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| 1 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 2 | Involvement of serum retinoids and Leiden mutation in patients with esophageal, gastric, liver, pancreatic, and colorectal cancers in Hungary显示文摘AIM: To analyze the serum levels of retinoids and Leiden mutation in patients with esophageal, gastric, liver,pancreatic, and colorectal cancers.METHODS: The changes in serum levels of retinoids (vitamin A, α- and β-carotene, α- and β-cryptoxanthin,zeaxanthin, lutein) and Leiden mutation were measured by high liquid performance chromatography (HPLC)and polymerase chain reaction (PCR) in 107 patients (70 males/37 females) with esophageal (0/8), gastric (16/5), liver (8/7), pancreatic (6/4), and colorectal (30/21including 9 patients suffering from in situ colon cancer)cancer. Fifty-seven healthy subjects (in matched groups)for controls of serum retinoids and 600 healthy blood donors for Leiden mutation were used.RESULTS: The serum levels of vitamin A and zeaxanthin were decreased significantly in all groups of patients with gastrointestinal (GI) tumors except for vitamin A in patients with pancreatic cancer. No changes were obtained in the serum levels of α- and β-carotene,α- and β-cryptoxanthin, zeaxanthin, lutein in patients with GI cancer. The prevalence of Leiden mutation significantly increased in all groups of patients with GI cancer.CONCLUSION: Retinoids (as environmental factors)are decreased significantly with increased prevalence of Leiden mutation (as a genetic factor) in patients before the clinical manifestation of histologically different (planocellular and hepatocellular carcinoma, and adenocarcinoma) GI cancer. | Gyula Mózsik Gy(o|¨)rgy Rumi András D(o|¨)m(o|¨)t(o|¨)r Mária Figler Beáta Gasztonyi El(?)d Papp Alajos Pár Gabriella Pár József Belágyi Zoltán Matus Béla Melegh | 2005 | World Journal of Gastroenterology2005，11，48： | 2 |
| 3 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | Brehm M Zeus T | 2002 | Circulation2002，106，15： | 1 |
| 4 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | Strauer BE Brehm M Zeus T | 2002 | Circulation2002，106，15： | 1 |
| 5 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | Strauer BE Brehm M Zeus T | 2002 | Circulation2002，106，15： | 1 |
| 6 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | Strauer BE Brehm M Zeus T | 2002 | Circulation2002，106，： | 1 |
| 7 | Repaird of infracted myocardium by autologous intraconronary mononuclear bone marrow cell transplantation in humans显示文摘 | Strauer BE Brehm M Zeus T | 2002 | Circulation2002，106，： | 1 |
| 8 | Intracoronary,human autologous stem cell transplantation for myocardial regeneration following myocardial infarction显示文摘 | Strauer BE Brehm M Zeus T | 2001 | Dtsch Med Wochenschr2001，126，： | 1 |
| 9 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | STRAUER BE BREHM M ZEUS T | 2002 | Circulation2002，106，15： | 1 |
| 10 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans 显示文摘 | Strauer BE Brehm M Zeus T | 2002 | Circulation2002，106，： | 1 |
| 11 | Limitations of microscopy to differentiate Plasmodium species in a region co- endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi显示文摘 | Barber BE William T Grigg M J | 2013 | Malar J2013，12，1： | 1 |
| 12 | Estimates of Illnesses, Hospitalizations and Deaths Caused by Major Bacterial Enteric Pathogens in Young Children in the United States显示文摘 | Scallan E Mahon BE Hoekstra R M e t 01 | 2013 | The Pediatric Infectious Disease Journal2013，32，： | 1 |
| 13 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | Strauer BE Brehm M Zeus T et cd | 2002 | Circulation2002，106，15： | 1 |
| 14 | 显示文摘 | Strauer BE Brehm M Zeus T | 2002 | Circulation2002，106，： | 1 |
| 15 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | Strauer BE Brehm M Zeus T | 2002 | Circulation2002，106，15： | 1 |
| 16 | Repair of infarcted myocardium by autologous intracoronary mononuclear marrow cell transplantation in humans显示文摘 | Brehm M Zeus T | 2002 | Circulation2002，106，15： | 1 |
| 17 | Repair of infarcted myocardium by autologus intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | Brehm M Zeus T | 2002 | Circulation2002，106，15： | 1 |
| 18 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | Strauer BE Brehm M Zeus T | 2002 | Circulation2002，106，15： | 1 |
| 19 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transp lantation in humans显示文摘 | Strauer BE Brehm M Zeus T | 2002 | Circulation2002，106，15： | 1 |
| 20 | Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans显示文摘 | Brehm M Zeus T | 2002 | Circulation2002，106，： | 1 |
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