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| 1 | Population Genomic Analysis and De Novo Assembly Reveal the Origin of Weedy Rice as an Evolutionary Game显示文摘Crop weediness,especially that of weedy rice(Oryza sativa f.spontanea),remains mysterious.Weedy rice possesses robust ecological adaptability;however,how this strain originated and gradually formed proprietary genetic features remains unclear?Here,we demonstrate that weedy rice at Asian high latitudes(WRAH)is phylogenetically well defined and possesses unselected genomic characteristics in many divergence regions between weedy and cultivated rice.We also identified novel quantitative trait loci underlying weedy-specific traits,and revealed that a genome block on the end of chromosome 1 is associated with rice weediness.To identify the genomic modifications underlying weedy rice evolution,we generated the first de novo assembly of a high-quality weedy rice genome(WR04-6),and conducted a comparative genomics study between WR04-6 with other rice reference genomes.Multiple lines of evidence,including the results of demographic scenario comparisons,suggest that differentiation between weedy rice and cultivated rice was initiated by genetic improvement of cultivated rice and that the essence of weediness arose through semi-domestication.A plant height model further implied that the origin of WRAH can be modeled as an evolutionary game and indicated that strategy-based selection driven by fitness shaped its genomic diversity. | Jian Sun Dianrong Ma Liang Tang Minghui Zhao Guangchen Zhangh Wenjia Wang Jiayu Song Xiang Li Zimeng Liu Wenxing Zhang Quan Xu Yuncheng Zhou Jianzhong Wu Toshio Yamamoto Fei Dai Yan Lei Song Li Gang Zhou Hongkun Zheng Zhengjin Xu Wenfu Chen | 2019 | Molecular Plant2019，12，5： | 9 |
| 2 | Application of Improved Hybrid Interface Substructural Component Modal Synthesis Method in Vibration Characteristics of Mistuned Blisk显示文摘The large and complex structures are divided into hundreds of thousands or millions degrees of freedom(DOF) when they are calculated which will spend a lot of time and the efficiency will be extremely low. The classical component modal synthesis method(CMSM) are used extensively, but for many structures in the engineering of high-rise buildings, aerospace systemic engineerings, marine oil platforms etc, a large amount of calculation is still needed. An improved hybrid interface substructural component modal synthesis method(HISCMSM) is proposed. The parametric model of the mistuned blisk is built by the improved HISCMSM. The double coordinating conditions of the displacement and the force are introduced to ensure the computational accuracy. Compared with the overall structure finite element model method(FEMM), the computational time is shortened by 23.86%–31.56% and the modal deviation is 0.002%–0.157% which meets the requirement of the computational accuracy. It is faster 4.46%–10.57% than the classical HISCMSM. So the improved HISCMSM is better than the classical HISCMSM and the overall structure FEMM. Meanwhile, the frequency and the modal shape are researched, considering the factors including rotational speed, gas temperature and geometry size. The strong localization phenomenon of the modal shape's the maximum displacement and the maximum stress is observed in the second frequency band and it is the most sensitive in the frequency veering. But the localization phenomenon is relatively weak in 1st and the 3d frequency band. The localization of the modal shape is more serious under the condition of the geometric dimensioning mistuned. An improved HISCMSM is proposed, the computational efficiency of the mistuned blisk can be increased observably by this method. | BAI Bin BAI Guangchen LI Chao | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 5 |
| 3 | MODEL STUDY OF DREDGED CHANNEL SILTATION IN OFFSHORE OPEN WATER显示文摘Based on the model study, the siltation of dredged channel under the condition of clear water and sediment-water mixture in Lianyun Harbor, Jiangsu Province and the experimental method under complex hydrodynamic elements such as tides, winds, waves and tidal currents are studied. The regularities of the variation of the velocity in the dredged channel in clear water are discussed as well. A group of curves such as water depth, velocity and angle has been plotted as a guide to the selection of a proper direction for a dredged channel. The intensity of siltation and the rate of deposition in the condition of sediment-water mixture, and the relationship between the dimensions of the dredged channel and the deposition amount can be estimated. | Li, Anzhong Li, Guochen Liu, Guangchen | 1990 | China Ocean Engineering1990，5，1： | 2 |
| 4 | Mitochon- drial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excit- ability of amygdala neurons and pain behavior 显示文摘 | LI Zhen JI Guangchen NEUGEBAUER V | 2011 | J Neurosci2011，31，3： | 1 |
| 5 | Discovery of small molecule degraders for modulating cell cycle显示文摘The cell cycle is a complex process that involves DNA replication,protein expression,and cell division.Dysregulation of the cell cycle is associated with various diseases.Cyclin-dependent kinases(CDKs)and their corresponding cyclins are major proteins that regulate the cell cycle.In contrast to inhibition,a new approach called proteolysis-targeting chimeras(PROTACs)and molecular glues can eliminate both enzymatic and scaffold functions of CDKs and cyclins,achieving targeted degradation.The field of PROTACs and molecular glues has developed rapidly in recent years.In this article,we aim to summarize the latest developments of CDKs and cyclin protein degraders.The selectivity,application,validation and the current state of each CDK degrader will be overviewed.Additionally,possible methods are discussed for the development of degraders for CDK members that still lack them.Overall,this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein degraders,which will be helpful for researchers working on this topic. | Liguo Wang Zhouli Yang Guangchen Li Yongbo Liu Chao Ai Yu Rao | 2023 | Frontiers of Medicine2023，17，5： | 0 |
| 6 | An Improved Navigation Pseudolite Signal Structure Based on the Kasami Sequences and the Pulsing Scheme显示文摘Pseudolites(PLs)are ground-based satellites,providing users with navigation solutions.However,implementation of the PL system leads to the near-far problem.In this paper,we proposed an improved navigation PL signal structure of combing Kasami sequences and the pulsing scheme to mitigate the near-far effect.The pulse modulation method is adopted to ensure that the PLs transmit signals at different timeslots and reduce the PL signals’mutual interference.Additionally,we employ the small set of Kasami sequences with good cross-correlation properties to improve the anti-interference ability.A simulation test based on software is carried out to evaluate the performance of the proposed signal.The simulation proves that the improved PL signal has an impulsive power spectral density,makes it a feasible solution to mitigate the near-far effect,and performs better in the capture. | TAO Lin SUN Junren LI Guangchen ZHU Bocheng | 2022 | Chinese Journal of Electronics2022，31，2： | 0 |
| 7 | Optimal Operation Strategy of Electricity-Hydrogen Regional Energy System under Carbon-Electricity Market Trading显示文摘Given the“double carbon”objective and the drive toward low-carbon power,investigating the integration and interaction within the carbon-electricity market can enhance renewable energy utilization and facilitate energy conservation and emission reduction endeavors.However,further research is necessary to explore operational optimization methods for establishing a regional energy system using Power-to-Hydrogen(P2H)technology,focusing on participating in combined carbon-electricity market transactions.This study introduces an innovative Electro-Hydrogen Regional Energy System(EHRES)in this context.This system integrates renewable energy sources,a P2H system,cogeneration units,and energy storage devices.The core purpose of this integration is to optimize renewable energy utilization and minimize carbon emissions.This study aims to formulate an optimal operational strategy for EHRES,enabling its dynamic engagement in carbon-electricity market transactions.The initial phase entails establishing the technological framework of the electricity-hydrogen coupling system integrated with P2H.Subsequently,an analysis is conducted to examine the operational mode of EHRES as it participates in carbon-electricity market transactions.Additionally,the system scheduling model includes a stepped carbon trading price mechanism,considering the combined heat and power generation characteristics of the Hydrogen Fuel Cell(HFC).This facilitates the establishment of an optimal operational model for EHRES,aiming to minimize the overall operating cost.The simulation example illustrates that the coordinated operation of EHRES in carbon-electricity market transactions holds the potential to improve renewable energy utilization and reduce the overall system cost.This result carries significant implications for attaining advantages in both low-carbon and economic aspects. | Jingyu Li Mushui Wang Zhaoyuan Wu Guizhen Tian Na Zhang Guangchen Liu | 2024 | Energy Engineering2024，121，3： | 0 |
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