis assessment. Patients suspected of having appendicitis were selected and their Alvarado and modif ied(m) Alvarado scores calculated. The specialists performed the BUS. Then, patients were given a formal US and surgery consultation if necessary. Preliminary diagnoses, admission or discharge from the emergency department(ED) and fi nal diagnosis were documented. The patients were also followed up after discharge from the hospital.RESULTS: The determined cut-off value was 2 for Alvarado and 3 for m Alvarado scores. The sensitivities of the two scores were 100%. Each score was used to rule out appendicitis. The results of EP-performed BUS were as follows: accuracy 70%, sensitivity 0.733, specifi city 0.673, + LR 2.24, and – LR 0.40(95%CI). Radiologists were better than EPs at diagnosing appendicitis and radiologists and EPs were equally strong at ruling out appendicitis by US. When US was combined with Alvarado and m Alvarado scores, EP US+Alvarado/m Alvarado scores ≤3 and radiology US+Alvarado/m Alvarado scores ≤4 perfectly ruled out appendicitis.CONCLUSION: BUS performed by EPs is moderately useful in detecting appendicitis. Combined with scoring systems, BUS may be a perfect tool for ruling out decisions in EDs. | Erden Erol Unluer Rifat Urnal Utku Eser Serkan Bilgin Mehmet Haciyanh Orhan Oyar Haldun Akoglu Arif Karagoz | 2016 | World Journal of Emergency Medicine2016，7，2： | 2 |
| 4 | Blue code: Is it a real emergency?显示文摘BACKGROUND: Cardiac arrests in hospital areas are common, and hospitals have rapid response teams or 'blue code teams' to reduce preventable in-hospital deaths. Education about the rapid response team has been provided in all hospitals in Turkey, but true 'blue code' activation is rare, and it is abused by medical personnel in practice. This study aimed to determine the cases of wrong blue codes and reasons of misuse.METHODS: This retrospective study analyzed the blue code reports issued by our hospital between January 1 and June 1 2012. A total of 89 'blue code' activations were recorded in 5 months. A 'blue code' was defined as any patient with an unexpected cardiac or respiratory arrest requiring resuscitation and activation of a hospital alert. Adherence to this definition, each physician classified their collected activation forms as either a true or a wrong code. Then, patient data entered a database(Microsoft Excel 2007 software) which was pooled for analysis. The data were analyzed by using frequencies and the Chi-square test on SPSSv16.0.RESULTS: The patients were diagnosed with cardiopulmonary arrest(8), change in mental status(18), presyncope(11), chest pain(12), conversive disorder(18), and worry of the staff for the patient(22). Code activation was done by physicians in 76% of the patients; the most common reason for blue code was concern of staff for the patient.CONCLUSION: The findings of this study show that more research is needed to establish the overall effectiveness and optimal implementation of blue code teams. | Serkan E.Eroglu Ozge Onur Oguz Urgan Arzu Denizbasi Haldun Akoglu | 2014 | World Journal of Emergency Medicine2014，5，1： | 2 |
| 5 | Digital computation of the fractional fourier transform 显示文摘 | Haldun M O Orhan A D | 1996 | IEEE Trans Signal Processing1996，44，9： | 1 |
| 6 | Low serum bilirubin levels are independently and inversely related to impaired flow-mediated vasodilation and increased carotid intima-media thickness in both men and women显示文摘 | Dogan Erdogan Hakan Gullu Erkan Yildirim Derya Tok Ismail Kirbas Ozgur Ciftci Semra Topcu Baycan Haldun Muderrisoglu | 2005 | Atherosclerosis2005，，2： | 1 |
| 7 | Evaluation of nutritional risk on admission to the general surgery department显示文摘 | Haldun G Eren E Recep A | 2008 | Bratisl Lek Listy2008，109，2： | 1 |
| 8 | Alper Kutay Gozde Bozdagi Digital Computation of the Fractional Fourier Transform显示文摘 | Haldun M Ozaktas M | 1996 | IEEE Transactions on signal processing1996，44，9： | 1 |
| 9 | Evaluation of nutritional risk on admission to the general surgery department 显示文摘 | Haldun G Eren E Recep A | 2008 | Bratisl Lek Listy2008，109，2： | 1 |
| 10 | A national Internet survey on rapid sequence intubation patterns from Turkey显示文摘 | Ozlem Guneysel Ozge Ecmel Onur Haldun Akoglu Serkan Eroglu Arzu Den?zbas? | 2008 | International Journal of Emergency Medicine2008，，4： | 1 |
| 11 | Use of Alpha-Lipoic Acid in Prevention of Contrast-Induced Nephropathy in Diabetic Patients显示文摘 | Mutlu Cicek Aylin Y?ld?r?r Kaan Okyay Ayse Canan Yazici Alp Aydinalp Suleyman Kanyilmaz Haldun Muderrisoglu | 2013 | Renal Failure2013，，5： | 1 |
| 12 | Digital computation of the fractional fourier transform显示文摘 | Haldun M O Orhan A M Alper K | 1996 | IEEE Transaction on Signal Processing1996，44，9： | 1 |
| 13 | Effects of spironolactone on heart rate variability and left ventricular systolic function in severe ischemic heart failure显示文摘 | Mehmet Emin Korkmaz Haldun Müderriso?lu Melek Ulu?am Bülent ?zin | 2000 | The American Journal of Cardiology2000，，6： | 1 |
| 14 | Fractional Correlation显示文摘 | DAVID MENDLOVIC HALDUN M OZAKTAS ADOLF W LOHMANN | 1995 | APPLIED OPTICS1995，34，2： | 1 |
| 15 | Usage of coal combustion bottom ash in concrete mixture显示文摘 | Haldun Kurama Mine Kaya | 2008 | Construction and Building Materials2008，，22： | 1 |
| 16 | Histopathological evaluation of melatonin as a protective agent in heart injury induced by radiation in a rat model显示文摘 | ?clal Gürses Murat ?zeren Meltem Serin Neslihan Yücel Haldun ?ükrü Erkal | 2014 | Pathology - Research and Practice2014，，： | 1 |
| 17 | Evaluation of nutritional risk on admission to the general surgery department 显示文摘 | Haldun G Eren E Recep A | 2008 | Bratisl Lek Listy2008，109，2： | 1 |
| 18 | Executing production schedules in the face of uncertainties: A review and some future directions显示文摘 | Haldun Aytug Mark A. Lawley Kenneth McKay Shantha Mohan Reha Uzsoy | 2003 | European Journal of Operational Research2003，，： | 1 |
| 19 | Effect of a multidimensional exerciseintervention on the physical capacity of mentally retardedchildren显示文摘 | Sirin K Naim N Haldun S | 2011 | Healthmed2011，5，1： | 1 |
| 20 | Distal computation of the fractional fourier transform显示文摘 | Haldun M | 1996 | IEEE Transactions on Signal Processing1996，44，9： | 1 |
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