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| 1 | 精子DNA完整性与形态超高倍检测在辅助生殖技术妊娠结局中的临床价值显示文摘近年来,涌现出许多重要的男性不育诊疗新技术。本研究旨在探讨精@DNA完整性与精子空泡率检测对以男性不育因素行IvF或IcsI治疗的不育症的治疗结局。本研究针对152对不育症夫妻行ART技术前进行的精子DNA碎片率与形态学超高倍分析进行队列研究。我们发现对妊娠结局最有预测价值的DNA碎片率切点值为25.5%,阴性预测值为72.7%(P=0.02)。在对空泡率的研究中发现,3、4级的空泡精子的最有预测价值切点值为73.5%,阴性预测值为39.4%(P=0.09),差异无统计学意义。总之,当精子DNA碎片率大于25%时,IVF失败的概率增大,而精子形态学超高倍检测结果对预测患者的妊娠结局无明显获益。 | Gemma López Rafael Lafuente Miguel A Checa Ramón Carreras Mario Brassesco | 2013 | Asian Journal of Andrology2013，15，6： | 12 |
| 2 | Effectiveness of an intervention for reducing social stigma towards mental illness in adolescents显示文摘AIM: To evaluate the effectiveness of an intervention for reducing social stigma towards mental illness in adolescents. The effect of gender and knowledge of someone with mental illness was measured. METHODS: Two hundred and eighty secondary school students were evaluated using the Community Attitudes towards Mental Illness(CAMI) questionnaire. The schools were randomized and some received the intervention and others acted as the control group. The programme consisted of providing information via a documentary film and of contact with healthcare staff in order to reduce the social stigma within the school environment. RESULTS: The intervention was effective in reducing the CAMI authoritarianism and social restrictiveness subscales. The intervention showed significant changes in girls in terms of authoritarianism and social restrictiveness, while boys only showed significant changes in authoritarianism. Following the intervention, a significant reduction was found in authoritarianism and social restrictiveness in those who knew someone with mental illness, and only in authoritarianism in those who did not know anyone with mental illness. CONCLUSION: The intervention was effective to reduce social stigma towards people with mental illness, especially in the area of authoritarianism. Some differences were found depending on gender and whether or not the subjects knew someone with mental illness. | Regina Vila-Badia Francisco Martínez-Zambrano Otilia Arenas Emma Casas-Anguera Esther García-Morales Raúl Villellas José Ramón Martín María Belén Pérez-Franco Tamara Valduciel Diana Casellas Mar García-Franco Jose Miguel Joaquim Balsera Gemma Pascual Eugènia Julia Susana Ochoa | 2016 | World Journal of Psychiatry2016，6，2： | 4 |
| 3 | Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line 显示文摘 | Gemma A Takenaka K Hosoya Y | 2001 | Euro J Cancer2001，37，： | 2 |
| 4 | Molecular genetics of berry colour variation in table grape显示文摘 | Diego Lijavetzky Leonor Ruiz-García José A. Cabezas María T. Andrés Gemma Bravo Ana Ibá?ez Juan Carre?o Félix Cabello Javier Ibá?ez José M. Martínez-Zapater | 2006 | Molecular Genetics and Genomics2006，，5： | 2 |
| 5 | Second-generation synthesis of azadirachtin:a concise preparation of the propargylic mesylate fragment显示文摘 | BOYER A GEMMA E V BECKMANN E | 2009 | Angew Chem Int Ed2009，48，7： | 1 |
| 6 | Mechanism of resistance to growth inhibition by transforming growth factor-beta 1 (TGF-beta 1) in primary lung cancer and new molecular targets in therapy显示文摘 | Gemma A Uematsu K Hagiwam K | 2000 | Gan To Kagaku Ryoho2000，27，8： | 1 |
| 7 | Activation of Auditory Cortex During Silent Lipreading显示文摘 | Gemma A Calvert Edward T Bullmore | 1997 | SCIE-NCE1997，276，25： | 1 |
| 8 | Phytosterols: physiologic and metabolic aspects related to cholesteol - lowering properties 显示文摘 | Gemma B Miguel A C Magda R | 2008 | Nutrition Research2008，，28： | 1 |
| 9 | Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA)显示文摘 | Kokubo Y Gemma A Noro R | 2005 | Br J Cancer2005，92，9： | 1 |
| 10 | Recent approaches using chemical treatments to preserve quality of fresh-cut fruit: a review显示文摘 | GEMMA 0 0 ALEJANDRA ROJAS-GRAU M LAURA A G | 2010 | Postharvest Biology and Technology2010，57，3： | 1 |
| 11 | Enhanced electrochemical detection of heavy metals at heated graphite nanoparticle-based screenprinted electrodes显示文摘 | GEMMA A JOSEFINA P ARBEN M | 2011 | Journal of Materials Chemistry2011，21，12： | 1 |
| 12 | Experimental and full scale pilot plant constructed wetlands for municipat wastewaters treatment显示文摘 | Gemma A Juan M G Ruben C and Estanistao de L | 2003 | Ecological Engineering2003，21，1： | 1 |
| 13 | Do collagen meshes offer any benefits over preclude? ePTFE implants in contaminated surgical fields? A comparative in vitro and in vivo study显示文摘 | Rubén García‐Pumarino Gemma Pascual Marta Rodríguez Bárbara Pérez‐K?hler Juan Manuel Bellón | 2014 | J. Biomed. Mater. Res2014，，： | 1 |
| 14 | Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line显示文摘 | Gemma A Takenaka K Hosoya Y | 2001 | Eur J Cancer2001，37，12： | 1 |
| 15 | Multiplexed Biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer显示文摘Colorectal cancer(CRC)is the second leading cause of cancer-related death worldwide.The five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced stages.Autoantibodies against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early diagnosis.Thus,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid biopsy.To that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to CRC.After bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(WB)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC prognosis.After validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC detection.Taken together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here could be integrated into a point-of-care(POC)device for CRC detection with high diagnostic ability. | Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz Jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo Barderas | 2021 | Engineering2021，7，10： | 1 |
| 16 | Gefitinib 0ressa) sensitive lung cancer cell lines show phesphorylation of Akt without ligand stimulation 显示文摘 | NORO R GEMMA A KOSAIHIREA S | 2006 | BMC Cancer2006，6，9： | 1 |
| 17 | Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA)显示文摘 | KOKUBO Y GEMMA A NORO R | 2005 | BrJ Cancer2005，92，9： | 1 |
| 18 | Drug-induced interstitial lung disease associat- ed with molecular-targeted anticancer agents 显示文摘 | Gemma A | 2009 | J Nip- pon Med Sch2009，76，1： | 1 |
| 19 | FHIT mutations in human primary gastric cancer显示文摘 | Gemma A Hagiwara K Ke Y | 1997 | Cancer Res1997，57，8： | 1 |
| 20 | Building nonredundant adaptive wavelets by update lifting 显示文摘 | Henk J A M Heijmans B eatrice Pesquet-Popescu Gemma Piella | 2005 | Applied Computer Harmonic Analysis2005，18，3： | 1 |
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