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| 1 | One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system显示文摘 | Haifeng Wan Chunjing Feng Fei Teng Shihua Yang Baoyang Hu Yuyu Niu Andy Peng Xiang Weizhen Fang Weizhi Ji Wei Li Xiaoyang Zhao Qi Zhou | 2015 | Cell Research2015，25，2： | 39 |
| 2 | Atg7 is required for acrosome biogenesis during spermatogenesis in mice显示文摘acrosome 是盖住精子原子核的前面的部分并且在授精的过程起一个必要作用的一个专业化细胞器。位于这个 lysosome 相关的细胞器(LRO ) 的生物的续生说下面的分子的机制大部分仍然是未知的。这里,我们显示出房间特定的 Atg7 大美人老鼠是的那个细菌由于在 acrosome 生物的续生说的一个缺点不肥沃并且显示了类似于人的 globozoospermia 的显型;这个繁殖缺点被 intracytoplasmic 精子注射成功地救。而且,在细菌房间的 Atg7 的弄空没影响细菌房间的开发的早阶段,但是精子发生在以后上演,在 Golgi 期间没有通过到保险丝进一个单个 acrosomal 泡的 proacrosomal 泡分阶段执行,它最后导致了不规则或将近 round-headed 精子。Autophagic 流动在弄空 Atg7 的细菌房间被破坏,最后导致 LC3 变化形式的失败到 Golgi 导出仪器的泡。另外, Atg7 部分调整了另一 globozoospermia 相关的蛋白质,联系 Golgi 的 PDZ 卷和卷卷包含主题的蛋白质(GOPC ) ,在 acrosome 生物的续生说期间。最后,任何一个 autophagy 的注射或进睾丸的 lysosome 禁止者导致了类似的显型到细菌的房间特定的 Atg7 大美人老鼠。总的来说,我们的结果揭开为在 acrosome 的生物的续生说的 Atg7 的一个新角色,并且我们提供证据为 acrosome 支持 autolysosome 起源假设。 | Hongna Wang Haifeng Wan Xixia Li Weixiao Liu Qi Chen Yaqing Wang Lin Yang Hongmei Tang Xiujun Zhang Enkui Duan Xiaoyang Zhao Fei Gao Wei Li | 2014 | Cell Research2014，24，7： | 25 |
| 3 | Radix Astragali-induced differentiation of rat bone marrow-derived mesenchymal stem cells显示文摘BACKGROUND:Chemical induction has been shown to be effective at promoting the differentiation of bone marrow-derived mesenchymal stem cells(MSCs).However,these inductors have cytotoxicity side effects that may damage cells over time.Traditional Chinese medicines avoid this disadvantage while still producing effective induction. OBJECTIVE:To investigate the influence of Radix Astragali(Huangqi) on the differentiation of MSCs. DESIGN,TIME AND SETTING:In vitro study of traditional Chinese medicine in neural stem cell differentiation.The experiment was performed at the Central Laboratory of Hebei North University between April and June 2007. MATERIALS:Radix Astragali solution(lot No.060105;license No.Z53021585) was purchased from Dali Pharmaceutical Co.,Ltd.,China;rabbit anti-rat nestin,rabbit anti-rat neuron-specific enolase (NSE),mouse anti-rat microtubule-associated protein 2,and rabbit anti-rat glial fibrillary acidic protein were purchased from Wuhan Boster,China. METHODS:Whole bone marrow was isolated from the femur and tibia of 6-week-old male Wistar rats and subcultured.The fourth passage of MSCs were harvested and induced by different concentrations(50,100,200,400 g/L) of Radix Astragali. MAIN OUTCOME MEASURES:Hematoxylin-eosin staining was used to observe MSC morphology after 24 hours of induction.Immunocytochemistry was employed to observe the expression of NSE (specific neuronal marker),nestin(marker of neural stem cell),glial fibrillary acidic protein and microtubule-associated protein 2(markers of astrocytes). RESULTS:Following Radix Astragalitreatment,changes occurred in cell morphology including:cell body pyknosis;thin and long processes formed in some cells,with growth corresponding to drug concentration and induction time;and the formation of network-like connections between some cells. With increasing drug concentration and induction time,nestin expression was upregulated,and the number of positive cells increased;cells produced NSE,glial fibrillary acidic protein and microtubule-associated protein 2;nestin was expressed earlier than glial fibrillary acidic protein and microtubule-associated protein 2 expression.In addition,the number of NSE-positive cells was increased significantly more than glial fibrillary acidic protein-positive cells. CONCLUSION:Radix Astragali promoted process formation in stem cells.It may induce the differentiation of MSCs into neural stem cells,and subsequently into neuronal-and glial-like cells. Radix Astragali exhibits stronger inductive effect on neuronal differentiation than glial differentiation of MSCs. | Xinsheng Wang Haifeng Li Ying Zhao Xiaoli Zhang Aihua Bo | 2009 | Neural Regeneration Research2009，4，7： | 21 |
| 4 | Downstaging and resection of hepatocellular carcinoma in patients with extrahepatic metastases after stereotactic therapy显示文摘Background:A combination of tyrosine kinase inhibitors(TKIs)and anti-PD-1 antibodies with local regional therapy has elicited yield substantial clinical benefits in patients who have hepatocellular carcinoma(HCC)with extrahepatic metastases.Using this treatment strategy to convert HCC patients with extrahepatic metastases from unresectable to resectable has not yet been reported.Methods:Consecutive hepatocellular carcinoma patients with extrahepatic metastases who received first-line therapy with a combination of TKIs and anti-PD-1 antibodies and at least one local regional therapy were analysed.Results:Nine patients with localized disease who received first-line systemic therapy were enrolled.At baseline,all of them had oligometastatic disease,namely,Barcelona Clinic Liver Cancer stage C(or Chinese Liver Cancer stage IIIB).The most common treatment administered was lenvatinib plus anti-PD-1 antibody and transarterial chemoembolization,and the median time span from systemic therapy to surgery was 3.2(IQR,2.8-6.2)months.Three patients achieved a pathological complete response.Six patients underwent laparoscopic surgery,and the other 3 patients underwent open surgery.After a median follow-up of 10.2(IQR,8.6-20.0)months,7 patients survived without disease recurrence,and 2 experienced tumour recurrence.All patients had any-grade AEs,and 55.6%of the patients experienced grade 3 AEs.Fatigue was the most common AE,followed by elevated aminotransferase levels and hypertension.Conclusions:Stereotactic therapy is a feasible conversion therapy for HCC patients with extrahepatic metastases to become resectable.This is the first study to analyse therapeutic outcomes of patients receiving these therapies for HCC with extrahepatic metastases. | Xiaobo Yang Haifeng Xu Bangyou Zuo Xu Yang Jin Bian Junyu Long Dongxu Wang Junwei Zhang Cong Ning Yanyu Wang Ziyu Xun Yunchao Wang Xin Lu Yilei Mao Xinting Sang Haitao Zhao | 2021 | Hepatobiliary Surgery and Nutrition2021，10，4： | 17 |
| 5 | Effect of alkalinity on nitrite accumulation in treatment of coal chemical industry wastewater using moving bed biofilm reactor显示文摘Nitrogen removal via nitrite(the nitrite pathway) is more suitable for carbon-limited industrial wastewater. Partial nitrification to nitrite is the primary step to achieve nitrogen removal via nitrite. The effect of alkalinity on nitrite accumulation in a continuous process was investigated by progressively increasing the alkalinity dosage ratio(amount of alkalinity to ammonia ratio, mol/mol). There is a close relationship among alkalinity, pH and the state of matter present in aqueous solution. When alkalinity was insufficient(compared to the theoretical alkalinity amount), ammonia removal efficiency increased first and then decreased at each alkalinity dosage ratio, with an abrupt removal efficiency peak. Generally, ammonia removal efficiency rose with increasing alkalinity dosage ratio. Ammonia removal efficiency reached to 88% from 23% when alkalinity addition was sufficient. Nitrite accumulation could be achieved by inhibiting nitrite oxidizing bacteria(NOB) by free ammonia(FA) in the early period and free nitrous acid in the later period of nitrification when alkalinity was not adequate. Only FA worked to inhibit the activity of NOB when alkalinity addition was sufficient. | Baolin Hou Hongjun Han Shengyong Jia Haifeng Zhuang Qian Zhao Peng Xu | 2014 | Journal of Environmental Sciences2014，26，5： | 16 |
| 6 | Advanced treatment of biologically pretreated coal gasification wastewater by a novel heterogeneous Fenton oxidation process显示文摘Sewage sludge from a biological wastewater treatment plant was converted into sewage sludge based activated carbon(SBAC) with Zn Cl2 as activation agent, which was used as a support for ferric oxides to form a catalyst(Fe Ox/SBAC) by a simple impregnation method.The new material was then used to improve the performance of Fenton oxidation of real biologically pretreated coal gasification wastewater(CGW). The results indicated that the prepared Fe Ox/SBAC significantly enhanced the pollutant removal performance in the Fenton process, so that the treated wastewater was more biodegradable and less toxic. The best performance was obtained over a wide p H range from 2 to 7, temperature 30°C, 15 mg/L of H2O2 and 1 g/L of catalyst, and the treated effluent concentrations of COD, total phenols,BOD5 and TOC all met the discharge limits in China. Meanwhile, on the basis of significant inhibition by a radical scavenger in the heterogeneous Fenton process as well as the evolution of FT-IR spectra of pollutant-saturated Fe Ox/BAC with and without H2O2, it was deduced that the catalytic activity was responsible for generating hydroxyl radicals, and a possible reaction pathway and interface mechanism were proposed. Moreover, Fe Ox/SBAC showed superior stability over five successive oxidation runs. Thus, heterogeneous Fenton oxidation of biologically pretreated CGW by Fe Ox/SBAC, with the advantages of being economical, efficient and sustainable, holds promise for engineering application. | Haifeng Zhuang Hongjun Han Wencheng Ma Baolin Hou Shengyong Jia Qian Zhao | 2015 | Journal of Environmental Sciences2015，27，7： | 15 |
| 7 | Parthenogenetic haploid embryonic stem cells produce fertile mice显示文摘 | Haifeng Wan Zhengquan He Mingzhu Dong Tiantian Gu Guan-Zheng Luo Fei Teng Baolong Xia Wei Li Chunjing Feng Xin Li Tianda Li Ling Shua Rui Fu Liu Wang Xiu-Jie Wang Xiao-Yang Zhao Qi Zhou | 2013 | Cell Research2013，23，11： | 13 |
| 8 | Genome Characteristics and Evolution of Pseudorabies Virus Strains in Eastern China from 2017 to 2019显示文摘Since late 2011,outbreaks of pseudorabies virus(PRV)have occurred in southern China causing major economic losses to the pig industry.We previously reported that variant PRV forms and recombination in China could be the source of continued epidemics.Here,we analyzed samples from intensive pig farms in eastern China between 2017 and 2019,and sequenced the main glycoproteins(gB,gC,gD,and gE)to study the evolution characteristics of PRV.Based on the gC gene,we found that PRV variants belong to clade 2 and detected a founder effect during by the PRV epidemic.In addition,we detected inter-and intra-clade recombination;in particular,inter-clade recombination in the gB genes of strains FJ-ZXF and FJ-W2,which were recombinant with clade 1 strains.We also found specific amino-acid changes and positively selected sites,possibly associated with functional changes.This analysis of the emergence of PRV in China illustrates the need for continuous monitoring and the development of vaccines against specific variants of PRV. | Xiaofeng Zhai Wen Zhao Kemang Li Cheng Zhang Congcong Wang Shuo Su Jiyong Zhou Jing Lei Gang Xing Haifeng Sun Zhiyu Shi Jinyan Gu | 2019 | Virologica Sinica2019，34，6： | 12 |
| 9 | Biosynthesis of Biocompatible Cadmium Telluride Quantum Dots Using Yeast Cells显示文摘We demonstrate a simple and efficient biosynthesis method to prepare easily harvested biocompatible cadmium telluride(CdTe)quantum dots(QDs)with tunable fluorescence emission using yeast cells.Ultraviolet-visible(UV-vis)spectroscopy,photoluminescence(PL)spectroscopy,X-ray diffraction(XRD),and transmission electron microscopy(TEM)confirm that the CdTe QDs are formed via an extracellular growth and subsequent endocytosis pathway and have size-tunable optical properties with fluorescence emission from 490 to 560 nm and a cubic zinc blende structure with good crystallinity.In particular,the CdTe QDs with uniform size(2-3.6 nm)are protein-capped,which makes them highly soluble in water,and in situ bio-imaging in yeast cells indicates that the biosynthesized QDs have good biocompatibility.This work provides an economic and environmentally friendly approach to synthesize highly fluorescent biocompatible CdTe QDs for bio-imaging and bio-labeling applications. | Haifeng Bao Na Hao Yunxia Yang Dongyuan Zhao | 2010 | Nano Research2010，3，7： | 11 |
| 10 | Successful generation of cloned mice using nuclear transfer from induced pluripotent stem cells显示文摘 | Shuya Zhou Chenhui Ding Xiaoyang Zhao Eryao Wang Xiangpeng Dai Lei Liu Wei Li Zichuan Liu Haifeng Wan Chunjing Feng Tang Hai Liu Wang Qi Zhou | 2010 | Cell Research2010，20，7： | 10 |
| 11 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 12 | Cascade effects of crop species richness on the diversity of pest insects and their natural enemies显示文摘Understanding how plant species richness influences the diversity of herbivorous and predatory/parasitic arthropods is central to community ecology.We explore the effects of crop species richness on the diversity of pest insects and their natural enemies.Using data from a four-year experiment with five levels of crop species richness,we found that crop species richness significantly affected the pest species richness,but there were no significant effects on richness of the pests’natural enemies.In contrast,the species richness of pest insects significantly affected their natural enemies.These findings suggest a cascade effect where trophic interactions are strong between adjacent trophic levels,while the interactions between connected but nonadjacent trophic levels are weakened by the intermediate trophic level.High crop species richness resulted in a more stable arthropod community compared with communities in monoculture crops.Our results highlight the complicated cross-trophic interactions and the crucial role of crop diversity in the food webs of agro-ecosystems. | SHI PeiJian HUI Cang MEN XingYuan ZHAO ZiHua OUYANG Fang GE Feng JIN XianShi CAO HaiFeng LI B.Larry | 2014 | Science China(Life Sciences)2014，57，7： | 6 |
| 13 | The temporal and spatial fluctuation of the groundwater level along the Tarim Desert Highway显示文摘In this work, a groundwater monitor section along the Tarim Desert Highway was set up, and the groundwater level data were recorded. The temporal and spatial fluctuations of the groundwater level were analyzed based on the groundwater level measurements, hydrologic data, the groundwater/surface water interconversion theory and the groundwater dynamics. The spatial distribution of groundwater is mostly affected by sand dune height and landform variation. The four primary temporal influence factors of groundwater level can be ordered in decreasing significance as: shelterbelt pumping > vertical leakage > river flow change > runoff replenishment. The runoff replenishment has the biggest influence range, and the shelterbelt pumping has the smallest influence range. The groundwater level fluctuates annually in a natural pattern. | FAN JingLong XU XinWen LEI JaQiang ZHAO JingFeng LI ShengYu WANG HaiFeng ZHANG JianGuo ZHOU HongWei | 2008 | Chinese Science Bulletin2008，53，S2： | 6 |
| 14 | Clinical diagnosis and treatment of alpha-fetoprotein-negative small hepatic lesions显示文摘Objective: We examined 103 cases over the last five years and discussed diagnosis and treatment of alpha- fetoprotein (AFP)-negative small hepatic lesions. Background: Small hepatic lesions (less than 2 cm in diameter) usually have no typical imaging characteristics and therefore are difficult to diagnose, especially when AFP tests provide a negative result. Methods: A total of 103 patients with AFP-negative small hepatic lesions from January 2003 to December 2008 were retrospectively reviewed. Differential diagnosis was performed by digital subtraction angiography (DSA), dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), contrast-enhanced ultrasound (CEUS), or positron emission tomography-computed tomography (PET-CT) based on the multiplicity of lesions. Ninety-four patients with suspected cancers underwent partial hepatectomy. Clinical data were collected from hospital records and follow-up questionnaires. Results: Hepatocellular carcinoma (HCC) diagnostic sensitivity of DSA, DCE-MRI, CEUS and PET-CT was 88.2%, 93.9%, 88.9% and 88.9%, respectively. The surgery-related complication rate was 6.4%. Prognosis was good, with 1- and 3-year survival rates of 98.8% and 76.1%, respectively. Conclusions: DSA, DCE-MRI, CEUS and PET-CT are valuable for diagnosis of small hepatic lesions. Partial hepatectomy is a preferred surgical procedure. Surgery for small liver cancers usually has little risk and good prognosis, therefore it can be actively applied in suspected HCC cases. | Yiyao Xu Xin Lu Yilei Mao Xinting Sang Haitao Zhao Shunda Du Haifeng Xu Yongliang Sun Huayu Yang Tianyi Chi Zhiying Yang Shouxian Zhong Jiefu Huang | 2013 | Chinese Journal of Cancer Research2013，25，4： | 6 |
| 15 | Anoxic degradation of nitrogenous heterocyclic compounds by activated sludge and their active sites显示文摘The potential for degradation of five nitrogenous heterocyclic compounds(NHCs), i.e.,imidazole, pyridine, indole, quinoline, and carbazole, was investigated under anoxic conditions with acclimated activated sludge. Results showed that NHCs with initial concentration of 50 mg/L could be completely degraded within 60 hr. The degradation of five NHCs was dependent upon the chemical structures with the following sequence:imidazole > pyridine > indole > quinoline > carbazole in terms of their degradation rates.Quantitative structure–biodegradability relationship studies of the five NHCs showed that the anoxic degradation rates were correlated well with highest occupied molecular orbital.Additionally, the active sites of NHCs identified by calculation were confirmed by analysis of intermediates using gas chromatography and mass spectrometry. | Peng Xu Hongjun Han Haifeng Zhuang Baolin Hou Shengyong Jia Dexin Wang Kun Li Qian Zhao | 2015 | Journal of Environmental Sciences2015，27，5： | 5 |
| 16 | The compensatory phenomenon of the functional connectome related to pathological biomarkers in individuals with subjective cognitive decline显示文摘Background Subjective cognitive decline(SCD)is a preclinical stage along the Alzheimer’s disease(AD)continuum.However,little is known about the aberrant patterns of connectivity and topological alterations of the brain functional connectome and their diagnostic value in SCD.Methods Resting-state functional magnetic resonance imaging and graph theory analyses were used to investigate the alterations of the functional connectome in 66 SCD individuals and 64 healthy controls(HC).Pearson correlation analysis was computed to assess the relationships among network metrics,neuropsychological performance and pathological biomarkers.Finally,we used the multiple kernel learning-support vector machine(MKL-SVM)to differentiate the SCD and HC individuals.Results SCD individuals showed higher nodal topological properties(including nodal strength,nodal global efficiency and nodal local efficiency)associated with amyloid-βlevels and memory function than the HC,and these regions were mainly located in the default mode network(DMN).Moreover,increased local and medium-range connectivity mainly between the bilateral parahippocampal gyrus(PHG)and other DMN-related regions was found in SCD individuals compared with HC individuals.These aberrant functional network measures exhibited good classification performance in the differentiation of SCD individuals from HC individuals at an accuracy up to 79.23%.Conclusion The findings of this study provide insight into the compensatory mechanism of the functional connectome underlying SCD.The proposed classification method highlights the potential of connectome-based metrics for the identification of the preclinical stage of AD. | Haifeng Chen Xiaoning Sheng Caimei Luo Ruomeng Qin Qing Ye Hui Zhao Yun Xu Feng Bai 无 | 2020 | Translational Neurodegeneration2020，9，2： | 5 |
| 17 | Au-Ag alloy nanoparticles with tunable cavity for plasmon-enhanced photocatalytic H2 evolution显示文摘Au-Ag alloy nanoparticles with different cavity sizes have great potential for improving photocatalytic performance due to their tunable plasmon effect.In this study,galvanic replacement was combined with co-reduction with the reaction kinetics processes regulated to rapidly synthesize Au-Ag hollow alloy nanoparticles with tunable cavity sizes.The position of the localized surface plasmon resonance(LSPR)peak could be effectively adjusted between 490 nm and 713 nm by decreasing the cavity size of the Au-Ag hollow nanoparticles from 35 nm to 20 nm.The plasmon-enhanced photocatalytic H2 evolution of alloy nanoparticles with different cavity sizes was investigated.Compared with pure P25(TiO2),intact and thin-shelled Au-Ag hollow nanoparticles(HNPs)-supported photocatalyst exhibited an increase in the photocatalytic H2 evolution rate from 0.48μmol h^−1 to 4μmol h^−1 under full-spectrum irradiation.This improved photocatalytic performance was likely due to the plasmon-induced electromagnetic field effect,which caused strong photogenerated charge separation,rather than the generation of hot electrons. | Xuanyu Yue Juan Hou Haifeng Zhao Pengcheng Wu Yali Guo Qin Shi Long Chen Shanglong Peng Zhiyong Liu Guozhong Cao | 2020 | Journal of Energy Chemistry2020，29，10： | 4 |
| 18 | Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes显示文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy. | Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu Yingfang Ao | 2022 | Bioactive Materials2022，7，2： | 4 |
| 19 | Identification of genes for normalization of quantitative real-time PCR data in ovarian tissues显示文摘增加的注意在最近的年里为卵巢的癌症对潜在的 biomarker 和治疗学的目标的决心被给予了。然而,量的即时 PCR 的正规化是重要的获得精确基因表示数据。我们在不同条件下面在卵巢的纸巾调查了 20 参考基因的稳定性决定为这应用最足够。学习在包含正常、非恶意、主要的卵巢的癌的 52 件卵巢的织物样品之中描绘了 20 可能的参考基因的表示。变化(ANOVA ) 的单程的分析方法被用来比较疾病前进引起的候选人基因变化。没有统计差别的基因的稳定性和适用性是进一步的采用 geNorm 和 NormFinder 软件验证。当尽管有不同卵巢的织物条件, RPL4, RPLP0, HSPCB, TPT1, RPL13A, 18S rRNA, PPIA, TBP,和 GUSB 使稳定性统计时,结果证明 20 参考基因的表示层次变化了。RPL4, RPLP0,和 HSPCB 作为最稳定的参考基因和 RPLP0 的联合被表明, RPL4 应该被推荐为更可靠的正规化策略。 | Jie Fu Lihong Bian Li Zhao Zhouhuan Dong Xin Gao Haofei Luan Yunjuan Sun Haifeng Song | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 4 |
| 20 | Nitrogen removal from coal gasification wastewater by activated carbon technologies combined with short-cut nitrogen removal process显示文摘A system combining granular activated carbon and powdered activated carbon technologies along with shortcut biological nitrogen removal(GAC-PACT-SBNR) was developed to enhance total nitrogen(TN) removal for anaerobically treated coal gasification wastewater with less need for external carbon resources. The TN removal efficiency in SBNR was significantly improved by introducing the effluent from the GAC process into SBNR during the anoxic stage, with removal percentage increasing from 43.8%–49.6% to 68.8%–75.8%. However, the TN removal rate decreased with the progressive deterioration of GAC adsorption. After adding activated sludge to the GAC compartment, the granular carbon had a longer service-life and the demand for external carbon resources became lower. Eventually, the TN removal rate in SBNR was almost constant at approx. 43.3%, as compared to approx. 20.0% before seeding with sludge. In addition,the production of some alkalinity during the denitrification resulted in a net savings in alkalinity requirements for the nitrification reaction and refractory chemical oxygen demand(COD)degradation by autotrophic bacteria in SBNR under oxic conditions. PACT showed excellent resilience to increasing organic loadings. The microbial community analysis revealed that the PACT had a greater variety of bacterial taxons and the dominant species associated with the three compartments were in good agreement with the removal of typical pollutants. The study demonstrated that pre-adsorption by the GAC-sludge process could be a technically and economically feasible method to enhance TN removal in coal gasification wastewater(CGW). | Qian Zhao Hongjun Han Baolin Hou Haifeng Zhuang Shengyong Jia Fang Fang | 2014 | Journal of Environmental Sciences2014，26，11： | 4 |
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