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| 1 | Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis显示文摘BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe hypertriglyceridemia.METHODS:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum triglycerides.The APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being taken.The patients' progression,etiological diagnosis,hospital stay and clinical and radiological severity were all recorded.RESULTS:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) origin.Compared with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes mellitus.They usually consumed alcohol or consumed it excessively on the days before admission.Also,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption. | Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos Pedro González-Santos Pedro Valdivielso | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 26 |
| 2 | Pro-oxidative and anti-oxidative imbalance in human semen and its relation with male fertility显示文摘Oxidative stress is a common condition suffered by biological systems in aerobic conditions.Human semen also has its own molecular guard against the free radicals created by normal respiratory process or from immune reactions.The equilibrium of the creation and scavenging of free radicals is mandatory in the spermatozoa to fertilize and initiate a full-term pregnancy.The paper is a systematic review of publications that evaluate oxidative stress in semen.The Cochrane Library,Medline (1966-2003),Embase (1988-2003),SciSearch (1981-2003) and the conference papers were searched,When sperm samples from fertile and infertile males were analyzed,some of the mechanisms that determine the oxidative stress level were found to be impaired while others were unaltered.In conclusion,the literature as a whole provides contradictory findings and it is necessary to carry out more work to identify all the enzymatic and non-enzymatic systems involved in oxidative stress in the ejaculate,in order to develop new diagnostic systems and therapeutic strategies for combating detrimental free radical imbalance in the semen.(Asian J Androl 2004 Mar;6:59-65) | Nicolás Garrido Marcos Meseguer Carlos Simon Antonio Pellicer José Remohi | 2004 | Asian Journal of Andrology2004，6，1： | 10 |
| 3 | Bibliometrics: tracking research impact by selecting Lhe appropriate metrics显示文摘 | Ashok Agarwal Damayanthi Durairajanayagam Sindhuja Tatagari Sandro C Esteves Avi Harlev Ralf Henkel Shubhadeep Roychoudhury Sheryl Homa Nicolas Garrido Puchalt Ranjith Ramasamy Ahmad Majzoub Kim Dao Ly Eva Tvrda Mourad Assidi Kavindra Kesai Reecha Sharma Saleem Banihani Edmund Ko Muhammad Abu-Elmagd Jaime Gosalvez Asher Bashiri | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 4 | Clinical significance of cytomegalovirus infection in patients with inflammatory bowel disease显示文摘Cytomegalovirus(CMV) infection is common in humans.The virus then enters a 'latency phase' and can reactivate to different stimuli such as immunosuppression.The clinical significance of CMV infection in inflammatory bowel disease is different in Crohn's disease(CD) and ulcerative colitis(UC).CMV does not interfere in the clinical course of CD.However,CMV reactivation is frequent in severe or steroid-resistant UC.It is not known whether the virus exacerbates the disease or simply appears as a bystander of a severe disease.Different methods are used to diagnose CMV colitis.Diagnosis is classically based on histopathological identification of viral-infected cells or CMV antigens in biopsied tissues using haematoxylin-eosin or immunohistochemistry,other tests on blood or tissue samples are currently being investigated.Polymerase chain reaction performed in colonic mucosa has a high sensitivity and a positive result could be associated with a worse prognosis disease;further studies are needed to determine the most appropriate strategy with positive CMV-DNA in colonic mucosa.Specific endoscopic features have not been described in active UC and CMV infection.CMV colitis is usually treated with ganciclovir for several weeks,there are different opinions about whether or not to stop immunosuppressive therapy.Other antiviral drugs may be used.Multicenter controlled studies would needed to determine which subgroup of UC patients would benefit from early antiviral treatment. | Elena Garrido Elisa Carrera Rebeca Manzano Antonio Lopez-Sanroman | 2013 | World Journal of Gastroenterology2013，19，1： | 7 |
| 5 | Use of testicular sperm for intracytoplasmic sperm injection in men with high sperm DNA fragmentation: a SWOT analysis显示文摘在整洁的精液与精子 DNA 破碎(SDF ) 的高水平从人的睾丸检索的精子趋于有更好的 DNA 质量。在帮助繁殖技术(艺术) 的结果上给 SDF 的否定影响,增加的兴趣为 intracytoplasmic 精子注射(Testi-ICSI ) 关于阴囊的精子的使用出现了。在这篇文章,我们使用了一 SWOT (力量,软弱,机会,和威胁) 总结这干预的优点和缺点的分析。Testi-ICSI 的基本原理是绕过 DNA 破碎通过 epididymis 在精子运输期间由氧化应力引起了的 posttesticular。因此,由 genomically 未经触动的阴囊的精子的卵母细胞授精可以被优化,因此增加创造一个正常胚胎的染色体和最近完成实时出生,,的可能性的机会与高 SDF 在人示威了。然而,仍然关于 Testi-ICSI 的临床的功效有有限证据,因此在除高 SDF 以外的临床的情形象 Testi-ICSI 的调查一样为进一步确定的临床的研究创造机会。而且, Testi-ICSI 能与为与损坏 DNA 取消选择精子的另外的实验室准备方法相比。目前,当在搭挡们其男性有 posttesticular SDF 的不肥沃的夫妇执行 ICSI 时,可得到的文学支持阴囊的精子的使用。由于精子检索的固有的风险,当为减轻 DNA 损坏的不太侵略的处理失败了时, Testi-ICSI 应该被提供。为连续监视的一个电话尽管如此有关产生后代的健康和精子检索的潜在的复杂并发症被要求。 | Sandro C Esteves Matheus Roque Nicolas Garrido | 2018 | Asian Journal of Andrology2018，20，1： | 6 |
| 6 | Diagnosis and management of functional symptoms in inflammatory bowel disease in remission显示文摘Inflammatory bowel disease(IBD) patients in remission may suffer from gastrointestinal symptoms that resemble irritable bowel syndrome(IBS). Knowledge on this issue has increased considerably in the last decade, and it is our intention to review and summarize it in the present work. We describe a problematic that comprises physiopathological uncertainties, diagnostic difficulties, as IBS-like symptoms are very similar to those produced by an inflammatory flare, and the necessity of appropriate management of these patients, who, although in remission, have impaired quality of life. Ultimately, from almost a philosophical point of view, the presence of IBS-like symptoms in IBD patients in remission supposes a challenge to the traditional functional-organic dichotomy, suggesting the need for a change of paradigm. | Carlos Teruel Elena Garrido Francisco Mesonero | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 6 |
| 7 | 新型分子靶向药物联合放疗在肺癌中的应用显示文摘非小细胞肺癌(non-small cell lung cancer,NSCLC)约占肺癌总病例数的80%-85%,对于Ⅲ期患者来说,NSCLC约占肺癌总病例数的40%。不可切除Ⅲ期NSCLC的治疗为以铂类为基础的化疗联合胸部放疗。本文将综述正在研发中且有可能用于联合治疗的新型靶向制剂。其中最具前景的策略之一为表皮生长因子受体(epidermal growth factor receptor,EGFR)通路的抑制。放疗可激活EGFR信号,通过诱导细胞增殖并增强DNA修复而导致放疗抵抗。几项临床前模型研究表明西妥昔单抗与放疗联合具有协同效应。几项Ⅱ期试验评估了西妥昔单抗与放疗同步使用的安全性与疗效,结果喜人。吉非替尼对多种细胞系具有放疗增敏作用,其与放疗的联合已被试验用于不可切除Ⅲ期NSCLC的治疗。然而,放化疗后使用吉非替尼作为维持治疗的结果不容乐观。一项Ⅰ期试验评估了厄洛替尼与放化疗联合的疗效。放疗可通过损伤细胞膜、DNA以及微血管内皮细胞而诱导肿瘤死亡,而这反过来可增加促血管生成生长因子的产生。抗血管生长制剂可降低血管密度,但可改善肿瘤的含氧量。应用血管内皮生长因子受体(vascular endothelial growth factor receptor,VEGFR)抑制剂可通过阻断亚致死量辐射损伤的修复而增强放疗对人NSCLC的疗效。厄洛替尼、贝伐珠单抗与胸部放疗联合试验正在进行中。该三种药物联合治疗的新策略尚需制订。由于放疗可增强HSP90分子伴侣的功能从而引起肺癌细胞的放疗抵抗,此通路的阻断剂可通过抑制HIF-1a和VEGF的表达进而抑制肺癌细胞的生存和血管生成,因而可能用于减少放疗抵抗。在NSCLC和间皮瘤的临床前模型中,Aurora激酶抑制剂似乎对放疗具有增效作用。 | Mariano PROVENCIO Antonio SANCHEZ Pilar GARRIDO Francisco VALCARCEL 丁燕 李军 | 2010 | 中国肺癌杂志2010，，8： | 6 |
| 8 | Changes in the sorption, desorption, distribution, and availability of copper, induced by application of sewage sludge on Chilean soils contaminated by mine tailings显示文摘The effect of mine tailings and sewage sludge was evaluated on sorption, desorption, availability and distribution of copper in two soils, one high (sandy soil) and one low in copper (clay soil). In both soils contaminated by mine tailings the copper sorption capacity and the affinity of the substrate for the metal decreased substantially compared to the uncontaminated soils, however, the sorption remained always high in the clay soil substrates. In the substrates with sandy soil, the high Cu content and lower clay content were determining factors in the lower magnitude of the sorption. Similarly, metal desorption was closely related to these two parameters, and it was higher in clay soil with lower pH. In general, the application of sewage sludge favored the sorption of Cu in soils contaminated and uncontaminated with mine tailings, and in all cases desorption decreased, an effect that remained for at least 30 days. Simple extraction of Cu with CaCl2 and diethylenetriaminepentaacetic acid gave contradictory results, so a careful choice of the procedure is required, depending on the level of metal in the soil and on the acting principle of the extracting agent. In that relation, more complete information on the changes in the metal forms was obtained by application of the sequential extraction procedure proposed by the European Community Bureau of Reference. | Tatiana Garrido Jorge Mendoza Francisco Arriagada | 2012 | Journal of Environmental Sciences2012，24，5： | 5 |
| 9 | MeSH pesticide trace analysis using solid-phase extraction and gas chromatography with electron capture and tandem mass spectrometric detection in water samples显示文摘 | Martinez Vidal J L Pablos Espada M C Garrido Frenich A | | Jounal of Chromatography A0，，： | 2 |
| 10 | Advantages of solitonic shape pulses for full-optical wireless communication links显示文摘We propose the use of a power pulse shape of the widely known optical soliton, corresponding to the hyperbolic secant square function, for both conventional atmospheric optical communication systems and, especially, for new full-optical wireless communications. We analyze the performance of the proposed pulse in terms of peak-to-average optical power ratio (PAOPR) and bit error rate (BER). During the analysis, we compare the proposed pulse shape against conventional rectangular and Gaussian pulse shapes with reduced duty cycle. Results show the noticeable superiority of the proposed pulse for atmospheric optical links. | José María Garrido Balsells Antonio Jurado-Navas Miguel Castillo-Vázquez Ana Belén Moreno-Garrido Antonio Puerta-Notario | 2012 | Chinese Optics Letters2012，10，4： | 2 |
| 11 | 在体外受精和卵母细胞单精子显微注射结局中由精子染色质散布试验测得的精子脱氧核糖核酸碎片水平的价值显示文摘Objective: To determine the prognostic value of sperm DNA fragmentation levels, as measured by the sperm chromatin dispersion (SCD) test, in predicting IVF and ICSI outcome. Design: Double- blind prospective study. Setting: University- affiliated private IVF setting. Patient(s): A total of 85 couples undergoing infertility treatment with IVF/ICSI. Intervention( s): Analysis of DNA fragmentation by the SCD test in 170 aliquots obtained from the ejaculate and from the processed semen used for assisted reproductive technologies (ART). Main Outcome Measure(s): Percentage of spermatozoa with fragmented DNA was statistically correlated with embryo quality and reproductive success. Result(s): Fertilization rate was inversely correlated with DNA fragmentation (r =- 0.245 P=.045). Higher DNA fragmentation rate gave an increased proportion of zygotes showing asynchrony between the nucleolar precursor bodies of zygote pronuclei (73.8% vs. 28.8% P < .001). In addition, the slower embryo development and worst morphology on day 6 was correlated with higher sperm DNA fragmentation (47.7% vs. 29.4% P=.044). We also observed a negative correlation between DNA fragmentation and the implantation rate (r =- 0.250 P=.042). However, SCD test values were not statistically different in cycles that resulted in a pregnancy compared with those that did not (33.2 vs. 28.2 and 32.4 vs. 34.7). Conclusion(s): This is the first report that describes a correlation between sperm DNA integrity, asmeasured by the SCD test, and fertilization rate, embryo quality, and implantation rate in IVF/ICSI. The degree of DNA fragmentation was inversely correlatedwith fertilization rate, synchrony of the nucleolar precursor bodies’ pattern in pronuclei, embryo ability to achieve blastocyst stage, and embryo morphological quality. Because SCD test values were correlated with embryo quality and blastocyst rate, the lack of correlation between sperm DNA fragmentation and pregnancy outcome in IVF might be due to embryo selection before transfer. The ability of the SCD test to predict the blastocyst rate after IVF/ICSI warrants further study. | Muriel L. Garrido N. Ferná ndez J.L. M.Meseguer 张旸 | 2006 | 世界核心医学期刊文摘(妇产科学分册)2006，2，6： | 2 |
| 12 | New Molecular Targeted Therapies Integrated With Radiation Therapy in Lung Cancer显示文摘 | Mariano Provencio Antonio Sánchez Pilar Garrido Francisco Valcárcel | 2010 | Clinical Lung Cancer2010，，2： | 2 |
| 13 | Efficacy of the vaccination in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD) is associated with conditions that may predispose to infections, such as the lack of an appropriate innate immune response to infectious agents, malnutrition, surgery, and immunosuppressive and biological drugs. Some of these infections may be preventable by vaccination. Therefore, for this particular patient population, the benefits of implementing a well-established immunization protocol in daily clinical practice are potentially even greater than for the general population. In recent years international consensus guidelines have been published, but in spite of theses recommendations, studies have shown that a significant number of patients with IBD remain inadequately immunized. Another important issue regarding immunization in this population is that vaccine efficacy among patients receiving immunosuppressive therapies has been variable. In a healthy population, a humoral immune response to hepatitis B vaccination (HBV) is expected in > 90%, whereas a much lower rate is achieved in the IBD patients. Immunosuppressive, anti-tumor necrosis factor therapy and disease activity have been implicated in the impaired efficacy of the vaccination. The serological response to HBV should be confirmed and patients with an inadequate response should receive a second full series of vaccine. Modified dosing regimens, including doubling the standard antigen dose, might increase the effectiveness. Response to influenza, pneumococcal and tetanus immunization is still not clear, as there are studies that show a normal response to the vaccination while others demonstrate a lack of efficacy. We pose a series of questions on the efficacy of the different vaccinations recommended for IBD patients and attempt to answer them using scientific evidence. | Elisa Carrera Rebeca Manzano Elena Garrido | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 14 | Randomized clinical study for assessment of incision characteristics and pain associated with LESS versus laparoscopic cholecystectomy显示文摘 | Fernando Athayde Veloso Madureira José Eduardo Ferreira Manso Delta Madureira Fo Antonio Carlos Garrido Iglesias | 2013 | Surgical Endoscopy2013，，3： | 2 |
| 15 | Start-up of the Anammox process in a membrane bioreactor显示文摘 | C. Trigo J.L. Campos J.M. Garrido R. Méndez | 2006 | Journal of Biotechnology2006，，4： | 2 |
| 16 | Sensory, physical, chemical and microbiological changes in aquacultured meagre ( Argyrosomus regius ) fillets during ice storage显示文摘 | M.D. Hernández M.B. López A. álvarez E. Ferrandini B. García García M.D. Garrido | 2008 | Food Chemistry2008，，1： | 2 |
| 17 | HLA class Ⅰ loss in colorectal cancer:implications for immune escape and immunotherapy显示文摘T cell-mediated immune therapies have emerged as a promising treatment modality in different malignancies including colorectal cancer(CRC).However,only a fraction of patients currently respond to treatment.Understanding the lack of responses and finding biomarkers with predictive value is of great importance.There is evidence that CRC is a heterogeneous disease and several classification systems have been proposed that are based on genomic instability,immune cell infiltration,stromal content and molecular subtypes of gene expression.Human leukocyte antigen class Ⅰ(HLA-Ⅰ)plays a pivotal role in presenting processed antigens to T lymphocytes,including tumour antigens.These molecules are frequently lost in different types of cancers,including CRC resulting in tumour immune escape from cytotoxic T lymphocytes during the natural history of cancer development.The aim of this review is to(i)summarize the prevalence and molecular mechanisms behind HLA-Ⅰ loss in CRC,(ii)discuss HLA-Ⅰ expression/loss in the context of the newly identified CRC molecular subtypes,(iii)analyze the HLA-Ⅰ phenotypes of CRC metastases disseminated via blood or the lymphatic system,(iv)discuss strategies to recover/circumvent HLA-I expression/loss and finally(v)review the role of HLA class Ⅱ(HLA-Ⅱ)in CRC prognosis. | Per Anderson Natalia Aptsiauri Francisco Ruiz-Cabello Federico Garrido | 2021 | Cellular & Molecular Immunology2021，18，3： | 2 |
| 18 | Towards curative therapy in gastric cancer:Faraway, so close!显示文摘Although recent diagnostic and therapeutic advances have substantially improved the survival of patients with gastric cancer(GC), the overall prognosis is still poor. Surgery is the only curative treatment and should be performed in experienced centers. Due to high relapse following surgery, complementary and systemic treatment aimed at eradicating micrometastasis should be performed in most cases. Cytotoxic treatments are effective in downstaging locally advanced cancer, but different sensitivities and toxicities probably exist in different GC subtypes. Current treatment protocols are based primarily on clinical data and histological features, but molecular biomarkers that would allow for the prediction of treatment responses are urgently needed. Understanding how host factors are responsible for inter-individual variability of drug response or toxicity will also contribute to the development of more effective and less toxic treatments. | Marília Cravo Catarina Fidalgo Rita Garrido Tania Rodrigues Gon?alo Luz Carolina Palmela Marta Santos Fábio Lopes Rui Maio | 2015 | World Journal of Gastroenterology2015，21，41： | 2 |
| 19 | Human haemoclassification by use of specific yolk antibodies obtained after immunization of chickens against human blood group antigens 显示文摘 | Calzado EG Garrido RMG Schade R | 2001 | ATLA2001，29，6： | 1 |
| 20 | Simultaneous urea hydrolysis, formaldehyde removal and denitrification in a multifed upflow filter under anoxic and anaerobic conditions显示文摘 | Garrido J M Mendez R Lema J M | 2001 | Water Res2001，35，3： | 1 |
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