Buyang Huanwu decoction increases vascular endothelial growth factor expression and promotes angiogenesis in a rat model of local cerebral ischemia

查看全文 作　　者：Guangxian Cai Baiyan [1]Liu

机构地区：[1]Key Laboratory of Internal Medicine, Hunan University of Traditional Chinese Medicine, Changsha 410007, Hunan Province, China

出　　处：《Neural Regeneration Research》索引2010年第5卷第22期,共6页

基　　金：the National Natural Science Foundation of China,No.30300470,30472217,30873355;the Key Project of Chinese Ministry Education of China,No.209087;the Key Project of Natural Science Foundation of Hunan Province,No.06JJ2052;a Grant from the Educational Commission of Hunan Province,No.08A049 摘　　要：Angiogenesis in the infarct periphery can improve blood flow.Vascular endothelial growth factor(VEGF) has been considered a potential therapeutic target for stroke.Buyang Huanwu decoction(BYHWD) is a classic traditional formula in traditional Chinese medicine and is used to treat stroke;in addition,the promotion effects on VEGF protein expression have been confirmed.However,little is known about how BYHWD regulates angiogenesis,or about the effects of BYHWD on VEGF mRNA expression.For this reason,the present study measured microvessel density in rats with cerebral ischemia using immunohistochemistry.In addition,VEGF expression was measured by reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assay to de-termine the effects of BYHWD on angiogenesis and VEGF expression in rats with cerebral ischemia.Results demonstrated that microvessel density,as well as VEGF mRNA and protein expression,increased after 7 and 14 days of BYHWD treatment,which suggests that BYHWD promoted an-giogenesis following cerebral ischemia and upregulated VEGF mRNA and protein expression in ischemic cerebral regions. 关键词：血管内皮生长因子补阳还五汤血管生成脑缺血大鼠脑酶联免疫吸附试验微血管密度模型

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Buyang Huanwu decoction increases vascular endothelial growth factor expression and promotes angiogenesis in a rat model of local cerebral ischemia

参考文献(43)

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耦合文献(57)

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