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| 1 | MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes显示文摘piRNA 机械在调停以它的角色著名 transposons 的 epigenetic silencing。最近的研究建议这功能也包含导出 transposon 的抄本的指导 piRNA 的劈开。同样多 piRNAs 也看起来有能力指向多样的 mRNAs,这提起 piRNAs 可以与 siRNAs 比广泛地扮演降级的吸引人的可能性特定的 mRNAs。直接测试这个假设,我们比较了联系的老鼠 PIWI (MIWI ) 有从老鼠睾丸的试验性地识别的劈开的 mRNA 碎片的 piRNAs,和主要发生在的观察劈开地点从 5 ′ 放 10;通常认为的指向结束 piRNAs。我们也注意了强壮的偏爱因为分别地,在核苷酸的 U 和 A 残余在 piRNAs 和 mRNA 碎片放 1 和 10,由“乒乓球”类似于 piRNA 扩大的模式的特征骑车。通过由介绍的 CLIP-seq 和基因表示 MIWI-RNA 相互作用印射,我们发现许多潜在的指向 piRNA 的 mRNAs 直接与 MIWI 交往,表演在 Miwi 的睾丸提高了表达式层次催化变异的鼠标。基于记者的试金进一步揭示了在调停 piRNA 的目标压抑的为 slicer 活动和 MIWI 的装载 piRNA 能力的在 piRNAs 和 mRNA 目标和要求之间的基础配对的重要性。重要地,我们证明某些关键 piRNA 目标的那合适的周转为精子形成是必要的。一起,这些调查结果为男细菌房间开发和成熟在鼠标睾丸和它的中央要求揭示 piRNA 机械的象 siRNA 一样函数。 | Peng Zhang Jun-Yan Kang Lan-Tao GOU Jiajia Wang Yuanchao Xue Geir Skogerboe Peng Dai Da-Wei Huang Runsheng Chen Xiang-Dong Fu Mo-Fang Liu Shunmin He | 2015 | Cell Research2015，25，2： | 35 |
| 2 | Targeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis显示文摘Idiopathic pulmonary fibrosis(IPF) is a chronic progressive fibrotic interstitial pneumonia with unknown causes. The incidence rate increases year by year and the prognosis is poor without cure.Recently, phosphatidylinositol 3-kinase(PI3 K)/protein kinase B(PKB/AKT) signaling pathway can be considered as a master regulator for IPF. The contribution of the PI3 K/AKT in fibrotic processes is increasingly prominent, with PI3 K/AKT inhibitors currently under clinical evaluation in IPF. Therefore,PI3 K/AKT represents a critical signaling node during fibrogenesis with potential implications for the development of novel anti-fibrotic strategies. This review epitomizes the progress that is being made in understanding the complex interpretation of the cause of IPF, and demonstrates that PI3 K/AKT can directly participate to the greatest extent in the formation of IPF or cooperate with other pathways to promote the development of fibrosis. We further summarize promising PI3 K/AKT inhibitors with IPF treatment benefits, including inhibitors in clinical trials and pre-clinical studies and natural products, and discuss how these inhibitors mitigate fibrotic progression to explore possible potential agents, which will help to develop effective treatment strategies for IPF in the near future. | Jincheng Wang Kaili Hu Xuanyan Cai Bo Yang Qiaojun He Jiajia Wang Qinjie Weng | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 31 |
| 3 | Mitochondria Play a Role in the Development of Non-Apoptotic Programmed Cell Death of Neutrophils Induced by ONO-AE-248显示文摘We previously reported that ONO-AE-248,a selective EP3 receptor agonist,has been shown to cause neutrophil death without the typical features of apoptosis and necrosis.However,the mechanism of the neutrophil death is unclear.By using Western blotting,flow cytometry(FACS)and confocal laser scanning microscopy(CLSM),we investigated the cellular signal transduction pathways of the neutrophil death.The research results showed that the neutrophil death induced by ONO-AE-248 did not show the morphologic changes of apoptosis and was not associated with the activity of caspase-3,caspase-8,and phosphorylation of p38-MAPK.However,impairment of mitochondria transmembrane potential has been found during the process of cell death.These findings suggested that ONO-AE-248 induced a non-apoptotic programmed cell death of neutrophils through partially mitochondria signaling transduction pathway. | Jiajia Liu Hao He Zi Zhang Shixu Jiang Tohru Akahoshi Jian Yang Juan Li Tao He | 2007 | Cellular & Molecular Immunology2007，4，6： | 11 |
| 4 | Microstructure and mechanical properties of A356 alloy with yttrium addition processed by hot extrusion显示文摘The effects of the rare earth element yttrium(Y) and hot extrusion on the microstructure and mechanical properties of A356 alloy were investigated by mechanical properties testing and microstructure observation. The results indicate that the addition of Y improves the microstructure of the as-cast alloy. The distribution of primary α-Al is uniform and orderly. The long needle-like eutectic Si phases and β-Fe phases turn to strips and short rods. When the content of Y increases to 0.2 wt%, the mean diameter of aAl(40.3 μm) and the aspect ratio of the eutectic Si phase(2.3) reach the minimum values, which are68.9% and 86.1% lower, respectively, than that of the alloy without Y addition. Under extrusion stress, the shape of the eutectic Si phase is changed from long rod-like to near grain-like after solution treatment.The size of the eutectic Si phase is significantly reduced. The needle-like β-Fe phases are squeezed and broken. The mechanical properties of the as-extruded alloy are significantly improved compared to the as-cast alloy. When the rare earth content is 0.2 wt%, the ultimate tensile strength, hardness and elongation of the alloy reach the maximum values, which are 328.2 MPa, 110.4 HV and 21.3%, respectively, and increase by 42.01%, 37.71% and 481.91%, respectively, in comparison to the as-cast alloy without Y addition. | Zhifan Wei Yushun Lei Hong Yan Xihao Xu Jiajia He | 2019 | Journal of Rare Earths2019，37，6： | 11 |
| 5 | The Inhibitory Effect of Quercetin on IL-6 Production by LPS-Stimulated Neutrophils显示文摘Quercetin is a herbal flavonoid derived from various foods of plant origin and plays a role in anti-inflammation. Although a number of researches in the field have been done, the mechanism of anti-inflammatory effect of quercetin should be further clarified. In the present study, we investigated the effects of quercetin on IL-6 production by LPS-stimulated neutrophils in human. Neutrophils were were pre-treated with quercetin at the final concentrations of ranging from 0-80 μM for 30 min, or not treated, and then incubated in the presence or absence of lipopolysaccharide (LPS) at a final concentration of 100 ng/ml for indicated time. The secretion level of IL-6 in the culture supernatants was assayed by ELISA, the intracellular level of IL-6 was detected by flow cytometry and the expression of IL-6 mRNA was analyzed by RT-PCR. The experiment results showed that neutrophils cultured with medium or quercetin alone did not express IL-6, but LPS (100 ng/ml) induced IL-6 expression of neutrophils. However, after pre-treatment of neutrophils with quercetin (40 μM) for 30 min, the inducible effects of LPS on the increase of IL-6 secretion, intracellular IL-6 level and IL-6 mRNA expression by neutrophils were abrogated. IL-6 is one of the important pro-inflammatory factors, especially in early phage of inflammation. Thus, our data suggested that quercetin might exert its anti-inflammatory effect through negatively modulating pro-inflammatory factors, such as IL-6. The inhibitory effects of quercetin on IL-6 production by neutrophils may provide a theoretical basis on future therapy of inflammation. | Jiajia Liu~(1,2) Xin Li~1 Yang Yue~1 Juan Li~1 Tao He~1 Yanzheng He~1 ~1Laboratory of Molecular Biology,Luzhou Medical College,Luzhou 646000,Sichuan,China ~2Laboratory of Molecular Biology,Luzhou Medical College,Luzhou 646000,Sichuan,China. | 2005 | Cellular & Molecular Immunology2005，2，6： | 9 |
| 6 | Blown sand motion within the sand-control system in the southern section of the Taklimakan Desert Highway显示文摘Although scientists have performed many studies in the Taklimakan Desert, few of them have reported the blown sand motion along the southern edge of the Taklimakan Desert Highway, which differs significantly from the northern region in terms of aeolian sand geomorphology and formation environment. Based on the field observation data of airflow and aeolian sand transport, continuous monitoring data of erosional and depositional processes between 14 April 2009 and 9 April 2011 and data of surface sand grains from the classical section along the southern edge of the Taklimakan Desert Highway, this paper reported the blown sand motion within the sand-control system of the highway. The main results are as follows: 1) The existing sand-control system is highly effective in preventing and controlling desertification. Wind velocities within the sand-control system were approximately 33%–100% of those for the same height above the mobile sand surface. Aeolian sand fluxes were approximately 0–31.21% of those of the mobile sand surface. Sand grains inside the system, with a mean diameter of 2.89 φ, were finer than those(2.15 φ) outside the system. In addition, wind velocities basically followed a logarithmic law, but the airflow along the classical section was mainly determined by topography and vegetation. 2) There were obvious erosional and depositional phenomena above the surface within the sand-control system, and these phenomena have very consistent patterns for all observation points in the two observed years. The total thicknesses of erosion and deposition ranged from 0.30 to 14.60 cm, with a mean value of 3.67 cm. In contrast, the deposition thicknesses were 1.90–22.10 cm, with a mean value of 7.59 cm, and the erosion thicknesses were 3.51–15.10 cm, with a mean value of 8.75 cm. The results will aid our understanding of blown sand within the sand-control system and provide a strong foundation for optimizing the sand-control system. | CHENG Hong HE Jiajia XU Xingri ZOU Xueyong WU Yongqiu LIU Chenchen DONG Yifan PAN Meihui WANG Yanzai ZHANG Hongyan | 2015 | Journal of Arid Land2015，7，5： | 8 |
| 7 | Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia显示文摘Male infertility, as a major issue of human reproduction health, prevents successful natural conception. Asthenoteratospermia mainly presents one or multiple anomalies in head, neck and tail of spermatozoa, and impairs sperm function and motility (Coutton et al., 2015). Recurrent abnormalities of the fibrous sheath lead to multiple morphological abnormaliries of the sperm flagella (MMAF), which is a quite frequent type of asthenoteratospermia in male infertility (Chemes et al., 1987;Ben Khelifa et al, 2014). | Wangjie Liu Huan Wu Li Wang Xiaoyu Yang Chunyu Liu Xiaojin He Weiyu Li Jiajia Wang Yujie Chen Hongyan Wang Yang Gao Shuyan Tang Shenmin Yang Li Jin Feng Zhang Yunxi Cao | 2019 | Journal of Genetics and Genomics2019，46，1： | 7 |
| 8 | Profiling the repertoire of T-cell receptor beta-chain variable genes in peripheral blood lymphocytes from subjects who have recovered from acute hepatitis B virus infection显示文摘T 房间受体贝它链的侧面变量(TRBV ) 基因通常与病毒感染或癌症在题目扭曲。融化的基因光谱模式(GMSP ) 能被用来决定 TRBV 基因家庭的侧面。从从尖锐肝炎 B 病毒感染(AHI ) 恢复了的题目在外部血淋巴细胞探索 TRBV 家庭的肖像,外部血 mononuclear 房间(PBMC ) 被分开并且进一步排序 + 和 CD8 +T 房间子集进 CD4。TRBV 的分子的特征补足的决定区域 3 (CDR3 ) 主题用 GMSP 分析被决定。当 GMSP 侧面显示出一座单个山峰时, monoclonally 扩展的 TRBV 基因被克隆并且定序。多重 TRBV 基因的扭曲的扩大在 CD4 + 和 CD8 +T 房间子集和 PBMC 之中被观察。在 CD8 +T 房间子集的 monoclonally 扩展的 TRBV 基因的频率比 CD4 +T 房间子集和 PBMC 的显著地高。比作 TRBV 基因家庭, TRBV11, BV15 和 BV20 的另外的成员主要在恢复 AHI 题目在外部血淋巴细胞的全部剧目被表示。TRBV5.1 和 BV20 CDR3 的相对保存的氨基酸主题也在 CD4 + 和 CD8 +T 房间子集被检测。这些结果在恢复 AHI 题目表明多重偏导的 TRBV 家庭的存在。特别从 CD8 +T 房间子集, TRBV11, BV15 和 BV20 可能与有 AHI 的题目的致病相关。有相对保存的 CDR3 主题的优先地选择的 TRBV5.1 和 BV20 可以是为长期的 HBV 感染的个性化的处理的潜在的目标。 | Jiezuan Yang | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 9 | Efficacy and advantages of modified Traditional Chinese Medicine treatments based on'kidney reinforcing'for chronic aplastic ane-mia:a randomized controlled clinical trial显示文摘OBJECTIVE:To compare the efficacy of modified treatments based on 'kidney reinforcing' in the management of chronic aplastic anemia(CAA),and explore their advantages and specialties.METHODS:One hundred and eleven patients with CAA were randomly divided into three groups:kidney reinforcing alone(KA),'kidney reinforcing and Qi tonifying'(KQ),and 'kidney reinforcing and blood circulation invigorating'(KC).Normal and positive control groups were also formed.All patients were treated for 6 months(two courses).Hemograms,Traditional Chinese Medicine(TCM) syndrome scores,and therapeutic effects were assessed,and changes in T-lymphocyte subsets,regulatory T cells and cytokines were detected.RESULTS:The KQ and KC groups had lower TCM syndrome scores than the positive control group after 6 months(P < 0.05).The KQ group had a higher overall efficacy than the positive control group after 3 months(P < 0.05),while platelet counts increased in the KC group after 6 months(P < 0.05).CD3+ T-lymphocyte ratios decreased only in the KQ group,while CD3 + CD4 + CD8-Tlymphocytes increased only in the KC group after 6 months(P <0.05).Levels of interferon-γ,tumor necrosis fac-tor-α,interleukin(IL)-2 and IL-6 decreased and levels of IL-4 and IL-10 increased in all treated groups after 6 months.Levels of IL-6 in the KQ and KC groups were lower than those in the positive control group(P < 0.05).CONCLUSION:Treatments based on kidney reinforcing have a rebalancing effect on cytotoxic and T helper cells,and regulate expression of interferon-γ,IL-2,IL-6 and IL-4.KQ may be more effective in treating CAA,and KC may have an advantage in platelet recovery. | Wu Dijiong Shen Yiping Ye Baodong Fang Bingmu Lin Shengyun Chen Zhilu Jiang Huifang Feng Changwei He Lüyuan Gao Yanting Liu Yonglin Liu Yonghua Zhu Jiajia Wu Liqiang Shao Keding Zhou Yuhong | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 6 |
| 10 | Comparative genomic and transcriptomic analyses uncover the molecular basis of high nitrogen-use efficiency in the wheat cultivar Kenong 9204显示文摘Studying the regulatory mechanisms that drive nitrogen-use efficiency(NUE)in crops is important for sustainable agriculture and environmental protection.In this study,we generated a high-quality genome assembly for the high-NUE wheat cultivar Kenong 9204 and systematically analyzed genes related to nitrogen uptake and metabolism.By comparative analyses,we found that the high-affinity nitrate transporter gene family had expanded in Triticeae.Further studies showed that subsequent functional differentiation endowed the expanded family members with saline inducibility,providing a genetic basis for improving the adaptability of wheat to nitrogen deficiency in various habitats.To explore the genetic and molecular mechanisms of high NUE,we compared genomic and transcriptomic data from the high-NUE cultivar Kenong 9204(KN9204)and the low-NUE cultivar Jing 411 and quantified their nitrogen accumulation under high-and low-nitrogen conditions.Compared with Jing 411,KN9204 absorbed significantly more nitrogen at the reproductive stage after shooting and accumulated it in the shoots and seeds.Transcriptome data analysis revealed that nitrogen deficiency clearly suppressed the expression of genes related to cell division in the young spike of Jing 411,whereas this suppression of gene expression was much lower in KN9204.In addition,KN9204 maintained relatively high expression of NPF genes for a longer time than Jing 411 during seed maturity.Physiological and transcriptome data revealed that KN9204 was more tolerant of nitrogen deficiency than Jing 411,especially at the reproductive stage.The high NUE of KN9204 is an integrated effect controlled at different levels.Taken together,our data provide new insights into the molecular mechanisms of NUE and important gene resources for improving wheat cultivars with a higher NUE trait. | Xiaoli Shi Fa Cui Xinyin Han Yilin He Long Zhao Na Zhang Hao Zhang Haidong Zhu Zhexin Liu Bin Ma Shusong Zheng Wei Zhang Jiajia Liu Xiaoli Fan Yaoqi Si Shuiquan Tian Jianqing Niu Huilan Wu Xuemei Liu Zhuo Chen Deyuan Meng Xiaoyan Wang Liqiang Song Lijing Sun Jie Han Hui Zhao Jun Ji Zhiguo Wang Xiaoyu He Ruilin Li Xuebin Chi Chengzhi Liang Beifang Niu Jun Xiao Junming Li Hong-Qing Ling | 2022 | Molecular Plant2022，15，9： | 6 |
| 11 | Measurement of laminar burning velocities and analysis of flame stabilities for hydrogen-air-diluent premixed mixtures显示文摘The laminar burning velocities and Markstein lengths of the hydrogen-air-diluent mixtures were meas-ured at different equivalence ratios (0.4―1.5), different diluents (N2, CO2 and 15%CO2+85%N2) and di-lution ratios (0, 0.05, 0.10 and 0.15) by using the outwardly expanding flame. The influences of flame stretch rate on the flame propagation characteristics were analyzed. The results show that both the laminar burning velocities and the Markstein lengths of the hydrogen-air-diluent mixtures decrease with the increase of dilution ratio. The decrease in Markstein lengths means that adding diluents into the hydrogen-air mixtures will decrease the diffusional-thermal instability of the flame front. For a specified dilution ratio, the laminar burning velocities give their maximum values at an equivalence ratio of 1.8. The Markstein lengths increase with the increase of the equivalence ratio monotonously regardless of the diluents. The study shows that CO2 as the diluent has a greater impact on the laminar flame speed and the flame front stability than N2 as the diluent. | HU ErJiang HUANG ZuoHua HE JiaJia JIN Chun MIAO HaiYan WANG XiBin | 2009 | Chinese Science Bulletin2009，54，5： | 4 |
| 12 | Numerical simulation of seismic wavefields in TTI media using the rotated staggered-grid compact finite-difference scheme显示文摘Numerical simulation in transverse isotropic media with tilted symmetry axis(TTI) using the standard staggered-grid finite-difference scheme(SSG)results in errors caused by averaging or interpolation. In order to eliminate the errors, a method of rotated staggered-grid finite-difference scheme(RSG) is proposed. However, the RSG brings serious numerical dispersion. The compact staggered-grid finite-difference scheme(CSG) is an implicit difference scheme, which use fewer grid points to suppress dispersion more effectively than the SSG. This paper combines the CSG with the RSG to derive a rotated staggered-grid compact finite-difference scheme(RSGC). The numerical experiments indicate that the RSGC has weaker numerical dispersion and better accuracy than the RSG. | Bing Bai Bingshou He Kairui Li Huaigu Tang Jiajia Yang | 2018 | Earthquake Science2018，31，2： | 3 |
| 13 | Cross-shelf carbon transport under different greenhouse gas emission scenarios in the East China Sea during winter显示文摘Based on Marx-Planck coupled model simulations and in situ hydrography measurements, the volume transport of ocean currents and associated carbon fluxes across the continental margin from the continental shelf to the deep ocean in the East China Sea during winter are estimated. Because cross-shelf currents in the Yellow and East China seas are much stronger in winter than in other seasons and are subducted into the subsurface Kuroshio, the cross-shelf burial of carbon takes place mainly in winter. The analyses show prominent cross-shelf transports during winter in the Yellow and East China seas, with annual mean offshore transport across a section from Taiwan to Cheju at 3.92 Sv(1 Sv=10~6 m^3 s^(-1)). Net transport across the section was0.82 Sv off the shelf, determined by the difference between Taiwan and Cheju strait transports. Net cross-shelf transports of dissolving inorganic carbon(DIC), dissolved organic carbon(DOC), and particulate organic carbon(POC) in winter were 98, 12,and 0.1 million tons, respectively. Under global greenhouse gas emission reduction(RCP4.5) and continuous increase(RCP8.5)scenarios, this cross-shelf transport has an increasing trend. The transports across the Taiwan-Cheju section in winter are predicted to increase by 0.54 and 0.65 Sv from 2006 to 2099, with rates of increase 15.3% and 19.6%, respectively. Associated with the transport increase, the cross-shelf fluxes of DIC, DOC and POC increase by as much as 15.4–25.2%. Cross-shelf carbon fluxes in the East China Sea during winter are evaluated for the first time under the global warming scenarios, showing the importance of cross-shelf transport in the carbon cycle of the China marginal seas. | Dongliang YUAN Jiajia HAO Jianle LI Lei HE | 2018 | Science China Earth Sciences2018，61，6： | 3 |
| 14 | Determination of time-and size-dependent fine particle emission with varied oil heating in an experimental kitchen显示文摘Particulate matter(PM) from cooking has caused seriously indoor air pollutant and aroused risk to human health.It is urged to get deep knowledge of their spatial-temporal distribution of source emission characteristics,especially ultrafine particles(UFP < 100 nm) and accumulation mode particles(AMP 100-555 nm).Four commercial cooking oils are auto dipped water to simulate cooking fume under heating to 255℃ to investigate PM emission and decay features between 0.03 and 10 μm size dimension by electrical low pressure impactor(ELPI) without ventilation.Rapeseed and sunflower produced high PM_(2.5) around5.1 mg/m^3,in comparison with those of soybean and corn(5.87 and 4.55 mg/m^3,respectively)at peak emission time between 340 and 450 sec since heating oil,but with the same level of particle numbers 6-9 × 10~5/cm^3.Mean values of PM_(1.0)/PM_(2.5) and PM_(2.5)/PM_(10) at peak emission time are around 0.51-0.55 and 0.23-0.29.After 15 min naturally deposition,decay rates of PM_(1.0),PM_(2.5) and PM_(10) are 13.3%-29.8%,20.1%-33.9%and 41.2%-54.7%,which manifest that PM_(1.0) is quite hard to decay than larger particles,PM_(2.5) and PM_(1.0).The majority of the particle emission locates at 43 nm with the largest decay rate at 75%,and shifts to a larger size between137 and 555 nm after 15 min decay.The decay rates of the particles are sensitive to the oil type. | Shuangde Li Jiajia Gao Yiqing He Liuxu Cao Ang Li Shengpeng Mo Yunfa Chen Yaqun Cao | 2017 | Journal of Environmental Sciences2017，29，1： | 3 |
| 15 | Structural engineering of cathodes for improved Zn-ion batteries显示文摘Aqueous zinc-ion batteries(ZIBs) are attracting considerable attention because of their low cost,high safety and abundant anode material resources.However,the major challenge faced by aqueous ZIBs is the lack of stable and high capacity cathode materials due to their complicated reaction mechanism and slow Zn-ion transport kinetics.This study reports a unique 3 D ’flower-like’ zinc cobaltite(ZnCo_(2)O_(4-x)) with enriched oxygen vacancies as a new cathode material for aqueous ZIBs.Computational calculations reveal that the presence of oxygen vacancies significantly enhances the electronic conductivity and accelerates Zn^(2+) diffusion by providing enlarged channels.The as-fabricated batteries present an impressive specific capacity of 148.3 mAh g^(-1) at the current density of 0.05 A g^(-1),high energy(2.8 Wh kg^(-1)) and power densities(27.2 W kg^(-1)) based on the whole device,which outperform most of the reported aqueous ZIBs.Moreover,a flexible solid-state pouch cell was demonstrated,which delivers an extremely stable capacity under bending states.This work demonstrates that the performance of Zn-ion storage can be effectively enhanced by tailoring the atomic structure of cathode materials,guiding the development of low-cost and eco-friendly energy storage materials. | Jiajia Huang Yuying Li Ruikuan Xie Jianwei Li Zhihong Tian Guoliang Chai Yanwu Zhang Feili Lai Guanjie He Chuntai Liu Tianxi Liu Dan J.L.Brett | 2021 | Journal of Energy Chemistry2021，30，7： | 3 |
| 16 | Formation and evolution of the tertiary carbonate reefs in the Madura Strait Basin of Indonesia显示文摘Analysis of 2 D seismic data over 4 500 km in length from the Madura Strait Basin in the East Java Sea reveals seismic re?ection characteristics of reefs and associated sedimentary bodies, including asymmetrical or symmetrical dome re?ections, slope progradational re?ections, chaotic re?ections and discontinuous strong re?ections inside the reef, which onlap the ?ank of the reef. It is concluded that the developmental paleo-environment of most reefs is mainly conducive to shallow marine carbonate platform facies and platform margin facies, based on well core data, variations in seismic facies and strata thickness.The formation and evolution of all reefs are primarily in?uenced by the tectonic framework of the Madura Strait Basin. Platform margin reefs are principally controlled by two types of structures: one is a series of E-W trending Paleogene normal faults, and the other is an E-W trending Neogene inversion structures. In addition, wave actions, tidal currents and other ocean currents play an accelerated role in sorting, rounding and redeposition for the accumulation and evolution of reefs. Tertiary reefs in the MSB can be divided into four types: 1) an open platform coral reef of Late Oligocene to Early Miocene, 2) a platform margin coral reef controlled by normal faults in Late Oligocene to Early Miocene, 3) a platform margin Globigerina moundreef controlled by a 'hidden' inversion structure in Early Pliocene, and 4) a platform margin Globigerina mound-reef controlled by thrust faults in the early Pliocene. Patterns of the formation and evolution of reefs are also suggested. | RAN Weimin LUAN Xiwu LU Yintao LIU Hong YANG Jiajia ZHAO Yang HE Wenchang YAN Zhonghui | 2019 | Journal of Oceanology and Limnology2019，37，1： | 3 |
| 17 | Investigation on induction brazing of profiled cBN wheel for grinding of Ti-6Al-4V显示文摘Profiled monolayer cBN wheel was induction brazed for grinding of titanium dovetail slot in this study.Aimed at acquiring a uniform temperature distribution along the profiled surface and reducing the thermal deformation of the brazed wheel,a finite element model was established to investigate the temperature uniformity during induction brazing.A suitable induction coil and the related working parameters were designed and chosen based on the simulation results.Ag-Cu-Ti alloy and cBN grains were applied in the induction brazing experiment.The results showed geometric deformation of the brazed wheel was no more than 0.01 mm and chemical reaction layer were found on the brazed joint interface.Further validation tests were carried out by grinding of Ti-6 Al-4 V alloy.Compared to the electroplated wheel,the brazed wheel showed better performance such as low specific grinding energy and good ground quality in grinding of Ti-6 Al-4 V alloy.Abrasion wear was found to be the main failure mode for the induction brazed wheel,while adhesion and grains pull-out were the main failure mode for the electroplated wheel. | Qilin LI Kai DING Weining LEI Jiajia CHEN Qingshan HE Zhenzhen CHEN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 2 |
| 18 | Cross-task emotion recognition using EEG measures: first step towards practical application显示文摘Electroencephalographic(EEG)-based emotion recognition has received increasing attention in the field of human-computer interaction(HCI)recently,there however remains a number of challenges in building a generalized emotion recognition model,one of which includes the difficulty of an EEG-based emotion classifier trained on a specific task to handle other tasks.Lit-tle attention has been paid to this issue.The current study is to determine the feasibility of coping with this challenge using feature selection.12 healthy volunteers were emotionally elicited when conducting picture induced and videoinduced tasks.Firstly,support vector machine(SVM)classifier was examined under within-task conditions(trained and tested on the same task)and cross-task conditions(trained on one task and tested on another task)for pictureinduced and videoinduced tasks.The within-task classification performed fairly well(classification accuracy:51.6%for picture task and 94.4%for video task).Cross-task classification,however,deteriorated to low levels(around 44%).Trained and tested with the most robust feature subset selected by SVM-recursive feature elimination(RFE),the performance of cross-task classifier was significantly improved to above 68%.These results suggest that cross-task emotion recognition is feasible with proper methods and bring EEG-based emotion recognition models closer to being able to discriminate emotion states for any tasks. | LIU Shuang MENG Jiayuan ZHAO Xin YANG Jiajia HE Feng QI Hongzhi ZHOU Peng HU Yong MING Dong | 2014 | Instrumentation2014，1，3： | 2 |
| 19 | Adaptor protein APPL1 interacts with EGFR to orchestrate EGF-stimulated signaling显示文摘表皮的生长因素受体(EGFR ) 调停调整细胞移植,增长,和区别的多重发信号小径。适配器蛋白质 APPL1 被报导了作为表明小径的 EGFR 的一个下游的受动器工作。然而,表明遗体的 EGFR 下游地位于 APPL1 的角色下面的分子的机制逃犯。这里,我们作为与 EGFR 交往的一个批评分子识别了 APPL1。由 siRNA 的 APPL1 的抑制禁止了刺激 EGF 的 Akt phosphorylation。机能上地,房间的 EGF 刺激在 Ser636 引起了 APPL1 的 phosphorylation,它随后支持了在 APPL1 和 EGFR 之间的相互作用,显示 APPL1 敏化由发信号的 EGFR 下游地在一个地点行动的 EGF 刺激。重要地, APPL1 变异的 non-phosphorylatable 以一种 Akt 依赖的方式与野类型的 APPL1 相比减少了房间移植。我们的学习在 EGF 发信号揭示 APPL1 的新奇功能并且定义在 EGF 刺激之上的 APPL1 的 phosphorylation 由调整位于刺激 EGF 的 Akt 小径下面的房间移植的新奇分子的机制。 | Jiajia Zhou Hongsheng Liu Shu Zhou Ping He Xing Liu | 2016 | Science Bulletin2016，61，19： | 2 |
| 20 | Synthesis, In vitro Coagulation Activities and Molecular Docking Studies on Three L-Histidine Amide Derivatives显示文摘 | HE Wei ZHAO Anran ZOU Jiajia LUO Xuan LIN Xiao WANG Lisheng LIN Cuiwu | 2018 | Chemical Research in Chinese Universities2018，34，1： | 1 |
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