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| 1 | Rice functional genomics:decades'efforts and roads ahead显示文摘Rice(Oryza sativa L.)is one of the most important crops in the world.Since the completion of rice reference genome sequences,tremendous progress has been achieved in understanding the molecular mechanisms on various rice traits and dissecting the underlying regulatory networks.In this review,we summarize the research progress of rice biology over past decades,including omics,genome-wide association study,phytohormone action,nutrient use,biotic and abiotic responses,photoperiodic flowering,and reproductive development(fertility and sterility).For the roads ahead,cutting-edge technologies such as new genomics methods,high-throughput phenotyping platforms,precise genome-editing tools,environmental microbiome optimization,and synthetic methods will further extend our understanding of unsolved molecular biology questions in rice,and facilitate integrations of the knowledge for agricultural applications. | Rongzhi Chen Yiwen Deng Yanglin Ding Jingxin Guo Jie Qiu Bing Wang Changsheng Wang Yongyao Xie Zhihua Zhang Jiaxin Chen Letian Chen Chengcai Chu Guangcun He Zuhua He Xuehui Huang Yongzhong Xing Shuhua Yang Daoxin Xie Yaoguang Liu Jiayang Li | 2022 | Science China(Life Sciences)2022，65，1： | 12 |
| 2 | Robotic and laparoscopic hybrid pancreaticoduodenectomy: surgical techniques and early outcomes显示文摘In recent years,the use of minimally invasive surgery in pancreas has been gradually rising in importance.There has been growing interest in performing pancreatectomy by the laparoscopic approach.However,laparoscopic pancreaticoduodenectomy (LPD) is very complicated and difficult to control and requires surgeons to have a high level of laparoscopic skills.Since LPD provides no significant benefits in terms of blood loss,morbidity rate,or median hospital stay,robotic pancreaticoduodenectomy (RPD) gained surgeons' attention.The increased dexterity granted by endo-wristed instruments,the improved three-dimensional vision,and the computer filtration of the surgeon's movements have brought minimally invasive surgery into a new era.1 RPD can overcome most of the natural limitations and drawbacks of LPD mentioned above.Therefore,we propose a hybrid of laparoscopic and robotic approaches (RLPD),which may be more beneficial and effective to pancreaticoduodenectomy as it combines the advantages of both LPD and RPD.In this paper,we report our initial experience with the new method RLPD and analyze its surgical techniques and early outcomes. | Ji Wu Ding Kai Kao Xiaoming He Changsheng Li Ning Li Jieshou | 2014 | Chinese Medical Journal2014，，16： | 4 |
| 3 | Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis显示文摘Implant loosening remains a major clinical challenge for osteoporotic patients.This is because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in the case of osteoporosis,which results in poor bone repair.Strontium(Sr)has been widely accepted as an anti-osteoporosis element.In this study,we fabricated a series of apatite and Sr-substituted apatite coatings via electrochemical deposition under different acidic conditions.The results showed that Ca and Sr exhibited different mineralization behaviors.The main mineralization products for Ca were CaHPO4⋅2H2O and Ca3(PO4)2 with the structure changed from porous to spherical as the pH values increased.The main mineralization products for Sr were SrHPO4 and Sr5(PO4)3OH with the structure changed from flake to needle as the pH values increased.The in vitro experiment demonstrated that coatings fabricated at high pH condition with the presence of Sr were favorable to MSCs adhesion,spreading,proliferation,and osteogenic differentiation.In addition,Sr-substituted apatite coatings could evidently inhibit osteoclast differentiation and fusion.Moreover,the in vivo study indicated that nano-needle like Sr-substituted apatite coating could suppress osteoclastic activity,improve new bone formation,and enhance bone-implant integration.This study provided a new theoretical guidance for implant coating design and the fabricated Sr-substituted coating might have potential applications for osteoporotic patients. | Zhen Geng Luli Ji Zhaoyang Li Jing Wang Hongyan He Zhenduo Cui Xianjin Yang Changsheng Liu | 2021 | Bioactive Materials2021，6，4： | 4 |
| 4 | Corrosion Behavior and Protection Efficiency of 2024Al and SiC_p/2024Al Metal Matrix Composite显示文摘The corrosion resistance of 2024 Al and SiC particle reinforced 2024 Al metal matrix composite (SiCp/2024Al MMC)in 3.5% NaCl solution was investigated with electrochemical method and immersion test, and the corrosion protection of sulfuric acid anodized coatings on both materials was evaluated by electrochemical impedance spectroscopy. The results showed that the SiCp/2024Al MMC is more susceptible to corrosion than its matrix alloy in 3.5% NaCl.For 2024Al, the anodized coating provides excellent corrosion resistance to 3.5% NaCl. The anodized coating on the SiCp/2024Al provides satisfactory corrosion protection, but it is not as effective as that for 2024Al because the structure of the anodized layer is affected by the SiC particulates. | Chunlin HE, Changsheng LIU, Fengqin LI and Qingkui CAISchool of Materials and Metallurgy, Northeastern University, Shenyang 110004, ChinaZhiming SHI, Liqing CHEN and Jing BIInstitute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China | 2002 | Journal of Materials Science & Technology2002，18，4： | 2 |
| 5 | Nitric oxide enhances the sensitivity of alpaca melanocytes to respond to α-melanocyte-stimulating hormone by up-regulating melanocortin-1 receptor显示文摘 | Yanjun Dong Jing Cao Haidong Wang Jie Zhang Zhiwei Zhu Rui Bai HuanQing Hao Xiaoyan He Ruiwen Fan Changsheng Dong | 2010 | Biochemical and Biophysical Research Communications2010，，4： | 2 |
| 6 | Selective potassium uptake via biocompatible zeolite–polymer hybrid microbeads as promising binders for hyperkalemia显示文摘Patients with chronic kidney disease are at high risk of hyperkalemia that is associated with various lifethreatening complications.Treatments primarily rely on orally administered potassium binding agents,along with low curative effects and various side effects.Herein,direct serum potassium uptake was realized via zeolite–heparin-mimicking-polymer hybrid microbeads.The preparation process involved the synthesis of the heparin-mimicking polymer via the in situ cross-linking polymerization of acrylic acid and N-vinylpyrrolidone in polyethersulfone solution,the fabrication of microbeads via zeolite-mixing,electro-spraying and phase-inversion,and the subsequent aqueous-phase modifications based on ion-exchange and metal-leaching.An ultra-high(about 88%)amount of zeolite could be incorporated and well locked inside the polymer matrix.Potassium uptake capability was verified in water,normal saline and human serum,showing high selectivity and fast adsorption.The microbeads exhibited satisfying blood compatibility,negligible hemolysis ratio,prolonged clotting time,inhibited contact activation,and enhanced antifouling property toward serum proteins and cells.The proposed approach toward zeolite–heparin-mimicking-polymer hybrid microbeads provided a cheap,efficient and safe treatment protocol of hyperkalemia for the high-risk patients. | Zhoujun Wang Wei Sun Zhiwei Wei Jianxu Bao Xin Song Yupei Li Haifeng Ji Jue Zhang Chao He Baihai Su Weifeng Zhao Changsheng Zhao | 2021 | Bioactive Materials2021，6，2： | 2 |
| 7 | Advances in the formulation and defivery technology of paclitaxel for injection显示文摘紫杉醇用于治疗人体各种实体瘤比如卵巢癌,乳腺癌,头颈部癌和黑色素瘤,是一个很有前景的抗癌药物。由于它的疏水性,紫杉醇的第一个给药剂型泰素是以非水浓缩液的形式存在,成分主要含有聚氧乙烯蓖麻油和乙醇,它在长时间的输注前必须用合适的水溶液稀释。基于它的成分和用法,泰素存在严重的不良反应并造成临床应用的不便。为了解决以上问题,科学家们开始致力于开发低毒、较好耐受性、不含聚氧乙烯蓖麻油的紫杉醇新剂型。最近几年,新的药物递送系统如白蛋白纳米粒、胶束、脂质体等已经处于研究中。在这篇综述中,我们提出了注射用紫杉醇的一些新剂型及递送技术,并且重点研究已经上市的或处于临床研究阶段的几个制剂的部分临床前和临床研究成果。最后,阐述纳米技术优势的几个原因及紫杉醇给药系统现存的挑战和展望。 | Jing Sun Wenbing Dai Zhe Liang Zhaoyang wang Changsheng Huang Bing He Hua Zhang Xueqing Wang Qiang Zhang | 2015 | Journal of Chinese Pharmaceutical Sciences2015，24，8： | 2 |
| 8 | Microstructure and mechanical properties of short-carbon-fiber/Ti_(3)SiC_(2) composites显示文摘Short-carbon-fibers(C_(sf))reinforced Ti_(3)SiC_(2) matrix composites(C_(sf)/Ti_(3)SiC_(2),the C_(sf) content was 0 vol%,2 vol%,5 vol%,and 10 vol%)were fabricated by spark plasma sintering(SPS)using Ti_(3)SiC_(2) powders and C_(sf) as starting materials at 1300℃.The effects of C_(sf) addition on the phase compositions,microstructures,and mechanical properties(including hardness,flexural strength(σ_(f)),and KIC)of C_(sf)/Ti_(3)SiC_(2) composites were investigated.The C_(sf),with bi-layered transition layers,i.e.,T_(IC) and SiC layers,were homogeneously distributed in the as-prepared C_(sf)/Ti_(3)SiC_(2) composites.With the increase of C_(sf) content,the K_(IC) of C_(sf)/Ti_(3)SiC_(2) composites increased,but the σ_(f) decreased,and the Vickers hardness decreased initially and then increased steadily when the C_(sf) content was higher than 2 vol%.These changed performances(hardness,σ_(f),and K_(IC))could be attributed to the introduction of C_(sf) and the formation of stronger interfacial phases. | Guangqi HE Rongxiu GUO Meishuan LI Yang YANG Linshan WANG Yuhai QIAN Jun ZUO Jingjun XU Changsheng LIU | 2020 | Journal of Advanced Ceramics2020，9，6： | 2 |
| 9 | The Temporal Relation between Cardiomyopathy and LBBB and Response to Cardiac Resynchronization Therapy:Case Series and Literature Review显示文摘Background:Left bundle branch block(LBBB)-induced cardiomyopathy has been proposed,but the association between LBBB and cardiac resynchronization therapy(CRT)response remains unclear and practical criteria for selecting CRT candidates are needed.Methods:One hundred and seventeen consecutive heart failure patients were reviewed,24 of whom received CRT.Only two patients had a clear temporal relation between cardiomyopathy and LBBB.Results:Compared with the patient with“cardiomyopathy-induced LBBB,”the patient with“LBBB-induced cardiomyopathy”had higher left ventricular(LV)wall thickness,higher LV wall thickening rate,higher peak circumferential strain,and longer peak circumferential strain delay.The LV deformation patterns in the two patients were obviously distinct on cardiovascular magnetic resonance tissue tracking.During follow-up,the patient with LBBB-induced cardiomyopathy had a good response to CRT(LV ejection fraction 23 before CRT vs.30%at 6 months vs.29 at 12 months vs.32%at 18 months;LV end-diastolic diameter 77 mm before CRT vs.66 mm at 6 months vs.62 mm at 12 months vs.63 mm at 18 months),and the other patient had no response to CRT(LV ejection fraction 29 before CRT vs.29%at 6 months vs.26 at 12 months vs.22%at 24 months;LV end-diastolic diameter 85 mm before CRT vs.88 mm at 6 months vs.85 mm at 12 months vs.84 mm at 24 months).Conclusion:The temporal relation between cardiomyopathy and LBBB could be a determinant for CRT response.Cardiovascular magnetic resonance tissue tracking may be a useful tool to identify the chronological order and a principal consideration for selecting candidates for CRT.Larger prospective clinical trials are needed to study the prevalence of,time course of,and risk factors for LBBB-induced cardiomyopathy. | Sanshuai Chang Yi He Hui Wang Fei Guo Qiang Lv Junping Kang Rong Bai Xiaohui Liu Xin Du Changsheng Ma Jianzeng Dong | 2020 | Cardiovascular Innovations and Applications2020，，1： | 1 |
| 10 | Context-aware local abnormality detection in crowded scene显示文摘In this paper, we propose a novel algorithm by jointly modeling motion and context information targeting at detecting abnormal events in crowded scenes. In our algorithm, context pattern information,extracted through volume local binary patterns computation on three orthogonal planes(LBP-TOP) between local target areas with surrounding areas, is explicitly taken into consideration for localizing abnormality. To capture motion information, a novel feature descriptor named Multi-scale Histogram of Frequency Coefficient is explored by taking Fourier Transform on the extracted dense trajectories. For detection of abnormality, sparse reconstruction cost from a learned event dictionary is adopted to classify local normal and abnormal events.Experiments conducted on three benchmark datasets show superior performance to many related state-of-the-art methods. | ZHU XiaoBin JIN Xin ZHANG XiaoYu LI ChangSheng HE FuGang WANG Lei | 2015 | Science China(Information Sciences)2015，58，5： | 1 |
| 11 | Multidisciplinary Stepwise Management Strategy for Acute Superior Mesenteric Venous Thrombosis: An Intestinal Stroke Center Experience显示文摘 | Shuofei Yang Xinxin Fan Weiwei Ding Baochen Liu Jiaxiang Meng Dandan Xu Changsheng He Wenkui Yu Xingjiang Wu Jieshou Li | 2014 | Thrombosis Research2014，，： | 1 |
| 12 | Geochemistry and environmental effect of cadmium in the super-large Jinding Pb-Zn deposit,Yunnan Province, China显示文摘The Jinding Pb-Zn deposit in Yunnan Province is the representative of a Cd-enriched area and mining activities lead to the release of Cd into the hypergenic ecosystem, resulting in Cd pollution. The concentrations of Cd vary greatly from one type to another type of rocks in the mining district. In the host rock, Cd concentrations range from 50×10-6 to 650×10-6 with an average of 310×10-6. In primary ores, Cd concentrations range from 14×10-6 to 2800×10-6 with an average of 767×10-6. However, in oxidized ores, Cd concentrations are highest, varying within the range of 110×10-6 to 8200×10-6 , averaging 1661×10-6. It is shown that the oxidized ores are the main carrier and environmental source of Cd. Leaching test showed that Pb/Zn ores are easy to oxidize and thereafter release Cd and other harmful elements. These leached elements in the leachate may be precipitated rapidly in the order of Zn>Pb>Cd. As for the concentration distribution of Cd in the Bijiang River, it is estimated to be 15.7 μg/L Cd in water, 49.3 mg/L in suspended substances, and 203.7 mg/L in sediments. The average value of Cd in soil from the polluted area is 83.0 mg/kg. Natural weathering of Cd-rich rocks and minerals imposes a potential environmental risk on the aquatic ecosystem of the Bijiang catchment. | LI Hang LI Dahua XIAO Tangfu HE Libin NING Zengping SUN Jialong ZHU Changsheng SHUANG Yan | 2008 | Chinese Journal Of Geochemistry2008，27，1： | 1 |
| 13 | Intramodulated photodetector显示文摘 | Long Li Chen Changsheng | 1993 | Sensors and Actuactors1993，35，： | 1 |
| 14 | Photodegradation of sulfapyridine under simulated sunlight irradiation: Kinetics, mechanism and toxicity evolvement显示文摘 | Jian Xu Zhineng Hao Changsheng Guo Yuan Zhang Yan He Wei Meng | 2013 | Chemosphere2013，，： | 1 |
| 15 | Migration and rotation of TiAl 3 particles in an Al-melt solidified under high magnetic field conditions显示文摘 | Changsheng Lou Qiang Wang Chunjiang Wang Tie Liu Keiji Nakajima Jicheng He | 2008 | Journal of Alloys and Compounds2008，，1： | 1 |
| 16 | Protective effects of capillary artemisia polysaccharide on oxidative inju- ry to the liver in rats with obstructive jaundice显示文摘 | HE Changsheng YUE Hongyi XU Jian | 2012 | EXPERIMENTAL AND THERAPEUTIC MEDICINE2012，4，4： | 1 |
| 17 | Liver Transplantation Versus Liver Resection in the Treatment of Hepatocellular Carcinoma: A Meta-Analysis of Observational Studies显示文摘 | Zheng Zheng Wenhua Liang Daniel P. Milgrom Zhouying Zheng Paul M. Schroder Ning S. Kong Changsheng Yang Zhiyong Guo Xiaoshun He | 2014 | Transplantation Journal2014，，2： | 1 |
| 18 | Occurrence of antibiotics and antibiotic resistance genes in a sewage treatment plant and its effluent-receiving river显示文摘 | Jian Xu Yan Xu Hongmei Wang Changsheng Guo Huiyun Qiu Yan He Yuan Zhang Xiaochen Li Wei Meng | 2014 | Chemosphere2014，，： | 1 |
| 19 | The Study of Nerve Conduit with Biocompatibility and Electrical Stimulation Effect显示文摘Conductive polymers show great promise because of their electrical property based on bioelectricity in vivo. In order to search electro-activity materials which insure abduction of tissue, we synthesized conductive nerve conduits with poly-dl-lactic-acid(PDLLA) and tetra-aniline(TA). Preparation technology of TA was optimized, and the properties of the conduit were studied. RSC96 cell were used to investigate the toxicity and electrical stimulation effect. SD rats were used to assess biocompatibility in vivo. The results showed that the reaction ratio of 1:1, the reaction time of 2 h and the HCl concentration of 2 mol/L were the optimum conditions for synthesis of TA. The influence of TA content on the mechanical properties, hydrophilicity, conductivity and microstructure of the nerve conduit was evaluated. Cell and histocompatibility study showed PDLLA/TA possessed good biocompatibility. These results showed it had application values in tissue projects. | 郭兴蕾 刘刚 HE Qundi 徐海星 YU Yunxuan KE Changsheng MING Xiaofei ZHAO Meng WANG Xiaobin HUANG Zhijun 许沛虎 | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，6： | 1 |
| 20 | Extraction, characterization of polysaccharides from Lycium barbarum and its effect on bone gene expression in rats显示文摘 | ZHU Mengyong MO Jinggang HE ChangSheng | 2010 | Carbohydrate Polymers2010，80，3： | 1 |
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