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| 1 | Human NK cells: surface receptors, inhibitory checkpoints, and translational applications显示文摘NK cells play important roles in innate defenses against viruses and in the control of tumor growth and metastasis.The regulation/induction of NK cell function is mediated by an array of activating or inhibitory surface receptors.In humans,major activating receptors involved in target cell killing are the natural cytotoxicity receptors(NCRs)and NKG2D.Activating receptors recognize ligands that are overexpressed or expressed de novo upon cell stress,viral infection,or tumor transformation.The HLA-class I-specific inhibitory receptors,including KIRs recognizing HLA-class I allotypic determinants and CD94/NKG2A recognizing the class-Ib HLA-E,constitute a fail-safe mechanism to avoid unwanted NK-mediated damage to healthy cells.Other receptors such as PD-1,primarily expressed by activated T lymphocytes,are important inhibitory checkpoints of immune responses that ensure T-cell tolerance.PD-1 also may be expressed by NK cells in cancer patients.Since PD-1 ligand(PD-L1)may be expressed by different tumors,PD-1/PD-L1 interactions inactivate both T and NK cells.Thus,the reliable evaluation of PD-L1 expression in tumors has become a major issue to select patients who may benefit from therapy with mAbs disrupting PD-1/PD-L1 interactions.Recently,NKG2A was revealed to be an important checkpoint controlling both NK and T-cell activation.Since most tumors express HLA-E,mAbs targeting NKG2A has been used alone or in combination with other therapeutic mAbs targeting PD-1 or tumor antigens(e.g.,EGFR),with encouraging results.The translational value of NK cells and their receptors is evidenced by the extraordinary therapeutic success of haploidentical HSCT to cure otherwise fatal high-risk leukemias. | Simona Sivori Paola Vacca Genny Del Zotto Enrico Munari Maria Cristina Mingari Lorenzo Moretta | 2019 | Cellular & Molecular Immunology2019，16，5： | 33 |
| 2 | Evaluation of physical properties of fine crumb rubbermodified binders 显示文摘 | Mc Gennis RB | 1995 | Transport Res Rec1995，1488，： | 1 |
| 3 | The cardiac toxicity of ana- bolic steroids 显示文摘 | Sullivan ML Martinez CM Gennis P | 1998 | Prog Cardiovasc Dis1998，41，1： | 1 |
| 4 | High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer 显示文摘 | Michael Krypuy Genni M Newnham David M Thomas | 2006 | BMC Cancer2006，6，： | 1 |
| 5 | Jacobi ring catheter treatment of Bartholin's abscesses 显示文摘 | Gennis P Li SF Provataris J | 2005 | Am J Emerg Med2005，23，3： | 1 |
| 6 | High resolution mehing analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non - small cell lung cancer显示文摘 | Michael Krypuy Genni M Newnham David M Thomas | 2006 | BMC Cancer2006，6，： | 1 |
| 7 | Electrocution-induced Brugada phenocopy显示文摘 | Jing Gennie Wang William F. McIntyre Waitak Kong Adrian Baranchuk | 2012 | International Journal of Cardiology2012，，3： | 1 |
| 8 | The cardiac toxicity of anabolic steroids显示文摘 | Sullivan ML Martinex CM Gennis P | 1998 | Prog Cardiovasc Dis1998，41，1： | 1 |
| 9 | The mechanism of action of rituximab in the elimination of tumor cells 显示文摘 | Johnson P Gennie M | 2003 | Semin ononl2003，30，2： | 1 |
| 10 | Site-directed mutagenesis studies on subunit I of the aa3-type cytochrome coxidase of Rhodobacter sphae- roides : a brief review of progress to data 显示文摘 | GENNIS R B | 1992 | Biochim biophys Acta1992，，1101： | 1 |
| 11 | Characteristics of diabetic ketoacidosis in older versus younger adults 显示文摘 | MALONE M L GENNIS V GOODWIN J S | 1992 | J Am Geriatr Soc1992，40，11： | 1 |
| 12 | Effectiveness of bystander cardiopulmonary resuscitation and survival following out-of-hospi- tal cardiac arrest显示文摘 | Gallagher E J Lombardi G Gennis P | 1995 | JAMA1995，，274： | 1 |
| 13 | Shock tube measurements of the rate constant for the reaction ethanol + OH显示文摘 | STRANIC Ivo PANG Genny A HANSON Ronald K | 2014 | Phys Chem A2014，118，5： | 1 |
| 14 | X- and W-band EPR and Q-band ENDOR Studies of the Flavin Radical in the Na+- translocating NADH: Quinone Oxidoreductase from Vibrio cholerae 显示文摘 | Scholes C P Gennis R B Nilges M J | 2003 | J Am Chem Soc2003，125，： | 1 |
| 15 | Effectiveness of bystander cardiopulmonary resuscitation and survival following out-of-hospital cardiac arrest显示文摘 | Gallagher E J Lombardi G Gennis P | 1995 | JAMA1995，274，24： | 1 |
| 16 | Slug/β-Catenin–Dependent Proinflammatory Phenotype in Hypoxic Breast Cancer Stem Cells显示文摘 | Gianluca Storci Sara Bertoni Sabrina De Carolis Alessio Papi Marina Nati Claudio Ceccarelli Chiara Pirazzini Paolo Garagnani Alberto Ferrarini Genny Buson Massimo Delledonne Michelangelo Fiorentino Elisa Capizzi Elisa Gruppioni Mario Taffurelli Donatella | 2013 | The American Journal of Pathology2013，，5： | 1 |
| 17 | Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model显示文摘 | Paolo Sbano Aldo Cuccia Benedetta Mazzanti Serena Urbani Betti Giusti Ilaria Lapini Luciana Rossi Rosanna Abbate Giuseppina Marseglia Genni Nannetti Francesca Torricelli Clelia Miracco Alberto Bosi Michele Fimiani Riccardo Saccardi | 2008 | Archives of Dermatological Research2008，，3： | 1 |
| 18 | value of routine admission chest radiographs in adult asthmatics显示文摘 | Gennis P Kelly D | 1989 | Ann Emerg Med1989，18，11： | 1 |
| 19 | Structure of cytochrome c oxidase,energy generator of aerobic life显示文摘 | GENNIS R FERGUSON MILLER S | 1995 | Science1995，269，5227： | 1 |
| 20 | The cardiac toxicity of anabolic steroids显示文摘 | Sullivan ML Martinez CM Gennis P Gallagher EJ | 1998 | Prog Cardiovasc Dis1998，41，1： | 1 |
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