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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | -765G > C COX-2 polymorphism may be a susceptibility marker for gastric adenocarcinoma in patients with atrophy or intestinal metaplasia显示文摘AIM: To investigate the relationship between the -765G > C COX-2 polymorphism and the development of different gastric lesions: atrophy or intestinal metaplasia and gastric adenocarcinoma. METHODS: A cross-sectional study was performed involving 320 Portuguese individuals (210 without evidence of neoplastic disease, 73 patients with gastric adenocarcinomas and 37 with atrophy or intestinal metaplasia) using a PCR-RFLP method. RESULTS: -765C allele was overrepresented in the patients with gastric adenocarcinoma (51%) when compared either with the control group (38%) or patients with atrophy or intestinal metaplasia (27%). Callele was found to be very common in our population (0.22), and a multivariate logistic regression analysis revealed nearly 3-fold increased risk for the progression to gastric adenocarcinoma in patients with atrophy or intestinal metaplasia carrying the -765C allele (OR = 2.67, 95% CI = 1.03-6.93; P = 0.04).considered as another susceptibility marker for gastric adenocarcinoma development in patients with atrophy or intestinal metaplasia. | Carina Pereira Hugo Sousa Paula Ferreira Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，34： | 16 |
| 3 | Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?显示文摘Helicobacter pylori(H.pylori)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human population.Infection is a risk factor for gastritis,ulcer disease and stomach cancer.Immunity against H.pylori is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including cancer.Furthermore,host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases.In this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H.pylori and discuss how such polymorphisms may influence infection/disease outcomes. | Camila A Figueiredo Cintia Rodrigues Marques Ryan dos Santos Costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 4 | 多发性脑膜瘤的临床和组织学特点显示文摘 | 黄红光 詹仁雅 R Buhl H H Hugo H M Mehdorn | 2005 | 中华神经外科杂志2005，21，8： | 8 |
| 5 | Gastric cancer in a Caucasian population: Role of pepsinogen C genetic variants显示文摘瞄准:在胃蛋白酶原 C (PGC ) 基因学习插入 / 删除多型性的角色,为胃粘膜的终端区别的一个有效标记,在到胃的损害的开发的危险性。方法:没有肿瘤的疾病的证据,学习与已知的胃的损害的 99 件样品和 127 件样品被执行。PCR 被采用, 6 多态的等位基因被放大:等位基因 1 (510 bp ) ,等位基因 2 (480 bp ) ,等位基因 3/4 (450/460 bp ) ,等位基因 5 (400 bp ) 并且等位基因 6 (310 bp ) 。结果:我们的结果表明等位基因 6 搬运人似乎对任何胃的损害的发展有保护(或 = 0.34;P<0.001 ) ,与象萎缩或肠的组织变形那样的胃的腺癌联系的 non-dysplastic 损害(或 = 0.28;P<0.001 ) 或侵略 GC (或 = 0.39;P = 0.004 ) 。结论:我们的学习表明等位基因 6 搬运人地位在胃的损害的发展有一个保护的角色,可能由于它有 PGC 的更高的表示的协会。而且,在控制组的等位基因 6 搬运人的频率比在亚洲人口获得了高是远的,它可能代表在白种人和亚洲人口之间的基因差距。 | Ana L Pinto-Correia Hugo Sousa Maria Fragoso Luís Moreira-Dias Carlos Lopes Rui Medeiros Mário Dinis-Ribeiro | 2006 | World Journal of Gastroenterology2006，12，31： | 6 |
| 6 | Effect of menstrual cycle and hormonal treatment on ki-67 and bcl-2 expression and adenomyosis 显示文摘 | Hugo MJ Amelia M Eduardo S | 2005 | Gynecol Endocrinol2005，20，： | 1 |
| 7 | Frey's Syndrome Prevention with Temporparietal Facial Flap Interposition显示文摘 | Sultan M R Wider T M Hugo N E | 1995 | Ann Plast Surg1995，34，3： | 1 |
| 8 | Frey's syndrome: Prevention with temporarietal fascial flap interposition 显示文摘 | Sultan M R Wider T M Hugo N E | 1995 | Arch Facial Plast Surg1995，34，3： | 1 |
| 9 | Dissminated intravascular coagulation显示文摘 | Levi M Ten Cate Hugo | 1999 | N Eng J Med1999，341，8： | 1 |
| 10 | Enrichment of butteroil with conjugated linoleic acid via enzymatic interesterification(acidolysis)reactions显示文摘 | Hugo S Garcia Jayne M Storkson Michael W Pariza | 1998 | Biotecbnology Letters1998，20，4： | 1 |
| 11 | Epithelial-mesenchymal and mesenehymal-epithelial transitions in carcinoma progression显示文摘 | Hugo H Ackland M L Blick T | 2007 | J Cell Phys-iol2007，213，2： | 1 |
| 12 | Acute endophthalmitis following intravitreal triamcinolone acetonide injection显示文摘 | Darius M Moshfeghi Peter K Kaiser Ingrid U Scott Jonathan E Sears Matthew Benz Juan P Sinesterra Richard S Kaiser Sophie J Bakri Raj K Maturi Jonathan Belmont Paul M Beer Timothy G Murray Hugo Quiroz-Mercado William F Mieler | 2003 | American Journal of Ophthalmology2003，，5： | 1 |
| 13 | Annexin A5 inhibits engulfment through internalization of PS-expressing cell membrane patches 显示文摘 | Heidi K Hugo G Niko M | 2006 | Experim Cell Res2006，319，6： | 1 |
| 14 | Weed seeds identification by machine vision显示文摘 | Pablo M Granitto Hugo D Navone Pablo F Verdes | 2002 | Computers and Electronics in Agriculture2002，33，2： | 1 |
| 15 | Large-scale investigation of weed seed identification by machine vision显示文摘 | Pablo M Granitto Hugo D Navone Ceccatto H Alejandro | 2005 | Computers and Electronics in Agriculture2005，47，1： | 1 |
| 16 | Synthesis and invitro trichomonicidal, giardicidal and amebicidal activity of N-acetamide (sulfona- mide)-2-methyl-4-nitm-IH-imidazoles显示文摘 | EMANUEL H N HUGO T ROSA M P | 2009 | Eur J Med Chem2009，44，7： | 1 |
| 17 | Healthy Hearts-A community-based primary prevention to reduce coronary heart disease 显示文摘 | Gill R Hugo C W Lucy M et a l | 2008 | BMC Cardio- vascular Disorders2008，26，8： | 1 |
| 18 | Metabolism of glyceryl trinitrate by skin staphylococci 显示文摘 | DENYER SP HUGO WB O'BRIEN M | 1984 | J Phann Pharmacol1984，36，： | 1 |
| 19 | Epi thelial mesenchymal and mesenchymal epithelial tran sitions in carcinoma progression显示文摘 | HUGO H ACKLAND M L BLICK T | 2007 | J Cell Physiol2007，213，： | 1 |
| 20 | Wear particle classifier system based on an artificial neural network显示文摘 | GONCALVES V D ALMEIDA L F HUGO M | 2010 | Journal of Mechanical Engineering2010，56，4： | 1 |
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