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| 1 | Blood platelet and monocyte activations and relation to stages of liver cirrhosis显示文摘AIM: Blood platelets (plt) and monocytes are the cells that play a crucial role in the pathogenesis of liver damage and liver cirrhosis (LC). In this paper, the analysis of mutual relationship between platelets and monocytes activation in LC was conducted.METHODS: Immunofluorescent flow cytometry was usedto measure the percentage of activated platelet populations(CD62P, CD63), the percentage of plt-monocyte aggregates (pma) (CD41/CD45), and activated monocytes (CD11b, CD14, CD16) in the blood of 20 volunteers and 40 patientswith LC. Platelet activation markers: sP-selectin, platelet factor 4 (PF4), beta-thromboglobulin (βTG) and monocyte chemotactic peptide-1 (MCP-1) were measured and compared in different stages of LC.RESULTS: Platelet activation with the increase in bothβTG serum concentration and elevation of plt population(CD62P and CD63 as well as MIF CD62P and CD63) is elevated as LC develops and thrombocytopenia rises. There is a positive correlation between medial intensityof fluorescence (MIF) CD62P and MIF CD63 in LC. We did not show any relationship between monocyte activation and pma level. SP-selectin concentration correlates positively with plt count and pma, and negatively with stage of plt activation and MIF CD62P and MIF CD63. There was no correlation between MCP-1 concentration andpit, monocyte activation as well as pma level in LC. CD16 monocytes and MIF CD16 populations are significantlyhigher in the end stage of LC. A positive correlation occurs between the value of CD11b monocyte population andMIF CD14 and MIF CD16 on monocytes in LC.CONCLUSION: Platelet and monocyte activation plays an important role in LC. Platelet activation stage does not influence monocyte activation and production of plt aggregates with monocytes in LC. With LC development, thrombocytopenia may be the result of plt consumption in platelet-monocyte aggregates. | Anatol Panasiuk Janusz Zak Edwina Kasprzycka Katarzyna Janicka Danuta Prokopowicz | 2005 | World Journal of Gastroenterology2005，11，18： | 11 |
| 2 | Constitutive androstane receptor agonist, TCPOBOP,attenuates steatohepatitis in the methionine choline-deficientdiet-fed mouse显示文摘AIM:To ascertain whether constitutive androstane receptor(CAR)activation by 1,4-bis-2-(3,5,-dichloropyridyloxy)benzene(TCPOBOP)modulates steatohepatitis in the methionine choline-deficient(MCD)diet-fed animal.METHODS:C57/BL6 wild-type mice were fed the MCD or standard diet for 2 wk and were treated with either the CAR agonist,TCPOBOP,or the CAR inverse agonist,androstanol.RESULTS:Expression of CYP2B10 and CYP3A11,known CAR target genes,increased 30-fold and 45-fold,respectively,in TCPOBOP-treated mice fed the MCD diet.TCPOBOP treatment reduced hepatic steatosis(44.6 ± 5.4% vs 30.4 ± 4.5%,P < 0.05)and serum triglyceride levels(48 ± 8 vs 20 ± 1 mg/dL,P < 0.05)in MCD diet-fed mice as compared with the standard diet-fed mice.This reduction in hepatic steatosis was accompanied by an increase in enzymes involved in fatty acid microsomal ω-oxidation and peroxisomal β-oxidation,namely CYP4A10,LPBE,and 3-ketoacyl-CoA thiolase.The reduction in steatosis was also accompanied by a reduction in liver cell apoptosis and inflammation.In contrast,androstanol was without effect on any of the above parameters.CONCLUSION:CAR activation stimulates induction of genes involved in fatty acid oxidation,and ameliorates hepatic steatosis,apoptosis and inflammation. | Edwina S Baskin-Bey Akira Anan Hajime Isomoto Steven F Bronk Gregory J Gores | 2007 | World Journal of Gastroenterology2007，13，42： | 3 |
| 3 | Interferon-γ and Tumor Necrosis Factor-α Synergize to Induce Intestinal Epithelial Barrier Dysfunction by Up-Regulating Myosin Light Chain Kinase Expression显示文摘 | Fengjun Wang W. Vallen Graham Yingmin Wang Edwina D. Witkowski Brad T. Schwarz Jerrold R. Turner | 2005 | The American Journal of Pathology2005，，2： | 2 |
| 4 | 肺癌全基因组测序显示文摘肺癌是全球肿瘤发病率和病死率的主因,且预后很差。加强对肿瘤生物学的认识对肺癌研究至关重要。被誉为'下一代测序技术'的NGS技术(next-generation sequencing)是一种针对全基因组鉴定的有力工具,可以对致癌体细胞突变进行全面检测。大多数的NGS技术是基于平台特异性DNA文库进行多重聚合酶链反应(polymerase chain reaction,PCR),从而对目的基因扩增后测序。这种技术适用于高通量测序,可以检测出肿瘤中出现的全部基因组变异。缺点是这种技术需要在时间、实验设备、计算机数据分析、生物信息技术等各方面的大量投入。NGS技术已广泛应用于全基因组、外显子组、转录组和表观基因组的研究中,为肺癌研究和医疗模式带来改变。这项新技术的开展将转变当前对致癌信号通路的认识,可为癌症诊疗提供新的分子靶点。肺癌体细胞突变已有NGS技术的分析报道,但大规模基因组研究仍在进行中。个体化治疗策略将改善那些潜在获益患者的治疗方式,避免'无辜'患者受无效治疗带来的高额费用和不良反应。NGS的组织化、计算机化和生物信息化技术推动了科技的进步,同时,患者知情权和数据发布的相关伦理问题也浮现出来。信号通路中,驱动基因(driver gene)突变和传递基因(passenger gene)突变的区别,需要对测序结果进行细致解读。解读准确与否取决于DNA提取的样本类型、样本处理技术和样本含量。肿瘤异质性也会降低肿瘤基因突变的检测效能。NGS技术将推动对肿瘤基因突变的基础和临床研究,而且,也可应用于单细胞和游离的循环DNA,未来还将用于从体液和肿瘤亚群中获取的DNA样本。如果能进一步降低费用、提高检验速度和精度,NGS技术无疑将会成为肺癌研究的绝佳选择。 | Marissa Daniels Felicia Goh Casey M. Wright Krishna B. Sriram Vandana Relan Belinda E. Clarke Edwina E. Duhig Rayleen V. Bowman Ian A Yang Kwun M. Fong 孙岚 何建行 | 2013 | 国际病理科学与临床杂志2013，33，4： | 2 |
| 5 | Hemochromatosis gene and nonalcoholic fatty liver disease: A systematic review and meta-analysis显示文摘 | Ruben Hernaez Edwina Yeung Jeanne M. Clark Kris V. Kowdley Frederick L. Brancati Wen Hong Linda Kao | 2011 | Journal of Hepatology2011，，5： | 2 |
| 6 | Genetics and biochemistry of anthocyanin biosynthesis显示文摘 | Timothy A Holton and Edwina C | 1995 | The Plant Cell1995，，7： | 1 |
| 7 | Needlestick injuries among health care wooers:A literature review显示文摘 | Edwina A | 2000 | AORN J2000，71，1： | 1 |
| 8 | ISPD Position Statement on Reducing the Risk of Peritoneal Dialysis-ralated Infections显示文摘 | Beth Piraino Judith Bernardini Edwina Brown | | 0，，： | 1 |
| 9 | Production of cytokines by mononuclear cells of hypertrophic adenoids in children with otitis media with effusion显示文摘 | Zelazowska-Rutkowska Beata Ilendo Elzbieta Skotnicka Bozena Wysocka Jolanta Kasprzycka Edwina | 2012 | Folia Histochemica et Cytobiologica2012，，4： | 1 |
| 10 | Diagnostic molecular biomarkers for malignant pleural effusions显示文摘 | Krishna B Sriram Vandana Relan Belinda E Clarke Edwina E Duhig Ian A Yang Rayleen V Bowman YC Gary Lee Kwun M Fong | 2011 | Future Oncol2011，，6： | 1 |
| 11 | An ethics core curriculum for Australasian medical schools, A Working Group, on behalf of the Association of Teachers of Ethics and Law in Australian and New Zealand Medical Schools (ATEAM) 显示文摘 | ANNETTE J B LYNN H G EDWINA F V | 2001 | MJA2001，，175： | 1 |
| 12 | The work environ- ment and its effect on engagement and retention of nuclear medicine technologists:Differences between public and pri- vate sectorworders显示文摘 | Edwina JA Jennifer MC Barbara JA | 2010 | The Journal of Nuclear Medicine2010，31，6： | 1 |
| 13 | Needlestick injuries among health care workers:a literature review显示文摘 | Edwina A | 2000 | AORN J2000，71，1： | 1 |
| 14 | Health-related quality of life in inflammatory bowel disease显示文摘 | Dr. Douglas A. Drossman MD Donald L. Patrick PhD C. Madeline Mitchell MURP Edwina A. Zagami BSN MEd Mark I. Appelbaum PhD | 1989 | Digestive Diseases and Sciences1989，，9： | 1 |
| 15 | Risk factors differ between recurrent and incident preeclampsia:a hospital-based cohort study显示文摘 | NS Boghossian Y Edwina M Pauline | 2014 | Annals of Epidemiology2014，24，12： | 1 |
| 16 | Preventing sharps injuries 显示文摘 | Edwina AM | 1998 | Nurs Manage1998，29，1： | 1 |
| 17 | Cruising into the 21st century显示文摘 | Finn Edwina | 1987 | Forbes August1987，，24： | 1 |
| 18 | Spatial patterning of endothelium modulates cell morphology, adhesiveness and transcriptional signature显示文摘 | Ngan F. Huang Edwina S. Lai Alexandre J.S. Ribeiro Stephen Pan Beth L. Pruitt Gerald G. Fuller John P. Cooke | 2013 | Biomaterials2013，，12： | 1 |
| 19 | Planned relocation of severely depopu lated rural settlements: A case study from Japan显示文摘 | Edwina Palmer | 1988 | Journal of Rural Studies1988，4，1： | 1 |
| 20 | Clinical and hitological manifestations of dental caries 显示文摘 | Ole Fejerskov Edwina A M Kidd | 2007 | In Dental Caires The disease and its clinical managemen :by BlackiweU Munks- gaard2007，，： | 1 |
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