|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 2 | Efficient alloy design of Sr-modified A356 alloys driven by computational thermodynamics and machine learning显示文摘A356 alloys are widely used in industries due to their excellent comprehensive performance.Sr is usually added in A356 alloys to improve their mechanical properties.There have been various experimental reports on the optimal additional amount of Sr in A356 alloys,but their results are inevitably inconsistent.In this paper,a combination of computational thermodynamic and machine learning approaches was employed to determine the optimal Sr content in A356 alloys with the best mechanical properties.First,a self-consistent thermodynamic database of quaternary Al-Si-Mg-Sr system was established by means of the Calculation of PHAse Diagram technique supported by key experiments.Second,the fractions for solidified phase/structures of A356-xSr alloys predicted by Scheil simulation,together with the measured mechanical properties were set as the input dataset in the machine learning model to train the relation of“composition-microstructure-properties”.The optimal addition of Sr in A356 alloy was designed as 0.005 wt.%and validated by key experiments.Furthermore,such a combinatorial approach can help to understand the strengthening/toughening mechanisms of Sr-modified A356 alloys.It is also anticipated that the present approach may provide a feasible means for efficient and accurate design of various casting alloys and understanding the alloy strengthening/toughening mechanisms. | Wang Yi Guangchen Liu Zhao Lu Jianbao Gao Lijun Zhang | 2022 | Journal of Materials Science & Technology2022，，17： | 3 |
| 3 | iTRAQ-Based Proteomics Investigation of Critical Response Proteins in Embryo and Coleoptile During Rice Anaerobic Germination显示文摘Direct-seeding of rice has become popular in recent years due to its low cost and convenience,however,hypoxic condition limits seedling establishment.In this study,weedy rice WR04-6 with high germination ability under anaerobic conditions was used as a gene donor,and we successfully improved the seedling establishment rate of rice cultivar Qishanzhan(QSZ)based on selection of a new rice line R42 from the recombinant inbred line population.R42 inherited high anaerobic germination(AG)ability,and was used for isobaric tags for relative and absolute quantitation(iTRAQ)-based comparative proteomic studies with QSZ to further explore the molecular mechanism of AG.A total of 719 differentially abundant proteins(DAPs)were shared by R42 and QSZ responded to AG,and thus defined as common response DAPs.A total of 300 DAPs that responded to AG were only identified from R42,which were defined as tolerance-specific DAPs.The common response and tolerance-specific DAPs had similar biochemical reaction processes and metabolic pathways in response to anoxic stress,however,they involved different proteins.The tolerance-specific DAPs were involved in amino acid metabolism,starch and sucrose metabolism,tricarboxylic acid cycle pathway,ethylene synthesis pathway,cell wall-associated proteins and activity of active oxygen scavenging enzyme.The in silico protein-protein interactions for the top 60 DAPs indicated that tolerance-specific DAPs had relatively independent protein interaction networks in response to an anoxic environment compared with common response DAPs.The results of physiological indicators showed thatα-amylase and superoxide dismutase activities of R42 were significantly increased under anoxic conditions compared with aerobic conditions.Multiple lines of evidence from western blot,physiological analysis and quantitatDirect seeding of rice has become popular in recent years due to its low cost and convenience,however,hypoxic conditions can limit seedling establishment.In the present study,weedy rice WR04-6 with high germination ability in anaerobic conditions was used as the gene donor and successfully improved the seedling establishment rate of rice cultivar Qishanzhan(QSZ)based on selection of a new rice line R42 from the recombinant inbred line(RIL)population.R42 inherited the had high anaerobic germination(AG)ability,which was used for the isobaric tags for relative and absolute quantitation(iTRAQ)based comparative proteomic studies with QSZ to further explore the molecular mechanism of AG.A total of 719 differentially abundant proteins(DAPs)shared by R42 and QSZ responded to AG and were thus defined as common response DAPs.A total of 300 DAPs that responded to AG were only identified from R42,which were defined as tolerance-specific DAPs.The common response and tolerance-specific DAPs had similar biochemical reaction processes and metabolic pathways in response to anoxic stress,however they involved different proteins.The 300 tolerance-specific DAPs were involved in amino acid metabolism,starch and sucrose metabolism,TCA cycle pathways,ethylene synthesis pathway,cell wall-associated proteins and activity of active oxygen scavenging enzyme.The in silico protein-protein interactions for the top 60 DAPs indicated that tolerance-specific DAPs had relatively independent protein interaction networks in response to an anoxic environment compared with common response DAPs.The results of physiological indicators showed thatα-amylase and SOD activities of R42 were significantly increased under anoxic conditions compared with aerobic conditions.Multiple lines of evidence from western blot,physiological analyses and real-time PCR jointly supported the reliability of proteomics data.In summary,our findings deepened the understanding of the molecular mechanism for the rice response to AG.ive real-time PCR jointly supported the reliability of proteomics data.In summary,our findings deepened the understanding of the molecular mechanism for the rice response to AG. | Zhang Guangchen Liu Zimeng Liu Yoxihong Kuya Noriyuki HuAYuchen Shi Hongru Zhao Weilin Han Yuqing Yamamoto Toshio Chen Wenfu Sun Jian | 2021 | Rice science2021，28，4： | 2 |
| 4 | MODEL STUDY OF DREDGED CHANNEL SILTATION IN OFFSHORE OPEN WATER显示文摘Based on the model study, the siltation of dredged channel under the condition of clear water and sediment-water mixture in Lianyun Harbor, Jiangsu Province and the experimental method under complex hydrodynamic elements such as tides, winds, waves and tidal currents are studied. The regularities of the variation of the velocity in the dredged channel in clear water are discussed as well. A group of curves such as water depth, velocity and angle has been plotted as a guide to the selection of a proper direction for a dredged channel. The intensity of siltation and the rate of deposition in the condition of sediment-water mixture, and the relationship between the dimensions of the dredged channel and the deposition amount can be estimated. | Li, Anzhong Li, Guochen Liu, Guangchen | 1990 | China Ocean Engineering1990，5，1： | 2 |
| 5 | The risk management of perishable supply chain based on coloured Petri Net modeling显示文摘The supply chain of perishable products is a combination of information organization,sharing and integration.The information modeling of supply chain is constructed to abstract key quality information including environment information,processing procedures and product quality assessments based on principle of quality safety factors and property of decay rate.The coloured Petri Net is applied for integrated description of independent information classification,aiming at risk identification and risk management framework.Well,according to the quality deterioration tendency,risk grades management and decision-making system are established.Practically,the circulation system of aquatic products is studied in this paper for full processing description.The simulation experiments are manipulated on environmental information,processing information and product quality information by the coloured Petri Net.Eventually,the conclusion turns out precisely as such that the coloured Petri Net conclusive for information classification and information transmission while integrated information management is available of efficient risk identification and decision-making system in supply chain of perishable products.Meanwhile,the validity of evaluating management and shelf-life estimation of perishable products are technically feasible. | Lu Liu Xinlei Liu Guangchen Liu | 2018 | Information Processing in Agriculture2018，5，1： | 1 |
| 6 | MicroRNA-708 inhibits the proliferation and chemoresistance of pancreatic cancer cells显示文摘Pancreatic cancer is one of the most aggressive malignancies with poor prognosis and high mortality.Recent studies showed that microRNAs are dysregulated and involved in the initiation and progression of pancreatic cancer.In this study,we found that miR-708 was significantly downregulated in pancreatic cancer tissues and cell lines.Lentivirus-mediated overexpression of miR-708 could significantly inhibit the proliferation and invasion,while enhanced chemosensitivity to gemcitabine in both Panc-1 and SW1990 cells.Luciferase reporter assay showed that miR-708 bound the 3’-untranslated region of survivin and suppressed the expression of survivin in pancreatic cancer cells.In pancreatic cancer tissues,survivin protein was highly expressed and negatively correlated with miR-708 expression.Furthermore,the restoration of survivin expression could partially antagonize proliferation inhibition and apoptosis induction by miR-708 in pancreatic cancer cells.The Panc-1 cells with overexpression of miR-708 also showed decreased proliferation capability in nude mouse model compared with parental cells.In conclusion,our results suggest that miR-708 inhibits pancreatic cancer and could be a novel potential candidate to treat pancreatic cancer. | Wensong LIU Yunjie LU Dong ZHANG Longqing SHI Guangchen ZU Haijiao YAN Donglin SUN | 2020 | BIOCELL2020，44，1： | 1 |
| 7 | Discovery of small molecule degraders for modulating cell cycle显示文摘The cell cycle is a complex process that involves DNA replication,protein expression,and cell division.Dysregulation of the cell cycle is associated with various diseases.Cyclin-dependent kinases(CDKs)and their corresponding cyclins are major proteins that regulate the cell cycle.In contrast to inhibition,a new approach called proteolysis-targeting chimeras(PROTACs)and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins,achieving targeted degradation.The field of PROTACs and molecular glues has developed rapidly in recent years.In this article,we aim to summarize the latest developments of CDKs and cyclin protein degraders.The selectivity,application,validation and the current state of each CDK degrader will be overviewed.Additionally,possible methods are discussed for the development of degraders for CDK members that still lack them.Overall,this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders,which will be helpful for researchers working on this topic. | Liguo Wang Zhouli Yang Guangchen Li Yongbo Liu Chao Ai Yu Rao | 2023 | Frontiers of Medicine2023，17，5： | 0 |
| 8 | Classifying Globular Clusters and Applying them to Estimate the mass of the Milky Way显示文摘We combine the kinematics of 159 globular clusters(GCs) provided by the Gaia Early Data Release 3(EDR3) with other observational data to classify the GCs,and to estimate the mass of the Milky Way(MW).We use the agemetallicity relation,integrals of motion,action space and the GC orbits to identify the GCs as either formed in situ(Bulge and Disk) or ex situ(via accretion).We find that 45.3% have formed in situ,while 38.4% may be related to known merger events:Gaia-Sausage-Enceladus,the Sagittarius dwarf galaxy,the Helmi streams,the Sequoia galaxy and the Kraken galaxy.We also further identify three new sub-structures associated with the Gaia-Sausage-Enceladus.The remaining 16.3% of GCs are unrelated to the known mergers and thought to be from small accretion events.We select 46 GCs which have radii 8.0 | GuangChen Sun Yougang Wang Chao Liu Richard J.Long Xuelei Chen Qi Gao | 2023 | Research in Astronomy and Astrophysics2023，23，1： | 0 |
| 9 | Effect of Ca Addition and Heat Treatment on the A390(S)/AM60(L) Interface Microstructure显示文摘Overcasting is a new kind of dissimilar joining technique used to produce the aluminum(solid)/magnesium(liquid) bonding bi-metallic material in this study. For the Al/Mg(A390/AM60) bi-metallic samples, the interface microstructures are the research points, which directly influence the mechanical properties. It is, therefore, of vital importance to find a method to improve the interface microstructures. This research focused on the effect of the calcium(Ca) addition in the liquid Mg alloys and the heat treatment on the A390/AM60 interface microstructures of the bi-metallic samples. The testing results showed that, with Ca addition in AM60, owing to two possible reasons, the interface microstructure and the shear strength of the A390/AM60 bi-metallic samples could be improved. The heat treatment could further improve the interface microstructure and the mechanical properties by dissolving β-Mg_(17)Al_(12) into α-Mg and destroying the Mg_2Si layer structure. | 马立坤 陈翌庆 LIU Lihua SU Yong XU Guangchen FANG Hongjiao | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，5： | 0 |
| 10 | Optimal Operation Strategy of Electricity-Hydrogen Regional Energy System under Carbon-Electricity Market Trading显示文摘Given the“double carbon”objective and the drive toward low-carbon power,investigating the integration and interaction within the carbon-electricity market can enhance renewable energy utilization and facilitate energy conservation and emission reduction endeavors.However,further research is necessary to explore operational optimization methods for establishing a regional energy system using Power-to-Hydrogen(P2H)technology,focusing on participating in combined carbon-electricity market transactions.This study introduces an innovative Electro-Hydrogen Regional Energy System(EHRES)in this context.This system integrates renewable energy sources,a P2H system,cogeneration units,and energy storage devices.The core purpose of this integration is to optimize renewable energy utilization and minimize carbon emissions.This study aims to formulate an optimal operational strategy for EHRES,enabling its dynamic engagement in carbon-electricity market transactions.The initial phase entails establishing the technological framework of the electricity-hydrogen coupling system integrated with P2H.Subsequently,an analysis is conducted to examine the operational mode of EHRES as it participates in carbon-electricity market transactions.Additionally,the system scheduling model includes a stepped carbon trading price mechanism,considering the combined heat and power generation characteristics of the Hydrogen Fuel Cell(HFC).This facilitates the establishment of an optimal operational model for EHRES,aiming to minimize the overall operating cost.The simulation example illustrates that the coordinated operation of EHRES in carbon-electricity market transactions holds the potential to improve renewable energy utilization and reduce the overall system cost.This result carries significant implications for attaining advantages in both low-carbon and economic aspects. | Jingyu Li Mushui Wang Zhaoyuan Wu Guizhen Tian Na Zhang Guangchen Liu | 2024 | Energy Engineering2024，121，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员