|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeted therapy of gastrointestinal stromal tumours显示文摘Gastrointestinal stromal tumours(GISTs) are mesen-chymal neoplasms originating in the gastrointestinal tract, usually in the stomach or the small intestine, and rarely elsewhere in the abdomen. The malignant potential of GISTs is variable ranging from small lesions with a benign behaviour to fatal sarcomas. The majo-rity of the tumours stain positively for the CD-117(KIT) and discovered on GIST-1(DOG-1 or anoctamin 1) expression, and they are characterized by the presence of a driver kinase-activating mutation in either KIT or platelet-derived growth factor receptor α. Although surgery is the primary modality of treatment, almost half of the patients have disease recurrence following surgery, which highlights the need for an effective adjuvant therapy. Traditionally, GISTs are considered chemotherapy and radiotherapy resistant. With the advent of targeted therapy(tyrosine kinase inhibitors), there has been a paradigm shift in the management of GISTs in the last decade. We present a comprehensive review of targeted therapy in the management of GISTs. | Ashish Jakhetiya Pankaj Kumar Garg Gaurav Prakash Jyoti Sharma Rambha Pandey Durgatosh Pandey | 2016 | World Journal of Gastrointestinal Surgery2016，8，5： | 14 |
| 2 | Surgical treatment of proximal humerus fractures using PHILOS plate显示文摘ObjectiveTo 与经历了的 51 个病人打开的为近似肱骨 fractures.MethodsWe 的板考察了的近似肱骨的内部锁住系统(PHILOS ) 评估开的减小和内部固定的功能的结果和复杂并发症有在年之间的 PHILOS 板的减小和内部固定 2007 ~ 2012。与 38 的吝啬的年龄有 35 个男人和 16 个女人;年(范围 24-68 ) 。在年龄组有 41 个病人 < 60 在年龄组的年和 10 个病人 > 60 年。根据更旧姓的分类系统, 8, 15 和 23 个病人有 2 部分, 3 部分,和 4 部分破裂,分别地并且 5 个病人让 4 部分断裂脱臼。所有手术在我们的第三级的照顾损伤中心被执行。在最后的后续的肩膀的功能的评估用 Constant-Murley score.ResultsThe 平均数后续被做经期是 30 月(范围 12-44 月) 。二个病人被失去到后续。留下 49 个病人,所有破裂临床上并且放射学地被统一。放射学的联合的吝啬的时间是 12 星期(范围 8-20 星期) 。在最后的后续,吝啬的 Constant-Murley 分数是 79 (范围 50-100 ) 。结果在 25 个病人,是优秀的在 13 个病人好、在 6 个病人公平、在 5 个病人差。在后续期间,内翻足 malunion, subacromial 冲击的一个盒子,深感染的一个盒子, intraarticular 螺丝钉穿入的一个盒子和固定的失败的一个盒子的四个盒子被注意。avascular 坏死的没有盒子,硬件失败,松开的锁住的螺丝钉或不属于工会 noted.ConclusionPHILOS 在近似肱骨破裂提供稳定的固定。为了阻止潜在的复杂并发症,希望 avascular 坏死,保存肱骨的头的由脉管形成的过细的外科的解剖是必要的。 | GN Kiran Kumar Gaurav Sharma Vijay Sharma Vaibhav Jain Kamran Farooque Vivek Morey | 2014 | Chinese Journal of Traumatology2014，17，5： | 14 |
| 3 | On-table reconstruction and fixation of Mason type III radial head fractures显示文摘 | G.N. Kiran Kumar Gaurav Sharma Kamran Farooque Vijay Sharma Vaibhav Jain Ravijot Singh Vivek Morey | 2015 | Chinese Journal of Traumatology2015，18，5： | 12 |
| 4 | Acute femoral artery pseudoaneurysm due to lesser trochanter fragment: an unusual complication of an intertrochanteric fracture显示文摘大腿骨的动脉的假动脉瘤是 intertrochanteric 骨折的稀罕复杂并发症。大多数这些状况由于因医生之治疗而引的损伤或损伤本身并且被打乱的骨头碎片很少引起。这里,我们报导从更小的 trochanter 碎片的尖铁与表面的大腿骨的动脉的 pseudoaneurysm 尖锐地介绍了的一个 72 岁的人的一个案例。有盖住的 stent 的 pseudoaneurysm 的经皮的 endovascular 处理在一个迫切基础上被承担。五天以后,病人被操作在之上,更小的 trochanter 碎片通过一个前面的切口被切除, intertrochanteric 骨折用动态新潮的螺丝钉被修理。破裂在 10 个星期被统一。在 one-year’s 后续,没有接枝相关的复杂并发症。这个案例说明那有代替的更小的 trochanter 碎片的 intertrochanteric 破裂能与流血和大腿骨的动脉的 pseudoaneurysm 尖锐地介绍。 | Gaurav Sharma Ravijot Singh Atin Kumar Vijay Sharma Kamran Farooque | 2013 | Chinese Journal of Traumatology2013，16，5： | 11 |
| 5 | Role of Moringa oleifera in regulation of diabetes-induced oxidative stress显示文摘Objective:To evaluate the antioxidant activity of aqueous extract of Atoringa oleifeta M.oleifera) young leaves by in vivo as well as in vitro assays.Methods:In vitro study included estimation of total phenolic,total ilavonol,total flavonoid and total antioxidant power(FRAP assay).Tn addition, in vivo study was done with the identified most effective dose of 200 nig/kg of its lyophilized powder on normal and diabetic rats.Its effect on different oxidative free radical scavenging enzymes,viz,superoxide dismutase(SOD),catalase(CAT),glutathione-S-transferase(GST),lipid peroxide(LPO) contents were measured.Results:Significant increase in activities of SOD.CAT, GST while,a decrease in LPO content was observed.Whereas,total phenolic,flavonoid and ilavonol contents in the extract were found to be 120 mg/g of CAK,40.5 mg/g of QEK and 12.12 mg/g of QE,respectively.On the other hand.FRAP assay results of M.oleifera leaves was(85.00±5.00)μM of Fe^+/g of extract powder.Conclusions:The significant antioxidant activities of M.oleifera leaves from both in vivo as well as in vitro studies suggests that the regular intake of its leaves through diet can protect normal as well as diabetic patients against oxidative damage. | Dolly Jaiswal Prashant Kumar Rai Shikha Mehta Sanjukta Chatterji Surekha Shukla Devendra Kumar Rai Gaurav Sharma Bechan Sharma Shahidul khair Geeta Watal | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，6： | 11 |
| 6 | Minimally invasive osteosynthesis of distal tibial fractures using anterolateral locking plate: Evaluation of results and complications显示文摘 | Devendra Lakhotia Gaurav Sharma Kavin Khatri G.N. Kiran Kumar Vijay Sharma Kamran Farooque | 2016 | Chinese Journal of Traumatology2016，19，1： | 11 |
| 7 | Effect of stacking sequence on physical, mechanical and tribological properties of glass-carbon hybrid composites显示文摘A study was done to determine the effect of best stacking sequence(position and orientation)on the mechanical properties,friction and wear response of hybrid composites.The main purpose of the study was to determine the best available stacking sequence for which the physical,mechanical and three body abrasive wear rate is optimum.Test for mechanical properties(tensile strength,flexural strength,inter laminar shear strength,impact strength and hardness)was done on glass-carbon hybrid composites.The composites were then subjected to test for three body abrasive wear on a designed experimental setup.Five different factors(sliding velocity,fabric weight percentage,normal load,sliding distance and abrasive particle size)varied in steps to evaluate the friction and three body abrasive wear response of the composites.The design of experiment using Taguchi’s orthogonal array and analysis of variance(ANOVA)was applied to find out minimum specific wear rate.The results revealed the significance in arrangement of two different layers of fabric(glass and carbon)and the difference in properties obtained by them.Using Taguchi experimental analysis it has been observed that three body abrasive wear rate is minimum at 72 cm/s sliding velocity,30 wt.%fabric content,80 N normal load,90 m sliding distance and 125μm abrasive particle size.The scanning electron microscope(SEM)studies revealed the dynamics of three‐body abrasive wear and underlying micro‐mechanisms that result in the analysis of three body abrasive wear. | Gaurav AGARWAL Amar PATNAIK Rajesh kumar SHARMA Jyoti AGARWAL | 2014 | Friction2014，2，4： | 4 |
| 8 | Molecular identification of sex in Hippophae rhamnoides L. using isozyme and RAPD markers显示文摘In many dioecious plants, gender affects economic value, breeding schemes and opportunities for commercial harvests. Hippophae rhamnoides L. is a dioecious plant species in which female genotypes are commercially preferred over male genotypes. Its berries have rich medicinal, nutritional and pharmaceutical properties because of their large amounts of vitamins, essential oils, proteins, fatty acids, free amino acids and flavanoids. Primary limitation for breeding H. rhamnoides L. is its dioecious nature, since gender cannot be identified by traditional methods. Therefore, some reliable and quick methods need to be developed. This communication deals with the development of isozyme and RAPD markers for early sex identification in this dioecious tree. The isozyme analysis was conducted with four enzyme systems, viz. peroxidase, esterase, malate dehydrogenase and catalase. The peroxidase enzyme system produced a female specific sex marker, which successfully differentiated between the staminate and pistillate genotypes of H. rhamnoides L. Thirty five random decamer primers were used in our study and one male sex linked marker was identified. OPD-20 (5′-ACTTCGCCAC-3′) displayed a band at 911 bp that expressed polymorphism between male and female genotypes. The staminate and pistillate genotypes could be distinguished using RAPD marker OPD-20911. These results revealed the immense potential of peroxidase isozyme patterns and RAPD as genetic markers for sex identification in H. rhamnoides L. | Amit SHARMA Gaurav ZINTA Satender RANA Poonam SHIRKOT | 2010 | Forestry Studies in China2010，12，2： | 3 |
| 9 | An Intelligent Fine-Tuned Forecasting Technique for Covid-19 Prediction Using Neuralprophet Model显示文摘COVID-19,being the virus of fear and anxiety,is one of the most recent and emergent of various respiratory disorders.It is similar to the MERS-COV and SARS-COV,the viruses that affected a large population of different countries in the year 2012 and 2002,respectively.Various standard models have been used for COVID-19 epidemic prediction but they suffered from low accuracy due to lesser data availability and a high level of uncertainty.The proposed approach used a machine learning-based time-series Facebook NeuralProphet model for prediction of the number of death as well as confirmed cases and compared it with Poisson Distribution,and Random Forest Model.The analysis upon dataset has been performed considering the time duration from January 1st 2020 to16th July 2021.The model has been developed to obtain the forecast values till September 2021.This study aimed to determine the pandemic prediction of COVID-19 in the second wave of coronavirus in India using the latest Time-Series model to observe and predict the coronavirus pandemic situation across the country.In India,the cases are rapidly increasing day-by-day since mid of Feb 2021.The prediction of death rate using the proposed model has a good ability to forecast the COVID-19 dataset essentially in the second wave.To empower the prediction for future validation,the proposed model works effectively. | Savita Khurana Gaurav Sharma Neha Miglani Aman Singh Abdullah Alharbi Wael Alosaimi Hashem Alyami Nitin Goyal | 2022 | Computers, Materials & Continua2022，，4： | 2 |
| 10 | Diagnostic assays developed for the control of foot-andmouth disease in India显示文摘Foot-and-mouth disease(FMD) is a highly contagious and economically devastating disease of livestock, primarily affecting cattle, buffalo and pigs. FMD virus serotypes O, A and Asia1 are prevalent in India and systematic efforts are on to control and eventually eradicate the disease from the country. FMD epidemiology is complex due to factors like co-circulation, extinction, emergence and re-emergence of genotypes/lineages within the three serotypes, animal movement, diverse farm practices and large number of susceptible livestock in the country. Systematic vaccination, prompt diagnosis, strict biosecurity measures, and regular monitoring of vaccinal immunity and surveillance of virus circulation are indispensible features for the effective implementation of the control measures. Availability of suitable companion diagnostic tests is very important in this endeavour. In this review, the diagnostic assays developed and validated in India and their contribution in FMD control programme is presented. | Gaurav Kumar Sharma Sonalika Mahajan Rakesh Matura Saravanan Subramaniam Rajeev Ranjan Jitendra Biswal Manoranjan Rout Jajati Keshari Mohapatra Bana Bihari Dash Aniket Sanyal Bramhadev Pattnaik | 2015 | World Journal of Virology2015，4，3： | 2 |
| 11 | Analysis of dose–volume parameters predicting radiation pneumonitis in patients with esophageal cancer treated with 3D-conformal radiation therapy or IMRT显示文摘 | Gaurav Kumar Sheh Rawat Abhishek Puri Manoj Kumar Sharma Pranav Chadha Anand Giri Babu Girigesh Yadav | 2012 | Japanese Journal of Radiology2012，，1： | 2 |
| 12 | A comprehensive review on bioactive peptides derived from milk and milkproducts of minor dairy species显示文摘Milk from different species has been exploited for the isolation of various functional ingredients for decades.Irrespective of the source,milk is considered as a complete food,as it provides essential nutrients required by the human body.Proteins and their fractions are valuable sources of bioactive peptides that might exert a health beneficial role in the human body such as immune-modulation,antioxidant activity,ACE-inhibitory activity,anti-neoplastic,anti-microbial,etc.In milk,bioactive peptides may either be present in their natural form or released from their parental proteins due to enzymatic action.The increasing interest in bioactive peptides among researchers has lately augmented the exploration of minor dairy species such as sheep,goat,camel,mithun,mare,and donkey.Alternative to cow,milk from minor dairy species have also been proven to be healthier from infancy to older age owing to their higher digestibility and other nutritive components.Therefore,realizing the significance of milk from such species and incentivized interest towards the derivatization of bioactive peptides,the present review highlights the significant research achievements on bioactive peptides from milk and milk products of minor dairy species. | Snigdha Guha Heena Sharma Gaurav Kr Deshwal Priyanka Singh Rao | 2021 | Food Production, Processing and Nutrition2021，3，1： | 1 |
| 13 | The CIEDE 2000 Color - Difference Formula: Implementation Notes, Supplementary Test Data, and Mathematical Observations 显示文摘 | SHARMA Gaurav WU Wen -cheng DALA Edul N | 2004 | Color Research and Application2004，，9： | 1 |
| 14 | Utility values and diabetic retinopathy显示文摘 | Melissa M Brown Gary C Brown Sanjay Sharma Gaurav Shah | 1999 | American Journal of Ophthalmology1999，，3： | 1 |
| 15 | Impact analysis of biodiesel on engine performance-A review显示文摘 | GAURAV D SIDDHARTH J SHARMA M P | 2011 | Re- newable and Sustainable Energy Reviews2011，15，9： | 1 |
| 16 | Feasibility and efficacy of delayed pharmacoinvasive therapy for STelevation myocardial infarction显示文摘BACKGROUND ST-elevation myocardial infarction(STEMI)refers to a clinical syndrome that features symptoms of myocardial ischemia with consequent ST-elevation on electrocardiography and an associated rise in cardiac biomarkers.Rapid restoration of brisk flow in the coronary vasculature is critical in reducing mortality and morbidity.In patients with STEMI who could not receive primary percutaneous coronary intervention(PCI)on time,pharmacoinvasive strategy(thrombolysis followed by timely PCI within 3-24 h of its initiation)is an effective option.AIM To analyze the role of delayed pharmacoinvasive strategy in the window period of 24-72 h after thrombolysis.METHODS This was a physician-initiated,single-center prospective registry between January 2017 and July 2017 which enrolled 337 acute STEMI patients with partially occluded coronary arteries.Patients received routine pharmacoinvasive therapy(PCI within 3-24 h of thrombolysis)in one group and delayed pharmacoinvasive therapy(PCI within 24-72 h of thrombolysis)in another group.The primary endpoint was major adverse cardiac and cerebrovascular events(MACCE)within 30 d of the procedure.The secondary endpoints included major bleeding as defined by Bleeding Academic Research Consortium classification,angina,and dyspnea within 30 d.RESULTS The mean age in the two groups was comparable(55.1±10.1 years vs 54.2±10.5 years,P=0.426).Diabetes was present among 20.2%and 22.1%of patients in the routine and delayed groups,respectively.Smoking rate was 54.6%and 55.8%in the routine and delayed groups,respectively.Thrombolysis was initiated within 6 h of onset of symptoms in both groups(P=0.125).The mean time from thrombolysis to PCI in the routine and delayed groups was 16.9±5.3 h and 44.1±14.7 h,respectively.No significant difference was found for the occurrence of measured clinical outcomes in the two groups within 30 d(8.7%vs 12.9%,P=0.152).Univariate analysis of demographic characteristics and risk factors for patients who reported MACCE in the two groups did not demonstrate any significant correlation.Secondary endpoints such as angina,dyspnea,and major bleeding were non-significantly different between the two groups.CONCLUSION Delayed PCI pharmacoinvasive strategy in a critical diseased but not completely occluded artery beyond 24 h in patients who have been timely thrombolyzed seems a reasonable strategy. | Rishi Sethi Lalit Mohan Pravesh Vishwakarma Abhishek Singh Swati Sharma Monika Bhandari Ayush Shukla Akhil Sharma Gaurav Chaudhary Akshyaya Pradhan Sharad Chandra Varun Shankar Narain Sudhanshu Kumar Dwivedi | 2023 | World Journal of Cardiology2023，15，1： | 1 |
| 17 | Analysis of Equations of State for Solids under High Compressions显示文摘 | Gaurav S Sharma B S Sharma S B | 2002 | Physica B2002，322，34： | 1 |
| 18 | Lossless generalized-LSB data embedding显示文摘 | Mehmet Utku Celik Gaurav Sharma Ahmet Murat Tekalp | 2005 | IEEE Trans Image Process2005，14，2： | 1 |
| 19 | Value of neutrophil-lymphocyte ratio in evaluating response to percutaneous catheter drainage in patients with acute pancreatitis显示文摘BACKGROUND Early prediction of response to percutaneous catheter drainage(PCD)of necrotic collections in acute pancreatitis(AP)using simple and objective tests is critical as it may determine patient prognosis.The role of white blood cell(WBC)count and neutrophil-lymphocyte ratio(NLR)has not been assessed as a tool of early prediction of PCD success and is the focus of this study.AIM To assess the value of WBC and NLR in predicting response to PCD in AP.METHODS This retrospective study comprised consecutive patients with AP who underwent PCD between June 2018 and December 2019.Severity and fluid collections were classified according to the revised Atlanta classification and organ failure was defined according to the modified Marshall Score.WBC and NLR were monitored 24 h prior PCD(WBC-0/NLR-0)and 24 h(WBC-1/NLR-1),48 h(WBC-2/NLR-2)and 72 h(WBC-3/NLR-3)after PCD.NLR was calculated by dividing the number of neutrophils by the number of lymphocytes.The association of success of PCD(defined as survival without the need for surgery)with WBC and NLR was assessed.The trend of WBC and NLR was also assessed post PCD.RESULTS One hundred fifty-five patients[median age 40±13.6(SD),64.5%males,53.5%severe AP]were included in the final analysis.PCD was done for acute necrotic collection in 99(63.8%)patients and walled-off necrosis in 56(36.1%)patients.Median pain to PCD interval was 24±69.89 d.PCD was successful in 109 patients(group 1)and 46 patients(group 2)who failed to respond.There was no significant difference in the baseline characteristics between the two groups except the severity of AP and frequency of organ failure.Both WBC and NLR showed an overall decreasing trend.There was a significant difference between WBC-0 and WBC-1(P=0.0001).WBC-1 and NLR-1 were significantly different between the two groups(P=0.048 and 0.003,respectively).The area under the curve of WBC-1 and NLR-1 for predicting the success of PCD was 0.602 and 0.682,respectively.At a cut-off value of 9.87 for NLR-1,the sensitivity and specificity for predicting the success of PCD were calculated to be 75%and 65.4%respectively.CONCLUSION WBC and NLR can be used as simple tests for predicting response to PCD in patients with acute necrotizing pancreatitis. | Pankaj Gupta Gaurav Chayan Das Akash Bansal Jayanta Samanta Harshal S Mandavdhare Vishal Sharma Shano Naseem Vikas Gupta Thakur Deen Yadav Usha Dutta Neelam Varma Manavjit Singh Sandhu Rakesh Kochhar | 2022 | World Journal of Clinical Cases2022，10，1： | 1 |
| 20 | LCDs Versus CRTs-Color-Calibrarion and Gamut Considerations显示文摘 | | 2002 | Proceedings of the IEEE2002，90，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员