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| 1 | A Snapshot of the Effective Indications and Results of Surgery for Hepatocellular Carcinoma in Tertiary Referral Centers: Is It Adherent to the EASL/AASLD Recommendations?: An Observational Study of the HCC East-West Study Group显示文摘 | Guido Torzilli Jacques Belghiti Norihiro Kokudo Tadatoshi Takayama Lorenzo Capussotti Gennaro Nuzzo Jean-Nicolas Vauthey Michael A. Choti Eduardo De Santibanes Matteo Donadon Emanuela Morenghi Masatoshi Makuuchi | 2013 | Annals of Surgery2013，，5： | 7 |
| 2 | Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells显示文摘In the last years,several studies have been focused on elucidate the role of tumor microenvironment(TME)in cancer development and progression.Within TME,cells from adaptive and innate immune system are one of the main abundant components.The dynamic interactions between immune and cancer cells lead to the activation of complex molecular mechanisms that sustain tumor growth.This important cross-talk has been elucidate for several kind of tumors and occurs also in patients with liver cancer,such as hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(iCCA).Liver is well-known to be an important immunological organ with unique microenvironment.Here,in normal conditions,the rich immune-infiltrating cells cooperate with non-parenchymal cells,such as liver sinusoidal endothelial cells and Kupffer cells,favoring self-tolerance against gut antigens.The presence of underling liver immunosuppressive microenvironment highlights the importance to dissect the interaction between HCC and iCCA cells with immune infiltrating cells,in order to understand how this cross-talk promotes tumor growth.Deeper attention is,in fact,focused on immune-based therapy for these tumors,as promising approach to counteract the intrinsic anti-tumor activity of this microenvironment.In this review,we will examine the key pathways underlying TME cell-cell communications,with deeper focus on the role of natural killer cells in primary liver tumors,such as HCC and iCCA,as new opportunities for immune-based therapeutic strategies. | Michela Anna Polidoro Joanna Mikulak Valentina Cazzetta Ana Lleo Domenico Mavilio Guido Torzilli Matteo Donadon | 2020 | World Journal of Gastroenterology2020，26，33： | 4 |
| 3 | Surgical treatment of synchronous colorectal liver and lung metastases: the usefulness of thoracophrenolaparotomy for single stage resection显示文摘When suitable, surgery still remains the therapeutic option to be preferred for patients carrier of colorectal liver and lung metastases. Since thoracophrenolaparotomy should be helpful during liver resection for some of these patients, simultaneous removal of right lung metastases can be proposed through this approach. Eleven consecutive patients(median age of 53 years) carrier of colorectal liver and lung metastases, underwent single session surgical resection of both liver and right lung lesions by means of J-shaped thoracophrenolaparotomy. The median number of liver metastases removed was 5(range 2-30) and of lung metastases removed was 2(range 1-3). Lung metastases were located in the upper lobe in 1 patient, in the middle lobe in 2, in the lower lobe in 6, and in the upper and lower lobe in 2. Mortality and major morbidity were nil. Two patients had a minor morbidity: one had wound infection and bile leakage treated conservatively and the other had transient fever. Mean overall survival was 24.4 months. An aggressive surgical approach should be undertaken for colorectal metastases: in case of multifocal liver disease with complex presentations, J-shaped thoracophrenolaparotomy could be considered as safe approach for combined liver and right lung metastasectomies. | Daniele Del Fabbro Marco Alloisio Fabio Procopio Matteo Cimino Matteo Donadon Angela Palmisano Luca Viganò Guido Torzilli | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，2： | 3 |
| 4 | A Comprehensive Meta-regression Analysis on Outcome of Anatomic Resection Versus Nonanatomic Resection for Hepatocellular Carcinoma显示文摘 | Alessandro Cucchetti Matteo Cescon Giorgio Ercolani Eleonora Bigonzi Guido Torzilli Antonio D. Pinna | 2012 | Annals of Surgical Oncology2012，，12： | 3 |
| 5 | Nested stromal-epithelial tumour of the liver:An unusual liver entity显示文摘Nested stromal-epithelial tumours(NSETs)of the liver have been reported to be extremely unusual primary hepatic neoplasms.To date,few cases have been described in the literature.NSETs have been defined as non-hepatocytic and non-biliary tumours of the liver consisting of nests of epithelial and spindled cells,myofibroblastic stroma and variable intralesional calcification and ossification.Here,we report a case of a young female who underwent liver resection for a large hepatic lesion that proved to be a calcifying NSET on pathological examination.Details about the clinical and histopathological features of the tumour are reported. | Fabio Procopio Luca Di Tommaso Silvia Armenia Vittorio Quagliuolo Massimo Roncalli Guido Torzilli | 2014 | World Journal of Hepatology2014，6，3： | 2 |
| 6 | Multiple focal nodular hyperplasias induced by oxaliplatin-based chemotherapy显示文摘Focal nodular hyperplasia (FNH) is a benign condition that affects normal liver with low prevalence. Recently, the extensive use of oxaliplatin to treat patients with colorectal cancer has been reported to be associated with the development of different liver injuries, as well as focal liver lesions. The present work describes two patients with multiple bilateral focal liver lesions mis-diagnosed as colorectal liver metastases, and treated with liver resection. The first patient had up to 15 small bilateral focal liver lesions, with magnetic resonance imaging consistent with colorectal liver metastases (CLM), and fluorodeoxyglucose (FDG)-positron emission tomography (PET) negative. The second patient had up to 5 small focal liver lesions, with computed tomography consistent with CLM, and FDG-PET negative. They had parenchyma sparing liver surgery, with uneventful postoperative course. At the histology the diagnosis was multiple FNHs. The risks of oxaliplatin- based chemotherapy regimens in development of liver injuries, such as FNH, should not be further denied.The value of the modern multidisciplinary management of patients with colorectal cancer relies also on the precise estimation of the risk/benefit for each patient. | Matteo Donadon Luca Di Tommaso Massimo Roncalli Guido Torzilli | 2013 | World Journal of Hepatology2013，5，6： | 2 |
| 7 | Tailoring the area of hepatic resection using inflow and outflow modulation显示文摘The performance of hepatic surgery without a parenchyma-sparing strategy carries significant risks for patient survival because of the not negligible occurrence of postoperative liver failure.The key factor of modern hepatic surgery is the use of the intraoperative ultrasound(IOUS),not only to stage the disease,but more importantly to guide resection with the specific aim to maximize the sparing of the functional parenchyma.Whether in patients with hepatocellular carcinoma and underlying liver cirrhosis,or in patients with colorectal liver metastasis,IOUS allows the performance of the so-called 'radical but conservative surgery',which is the pivotal factor to offer a chance of cure to an increasing proportion of patients,who until few years ago were considered only for palliative care.Using some new IOUS-guided surgical maneuvers,which are based on the liver inflow and outflow modulations,more precise anatomically subsegmental-and segmentaloriented resections can be effectively performed.The present work describes the rationale and the surgical technique for a precise tailoring of the area of hepatic resection using the most recent attainments in IOUS.Such important technical achievements should be a fundamental part of the surgical armamentarium of the modern liver surgeon. | Matteo Donadon Fabio Procopio Guido Torzilli | 2013 | World Journal of Gastroenterology2013，19，7： | 1 |
| 8 | Is Stereotactic Body Radiation Therapy an Attractive Option for Unresectable Liver Metastases? A Preliminary Report from a Phase II Trial显示文摘 | Marta Scorsetti Stefano Arcangeli Angelo Tozzi Tiziana Comito Filippo Alongi Pierina Navarria Pietro Mancosu Giacomo Reggiori Antonella Fogliata Guido Torzilli Stefano Tomatis Luca Cozzi | 2012 | International Journal of Radiation Oncology Biology Physics2012，，： | 1 |
| 9 | A new sys- tematic small for size resection for liver tumors invading the middle hepatic vein at its caval confluence mini-mesohepatectomy 显示文摘 | Guido Torzilli Angela Palmisano Fabio Procopio | 2010 | Ann Surg2010，251，： | 1 |
| 10 | Liver Resection Without Total Vascular Exclusion: Hazardous or Beneficial?: An Analysis of Our Experience显示文摘 | Guido Torzilli Masatoshi Makuuchi Yutaka Midorikawa | 2001 | Ann Surg2001，233，2： | 1 |
| 11 | Contrast-Enhanced Intraoperative Ultrasonography During Surgery for Hepatocellular Carcinoma in Liver Cirrhosis: Is It Useful or Useless? A Prospective Cohort Study of Our Experience显示文摘 | Guido Torzilli Angela Palmisano Daniele Fabbro Matteo Marconi Matteo Donadon Antonino Spinelli Paolo Pietro Bianchi Marco Montorsi | 2007 | Annals of Surgical Oncology2007，，4： | 1 |
| 12 | Intralesional ethanol in the treatment of unresectable liver cancer显示文摘 | Tito Livraghi M.D. Sergio Lazzaroni M.D. Franca Meloni M.D. Guido Torzilli M.D. Claudio Vettori M.D | 1995 | World Journal of Surgery1995，，6： | 1 |
| 13 | Safe Hepatectomy Selection Criteria for Hepatocellular Carcinoma Patients: A Validation of 336 Consecutive Hepatectomies. The BILCHE Score显示文摘 | Matteo Donadon Guido Costa Matteo Cimino Fabio Procopio Daniele Del Fabbro Angela Palmisano Guido Torzilli | 2015 | World Journal of Surgery2015，，1： | 1 |
| 14 | A New Technical Aspect of Ultrasound - guided Liver Surgery 显示文摘 | Guido Torzilli M D FPCR Tadatoshi Takayama | 1999 | THE AMERICAN JOURNAL OF SURGERY1999，178，9： | 1 |
| 15 | Endoscopic ultrasonography and magnetic resonance in preoperative staging of rectal cancer: Comparison with histologic findings显示文摘 | Paolo P. Bianchi M.D. Chiara Ceriani M.D. Matteo Rottoli M.D. Guido Torzilli M.D. Giovanni Pompili M.D. Alberto Malesci M.D. Monica Ferraroni Ph.D. Marco Montorsi M.D | 2005 | Journal of Gastrointestinal Surgery2005，，9： | 1 |
| 16 | Long-term effectiveness of resection and radiofrequency ablation for single hepatocellular carcinoma ?3<ce:hsp sp='0.25'/>cm. Results of a multicenter Italian survey<!-- Doctopic: CAN -->显示文摘 | Maurizio Pompili Antonio Saviano Nicoletta de Matthaeis Alessandro Cucchetti Francesco Ardito Bruno Federico Franco Brunello Antonio D. Pinna Antonio Giorgio Stefano M. Giulini Ilario De Sio Guido Torzilli Fabio Fornari Lorenzo Capussotti Alfredo Guglielm | 2013 | Journal of Hepatology2013，，1： | 1 |
| 17 | Long-term survival and prognostic factors in the surgical treatment of mass-forming type cholangiocarcinoma显示文摘 | Kazuto Inoue Masatoshi Makuuchi Tadatoshi Takayama Guido Torzilli Junji Yamamoto Kazuaki Shimada Tomoo Kosuge Susumu Yamasaki Masaru Konishi Taira Kinoshita Shinichi Miyagawa Seiji Kawasaki | 2000 | Surgery2000，，5： | 1 |
| 18 | A New Systematic Small for Size Resection for Liver Tumors Invading the Middle Hepatic Vein at its Caval Confluence: Mini-Mesohepatectomy显示文摘 | Guido Torzilli Angela Palmisano Fabio Procopio Matteo Cimino Florin Botea Matteo Donadon Daniele Del Fabbro Marco Montorsi | 2010 | Annals of Surgery2010，，： | 1 |
| 19 | Intralesional ethanol in the treatment of unresectable liver cancer显示文摘 | Tito Livraghi M.D. Sergio Lazzaroni M.D. Franca Meloni M.D. Guido Torzilli M.D. Claudio Vettori M.D | 1995 | World Journal of Surgery1995，，6： | 1 |
| 20 | “Radical but Conservative” Is the Main Goal for Ultrasonography-Guided Liver Resection: Prospective Validation of this Approach显示文摘 | Guido Torzilli Marco Montorsi Matteo Donadon Angela Palmisano Daniele Del Fabbro Andrea Gambetti Natale Olivari Masatoshi Makuuchi | 2005 | Journal of the American College of Surgeons2005，，： | 1 |
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