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| 1 | Buyang Huanwu Decoction regulates neural stem cell behavior in ischemic brain显示文摘The traditional Chinese medicine Buyang Huanwu Decoction has been shown to improve the neurological function of patients with stroke.However,the precise mechanisms underlying its effect remain poorly understood.In this study,we established a rat model of cerebral ischemia by middle cerebral artery occlusion and intragastrically administered 5 g/kg Buyang Huanwu Decoction,once per day,for 1,7,14 and 28 days after cerebral ischemia.Immunohistochemical staining revealed a number of cells positive for the neural stem cell marker nestin in the cerebral cortex,the subventricular zone and the ipsilateral hippocampal dentate gyrus in rat models of cerebra ischemia.Buyang Huanwu Decoction significantly increased the number of cells positive for5-bromodeoxyuridine(BrdU),a cell proliferation-related marker,microtubule-associated protein-2,a marker of neuronal differentiation,and growth-associated protein 43,a marker of synaptic plasticity in the ischemic rat cerebral regions.The number of positive cells peaked at 14 and 28 days after intragastric administration of Buyang Huanwu Decoction.These findings suggest that Buyang Huanwu Decoction can promote the proliferation and differentiation of neural stem cells and enhance synaptic plasticity in ischemic rat brain tissue. | Baiyan Liu Guangxian Cai Jian Yi Xuemei Chen | 2013 | Neural Regeneration Research2013，8，25： | 17 |
| 2 | Distribution and origin of aerosol and its transform relationship with CCN derived from the spring multi-aircraft measurements of Beijing Cloud Experiment(BCE)显示文摘The atmospheric aerosol distribution,source and relationship with cloud condensation nuclei(CCN) observed during the Beijing Cloud Experiment(BCE) are analyzed.The results show that the high number concentrations of aerosol mainly distributed below 4500 m,and the magnitude could reach to 103 cm 3.Above 4500 m,the aerosol number concentrations decreased to 101 cm 3 as the altitude increases,and the aerosol mean diameters were between 0.16 and 0.19 μm.Below 4500 m,the number size distributions of aerosol showed a bimodal(multimodal) mode,and an unimodal mode above it.Due to the different sources of aerosol,the conversion ratios of aerosol to CCN were less than 20% below 4500 m,and reached 50% above the level at 0.3% supersaturation.The back trajectories showed that aerosols at higher levels above 4500 m were strongly affected by large-size particles and those below 4500 m were strongly affected by local or regional pollution.Based on observations,a relationship between the CCN number concentration and aerosol number concentration is established. | LU GuangXian GUO XueLiang | 2012 | Chinese Science Bulletin2012，57，19： | 14 |
| 3 | PREFACE显示文摘China,as a major country in natural resources, productions and applications of rare earths, has witnessed during the past two decades an astounding development of rare earths in both fundamental and industrial aspects. | Guangxian | 2010 | Journal of Rare Earths2010，28，6： | 14 |
| 4 | Buyang Huanwu decoction increases vascular endothelial growth factor expression and promotes angiogenesis in a rat model of local cerebral ischemia显示文摘Angiogenesis in the infarct periphery can improve blood flow.Vascular endothelial growth factor(VEGF) has been considered a potential therapeutic target for stroke.Buyang Huanwu decoction(BYHWD) is a classic traditional formula in traditional Chinese medicine and is used to treat stroke;in addition,the promotion effects on VEGF protein expression have been confirmed.However,little is known about how BYHWD regulates angiogenesis,or about the effects of BYHWD on VEGF mRNA expression.For this reason,the present study measured microvessel density in rats with cerebral ischemia using immunohistochemistry.In addition,VEGF expression was measured by reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assay to de-termine the effects of BYHWD on angiogenesis and VEGF expression in rats with cerebral ischemia.Results demonstrated that microvessel density,as well as VEGF mRNA and protein expression,increased after 7 and 14 days of BYHWD treatment,which suggests that BYHWD promoted an-giogenesis following cerebral ischemia and upregulated VEGF mRNA and protein expression in ischemic cerebral regions. | Guangxian Cai Baiyan Liu | 2010 | Neural Regeneration Research2010，5，22： | 10 |
| 5 | THE 3-D BOUNDARY ELEMENT METHOD OF ROLLER BEARING BY PLATE ELEMENT ANALOGUE显示文摘The mill roller beating is made up of an internal ring,middle rolls and an external ring,theanalysis of whieh is a multi-bodies contact problem.In this paper,based on the three-dimensional elasticcontact BEM without friction,and using the structural characteristics of roller bearings,middle rolls are de-scribed by elastic plate units of different shapes,which is placed on the internal ring.The discontinuoustraction problem of the contact element can be dealt with by the traction sub-element method.Therefore thecontact problem can be changed froin one of multi-bodies to one of two-bodies.As an elastic deformation ofthe plate element,it can be calculated by an elastic contact formula and is regarded an an equivalent gap tobe put into the total matrix equality.The face-to-face contact condition of displacement and traction on theelement will nerve as the convergence judging condition.So convergence solution can be obtained before anygeometry inconsistent on the contact element may take place.Therefore,the three-dimensional distribution ofload of the mill roller bearing can be achieved,It has been proved that the calculating model of this methodis visualized and simple,has last convergence solution and higher accuracy,making it an effective numericalmethod of designing and analyzing load characteristics of the mill roller bearing. | Shen Guangxian Shu xuedao Li Ming | 2001 | Acta Mechanica Solida Sinica2001，14，3： | 9 |
| 6 | 扫路车反吹式吸嘴运行参数的CFD分析显示文摘以国内某扫路车的反吹式吸嘴为研究对象,根据实际尺寸建立三维计算模型。通过气固两相流动的数值模拟,以除尘效率为评定指标,得出最佳运行参数组合,最后结合试验验证数值模拟的准确性。研究结果表明:车速或离地间隙增加,除尘效率降低;压降提高,除尘效率也随之提高;反吹风量增大,除尘效率先提高后降低;为了实现扫路车高速低能耗作业,通过优化获得最佳运行参数组合为:反吹风量为2 172 m3/h,车速为10 km/h,压降为2.4 k Pa,离地间隙为10 mm。 | 郗元 成凯 LI Guangxian 程磊 高学亮 董超 | 2016 | 中南大学学报(自然科学版)2016，47，4： | 7 |
| 7 | ANALYSIS OF ROLLING BY ELASTO-PLASTIC FINITE DEFORMATION CONTACT BOUNDARY ELEMENT METHOD显示文摘ANALYSISOFROLLINGBYELASTOPLASTICFINITEDEFORMATIONCONTACTBOUNDARYELEMENTMETHODHuangQingxueShenGuangxianXiaoHongTaiyuanHeavyMa... | Huang Qingxue Shen Guangxian Xiao Hong Taiyuan Heavy Mahcinery Institute Yanshan University | 1997 | Chinese Journal of Mechanical Engineering1997，10，4： | 7 |
| 8 | THREE DIMENSIONAL ELASTO-PLASTIC CONTACT BOUNDARY ELEMENT ANALYSIS FOR ROLLING WITH CONSIDERATION OF FRICTION显示文摘THREEDIMENSIONALELASTOPLASTICCONTACTBOUNDARYELEMENTANALYSISFORROLLINGWITHCONSIDERATIONOFFRICTION①XiaoHongChenYimingShenGuang... | Xiao, Hong Chen, Yiming Shen, Guangxian Aizawa, Tatsuhiko Kihara, Junji | 1998 | Chinese Journal of Mechanical Engineering1998，11，1： | 5 |
| 9 | Exosomal lncRNA FOXD3-AS1 upregulates ELAVL1 expression and activates PI3K/Akt pathway to enhance lung cancer cell proliferation, invasion, and 5-fluorouracil resistance显示文摘Long non-coding RNA (lncRNA) FOXD3-AS1 expression is upregulated in lung cancer;however, its effect and mechanism on 5-fluorouracil (5-FU) resistance remain unclear. In this study, we determined the effects of FOXD3-AS1-enriched exosomes derived from lung cancer cells on the proliferation, invasion, and 5-FU resistance of lung cancer cells. Online bioinformatics database analysis showed that FOXD3-AS1 was upregulated in lung cancer progression. Real-time quantitative PCR results confirmed that FOXD3-AS1 expression was upregulated in lung cancer tissues and cell lines, and FOXD3-AS1 was greatly enriched in lung cancer cell-derived exosomes. ELAV-like RNA-binding protein 1 (ELAVL1) was identified as an RNA-binding protein of FOXD3-AS1. The lung cancer cell-derived exosomes promoted A549 cell proliferation and invasion and inhibited apoptosis caused by 5-FU, and transfection of si-FOXD3-AS1 or si-ELAVL1 in exosome-incubated A549 cells reversed these effects. Moreover, exosome-incubated A549 cells were co-transfected with si-FOXD3-AS1 and pcDNA-ELAVL1, showing the same cell proliferation, invasion, and 5-FU resistance as those of A549 cells treated with lung cancer cell-derived exosomes alone. Mechanistic studies identified that lung cancer cell-derived exosomes activated the PI3K/Akt pathway, and transfection of si-FOXD3-AS1 or treatment with the PI3K inhibitor LY294002 reversed the activation of the PI3K/Akt axis induced by exosomes. In conclusion, our study revealed that lung cancer cell-derived exosomal FOXD3-AS1 upregulated ELAVL1 expression and activated the PI3K/Akt pathway to promote lung cancer progression. Our findings provide a new strategy for lung cancer treatment. | Guangxian Mao Zhimin Mu Da Wu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，11： | 5 |
| 10 | Influence of Surface-functionalized Graphene Oxide on the Cell Morphology of Poly(methyl methacrylate) Composite显示文摘The surface chemistry of filler is closely related to the structure and morphology of nanocomposite foams.Changing the property of filler is widely used to control the cell structures and functionalize the composite foams.Surface-functionalized graphene oxide(GO-ODA) was prepared by grafting octadecylamine(ODA) on the surface of graphene oxide(GO) to make the filler disperse better in the nanocomposites and have a strong interfacial interaction with polymer matrix.Poly(methyl methacrylate)(PMMA)/GO-ODA nanocomposite foams were obtained by solution blending and foamed using supercritical carbon dioxide(scCO_2).Compared to neat PMMA and PMMA/GO samples,the PMMA/GO-ODA nanocomposite foams showed improved cell structures with smaller size,higher cell density and more homogeneous distribution,which should be attributed to the heterogeneous nucleation caused by well-dispersed GO-ODA nanosheets.This work not only improved the compatibility and interfacial interaction of GO with polymer matrix but also indicated that the modified GO sheets can act as ideal filler to control the cell density,size and size distribution efficiently. | Yuwei Wang Xia Liao Yong Luo Qi Yang Guangxian Li | 2015 | Journal of Materials Science & Technology2015，31，5： | 3 |
| 11 | Novel electric conductive polylactide/carbon nanotubes foams prepared by supercritical CO_2显示文摘In this paper,novel electric conductive polylactide/carbon nanotubes(PLA/CNTs) foams were fabricated by a pressure-quench process using supercritical CO2as a blowing agent.The morphology of PLA/CNTs nanocomposites prepared by solution blending was characterized using SEM and the results indicate that CNTs well dispersed in PLA matrix.The introduction of CNTs improved the thermal stability of PLA.The morphology and electrical properties of PLA/CNTs foams were characterized and discussed.Depending on the process parameters,such as saturation temperature and pressure,nanocellular or microcellular structure of PLA/CNTs nanocomposites were obtained.The volume resistivity of PLA/CNTs foams was from 0.53 103Ω cm to 15.13 103Ω cm,which was affected by cell structure and crystallization of foams oppositely.Foaming reduced the electrical conductivity due to the decrease of CNTs volume content and the break of conductive pathways.However,crystallization increased the electrical conductivity possibly because of the CNTs structural change in which the CNTs were less curled and more connected. | Ting He Xia Liao Yunchuan He Guangxian Li | 2013 | Progress in Natural Science:Materials International2013，23，4： | 3 |
| 12 | A Precision Fiber Bragg Grating Interrogation System Using Long-Wavelength Vertical-Cavity Surface-Emitting Laser显示文摘这份报纸论述一个划算的精确纤维布拉格栅栏(FBG ) 的发展用长波长的垂直洞的射出表面的激光(VCSEL ) 的讯问系统。调节长波长的 VCSEL 的性质试验性地被学习了。它注射水流上的波长的近似二次的依赖被观察了。全面设计和包括紧张正规化,山峰察觉,和二次的曲线试穿的这个系统的关键操作详细被介绍。结果证明系统与 3 nm 的一个调节范围和 1 kHz 的调节的率完成 1.2 下午的精确性。这个系统由实际、有效,这被表明在监视的 FBG 变压器温度适用。 | Binxin HU Guangxian JIN Tongyu LIU Jinyu WANG | 2016 | Photonic Sensors2016，6，4： | 3 |
| 13 | An atlas of CNV maps in cattle, goat and sheep显示文摘Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and plants.However,the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain unknown.Here,we generated CNV region(CNVR)datasets which were diverged or shared among cattle,goat,and sheep,including 886 individuals from 171 diverse populations.Using 9 environmental factors for genome-wide association study(GWAS),we identified a series of candidate CNVRs,including genes relating to immunity,tick resistance,multi-drug resistance,and muscle development.The number of CNVRs shared between species is significantly higher than expected(P<0.00001),and these CNVRs may be more persist than the single nucleotide polymorphisms(SNPs)shared between species.We also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional genes.This study provides the evidence that balancing selection might be more common in mammals than previously considered,and might play an important role in the daily activities of these ruminant species. | Yongzhen Huang Yunjia Li Xihong Wang Jiantao Yu Yudong Cai Zhuqing Zheng Ran Li Shunjin Zhang Ningbo Chen Hojjat Asadollahpour Nanaei Quratulain Hanif Qiuming Chen Weiwei Fu Chao Li Xiukai Cao Guangxian Zhou Shudong Liu Sangang He Wenrong Li Yulin Chen Hong Chen Chuzhao Lei Mingjun Liu Yu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 14 | Monocyte chemotactic protein-1 and CC chemokine receptor 2 polymorphisms and prognosis of renal cell carcinoma 显示文摘 | Liu Guangxian Zhang Xin Li Su | 2013 | Tumour Biol2013，34，： | 1 |
| 15 | Comparison of glycation in conventionally and microwave-heated ovalbumin by high resolution mass spectrometry显示文摘 | WANG Hui TU Zongcai LIU Guangxian | | 0，，02： | 1 |
| 16 | 显示文摘 | Chunga J K Yuan Wei Liu Guangxian | 2006 | Toxicology2006，226，： | 1 |
| 17 | Investigation of aggregation in solvent extraction of lanthanides by acidic extractants (organophosphorus and naphthenic acid)显示文摘 | Naifu Zhou Jinguang Wu Zhijian Yu R. D. Neuman Dujin Wang Guangxian Xu | 1997 | Science in China Series B: Chemistry1997，，1： | 1 |
| 18 | The research of decision tree learning algo- rithm in technology of data mining classification显示文摘 | Guangxian Ji | 2012 | Journal of Convergence Information Technology2012，，7： | 1 |
| 19 | Monocyte chemotactic protein-1 and CC chemokine receptor 2 polymorphisms and prognosis of renal cell carcinoma显示文摘 | LIU Guangxian ZHANG Xin LI Su | 2013 | Tumour Biol2013，34，5： | 1 |
| 20 | MicroRNA‐149 Negatively Regulates TLR‐Triggered Inflammatory Response in Macrophages by Targeting MyD88显示文摘 | Guangxian Xu Zhaobo Zhang Yiwen Xing Jun Wei Zhaohui Ge Xiaoming Liu Ying Zhang Xuelan Huang | 2014 | J Cell Biochem2014，，5： | 1 |
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