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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Acute liver injury induced by weight-loss herbal supplements显示文摘We report three cases of patients with acute liver injury induced by weight-loss herbal supplements. One patient took Hydroxycut while the other two took Herbalife supplements. Liver biopsies for all patients dem onstrated f indings consistent with drug-induced acute liver injury. To our knowledge, we are the fi rst instit ute to report acute liver injury from both of these two typ es of weight-loss herbal supplements together as a case series. The series emphasizes the importance of taking a cautious approach when consuming herbal supp lements for the purpose of weight loss. | Gary C Chen Vivek S Ramanathan David Law Pauline Funchain George C Chen Samuel French Boris Shlopov Viktor Eysselein David Chung Sonya Reicher Binh V Pham | 2010 | World Journal of Hepatology2010，2，11： | 5 |
| 4 | 显示文摘 | Peter I Ravikoviteh Gary L Haller Alexander V Neimark | 1998 | Advances in Colloid and Interface Science1998，7677，： | 1 |
| 5 | Development of sediment quality values for Hong Kong Special Administrative Region: a possible model for other jurisdictions显示文摘 | Peter M C Pcitrick J A Gary A V | 1999 | Marine Pollution Bulletin1999，38，3： | 1 |
| 6 | House Prices and the Decision toSave for Down Payments显示文摘 | Engelhardt Gary V | | 0，，03： | 1 |
| 7 | Diversity,Pathoge- nicity,and Management of Verticillium Species显示文摘 | Steven J K Zahi K A Gary E V | 2009 | Annu Rev Phytopat hol2009，47，： | 1 |
| 8 | Effects of Sublethal Doses of Acetamiprid and Thiamethoxam on the Behavior of the Honeybee (Apis mellifera)显示文摘 | EL HASSANI A K DACHER M GARY V | 2008 | Archives of Environmental Contamination and Toxicology2008，54，： | 1 |
| 9 | Subehronic Exposure of Honeybees to Sublethal Doses of Pesticides: Effects on Behavior显示文摘 | ALIOUANE Y EL HASSANI A K GARY V | 2009 | Environmental Toxicology and Chemistry2009，28，： | 1 |
| 10 | Bed and breakfasts in Arizona Demographic and Operating Statistics显示文摘 | GARY V RANDE W | 1997 | Hospitality Quarterly1997，38，4： | 1 |
| 11 | Examining the value of pharmacy benefit management companies显示文摘 | Garis Robert I Clark Bartholomew E Siracuse Mark V | 2004 | American Journal of Health-System Pharma- cy2004，，61： | 1 |
| 12 | Nitrogen deficiency detection using reflected short-wave radiation from irrigated corn canopies显示文摘 | Jaraes S S Gary E V | 1996 | Agronomy Journal1996，88，： | 1 |
| 13 | Knowledge sharing in high technology companies显示文摘 | Inger V E Gary W D | 2000 | Journal of Marketing2000，48，： | 1 |
| 14 | Diagnostic molecular biomarkers for malignant pleural effusions显示文摘 | Krishna B Sriram Vandana Relan Belinda E Clarke Edwina E Duhig Ian A Yang Rayleen V Bowman YC Gary Lee Kwun M Fong | 2011 | Future Oncol2011，，6： | 1 |
| 15 | Biomedical Appli- cations of Carbon Adsorbents显示文摘 | Sergey V Susan R Carol A Gary J etal | 2012 | Novel Carbon Adsorbents2012，，： | 1 |
| 16 | Density functional theory model for calculating pore size distributions: pore structure of nanoporous catalysts 显示文摘 | Peter I Ravikovitch Gary L Hailer Alexander V Neimark | 1998 | Advances in Colloid and Interface Science1998，7677，： | 1 |
| 17 | What is driving China's decline in energy intensity显示文摘 | FISHER K V GARY H J LIU Hongmei | 2004 | Resource and Energy Economics2004，26，1： | 1 |
| 18 | A statewide analysis of level I and II trau- ma centers for patients with major injuries显示文摘 | CLANCY T V GARY MAXWELL J COVINGTON D L | 2001 | J Trauma2001，51，： | 1 |
| 19 | House Price and Home Owner Saving Behavior显示文摘 | Engelhardt Gary V | 1996 | Regional Science and Urban Economics1996，26，3： | 1 |
| 20 | Effects of sublethal doses of acetamiprid and thiamethoxam on the behavior of the honeybee(Apis mellifera)显示文摘 | Hassani A K E Dacher M Gary V | 2008 | Archives of Environmental Contamination and Toxicology2008，54，： | 1 |
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