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| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Oral insulin delivery 显示文摘 | Gerardo P C Edith M | 1999 | Adv Drug Del Rev1999，35，： | 1 |
| 3 | Determination of fat, protein, and total solids in ovine milk by near-infrared spectroscopy显示文摘 | ELENA A PALOMA C GERARDO C | 1999 | Journal of AOAC International1999，82，3： | 1 |
| 4 | Dietary antioxidants:im- munity and host defense 显示文摘 | Maria A P Elena P Gerardo A de C | 2011 | Current Topics in Medicinal Chemistry2011，11，14： | 1 |
| 5 | Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: the NHLBI family heart study显示文摘 | Steven C Hunt Florian Kronenberg John H Eckfeldt Paul N Hopkins Richard H Myers Gerardo Heiss | 2001 | Atherosclerosis2001，，3： | 1 |
| 6 | Analysis anddesign of direct power control (DPC) for a three phase synchronous rectifier via output regulation subspaces显示文摘 | Gerardo E Aleksandar M S Juan M C | 2003 | IEEE Transactions on Power Electronics2003，18，3： | 1 |
| 7 | Mulch effects on rainfall interception, soil physical characteris ties and temperature under Zea rnays L显示文摘 | Hadrian F C Gerardo S B V Howard C L | 2006 | Soil and Tillage Research2006，91，12： | 1 |
| 8 | Sodium Isopropyl Xanthate Degradation by Advanced Oxidation Processes显示文摘 | Gerardo Cifuentes Molina Cármen Herrera Cayo Marco Ant?nio Siqueira Rodrigues Andréa Moura Bernardes | 2012 | Minerals Engineering2012，，： | 1 |
| 9 | Early transmission dynamics of COVID-19 in a southern hemisphere setting:Lima-Peru:February 29^(th)-March 30^(th),2020显示文摘The COVID-19 pandemic that emerged in Wuhan China has generated substantial morbidity and mortality impact around the world during the last four months.The daily trend in reported cases has been rapidly rising in Latin America since March 2020 with the great majority of the cases reported in Brazil followed by Peru as of April 15th,2020.Although Peru implemented a range of social distancing measures soon after the confirmation of its first case on March 6th,2020,the daily number of new COVID-19 cases continues to accumulate in this country.We assessed the early COVID-19 transmission dynamics and the effect of social distancing interventions in Lima,Peru.We estimated the reproduction number,R,during the early transmission phase in Lima from the daily series of imported and autochthonous cases by the date of symptoms onset as of March 30th,2020.We also assessed the effect of social distancing interventions in Lima by generating short-term forecasts grounded on the early transmission dynamics before interventions were put in place.Prior to the implementation of the social distancing measures in Lima,the local incidence curve by the date of symptoms onset displays near exponential growth dynamics with the mean scaling of growth parameter,p,estimated at 0.96(95%CI:0.87,1.0)and the reproduction number at 2.3(95%CI:2.0,2.5).Our analysis indicates that school closures and other social distancing interventions have helped slow down the spread of the novel coronavirus,with the nearly exponential growth trend shifting to an approximately linear growth trend soon after the broad scale social distancing interventions were put in place by the government.While the interventions appear to have slowed the transmission rate in Lima,the number of new COVID-19 cases continue to accumulate,highlighting the need to strengthen social distancing and active case finding efforts to mitigate disease transmission in the region. | César V.Munayco Amna Tariq Richard Rothenberg Gabriela G.Soto-Cabezas Mary F.Reyes Andree Valle Leonardo Rojas-Mezarina César Cabezas Manuel Loayza Gerardo Chowell 无 | 2020 | Infectious Disease Modelling2020，5，1： | 1 |
| 10 | Nanosphere based oral insulin delivery显示文摘 | Gerardo P C Jules S J Edith M | 2000 | J Controlled Release2000，65，12： | 1 |
| 11 | Geomorphology of a sand wave in lower Chesapeake Bay, Virginia, U S A显示文摘 | Gerardo M E Perillo John C Ludwick | 1984 | Geo-Marine Letters1984，4，2： | 1 |
| 12 | Low-resistivity Zn O∶F∶Al Transparent Thin Films显示文摘 | Delia C A Gerardo T D Sergio J S | 2004 | Solar Energy Material&Solar Cells2004，82，1： | 1 |
| 13 | Testing services and service-centric systems:challenges and opportunities显示文摘 | Gerardo C Massimiliano D | 2006 | IT Professional2006，8，2： | 1 |
| 14 | Influence of tungsten on the carbon nanotubes growth by CVD process显示文摘 | MARIANO E GERARDO H R MORENO M S SILVIA G ROBERTO C | 2009 | Journal of Alloys and Compounds2009，479，12： | 1 |
| 15 | Production and characteristics of the lipase from Yarrowia lipolytica 681显示文摘 | Gerardo C Sergio R | 1999 | Bioresource Technology1999，70，： | 1 |
| 16 | Clinical policy: procedural sedation and analgesia in the emergency department显示文摘 | Godwin SA Burton JH Gerardo C J | 2014 | Ann Emerg Med2014，63，2： | 1 |
| 17 | The opening of maitotoxin-sensitive calcium channels induces the acrosome reaction in human spermatozoa: differences from the zona pellucida显示文摘acrosome 反应(AR ) ,为精子的一个绝对要求和卵熔化,通过电压依赖者 Ca2+ 隧道和操作店的隧道要求 Ca2+ 的流入进精子。Maitotoxin (MTx ) ,一个动员 Ca2+ 代理人,被显示了是老鼠精子 AR 的有势力 inducer 与类似于带 pellucida (ZP ) 的药理学,可能为两 inducers 建议一条普通小径。使用的 recombinant 人 ZP3 (rhZP3 ) ,老鼠 ZP 和二 MTx 隧道 blockers (U73122 和 U73343 ) ,我们在人和老鼠精子调查了并且比较导致 MTx 、导致 ZP 的艺术。此处,我们报导 MTx 导致了 AR 并且提高了细胞内部的 Ca2+([Ca2+] 我) 在人的精子,哪个被 U73122 和 U73343 堵住。这二混合物也在老鼠精子禁止了导致 MTx 的 AR。在有我们的以前的建议的争论, AR 由 rhZP3 被触发或老鼠 ZP 没被 U73343 堵住,显示在人和老鼠精子,由生理的 ligands 或由 MTx 的 AR 正式就职通过不同小径发生了。U73122,然而并非 U73343 (不活跃的类似物) ,能堵住 phospholipase C (PLC ) 。另一个 PLC 禁止者, edelfosine,也堵住了导致 rhZP3 、导致 ZP 的艺术。这些调查结果在人和老鼠带证实了一条 PLC 依赖的发信号小径的参予导致蛋白质的 AR。尤其是, edelfosine 也禁止了导致 MTx 的老鼠精子 AR 然而并非人的,建议导致毒素的 AR 在老鼠是 PLC 依赖的并且在人 PLC 独立。 | lulio C Chaivez Gerardo A de Blas Josd L de la Vega-Beltran Takuya Nishigaki Mayel Chirinos Maria Elena Gonzaez-Gonzalez Fernando Larrea Alejandra Soiis Alberto Darszon Claudia L Trevino | 2011 | Asian Journal of Andrology2011，13，1： | 1 |
| 18 | Mulch effects on rainfall interception, soil physical characteristics and temperature under Zea mays L 显示文摘 | Hadrian F C Gerardo S B V Howard C L | 2006 | Soil and Tillage Research2006，91，12： | 1 |
| 19 | Stereoselective hydrogenation of terpenes using platinum-based catalysts显示文摘 | Monica L C Gerardo F S ALBERTINA M | 2007 | Applied Catalysis A:General2007，318，20： | 1 |
| 20 | A new simpli- fied multilevel inverter topology for DC-AC conversion 显示文摘 | GERARDO C VICTOR G CARLOS S | 2006 | IEEE Transactions on power electronics2006，21，5： | 1 |
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