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| 1 | Assessment of oxidative stress in chronic pancreatitis patients显示文摘AIM: To assess the levels of antioxidant capacity and oxidative damage in blood of chronic pancreatitis (CP) patients in comparison with those in healthy control sub- jects, by using several different analytical techniques. METHODS: Thirty-five CP patients and 35 healthy con- trol subjects were investigated prospectively with re- spect to plasma levels of thiols, ferric reducing ability of plasma (FRAP, i.e. antioxidant capacity), levels of protein carbonyls and thiobarbituric acid reactive substances (TBARS). Additionally, we evaluated the production of reactive oxygen species (ROS) in whole blood. RESULTS: The antioxidative thiols including cysteine, cysteinylglycine and glutathione were significantly lower in CP patients. In addition, the non-enzymatic antioxi- dant capacity was significantly lower in CP patients, which correlated with the amount of oxidative protein (protein carbonyls) and the extent of lipid damage (TBARS), both were significantly higher in CP patients. The ROS production in whole blood after stimulation with phorbol 12-myritate 13-acetaat, demonstrated a strong tendency to produce more ROS in CP patients. CONCLUSION: Oxidative stress may contribute to the pathogenesis of chronic pancreatitis by decreasing anti- oxidant capacity and increasing oxidative damage in CP patients may be a rationale for intervention with antioxi- dant therapy. | Mariette Verlaan Hennie MJ Roelofs Annie van Schaik Geert JA Wanten Jan BMJ Jansen Wilbert HM Peters Joost PH Drenth | 2006 | World Journal of Gastroenterology2006，12，35： | 3 |
| 2 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D’Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 3 | Risk of dementia in diabetes mellitus: a systematic review显示文摘 | Geert Jan Biessels Salka Staekenborg Eric Brunner Carol Brayne Philip Scheltens | 2006 | Lancet Neurology2006，，1： | 2 |
| 4 | Diabetes, hyperglycaemia, and acute ischaemic stroke显示文摘 | Merel JA Luitse Geert Jan Biessels Guy EHM Rutten L Jaap Kappelle | 2012 | Lancet Neurology2012，，3： | 2 |
| 5 | <ce:link locator='fx1'/> A Review of Activity Indices and Efficacy End Points for Clinical Trials of Medical Therapy in Adults With Ulcerative Colitis显示文摘 | Geert D'Haens William J. Sandborn Brian G. Feagan Karel Geboes Stephen B. Hanauer E. Jan Irvine Marc Lémann Philippe Marteau Paul Rutgeerts Jurgen Sch?lmerich Lloyd R. Sutherland | 2007 | Gastroenterology2007，，2： | 2 |
| 6 | Aging and diabetes:implications for brain function显示文摘 | Geert Jan Biessels Lars P Amer Kamal | 2002 | Eur J o fPharmaco2002，441，： | 1 |
| 7 | Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization显示文摘 | Lieben Liesbet Masuyama Ritsuko Torrekens Sophie Van Looveren Riet Schrooten Jan Baatsen Pieter Lafage-Proust Marie-Hélène Dresselaers Tom Feng Jian Q Bonewald Lynda F Meyer Mark B Pike J Wesley Bouillon Roger Carmeliet Geert | 2012 | EN2012，，5： | 1 |
| 8 | The metagenome of the marine anammox bacterium ‘ Candidatus Scalindua profunda’ illustrates the versatility of this globally important nitrogen cycle bacterium显示文摘 | Jack van de Vossenberg Dagmar Woebken Wouter J. Maalcke Hans J. C. T. Wessels Bas E. Dutilh Boran Kartal Eva M. Janssen‐Megens Guus Roeselers Jia Yan Daan Speth Jolein Gloerich Wim Geerts Erwin van der Biezen Wendy Pluk Kees‐Jan Francoijs Lina Russ Phylli | 2012 | Environmental Microbiology2012，，5： | 1 |
| 9 | Discriminating between critical and nncritical disturbances in (Bio) chemical bach processes prediction Research, NAES T, using m 显示文摘 | GEERT G JEF V JAN F | 2012 | ulti-model fault detection and end-quality Industrial and Engineering Chemistry2012，51，1： | 1 |
| 10 | Feasibility study of floating windfarms in shallow offshore sites显示文摘 | Andrew R. Henderson Bernard Bulder Rene Huijsmans Johan Peeringa Jan Pierik Erik Snijders Martin van Hees Geert H. Wijnants Martijn J. Wolf | 2009 | Wind Engineering2009，，5： | 1 |
| 11 | Diabetes and other vascular risk factors for dementia: Which factor matters most? A systematic review显示文摘 | Raoul P. Kloppenborg Esther van den Berg L. Jaap Kappelle Geert Jan Biessels | 2008 | European Journal of Pharmacology2008，，1： | 1 |
| 12 | Optimal training for ML and LMMSE channel estimation in MIMO systems 显示文摘 | GEERT L ALLE JAN V | 2005 | IEEE/SP Statistical Signal Processing2005，，： | 1 |
| 13 | Ageing and diabetes:implications for brain functin显示文摘 | Geert Jan Biessels H Lars P | 2002 | Neurophysiol2002，15，3： | 1 |
| 14 | Cerebral complication of diabetes: Clinical findings and patho - genetic mechanisms显示文摘 | Geert Jan | 1999 | Neth J Med1999，54，： | 1 |
| 15 | A mixed effects least squares support vector machine model for classification of longitudinal data显示文摘 | Jan Luts Geert Molenberghs Geert Verbeke Sabine Van Huffel Johan A K Suykens | 2012 | Com- putational Statistics and Data Analysis2012，56，3： | 1 |
| 16 | Diabetes, hyperglycaemia, and acute ischaemic stroke 显示文摘 | Merel JA Luitse Geert Jan Biessels Guy EHM Rutten etal | 2012 | Lancet Neurol2012，11，3： | 1 |
| 17 | Eigenvalues of dynamic max-min systems显示文摘 | Geert Jan Olsder | 1991 | Discrete Event Dynamic Systems1991，，2： | 1 |
| 18 | Acute lower gastrointestinal bleeding in Crohn’s disease: characteristics of a unique series of 34 patients显示文摘 | Jacques Belaiche Edouard Louis Geert D’Haens Marc Cabooter Serge Naegels Martine De Vos Fernand Fontaine Piet Schurmans Filip Baert Marc De Reuck René Fiasse Jan Holvoet Alain Schmit Marc Van Outryve | 1999 | The American Journal of Gastroenterology1999，，8： | 1 |
| 19 | Diabetes, hyperglycaemia, and acute ischaemic stroke显示文摘 | Merel JA Luitse Geert Jan Biessels Guy EHM Rutten L Jaap Kappelle | 2012 | Lancet Neurology2012，，3： | 1 |
| 20 | Prognostic factors for medium‐ and long‐term survival of esophageal cancer patients in the Netherlands显示文摘 | Pauline Bus Valery E. Lemmens Martijn G. van Oijen Geert‐Jan Creemers Grard A. Nieuwenhuijzen Jantine W. van Baal Peter D. Siersema | 2014 | J Surg Oncol2014，，5： | 1 |
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