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| 1 | Ent-11α-Hydroxy-15-oxo-kaur-16-en-19-oic-acid Inhibits Growth of Human Lung Cancer A549 Cells by Arresting Cell Cycle and Triggering Apoptosis显示文摘Objective: To examine the apoptotic effect of ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid (5F), a compound isolated from Pteris semipinnata L (PsL), in human lung cancer A549 cells. Methods: A549 cells were treated with 5F (0-80 μg/ml) for different time periods. Cytotoxicity was examined using a MTT method. Cell cycle was examined using propidium iodide staining. Apoptosis was examined using Hoechst 33258 staining, enzyme-linked immunosorbent assay (ELISA) and caspase-3 activity analysis. Expression of representative apoptosis-related proteins was evaluated by Western blot analysis. Reactive oxygen species (ROS) level was measured using standard protocols. Potential interaction of 5F with cisplatin was also examined. Results: 5F inhibited the proliferation of A549 cells in a concentration-and time-dependent manner. 5F increased the accumulation of cells in sub-G1 phase and arrested the cells in the G2 phase. Exposure to 5F induced morphological changes and DNA fragmentation that are characteristic of apoptosis. The expression of p21 was increased. 5F exposure also increased Bax expression, release of cytochrome c and apoptosis inducing factor (AIF), and activation of caspase-3. 5F significantly sensitized the cells to cisplatin toxicity. Interestingly, treatment with 5F did not increase ROS, but reduced ROS production induced by cisplatin. Conclusion: 5F could inhibit the proliferation of A549 cells by arresting the cells in G2 phase and by inducing mitochondrial-mediated apoptosis. | Li Li George G Chen Ying-nian Lu Yi Liu Ke-feng Wu Xian-ling Gong Zhan-ping Gou Ming-yue Li Nian-ci Liang | 2012 | Chinese Journal of Cancer Research2012，24，2： | 10 |
| 2 | JWA regulates melanoma metastasis by integrin alpha(V)beta(3) signaling(摘要)显示文摘 | Bai, J Zhang, J Wu, J Shen, L Zeng, J Ding, J Wu, Y Gong, Z Li, A Xu, S Zhou, J Li, G | 2010 | 南京医科大学学报(自然科学版)2010，30，8： | 4 |
| 3 | Position and Velocity Estimation Via Bearings-only Observations 显示文摘 | Lindgren A G Gong K F | 1978 | IEEE Transactions on Aerospace and Electronic Systems1978，14，4： | 3 |
| 4 | Electrophosphorescence from a conjugated copolymer doped with an iridium complex: high brightness andimproved operational stability显示文摘 | Gong X Ostrowski J C Bazan G C | 2003 | Advanced Materials2003，15，1： | 1 |
| 5 | Calmodulin-binding proteins from zea mays germs 显示文摘 | Gong M Li Z G | 1995 | Phytochemistry1995，40，5： | 1 |
| 6 | Growth enhancement in transgenic Adantic salmon by the use of an all fish chimeric growth hormone gene construct 显示文摘 | Du S J Gong Z Fletcher G L | 1992 | Biol Technol1992，10，： | 1 |
| 7 | Spatial and temporal variation of chlorophyll distribution and primary productivity related to chemical hydrography in the southern East China Sea显示文摘 | GONG G C LIU K K SHIAH F K | 2000 | Continental Shelf Research2000，20，： | 1 |
| 8 | Annealing effects on electrical and optical properties of ZnO thin film samples deposited by radio frequency magnetron sputtering on GaAs(001) substrates显示文摘 | LIU H F CHUA S J HU G X GONG H XIANG N | 2007 | Journal of Applied Physics2007，102，6： | 1 |
| 9 | 显示文摘 | Gong H Wilk G D | 2002 | Appl Phys Lett2002，81，： | 1 |
| 10 | Deposition ofCr-modified silicide coatings on Nb-Si system intermetallics显示文摘 | ZHOU C G GONGS K | 2007 | Intermetallics2007，15，： | 1 |
| 11 | Development of 61-channel digital beam forming (DBF) transmitter array for mobile satellite communication显示文摘 | Liang G Gong W Yu J | | Progress in Electro-magnetics Research0，97，9： | 1 |
| 12 | Constructions of quadratic Bent functions in polynomial forms 显示文摘 | Yu N Y Gong G | 2006 | IEEE Trans lnf Theory2006，52，7： | 1 |
| 13 | Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for largescale production of functional human laetoferrin 显示文摘 | Yang P H Wang J W Gong G C | 2008 | PLoS One2008，3，10： | 1 |
| 14 | New designs for signal sets with low cross correlation, balance property, and large linear span: GF(p) case显示文摘 | Gong G | 2002 | IEEE Transactions on Information Theory2002，48，11： | 1 |
| 15 | Three- dimensional modeling and application in geological exploration engineering显示文摘 | GONG J Y CHENG P G WANG Y D | 2004 | Computers & Geosciences2004，30，4： | 1 |
| 16 | Effects of PPAR gagonist pioglitazone on rat hepatic fibrosis显示文摘 | YUAN G J ZHANG M L GONG Z J | 2004 | World J Gastroenterol2004，10，： | 1 |
| 17 | The association of bone mineral density with vitamin D receptor gene polymorphisms显示文摘 | Gong G Stem HS Cheng SC | 1999 | Osteoporos Int1999，9，： | 1 |
| 18 | Three-dimensional modeling and application in geological exploration engineering显示文摘 | Gong J Y Cheng P G Wang Y D | 2004 | Computers and Geosciences2004，30，4： | 1 |
| 19 | Luminescent properties of Sr2 MgSi2 07 : Eu2 - as blue phosphor for NUV light-emitting diodes显示文摘 | Zhang X G Tang X P Zhang J L Wang H H Shi J X Gong M L | 2010 | Powder Technology2010，204，： | 1 |
| 20 | Molecular breeding of agricul-ture ,a technique for introducing exogenous DNA into plants after selfpollination显示文摘 | Zhou G Y Weng J Gong Z Z | 1988 | Scientia Agricultura Sinica1988，，3： | 1 |
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