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| 1 | Device-associated infection rates, mortality, length of stay and bacterial resistance in intensive care units in Ecuador: International Nosocomial Infection Control Consortium's findings显示文摘AIM To report the results of the International Nosocomial Infection Control Consortium(INICC) study conducted in Quito, Ecuador.METHODS A device-associated healthcare-acquired infection(DAHAI) prospective surveillance study conducted from October 2013 to January 2015 in 2 adult intensive care units(ICUs) from 2 hospitals using the United States Centers for Disease Control/National Healthcare Safety Network(CDC/NHSN) definitions and INICC methods. RESULTS We followed 776 ICU patients for 4818 bed-days. The central line-associated bloodstream infection(CLABSI) rate was 6.5 per 1000 central line(CL)-days, the ventilator-associated pneumonia(VAP) rate was 44.3 per 1000 mechanical ventilator(MV)-days, and the catheterassociated urinary tract infection(CAUTI) rate was 5.7 per 1000 urinary catheter(UC)-days. CLABSI and CAUTI rates in our ICUs were similar to INICC rates [4.9(CLABSI) and 5.3(CAUTI)] and higher than NHSN rates [0.8(CLABSI) and 1.3(CAUTI)]- although device use ratios for CL and UC were higher than INICC and CDC/NSHN's ratios. By contrast, despite the VAP rate was higher than INICC(16.5) and NHSN's rates(1.1), MV DUR was lower in our ICUs. Resistance of A. baumannii to imipenem and meropenem was 75.0%, and of Pseudomonas aeruginosa to ciprofloxacin and piperacillin-tazobactam was higher than 72.7%, all them higher than CDC/NHSN rates. Excess length of stay was 7.4 d for patients with CLABSI, 4.8 for patients with VAP and 9.2 for patients CAUTI. Excess crude mortality in ICUs was 30.9% for CLABSI, 14.5% for VAP and 17.6% for CAUTI. CONCLUSION DA-HAI rates in our ICUs from Ecuador are higher than United States CDC/NSHN rates and similar to INICC international rates. | Estuardo Salgado Yepez Maria M Bovera Victor D Rosenthal Hugo A González Flores Leonardo Pazmino Francisco Valencia Nelly Alquinga Vanessa Ramirez Edgar Jara Miguel Lascano Veronica Delgado Cristian Cevallos Gasdali Santacruz Cristian Pelaéz Celso Zaruma Diego Barahona Pinto | 2017 | World Journal of Biological Chemistry2017，8，1： | 23 |
| 2 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 3 | Systemic inflammatory response syndrome and primary of spontaneous intracerebral haemorrhage显示文摘 | Godoy D Boccio A Hugo N | 2002 | Rev Neurol2002，35，： | 4 |
| 4 | Site preference of ternary alloying additions to NiTi: Fe, Pt, Pd, Au, A1, Cu, Zr and Hl'显示文摘 | Guillenno Bozzolo Ronald D Noebe Hugo O Mosca | 2005 | Journal of Alloys and Compounds2005，389，： | 1 |
| 5 | Effects of weight lifting training combined with plyometric exercise on physical fitness,body composition,and knee extension velocity during kicking in football显示文摘 | JORGE P G HUGO O SAFIRA D G | | 0，，： | 1 |
| 6 | Exposure of the Flemish population to brominated flame retardants: Model and risk assessment显示文摘 | Laurence Roosens Christa Cornelis Wendy D’Hollander Lieven Bervoets Hans Reynders Karen Van Campenhout Rosette Van Den Heuvel Hugo Neels Adrian Covaci | 2010 | Environment International2010，，4： | 1 |
| 7 | Smith Psammoma booties in meningioma显示文摘 | Hugo V R Juno D R Donald R | 1978 | Virchows Archly1978，380，4： | 1 |
| 8 | Weed seeds identification by machine vision显示文摘 | Pablo M Granitto Hugo D Navone Pablo F Verdes | 2002 | Computers and Electronics in Agriculture2002，33，2： | 1 |
| 9 | Auditory Steadystate responses for children with servere to profound hearing loss 显示文摘 | Swanepoel D Hugo R Roode R | 2004 | Arch Otolaryngol headneck surg2004，130，： | 1 |
| 10 | The cost of accuracy in crop area estimation显示文摘 | Hugo D G Oumar T | 2005 | Agricultural systems2005，84，： | 1 |
| 11 | Large-scale investigation of weed seed identification by machine vision显示文摘 | Pablo M Granitto Hugo D Navone Ceccatto H Alejandro | 2005 | Computers and Electronics in Agriculture2005，47，1： | 1 |
| 12 | Economics of exhaust air heat recovery systems for mine ventilation显示文摘 | Hugo D S Kostas F Jacek P | 2012 | Reclamation and Environment2012，26，3： | 1 |
| 13 | Systemic inflammatory response syndrome and p rimary of spontaneous intracerebral haemorrhage显示文摘 | Godoy D Boccio A Hugo N | 2002 | Rev Neurol2002，35，11： | 1 |
| 14 | Rapid and efficient purification of hepatitis A virus from cell culture显示文摘 | Bishop N E Hugo D L Borovec S V | 1994 | J Virol Method1994，47，： | 1 |
| 15 | Theories of International Migration:A Review and Appraisal显示文摘 | Arango J Hugo G | 1993 | Population and Development Review1993，19，3： | 1 |
| 16 | Rapid and efficient purification of hepatitis A virus from cell culture 显示文摘 | Bishop N E Hugo D L Borovec S V | 1994 | J Virol Method1994，47，： | 1 |
| 17 | Bioproduction of Conjugated Linoleic Acid by ProbioticBacteria Occurs In Vitro and In Vivo in Mice 显示文摘 | JULIA B E JOHN W W HUGO D | 1996 | A-meriean Society for Nutrition J Nutr1996，，136： | 1 |
| 18 | Antimicrobial activity and action of silver显示文摘 | RUSSEL A D HUGO W B | 1994 | Proceedings in Medical Chemistry1994，31，： | 1 |
| 19 | Theα2-adrenoceptor agonist dexmedetomidine suppresses memory formation only at doses attenuating the perception of sensory input显示文摘 | Hugo van O Peter JS Arie D | 2010 | European Journal of Pharmacology2010，62，9： | 1 |
| 20 | Wear particle classifier system based on an artificial neural network显示文摘 | GONCALVES V D ALMEIDA L F HUGO M | 2010 | Journal of Mechanical Engineering2010，56，4： | 1 |
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