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| 1 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 2 | Cancer-testis Antigen OY-TES-1 Expression and Immunogenicity in Hepatocellular Carcinoma显示文摘Summary:Cancer testis(CT)antigens have received particular attention in cancer immunotherapy.OY-TES-1 is a member of CT antigens.This study was to evaluate OY-TES-1 expression and immunogenicity in hepatocelluar carcinoma(HCC).OY-TES-1 mRNA expression was detected in 56 HCC tissues and 5 normal liver tissues by reverse transcriptase PCR(RT-PCR).Of the 56 cases of HCC tissues tested,37 cases had tumor and matched adjacent non-cancer tissues and were subjected to both RT-PCR and quantitative real-time PCR.OY-TES-1 protein was subsequently observed on a panel of tissue microarrays.Sera from patients were tested for OY-TES-1 antibody by ELISA.To identify OY-TES-1 capable of inducing cellular immune response,OY-TES-1 protein was used to sensitize dentritic cells and the cytotoxicity effect was measured in vitro.The results showed that OY-TES-1 mRNA was highly expressed in 41 of the 56(73.21%)HCC tissues,whereas none in 5 normal liver tissues.OY-TES-1 mRNA was frequently expressed not only in HCC tissues(72.97%,27/37),but also in paired adjacent non-cancer tissues(64.86%,24/37).But the mean expression level of OY-TES-1 mRNA in HCC tissues was significantly higher than that in adjacent non-cancer tissues(0.76854 vs.0.09834,P=0.021).Immunohistochemistry showed that OY-TES-1 protein expression was detected in 6 of the 49 cases of HCC tissues,and absent in 9 cases of normal liver and 6 cases of cirrhosis tissues.Seropositivity was detected in 10 of the 45 HCC patients,but not detected in 17 cirrhosis patients and 76 healthy donors.The specific cytotoxic T cells elicited by OY-TES-1 could kill HLA-A2^+HCC cell line which expressed OY-TES-1.The target lysis was mainly HLA class I-dependent and could be blocked by antibodies against monomorphic HLA class I but not HLA class II molecule.In summary,OY-TES-1 expression is upregulated in HCC tissues and can be recognized by humoral and cellular responses,which suggests that OY-TES-1 is an attractive target for tumor immunotherapy in HCC. | Bin LUO Xiang YUN Jing LI Rong FAN Wen-wen GUO Chang LIU Yong-da LIN Ying-ying GE Xia ZENG Shui-qing BI Wei-xia NONG Qing-mei ZHANG Xiao-xun XIE | 2020 | Current Medical Science2020，40，4： | 2 |
| 3 | On the Provision of Quality-of-Service Guarantees for Input Queued Switches显示文摘 | Ge Nong Mounir Hamdi | 2000 | IEEE Communication Magazine2000，12，： | 1 |
| 4 | Analysis of Nonblocking ATM Switches with Multiple Input Queues 显示文摘 | Ge Nong Jogesh K Muppala Mounir Hamdi | 1999 | IEEE/ACM Transactions on Networking1999，7，1： | 1 |
| 5 | Linear time suffix array construction using D-critical substrings 显示文摘 | GE NONG SEN ZHANG WAI HONG CHAN | 2009 | Lecture Notes in Computer Science2009，5577，： | 1 |
| 6 | Analysis of Nonblocking ATM Switches with Multiple Input Queues显示文摘 | Nong Ge | 1999 | IEEE/ACM Transactions on Net working1999，7，1： | 1 |
| 7 | Seroprevalence of hepatitis E virus infection,rural southern People's Republic of China显示文摘 | Li R C Ge S X Li Y P Zheng Y J Nong Y Guo Q S Zhang J Ng M H Xia N S | 2006 | Emerg Infect Dis2006，12，11： | 1 |
| 8 | Aggregation-enabled alkene insertion into carbon–halogen bonds显示文摘Molecular aggregation affects the electronic interactions between molecules and has emerged as a powerful tool in material science.Aggregate effect finds wide applications in the research of new physical phenomena;however,its value for chemical reaction development has been far less explored.Herein,we report the development of aggregation-enabled alkene insertion into carbon–halogen bonds.The spontaneous cleavage of C–X(X=Cl,Br,or I)bonds generates an intimate ion pair,which can be quickly captured by alkenes in an aggregated state.Additional catalysts or promoters are not necessary under such circumstances,and solvent quenching experiments indicate that the aggregated state is critical for achieving such sequences.The ionic insertion mode is supported by mechanistic studies,density functional theory calculations,and symmetry-adapted perturbation theory analysis.Results also show that the non-aggregated state may quench the transition state and terminate the insertion process. | Meng-Yao Li Xiao-Mei Nong Han Xiao Ao Gu Shuyang Zhai Jiatong Li Ge Zhang Ze-Jian Xue Yingbin Liu Chunsen Li Guo-Qiang Lin Chen-Guo Feng | 2023 | Aggregate2023，4，5： | 0 |
| 9 | FMR1NB Involved in Glioma Tumorigenesis Is a Promising Target for Prognosis and Therapy显示文摘Objective:Cancer/testis antigen FMR1NB is aberrantly expressed in various types of cancer,but not in normal tissues except for testis.This study aimed to investigate the expression and functional role of FMR1NB in glioma.Methods:The expression of FMR1NB mRNA and protein was determined using RT-PCR and immunohistochemistry,respectively,in glioma specimens from 83 patients at follow-up.The effects of siRNA-mediated FMR1NB silencing on malignant biological behaviors were evaluated in glioma cell lines Al 72 and U251.Results:FMR1NB mRNA and protein expression was detected in 58.8%(77/131)and 46.34%(57/123)of glioma tissues,respectively.FMR1NB protein was positively correlated with World Health Organization grade and found to be an independent prognostic marker for poor outcome.Knockdown of FMR1NB induced apoptosis and suppressed proliferation,adhesion,migration,and invasion by modulating the expression of cyclin A,CDK2,caspase-3,E-cadherin,and N-cadherin in A172 and U251 cells.Conclusion:Our findings suggest that FMR1NB contributes to the tumorigenesis of glioma cells and may represent a potential prognostic biomarker and an attractive therapeutic target in glioma. | Shui-qing BI Ya PENG Zong-dang WEI Sheng-zhong YAO Bin LUO Ying-ying GE Xiao-xun XIE Wei-xia NONG Chang LIU Shao-wen XIAO Qing-mei ZHANG | 2022 | Current Medical Science2022，42，4： | 0 |
| 10 | miR-200a suppresses glioma cell migration and invasion via directly targeting MAGED4显示文摘Melanoma-associated antigen D4(MAGED4)is overexpressed in glioma and has been associated with WHO grade and survival.Here we investigated the exact function of MAGED4 during glioma progression and its regulatory mechanism.Cell migration and invasion were evaluated following up-and down-regulation of MAGED4 expression in glioma cell lines U87MG,U251,A172 and SHG44.Furthermore,we combined bioinformatics tools with biological validation assays to determine the miRNA targeting MAGED4. | Zhang Qing mei Wu Huixcian Liu Chang Luo Xin Zhao Wenjing Ge Yingying Chen Fang Nong Weixia Xiao Shaowen Xie Xiaoxtun Luo Bin | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 11 | Genome-wide selection and introgression of Chinese rice varieties during breeding显示文摘China is the largest rice-producing country,but the genomic landscape of rice diversity has not yet been clarified.In this study,we re-sequence 1070 rice varieties collected from China(400)and other regions in Asia(670).Among the six major rice groups(aus,indica-I,indica-II,aromatic,temperate japonica,and tropical japonica),almost all Chinese varieties belong to the indica-II or temperate japonica group.Most Chinese indica varieties belong to indica-II,which consists of two subgroups developed during different phases of rice breeding.The genomic segments underlying the differences between these subgroups span36.32 Mb.The Chinese japonica rice varieties fall into the temperate japonica group,consisting of two subgroups based on their geographical distribution.The genomic segments underlying the differences between these subgroups span 27.69 Mb.These differentiated segments in the Chinese indica varieties span 45 genes with nonsynonymous mutations that are closely related to variations in plant height and grain width.Fifty-four genes with nonsynonymous mutations are associated with the differences in heading date between the two Chinese japonica subgroups.These findings provide new insights into rice diversity in China that will facilitate the molecular breeding. | Jinyue Ge Junrui Wang Hongbo Pang Fei Li Danjing Lou Weiya Fan Ziran Liu Jiaqi Li Danting Li Baoxuan Nong Zongqiong Zhang Yanyan Wang Jingfen Huang Meng Xing Yamin Nie Xiaorong Xiao Fan Zhang Wensheng Wang Jianlong Xu Sung Ryul Kim Ajay Kohli Guoyou Ye Weihua Qiao Qingwen Yang Xiaoming Zheng | 2022 | Journal of Genetics and Genomics2022，49，5： | 0 |
| 12 | NVM Storage in IoT Devices:Opportunities and Challenges显示文摘Edge storage stores the data directly at the data collection point,and does not need to transmit the collected data to the storage central server through the network.It is a critical technology that supports applications such as edge computing and 5G network applications,with lower network communication overhead,lower interaction delay and lower bandwidth cost.However,with the explosion of data and higher real-time requirements,the traditional Internet of Things(IoT)storage architecture cannot meet the requirements of low latency and large capacity.Non-volatile memory(NVM)presents new possibilities regarding this aspect.This paper classifies the different storage architectures based on NVM and compares the system goals,architectures,features,and limitations to explore new research opportunities.Moreover,the existing solutions to reduce the write latency and energy consumption and increase the lifetime of NVM IoT storage devices are analyzed.Furthermore,we discuss the security and privacy issues of IoT devices and compare the mainstream solutions.Finally,we present the opportunities and challenges of building IoT storage systems based on NVM. | Yang Liu Shan Zhao Wenhan Chen Xuran Ge Fang Liu Shuo Li Nong Xiao | 2021 | Computer Systems Science & Engineering2021，38，9： | 0 |
| 13 | Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma:Integrating Bioinformatics and Clinical Analyses显示文摘Objective Glioblastoma(GBM)is the most common,invasive,and malignant primary brain tumor with a poor prognosis and high recurrence rate.It’s known that some microRNAs(miRNAs)which are associated with tumorigenesis and progression can be considered as prognostic and therapeutic targets in tumors including GBM.This study aims to highlight the potential role of the core miRNAs in GBM and their potential use as a prognostic and therapeutic biomarker.Methods Differentially expressed miRNAs(DEmiRNAs)were identified in GBM by integrating miRNA-sequencing results and a GBM microarray dataset from the Gene Expression Omnibus(GEO)database through bioinformatics tools.The dysregulated miRNAs were identified by survival analysis through Chinese Glioma Genome Atlas(CGGA).Target genes of the dysregulated miRNAs were predicted on MiRWalk and miRTarBase database.TAM2.0 database,Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways analysis were used to analyze the function of the dysregulated miRNAs.Subsequently,protein-protein interaction(PPI)network analysis was used to identify the top 20 hub targets of the up-regulated and down-regulated miRNAs,respectively.Then,core miRNAs in GBM were identified by constructing dysregulated miRNA-differentially expressed hub gene networks.Validation of the core miRNAs expression was detected in 41 GBM tissues compared to 8 normal brain tissues.Furthermore,the potential biomarkers were identified by clinical correlation analysis and survival analysis.Results Totally,68 intersecting DEmiRNAs were identified,40 of which were upregulated and the other 28 miRNAs were downregulated.Two upregulated and 4 downregulated miRNAs showed prognostic significance.Most differentially expressed hub genes were regulated by the miR-28-5p and miR-1224-5p,which were respectively upregulated and downregulated in GBM.The correlation between miR-1224-5p level and recurrence was statistically significant(P=0.011).Survival analysis showed that high miR-28-5p level and high miR-1224-5p level were both associated with better prognosis.Moreover,high miR-1224-5p level was an independent prognosis factor for GBM patients according to the cox regression analysis.Conclusion MiRNA-1224-5p could be a potential target for the prognosis and treatment in GBM. | Xing WEI Qing-mei ZHANG Chang LIU Song WU Wei-xia NONG Ying-ying GE Li-na LIN Feng LI Xiao-xun XIE Bin LUO | 2022 | Current Medical Science2022，42，3： | 0 |
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