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| 1 | Treatment of rectal cancer by transanal endoscopic microsurgery: Experience with 425 patients显示文摘AIM:To describe our experience in treating rectal cancer by transanal endoscopic microsurgery(TEM),report morbidity and mortality and oncological outcome.METHODS:A total of 425 patients with rectal cancer(120 T1,185 T2,120 T3 lesions)were staged by digital rectal examination,rectoscopy,transanal endosonography,magnetic resonance imaging and/or computed tomography.Patients with T1-N0 lesions and favourable histological features underwent TEM immediately.Patients with preoperative stage T2-T3-N0 underwent preoperative high-dose radiotherapy;from 1997 those aged less than 70 years and in good general health also underwent preoperative chemotherapy.Patients with T2-T3-N0 lesions were restaged 30 d after radiotherapy and were then operated on 40-50 d after neoadjuvant therapy.The instrumentation designed by Buess was used for all procedures.RESULTS:There were neither perioperative mortality nor intraoperative complications.Conversion to other surgical procedures was never required.Major complications(urethral lesions,perianal or retroperitoneal phlegmon and rectovaginal fistula)occurred in six(1.4%)patients and minor complications(partial suture line dehiscence,stool incontinence and rectal haemorrhage)in 42(9.9%).Postoperative pain was minimal.Definitive histological examination of the 425 malignant lesions showed 80(18.8%)pT0,153(36%)pT1,151(35.5%)pT2,and 41(9.6%)pT3 lesions.Eighteen(4.2%)patients(ten pT2 and eight pT3)had a local recurrence and 16(3.8%)had distant metastasis.Cancer-specific survival rates at the end of follow-up were100%for pT1 patients(253 mo),93%for pT2 patients(255 mo)and 89%for pT3 patients(239 mo).CONCLUSION:TEM is a safe and effective procedure to treat rectal cancer in selected patients without evidence of nodal involvement.T2-T3 lesions require preoperative neoadjuvant therapy. | Mario Guerrieri Rosaria Gesuita Roberto Ghiselli Giovanni Lezoche Andrea Budassi Maddalena Baldarelli | 2014 | World Journal of Gastroenterology2014，20，28： | 6 |
| 2 | Totally robotic vs 3D laparoscopic colectomy: A single centers preliminary experience显示文摘AIM: to compare robotic and three-dimensional(3D) laparoscopic colectomy based on the literature and our preliminary experience.METHODS: This retrospective observational study compared operative measures and postoperative outcomes between laparoscopic 3D and robotic colectomy for cancer. From September 2013 to September 2014,24 robotic colectomies and 23 3D laparoscopic colectomy were performed at our Department. Data were analyzed and reported both by approach and by colectomy side. Robotic left colectomy(RL) vs laparoscopic 3D left colectomy(LL 3D) and Robotic right colectomy(RR) vs laparoscopic 3D(LR 3D). Rectal cancer procedures were not included.RESULTS: There were 18 RR and 11 LR 3D,6 RL and 12 LL 3D. As regards LR 3D,extracorporeal anastomosis(EA) was performed in 7 patients and intracorporeal anastomosis(IA) in 4; the RR group included 14 IA and 4 EA. There was no mortality. Median operative time was higher for the robotic group while conversion rate(12.5% vs 13%) and lymph nodes removed(14 vs 13) were similar for both. First flatus time was 1 d for RR and 2 d the other patient groups. Oral intake was resumed in 1 d by LR and in 2 d by the other patients(P = 0.012). Overall cost was €4950 and €1950 for RL and LL 3D,and €4450 and €1450 for RR and LR 3D,respectively. CONCLUSION: There were no differences betweenRR and LR 3D,except that IA was easier with RR,and probably contributed with the learning curve to the longer operative time recorded. Both techniques offer similar advantages for the patient with significantly different costs. In left colectomies robotic colectomy provided better outcomes,especially in resections approaching the rectum. | Mario Guerrieri Roberto Campagnacci Pierluigi Sperti Giulio Belfiori Rosaria Gesuita Roberto Ghiselli | 2015 | World Journal of Gastroenterology2015，21，46： | 5 |
| 3 | Transanal endoscopic microsurgery as optimal option in treatment of rare rectal lesions:a single centre experience显示文摘AIM To analyze the outcomes of transanal endoscopic microsurgery(TEM) in the treatment of rare rectal condition like mesenchymal tumors, condylomas, endometriosis and melanoma. METHODS We retrospectively reviewed a twenty-three years database. Fifty-two patients were enrolled in this study. The lesions were considered suitable for TEM if they were within 20 cm from the anus. All of them underwent an accurate preoperative workup consisting in clinical examination, total colonoscopy with biopsies, endoscopic ultrasonography, and pelvic computerized tomography or pelvic magnetic resonance imaging. Operative time, intraoperative complications, rate of conversion, tumor size, postoperative morbidity, mortality, the length of hospital stay, local and distant recurrence were analyzed.RESULTS Among the 1328 patients treated by TEM in our department, the 52 patients with rectal abnormalities other than adenoma or adenocarcinoma represented 4.4%. There were 30 males(57.7%) and 22 females(42.3%). Mean age was 55 years(median = 60, range = 24-78). This series included 14(26.9%) gastrointestinal stromal tumors, 21 neuroendocrine tumors(40.4%), 1 ganglioneuroma(1.9%), 2 solitary ulcers in the rectum(3.8%), 6 cases of rectal endometriosis(11.5%), 6 cases of rectal condylomatosis(11.5%) and 2 rectal melanomas(3.8%). Mean lesion diameter was 2.7 cm(median: 4, range: 0.4-8). Mean distance from the anal verge was 9.5 cm(median: 10, range: 4-15). One patient operated for rectal melanoma developed distant metastases and died two years after the operation. We experienced 2 local recurrences(3.8%) with an overall survival equal to 97.6%(95%CI: 95%-99%) at the end of follow-up and a disease free survival of 98%(95%CI: 96%-99%).CONCLUSION We could conclude that TEM is an important therapeutical option for rectal rare conditions. | Monica Ortenzi Roberto Ghiselli Maria Michela Cappelletti Trombettoni Luca Cardinali Mario Guerrieri | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 5 |
| 4 | Mitochondrial selfish elements and the evolution of biological novelties显示文摘 | Liliana MILANI Fabrizio GHISELLI Marco PASSAMONTI | 2016 | Current Zoology2016，62，6： | 2 |
| 5 | An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy显示文摘 | D. Scott Kreiner Steven W. Hwang John E. Easa Daniel K. Resnick Jamie L. Baisden Shay Bess Charles H. Cho Michael J. DePalma Paul Dougherty Robert Fernand Gary Ghiselli Amgad S. Hanna Tim Lamer Anthony J. Lisi Daniel J. Mazanec Richard J. Meagher Robert C | 2014 | The Spine Journal2014，，： | 2 |
| 6 | Total antioxidant capacity as a tool to assess redox status: Critical view and experimental data 显示文摘 | Ghiselli A Serafini M Natella F | 2000 | Free Radical Biology and Medicine2000，29，11： | 1 |
| 7 | Transgenic mouse model for estrogen-regulated lipoprotein metabolism: studies on apoVLDL-II expression in transgenic mice 显示文摘 | Zsigmond E Nakanishi M K Ghiselli F E | 1995 | J Lipid Res1995，36，7： | 1 |
| 8 | Transgenic mouse model for estrogen-regulated lipo- protein metabolism: Studies on ApoVLDL-II expression in transgenic mice 显示文摘 | ZSIGMOND E NAKANISHI M K GHISELLI F E | 1995 | Journal of Lipid Research1995，36，7： | 1 |
| 9 | Job satisfaction, life satisfaction, and turnover intent among food-service managers 显示文摘 | Richard F Ghiselli Joseph M La Lopa and Billy Bai | 2001 | Cornell Hotel and Restaurant Ad- ministration Quarterly2001，42，2： | 1 |
| 10 | Determination of free and bound phenolic acids in beer显示文摘 | M Nardini A Ghiselli | 2002 | Food Chemistry2002，，84： | 1 |
| 11 | The lipopeptides Pal-Lys- Lys-NH(2) and Pal-Lys-Lys soaking alone and in combination with intraperitoneal vancomycin prevent vascular graft biofilm in a subcutaneous rat pouch model of staphylococcal infection 显示文摘 | Cirioni O Giacometti A Ghiselli R | 2007 | Peptides2007，28，6： | 1 |
| 12 | Adjacent segmentdegeneration in the lumbar spine显示文摘 | Ghiselli G Wang JC Bhatia NN | | 0，，： | 1 |
| 13 | The validity of management traits in relation to occupa- tionallevel显示文摘 | Ghiselli EE | 1963 | Pers Psycho11963，16，2： | 1 |
| 14 | L5S1 segment survivorship and clinical outcome analysis after L4,5 isolated fusion显示文摘 | Ghiselli G Wang JC Hsu WK et od | 2003 | Spine2003，28，： | 1 |
| 15 | Antioxidant activity of different phenolic fractions separated from an Italian red wine显示文摘 | GHISELLI A NARDINI M BALDI A | 1998 | Journal of Agricultural and Food Chemistry1998，46，2： | 1 |
| 16 | RNAIII-inhibiting peptide significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of central venous catheter-associated Staphylococcus aureus infections显示文摘 | Cirioni O Giacometti A Ghiselli R | | 0，，2： | 1 |
| 17 | Adjacent segment degeneration in the lumbar spine显示文摘 | Ghiselli G Wang J C Bhatia N N | 2004 | J Bone Joint Surg Am2004，86，7： | 1 |
| 18 | Global gene expression profiling of cells overexpressing SMC3显示文摘 | Ghiselli G Liu CG | 2005 | Mol Cancer2005，4，： | 1 |
| 19 | Determination of free and bound phenolic acids in beer显示文摘 | NARDINI M GHISELLI A | 2004 | Food Chem2004，84，： | 1 |
| 20 | A characterization of a general class of ranking functions on triangular fuzzy numbers显示文摘 | Faechinetti Gisella Ghiselli Ricci Roberto | 2004 | Fuzzy Sets and Systems2004，146，2： | 1 |
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