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| 1 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 2 | Hypoxia induces T-cell apoptosis by inhibiting chemokine C receptor 7 expression:the role of adenosine receptor A2显示文摘Hypoxia is a major characteristic of the tumor microenvironment,and its effects on immune cells are proposed to be important factors for the process of tumor immune escape.It has been reported that hypoxia affects the function of dendritic cells and the antitumor function of T cells.Here we discuss the effects of hypoxia on T-cell survival.Our results showed that hypoxia induced apoptosis of T cells.Adenosine and adenosine receptors(AR)are important to the hypoxia-related signaling pathway.Using AR agonists and antagonists,we demonstrated that hypoxia-induced apoptosis of T cells was mediated by A^(2a)and A^(2b)receptors.Furthermore,we are the first,to our knowledge,to report that hypoxia significantly inhibited the expression of chemokine C receptor 7(CCR7)of T cells via the A^(2)R signal pathway,perhaps representing a mechanism of hypoxia-induced apoptosis of T cells.Collectively,our research demonstrated that hypoxia induces T-cell apoptosis by the A^(2)R signaling pathway partly by suppressing CCR7.Blocking the A^(2)R signaling pathway and/or activation of CCR7 can increase the anti-apoptosis function of T cells and may become a new strategy to improve antitumor potential. | Jintang Sun Yan Zhang Meixiang Yang Yun Zhang Qi Xie Zewu Li Zhaogang Dong Yongmei Yang Biping Deng Alei Feng Weixu Hu Haiting Mao Xun Qu | 2010 | Cellular & Molecular Immunology2010，7，1： | 3 |
| 3 | A phase 3, randomized, double-blind, placebo-controlled study of the safety and efficacy of the live, oral adenovirus type 4 and type 7 vaccine, in U.S. military recruits显示文摘 | Robert A. Kuschner Kevin L. Russell Mary Abuja Kristen M. Bauer Dennis J. Faix Howard Hait Jennifer Henrick Michael Jacobs Alan Liss Julia A. Lynch Qi Liu Arthur G. Lyons Mohammad Malik James E. Moon Jeremiah Stubbs Wellington Sun Doug Tang Andrew C. Towl | 2013 | Vaccine2013，，28： | 1 |
| 4 | Sound scattering from underwater elastic spherical shell covered with multilayered medium approximated acoustic cloak显示文摘The anechoic performance and mechanism of underwater elastic spherical shell covered with coating are studied at low frequencies.The acoustic cloak is anisotropic material,which can be designed with homogeneous isotropic materials on the basis of effective medium approximation theory.The analytic expression of scattering acoustic field from the shell covered with multilayered medium is formulated and the scattering form function,resonance mode,acoustic field distribution are computed,the scattering characteristics and mechanism of transmission are analyzed.The results show that the direction of sound transmission inside the multilayered medium is changed,the acoustic field is deflected gradually,and the acoustic energy flux is guided around the target,which reduces the scattering intensity at low frequencies,the acoustic intensity of target's surface is very weak.Excepting the first resonance peak in spectrum produced by the zero order partial wave,the other resonance modes of elastic spherical shell are not excitated and the multilayered medium can suppress the resonance of the spherical shell effectively. | SUN Yang AN Junying XU Haiting | 2014 | Chinese Journal of Acoustics2014，33，2： | 1 |
| 5 | Adaptor protein APPL1 links neuronal activity to chromatin remodeling in cultured hippocampal neurons显示文摘Local signaling events at synapses or axon terminals are communicated to the nucleus to elicit transcriptional responses,and thereby translate information about the external environment into internal neuronal representations.This retrograde signaling is critical to dendritic growth,synapse development,and neuronal plasticity.Here,we demonstrate that neuronal activity induces retrograde translocation and nuclear accumulation of endosomal adaptor APPL1.Disrupting the interaction of APPL1 with Importin ocl abolishes nuclear accumulation of APPL1,which in turn decreases the levels of histone acetylation.We further demonstrate that retrograde translocation of APPL1 is required for the regulation of gene transcription and then maintenance of hippocampal late-phase long-term potentiation.Thus,these results illustrate an APPLl-mediated pathway that contributes to the modulation of synaptic plasticity via coupling neuronal activity with chromatin remodeling. | Yu Wu Xinyou Lv Haiting Wang Kai Qian Jinjun Ding Jiejie Wang Shushan Hua Tiancheng Sun Yiting Zhou Lina Yu Shuang Qiu | 2021 | Journal of Molecular Cell Biology2021，13，5： | 1 |
| 6 | MIRROR IMAGE San Bao Peng Art Museum Blends in with the Scenery显示文摘The brief:Dubbed the‘porcelain capital of China’,Jingdezhen has gained international recognition for its long history of potteiy making,and flocks of tourists from around the world travel to the city each year for its famous ceramics. | Dominic Ngai Sun Haiting(图) | 2017 | 城市漫步(上海版、英文)2017，，12： | 0 |
| 7 | Identification of Pathogens from Rotted Potato Tubers in Ventilated Storage House of Huade County,Inner Mongolia during the Storage Period显示文摘Rotted potato samples were collected from ventilated storage house of Huade County,Inner Mongolia from October 2015 to April 2016. Pathogens were isolated,purified and cultured with tissue separation method,and identified by morphological observation and molecular identification. The results showed that there were five main diseases that caused potato rotting in Huande County,Inner Mongolia during the storage period,including dry rot,late blight,early blight,ring rot and soft rot. Specifically,potato dry rot was the most serious disease,which was induced by four pathogens: Fusarium sambucinum,Fusarium Link,Fusarium acuminatum and Fusarium equiseti. Late blight caused by Phytophthora infestans and early blight caused by Alternaria solani could easily result in complex infection,which were mostly found in seriously rotted potato tubers. Moreover,these potatoes were always co-infected with fungal diseases at late stage of storage or even subject to complex infection with bacteriosis in serious cases. This study provided theoretical basis for the prevention of potato diseases during the storage period. | Kai ZHANG Xizhuo WANG Jie SUN Qin Yang Haiting SUN | 2017 | Agricultural Biotechnology2017，6，5： | 0 |
| 8 | Sound scattering from partially water-filled elastic spherical shell with an internal elastic plate显示文摘根据在有弹性的媒介的运动的方程和目标散布的不可分的方程,有或没有一个内部盘子从部分充满水的有弹性的球形的壳散布的声音用有限元素和边界元素方法被学习,并且散布充满水的不同体积的壳的规范的表格功能被计算,回声散布的机制被分析。结果证明壳与的回声部分充满水并且没有板,主要与水的音量有关,并且回声被内部水和球形的壳生产。有板的部分充满水的有弹性的壳的回声特征类似于空结构化的有弹性的球形的壳的,并且内部水里的健全的地更弱它显示主要回声特征被球形的壳和板决定。另外,有板和一个方面的球形的壳的散布特征完整充满水极大地与部分充满水的不同。 | SUN Yang XU Haiting | 2008 | Chinese Journal of Acoustics2008，27，2： | 0 |
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