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| 1 | 美国临床肿瘤学会IV期非小细胞肺癌化疗的临床实践指南更新显示文摘本文旨在为IV期非小细胞肺癌患者的治疗提供更新版推荐。本文资料检索源自2002年以来公布的相关随机试验文献。此指南范围限于化疗与生物治疗。更新委员会对这些文献进行了总结并提供了推荐更新。162篇文献符合标准被纳入参考。本推荐基于可改善总生存期的治疗方法。仅改善无进展生存期的治疗方法推动了对毒性及生存质量的监测。对于体力状态评分为0分或1分患者的一线治疗,可推荐以铂类为基础的细胞毒性药物的两药联用。对铂类治疗有禁忌的患者,可采用非铂类细胞毒性两药联合。对于体力状态评分为2分的患者,单一细胞毒性药物即可。对于疾病进展或经过4个周期的治疗仍对治疗无反应的患者,应停止一线细胞毒性化疗。即使在6个周期后患者对治疗仍有反应,亦应停止两药细胞毒性化疗。对于伴有明确的表皮生长因子受体(epidermal growth factor receptor,EGFR)突变的患者,可推荐一线采用吉非替尼治疗;对于EGFR突变为阴性或不明确的患者,细胞毒性化疗更佳。除具有特定临床特征的患者外,可推荐贝伐单抗与卡铂-紫杉醇联用。对于通过免疫组化证实EGFR阳性的肿瘤患者,可推荐西妥昔单抗与顺铂-长春瑞滨联用。多西紫杉醇、厄洛替尼、吉非替尼或培美曲塞被推荐作为二线治疗。对于未曾接受过厄洛替尼或吉非替尼治疗的患者,可推荐厄洛替尼作为三线治疗。现有数据不足以推荐常规三线采用细胞毒性药物。已有的证据也不足以推荐常规应用分子标记物选择化疗。 | Christopher G. AZZOLI Sherman Baker JR Sarah TEMIN William PAO Timothy ALIFF Julie BRAHMER David H. JOHNSON Janessa L. LASKIN Gregory MASTERS Daniel MILTON Luke NORDQUIST David G. PFISTER Steven PIANTADOSI Joan H. SCHILLER Reily SMITH Thomas J. SMITH John R. STRAWN David TRENT Giuseppe GIACCONE 丁燕(翻译) 南娟(翻译) 刘谦(翻译) 周清华(校对) 陈军(校对) | 2010 | 中国肺癌杂志2010，13，3： | 43 |
| 2 | 黄河三角洲滨海湿地健康条件评价概念模型显示文摘滨海湿地健康与生物学特征主要取决于区域上的水文与盐度体制以及景观尺度上的土地利用现状。然而,由于滨海湿地条件评价的指标和标准并不十分清楚,因此,对滨海湿地系统条件进行评价,目前仍是环境科学的难点。中国地质调查局(CGS)青岛海洋地质研究所与美国地质调查局湿地研究中心合作先后为美国密西西比河下游生态环境及中国黄河三角洲(YRD)滨海湿地评价建立了概念模型。本文将陈述YRD湿地评价的概念模型。此模型的建立在于确定滨海湿地当前的条件和随时间改善或退化的过程,以及确定优先管理的区域。CGS项目之所以选取YRD作为滨海湿地的研究对象主要是因为它具有重要的生态意义。由于上游来水减少或黄河断流,该区湿地生境十分脆弱。本文提出此概念模型可为今后湿地条件评价指标确定、调查研究活动和数据采集提供指导。通过该模型的构建,使环境变化可用具体指标来度量,从而服务于滨海湿地生态系统的保护与管理活动。 | 叶思源 SMITH Gregory Jame 高茂生 丁喜桂 刘强 | 2009 | 地质论评2009，55，4： | 11 |
| 3 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 4 | Developing schools as professional learning communities: The TL21 experience显示文摘 | Anthony Malone Gregory Smith | 2010 | 美中教育评论2010，7，9： | 3 |
| 5 | Diabetes and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association显示文摘 | Scott M. Grundy Ivor J. Benjamin Gregory L. Burke Alan Chait Robert H. Eckel Barbara V. Howard William Mitch Sidney C. Smith James R. Sowers | 1999 | Circulation1999，，10： | 3 |
| 6 | Definitive management of severe facial trauma utilizing free tissue transfer显示文摘 | Neal D. Futran D. Gregory Farwell Russell B. Smith Paul E. Johnson Gerry F. Funk | 2005 | Otolaryngology - Head and Neck Surgery2005，，1： | 3 |
| 7 | Diabetes and Cardiovascular Disease: A Statement for Healthcare Professionals From the American Heart Association显示文摘 | Scott M. Grundy Ivor J. Benjamin Gregory L. Burke Alan Chait Robert H. Eckel Barbara V. Howard William Mitch Sidney C. Smith James R. Sowers | 1999 | Circulation1999，，10： | 2 |
| 8 | Epidemiologic evaluation of reoperation for surgically treated pelvic organ prolapse and urinary incontinence显示文摘 | Clark AL Gregory T Smith V J | 2003 | Am J Obstet Gynecol2003，189，5： | 1 |
| 9 | An autocrine TGF -beta/ZEB/miR-200 signaling network regulates establish- ment and maintenance of epithelial-mesenchymal transition 显示文摘 | Gregory PA Bracken CP Smith E | 2011 | MolBiolCell2011，22，10： | 1 |
| 10 | Apolipoprotein A-I Tryptophan Substitution Leads to Resistance to Myeloperoxidase-Mediated Loss of Function显示文摘 | Dao-Quan Peng Gregory Brubaker Zhiping Wu Lemin Zheng Belinda Willard Michael Kinter Stanley L. Hazen Jonathan D. Smith | 2008 | Arteriosclerosis, Thrombosis, and Vascular Biology2008，，11： | 1 |
| 11 | An autocrine TGF-beta/ ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial -mesenchymal transition 显示文摘 | Gregory PA Bracken CP Smith E | 2011 | Mol Biol Cell2011，22，10： | 1 |
| 12 | Epidemiologic evaluation of reoperation for surgically treated pelvic organ prolapse and urinary incontinence显示文摘 | Clark AL Gregory T Smith VJ | 2003 | American J Obstet Gynecol2003，189，5： | 1 |
| 13 | Antigonadotropins : a novel strategy to halt Alzheimer's disease显示文摘 | Gregory CW Atwood CS Smith MA | 2006 | Curr Pharm Des2006，12，6： | 1 |
| 14 | An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition显示文摘 | Gregory PA Bracken CP Smith E | | 0，，： | 1 |
| 15 | An autocrine TGF-β/ZEB/ miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition显示文摘 | Gregory PA Bracken CP Smith E | | 0，，： | 1 |
| 16 | Epidemiologic evaluation of reo-peration for surgically treated pelvic organ prolapse and urinary incoti-nence显示文摘 | Clark AL Gregory T Smith VJ | 2003 | Am J Obstet Gynecol2003，189，5： | 1 |
| 17 | An autocrine TGF-β/ ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition显示文摘 | Gregory PA Bracken CP Smith E | 2011 | Mol Biol Cell2011，22，10： | 1 |
| 18 | Mitomycin C,vinblastine and carboplatin: effective outpatient chemotherapy for advanced non-small cell carcinoma of the lung(NSCLC) 显示文摘 | Gregory RK Smith IE Norton A | 2001 | J Clin Oncol( R Coil Radiol )2001，13，6： | 1 |
| 19 | Technologies for Imaging the Normal and Diseased Pancreas显示文摘 | Gregory A. Coté Jeffrey Smith Stuart Sherman Kimberly Kelly | 2013 | Gastroenterology2013，，6： | 1 |
| 20 | Theoretical investigation of the role of the RANK–RANKL–OPG system in bone remodeling显示文摘 | Peter Pivonka Jan Zimak David W. Smith Bruce S. Gardiner Colin R. Dunstan Natalie A. Sims T. John Martin Gregory R. Mundy | 2009 | Journal of Theoretical Biology2009，，： | 1 |
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