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| 1 | Pancreatic ductal adenocarcinoma: Risk factors, screening, and early detection显示文摘Pancreatic cancer is the fourth most common cause of cancer-related deaths in the United States, with over 38000 deaths in 2013. The opportunity to detect pancreatic cancer while it is still curable is dependent on our ability to identify and screen high-risk populations before their symptoms arise. Risk factors for developing pancreatic cancer include multiple genetic syndromes as well as modifiable risk factors. Genetic conditions include hereditary breast and ovarian cancer syndrome, Lynch Syndrome, familial adenomatous polyposis, Peutz-Jeghers Syndrome, familial atypical multiple mole melanoma syndrome, hereditary pancreatitis, cystic fibrosis, and ataxia-telangiectasia; having a genetic predisposition can raise the risk of developing pancreatic cancer up to 132-fold over the general population. Modifiable risk factors, which include tobacco exposure, alcohol use, chronic pancreatitis, diet, obesity, diabetes mellitus, as well as certain abdominal surgeries and infections, have also been shown to increase the risk of pancreatic cancer development. Several largevolume centers have initiated such screening protocols, and consensus-based guidelines for screening high-riskgroups have recently been published. The focus of this review will be both the genetic and modifiable risk factors implicated in pancreatic cancer, as well as a review of screening strategies and their diagnostic yields. | Andrew E Becker Yasmin G Hernandez Harold Frucht Aimee L Lucas | 2014 | World Journal of Gastroenterology2014，20，32： | 24 |
| 2 | Metastatic breast cancer to the gastrointestinal tract:A case series and review of the literature显示文摘Metastatic breast cancer involving the hepatobiliary tract or ascites secondary to peritoneal carcinomatosis has been well described. Luminal gastrointestinal tract involvement is less common and recognition of the range of possible presentations is important for early and accurate diagnosis and treatment. We report 6 patients with a variety of presentations of metastatic breast cancer of the luminal gastrointestinal tract. These include oropharyngeal and esophageal involvement presenting as dysphagia with one case of pseudoachalasia, a linitis plastica-like picture with gastric narrowing and thickened folds, small bowel obstruction and multiple strictures mimicking Crohn’s disease, and a colonic neoplasm presenting with obstruction. Lobular carcinoma, representing only 10% of breast cancers is more likely to metastasize to the gastrointestinal tract. These patients presented with gastrointestinal manifestations after an average of 9.5 years and as long as 20 years from initial diagnosis of breast cancer. Given the increased survival of breast cancer patients with current therapeutic regimes, more unusual presentations of metastatic disease, including involvement of the gastrointestinal tract can be anticipated. | Jose Nazareno Donald Taves Harold G Preiksaitis | 2006 | World Journal of Gastroenterology2006，12，38： | 3 |
| 3 | Elevated Aortic Pulse Wave Velocity, a Marker of Arterial Stiffness, Predicts Cardiovascular Events in Well-Functioning Older Adults显示文摘 | Kim Sutton-Tyrrell Samer S. Najjar Robert M. Boudreau Lakshmi Venkitachalam Varant Kupelian Eleanor M. Simonsick Richard Havlik Edward G Lakatta Harold Spurgeon Stephen Kritchevsky Marco Pahor Douglas Bauer Anne Newman | 2005 | Circulation2005，，25： | 2 |
| 4 | Distribution of permeability factor in tumors:concentration in tumor blood vessels显示文摘 | HAROLD G TRACY M | 1991 | Exp Med1991，174，5： | 2 |
| 5 | Characterization of microbial contamination in united states air force aviation fuel tanks显示文摘 | MICHELLE E R HAROLD W G | 2006 | J Ind Microbiol Biotechnol2006，33，： | 1 |
| 6 | Acinetobacter calcoaceticus genes involved in biosynthesis of the coenzyme pyrrolo-quinoline-quinone:nuleotide sequence and expression in Escherichia coli K-12显示文摘 | Goosen N Harold P A H Rene G M H | 1989 | J Bacteriol1989，171，1： | 1 |
| 7 | Tsunami prediction using the reciprocal property of Green's function显示文摘 | Harold G Loomis | 1979 | Marine geodesy1979，2，1： | 1 |
| 8 | Characterization of sugarcane response to Bipolaris sacchari : Inoculations and host - specific HS - toxin显示文摘 | Brain L B Harold S G Susan S | 1994 | Phytopathol1994，，： | 1 |
| 9 | Mammalian cDNA and prokaryotic reporter sequences silence adjacent transgenes in transgenic mice显示文摘 | Clark AJ Harold G Yull F | 1997 | Nucleic Acids Res1997，25，5： | 1 |
| 10 | Turbidite systems in deep water basin margins classified by grain size and feeder system显示文摘 | Harold G Marcus R | 1994 | AAPG Bulletin1994，78，5： | 1 |
| 11 | Characterization and rugulation of Ca2+ activated K+ channels in human esophageal smooth muscle显示文摘 | Hurley M Berrard R Harold G | 1999 | Am J Physiol1999，276，7： | 1 |
| 12 | ICA over Finite Fields--Separability and Algorithms显示文摘 | Harold W G Peter G | 2012 | Signal Processing2012，92，2： | 1 |
| 13 | Inter-parental conflict and children's academic attainment: a longitudinal analysis显示文摘 | Harold G Aitken J Shelton K | 2007 | J Child psychological Psychiatry2007，48，12： | 1 |
| 14 | Metal sulfide catalysts for hydrogena- tion of halonitrobenzenes to haloanilines 显示文摘 | Dovell F S Harold G | 1967 | J Org Chem1967，32，11： | 1 |
| 15 | The bridging scale for two-dimensional atomistic/continuum coupling显示文摘 | HAROLD S P EDUARD G K LIU W K | 2005 | Philosophical Magazine2005，85，1： | 1 |
| 16 | Environmental scanning electron microscopy of activated carbon production from anthraeite by one-step pyrolysis-activation显示文摘 | Katia G Semih E Harold S H | 1995 | Fuel1995，74，7： | 1 |
| 17 | Design Considerations for A Fiber Optic Communications Network for Power System显示文摘 | Kirkhan Harold Johnston A R Allen G D | 1994 | IEEE Transactions on Power Delivery1994，9，1： | 1 |
| 18 | Strong evidence that KIAA0319 on chromosome 6p is a susceptibility gene for developmental dys- lexia显示文摘 | Cope N Harold D Hill G | 2005 | Am J Hum Genet2005，76，： | 1 |
| 19 | V ertica 1 Integ ra tionin Am er icanM anufacturing, 1899-1948显示文摘 | Harold C L ivesay Patrick G Porter | 1969 | The Journalof Econom icH isto ry1969，29，3： | 1 |
| 20 | The 1962 John Arthur Wilson Memorial Lecture: Tanning Research in Retrospect and Prospect显示文摘 | Harold G Turley | 1993 | Journal of the American Leather Chemists Association1993，，88： | 1 |
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