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| 1 | Influence of vitamin D on liver fibrosis in chronic hepatitis C: A systematic review and meta-analysis of the pooled clinical trials data显示文摘AIM To investigate the relationship between vitamin D and liver fibrosis in hepatitis C-monoinfected or hepatitis C virus(HCV)-human immunodeficiency virus(HIV) coinfected patients. METHODS Pertinent studies were located by a library literature search in PubM ed/Embase/Cochrane/Scopus/LILACS by two individual reviewers. Inclusion criteria:(1) studies with patients with HCV or co-infected HCV/HIV;(2) studies with patients ≥ 18 years old;(3) studies that evaluated liver fibrosis stage, only based on liver biopsy; and(4) studies that reported serum or plasma 25(OH)D levels. Studies that included pediatric patients, other etiologies of liver disease, or did not use liver biopsy for fibrosis evaluation, or studies with inadequate data were excluded. Estimated measures of association reported in the literature, as well as corresponding measures of uncertainty, were recorded and corresponding odds ratios with 95%CI were included in a meta-analysis. RESULTS The pooled data of this systematic review showed that 9 of the 12 studies correlated advanced liver disease defined as a Metavir value of F3/4 with 25(OH) D level insufficiency. The meta-analysis indicated a significant association across studies.CONCLUSION Low vitamin D status is common in chronic Hepatitis C patients and is associated with advanced liver fibrosis. | Alia S Dadabhai Behnam Saberi Katie Lobner Russell T Shinohara Gerard E Mullin | 2017 | World Journal of Hepatology2017，9，5： | 6 |
| 2 | Vitamin D levels do not predict the stage of hepatic fibrosis in patients with non-alcoholic fatty liver disease: A PRISMA compliant systematic review and meta-analysis of pooled data显示文摘AIM To investigate the relationship between 25-hydroxyvitamin D [25(OH)D] levels and fibrosis stage in patients with non-alcoholic fatty liver disease(NAFLD).METHODS Two individual reviewers identified relevant studies using the Pub Med, EMBASE, Cochrane, and Scopus databases. Inclusion criteria were as follows:(1) Studies that evaluated adults with NAFLD and serum or plasma 25(OH)D levels; and(2) assessed fibrosis stage using liver biopsy. A rigorous analysis yielded six articles as having sufficient data to employ in evaluating the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. To meta-analyze vitamin D levels in F0-F2 vs F3-F4 fibrosis, a random-effects meta-analysis fit using restricted maximum likelihood was applied. To examine trends across each stage of fibrosis with respect to vitamin D levels, a meta-regression was performed. P < 0.05 was considered statistically significant. RESULTS A total of 937 subjects from six studies were included in the final analysis to evaluate the association of serum vitamin D levels in patients with NAFLD based on their liver fibrosis stage by histopathological analysis. The lead investigators of each of the six studies were contacted and the data were collected. First, the investigators performed a meta-analysis to compare serum vitamin D levels in patients with NAFLD with stage F0-F2 compared to F3-F4, which did not show significance [meta-estimate of the pooled mean difference =-0.86, P = 0.08(-4.17, 2.46)]. A metaregression evaluation of serum vitamin 25(OH)D levels across the individual stages(F0-F4) of fibrosis did not show an association for the six included studies.CONCLUSION Low vitamin D status is not associated with higher stages of liver fibrosis in patients with NAFLD. | Behnam Saberi Alia S Dadabhai Julie Nanavati Lin Wang Russell T Shinohara Gerard E Mullin | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 3 | Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203 显示文摘 | Gerard JP Conroy T Bonnetain F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 4 | The deep EGS project at Soultz-Sous-Forest ( Alsace, France ) 显示文摘 | Gerard A Genter A Kohl T | 2006 | Geother- mics2006，35，： | 1 |
| 5 | Threonine and crude protein responses in broiler chicks显示文摘 | Kidd M T Gerard P D Heger J | 2001 | Animal Feed Science and Technology2001，94，： | 1 |
| 6 | 查看详情显示文摘 | Peprnicek T Kalendova A Pavlova E Simonik J. Duchet J.and Gerard J.F | | 0，，： | 1 |
| 7 | The influence of cigarette smoking on human spem quality and DNA fragmentation显示文摘 | SEPANIAK S FORGES T GERARD H | 2006 | Toxicology2006，223，12： | 1 |
| 8 | A generic fra- mework for spatial prediction of soil variables based on regres- sion-kriging 显示文摘 | HENGL T GERARD B M HEUVELINK | 2004 | Geoderma2004，120，： | 1 |
| 9 | Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203显示文摘 | Gerard JP Conroy T Bonnetain F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 10 | Osmotic adjustment, gas exchanges and chlorophyll fluorescence of a hexa-ploid triticale and its parental species under salt stress显示文摘 | Annick M Elisabeth P Gerard T | 2004 | Joumal of Plant Physiology2004，161，1： | 1 |
| 11 | Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203显示文摘 | Gerard JP Conroy T Bonnetain F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 12 | On the quantum structure of a black hole显示文摘 | | 1985 | Nuclear Physics1985，256，： | 1 |
| 13 | Electrochemical and electrical properties of copper organic complexing films deposited on a platinum electrode显示文摘 | Minh C P Gerard T Pierre C L | 1980 | Electroanal Chem1980，111，： | 1 |
| 14 | Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203显示文摘 | Gerard JP Conroy T Bonnetain F | 2006 | J Clin Oncol2006，24，28： | 1 |
| 15 | Developmental pathway for biofilm formation in curli-producing Escherichia coli strains: role of flagella, curli and colanic acid显示文摘 | CLAIRE P C GERARD P THANH T L | 2000 | Environ Mierobiol2000，2，4： | 1 |
| 16 | The effects of key switch stiffness on typing force, finger electromyography, and subjective discomfort显示文摘 | Gerard M J Armstrong T J Franzblau A | 1999 | American Industrial Hygiene Association Journal1999，60，6： | 1 |
| 17 | Efficacy and compliance with noninvasive positive pressure ventilation in patients with chronic respiratory failure显示文摘 | GERARD J C KATHLEEN B JOHN M T | 1999 | Chest1999，116，3： | 1 |
| 18 | Effects of tillage on runoff and erosion patterns显示文摘 | Ingrid T Gerard G Victor J | 2001 | Soil & Tillage research2001，61，1： | 1 |
| 19 | The Use of Endogenous Antioxidants to Improve Photoprotection显示文摘 | DAVID P T GERARD M J | 1997 | Photochem Photobiol1997，，： | 1 |
| 20 | Natural area visitors' place meaning and place attachment ascribed to a marine setting 显示文摘 | Christopher J W Gerard T K Stephen G S | 2012 | Journal of Environmental Psychology2012，32，4： | 1 |
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