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75篇 您的检索式:作者名="Grogan T"
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1被激光损伤软骨释放的凋亡因子诱导软骨细胞凋亡的研究显示文摘目的探讨组织损伤后凋亡信号怎样促进细胞的死亡进程。方法在激光照射后猪软骨块置培液中,在不同时间(3、6、9、12、24 h)收集的培液,即实验条件培养液(TCM),从未经激光照射的软骨块培液取得的为对照条件培养液(CCM)。软骨块继续培养28 d,用聚焦显微镜评价其受损区的进展。分离的软骨细胞单层放于 TCM、CCM 或正常培养液(NM)培养,阳性对照组单层细胞经紫外线照射10 min 后继续用正常培养液培养,培养24 h 后,收集细胞并用荧光标记物染色,经流式细胞仪分析。结果所有经 TCM 培养的细胞显现半胱氨酸蛋白水解酶(caspase)-3阳性、CMXRos 和一氧化氮信号减少或失去;经 CCM 或 NM 培养的细胞显现 caspase-3阴性、CMXRos 和一氧化氮信号完好;阳性对照组细胞显现 Caspase-3和 CMXRos 均阳性、一氧化氮信号减少或失去,代表处于凋亡早期的细胞。不同 TCM 浓度(100%、50%、25%、12.5%)和时间(0.5、1、3、9、12 h)对细胞作用后,所有细胞均呈现 caspase-3阳性、CMXRos 和一氧化氮信号减少或失去。结论激光照射受损软骨释放凋亡因子,可诱导单层细胞死亡。郑敏 Grogan SP Schaffner T Mainil-Varlet P 2007中华医学杂志2007,87,21:3
2Fire effects on ecosystem nitrogen cycling in a Californian bishop pine forest显示文摘Grogan P Bruns T D Chapin III F S 2000Oecologia2000,122,:1
3Planarizing technique for ion-beam polishing of diamond films 显示文摘Grogan D F Zhao T Bovard B G 1992Applied Optics1992,31,10:1
4The role of molecular diffusion processes in tertiary COs flooding 显示文摘Grogan A T Pinczewski W V 1987SPE J Petrol Technol1987,39,5:1
5The synthesis of R-(+) -ct-lipoic acid using a monooxygenase 显示文摘Adger B Bes M T Grogan G 1998Bioorganic Chemistry1998,,2:1
6Multidrug resistance protein (MRP) expression in retinoblastoma correlates with the rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein显示文摘CHAN H S LU Y GROGAN T M 1997Cancer Res1997,57,12:1
7Prognostic signficance of the Ki-67-assiciated proliferative antigen in aggressive non-Hodgkin's lymphomas:a prospective southwest oncology group trial显示文摘Miller T P Grogan T M Dahiberg S 1994Blood1994,83,6:1
8The Rectal Trumpet: Use of a Nasopharyngeal Airway to Contain Fecal Incontinence in Critically Ill Patients显示文摘Grogan T A Kramer D J 2002J Wound Ostomy Continence Nurs2002,29,4:1
9Mesenchymal progenitor cells in adult human articular cartilage显示文摘Hiraoka K Grogan S Olee T 2006Biorheology2006,43,:1
10One hundred two patients with pheochromocytoma treated at a single institution since the introduction of laparoscopic adrenalectomy显示文摘Shen W T Grogan R Vriens M 2010Arch Surg2010,145,9:1
11Association between tumor associated macrophage infiltration,high grade prostate cancer,and biochemical recurrence after radical prostatectomy显示文摘Gollapudi K Galet C Grogan T 2013Am J Cancer Res2013,3,5:1
12The synthesis of R-(+)-Iipoic acid using a monooxygenase 显示文摘ADGER B BES M T GROGAN G 1998Bioorganic Chemistry1998,2,:1
13Tumours of histiocytes and accessory dendritic cells: an immunohisto-chemical approach to classification from the International Lymphoma Study Group based on 61 cases 显示文摘Pileri S A Grogan T M Harris N L 2002Histopathology2002,41,1:1
14MicroRNA-140 is expressed in dif- ferentiated human articular chondrocytes and modulates interleukin-1 responses显示文摘Miyaki S Nakasa T Otsuki S Grogan S P Higashiya- ma R Inoue A 2009Arthritis Rheum2009,60,:1
15Use of allograft bone for posterior spinal fusion in idiopathic scoliosis 显示文摘GROGAN D P KALEN V ROSS T I 1999Clin Orthop Relat Res1999,369,:1
16Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site显示文摘Grogan SP Olee T Hiraoka K 0,,09:1
17Coordinate Transformation between Sensor and Observe Vehicle显示文摘GROGAN T A ANGRISANNI D 0,,01:1
18Multidrug-resistanxe melanome:Laboratory and clinical effects of verapamail as a chemosensitizer显示文摘SALMON S E DALTON W S GROGAN T M 1991Blood1991,78,1:1
19Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site 显示文摘Grogan SP Olee T Himoka K Arthritis Rheum0,58,9:1
20Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 en- hancer site显示文摘Grogan SP Olee T Hiraoka K Lotz MK 2008Arthritis Rheum2008,58,:1
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