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| 1 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 2 | Thrombolytic therapy preserves vagal activity early after acute myocardial infarction显示文摘 | Lind P Hintze U Moller M | 2001 | Scand Cardiovase J2001，35，2： | 1 |
| 3 | Electrochemical properties and corrosion protection of organosilane self-assem-bled monolayers on aluminum 2024-T3 显示文摘 | Hintze P E Calle L M | 2006 | Electro- chimica Acta2006，51，8： | 1 |
| 4 | Accuracy of caries detection with four storage phosphor systems and E - speed radiographs 显示文摘 | Hintze H Wenzel A Frydenberg M | 2002 | Dentomaxillofac Radiol2002，31，3： | 1 |
| 5 | Cone beam CT and conventional tomography for the detection of morphological temporomandibular joint changes显示文摘 | Hintze H Wiese M Wenzel A | 2007 | Dentomaxillofac Radiol2007，36，4： | 1 |
| 6 | Influence of culture parameters on biological hydrogen production by Clostridium saccharoperbutylacetonicum ATCC 27021 显示文摘 | Ferchichi M Crabbe E Hintz W | 2005 | World Journal of Microbiology and Biotechnology2005，2，67： | 1 |
| 7 | Apoptosis in sulfur mustard treated A549 cell cultures显示文摘 | Steinritz D Emmler J Hintz M Worek F Kreppel H Szinicz L | 2007 | Life Sci2007，80，2425： | 1 |
| 8 | Non- destructive testing of rails today and in the future显示文摘 | KRULL R HINTZE H THOMAS M | 2003 | ZEVrail Glasers Annalen2003，127，： | 1 |
| 9 | Nitric oxide as a regulator of tissue oxygen consumption显示文摘 | Wolin M S Xie Y W Hintze T H | 1999 | Curr Opin Nephrol Hypertens1999，8，1： | 1 |
| 10 | Low temperature precursor route for highly efficient spherically shaped LED-phosphors M2Si5N8:Eu2+(M=Eu,Sr,Ba)显示文摘 | Zeuner M Hintze F Schnick F | 2009 | Chem Mater2009，21，： | 1 |
| 11 | Spontane- ous serum gonadotropin concentrations in the evaluation of preco- cious puberty显示文摘 | Neely EK Wilson DM Lee PA Stene M Hintz RL | 1995 | J Pediatr1995，127，1： | 1 |
| 12 | Identification of (E)-4-hydroxy 3-methyl-but 2-enyl pyrophosphate as a major activator for human gammadeha T cells in Escherichia coli 显示文摘 | Hintz M Reichenberg A Ahincicek B | 2001 | FEBS Lett2001，509，2： | 1 |
| 13 | Cel- acinnine, a novel macrocyclic spermidine alkaloid prototype显示文摘 | S MorrisKupchan Harold P J Hintz Roger M Smith | 1974 | Cbem Soc Chem Commun1974，9，： | 1 |
| 14 | Apoptosis in sulfur mustard treated A549 cell cultures显示文摘 | Steinritz D Emmler J Hintz M | 2007 | Life Sci2007，80，2425： | 1 |
| 15 | Using LTCC for microsystems 显示文摘 | Thelemann T Thust H Hintz M | 2002 | Microelectronics International2002，19，3： | 1 |
| 16 | Artificial extracel ular matrices composed of col agen I and sulfated hyaluronan with adsorbed transforming growth factor β1 promote col agen synthesis of human mesenchymal stromal cel s显示文摘 | Hempel U Hintze V M?l er S | | 0，，02： | 1 |
| 17 | Modification and validation of the linear amplitude sweep test for binder fatigue specification 显示文摘 | HINTZ C VELASQUEZ R A JOHNSON C M | 2011 | Transportation Research Record: Journal of the Transportation Research Board2011，2207，： | 1 |
| 18 | Identification of a new C- type lectin, TES-70, secreted by infective larvae of Toxocara canis,which binds to host ligands显示文摘 | Loukas A Doedens A Hintz M | 2000 | Parasitology2000，121，： | 1 |
| 19 | Strength and conditioning practices of Major League Baseball strength and conditioning coaches显示文摘 | Ebben WP Hintz M J Simenz CJ | 2005 | J Strength Cond Res2005，19，3： | 1 |
| 20 | Modifications of hyaluronan influence the interaction with human bone morphogenetic protein-4(hBMP-4)显示文摘 | Hintze V Moel er S Schnabelrauch M | | 0，，12： | 1 |
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