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		题名	作者	年代	出处	被引量
	1	HLA class Ⅰ loss in colorectal cancer:implications for immune escape and immunotherapy显示文摘T cell-mediated immune therapies have emerged as a promising treatment modality in different malignancies including colorectal cancer(CRC).However,only a fraction of patients currently respond to treatment.Understanding the lack of responses and finding biomarkers with predictive value is of great importance.There is evidence that CRC is a heterogeneous disease and several classification systems have been proposed that are based on genomic instability,immune cell infiltration,stromal content and molecular subtypes of gene expression.Human leukocyte antigen class Ⅰ(HLA-Ⅰ)plays a pivotal role in presenting processed antigens to T lymphocytes,including tumour antigens.These molecules are frequently lost in different types of cancers,including CRC resulting in tumour immune escape from cytotoxic T lymphocytes during the natural history of cancer development.The aim of this review is to(i)summarize the prevalence and molecular mechanisms behind HLA-Ⅰ loss in CRC,(ii)discuss HLA-Ⅰ expression/loss in the context of the newly identified CRC molecular subtypes,(iii)analyze the HLA-Ⅰ phenotypes of CRC metastases disseminated via blood or the lymphatic system,(iv)discuss strategies to recover/circumvent HLA-I expression/loss and finally(v)review the role of HLA class Ⅱ(HLA-Ⅱ)in CRC prognosis.	Per Anderson Natalia Aptsiauri Francisco Ruiz-Cabello Federico Garrido	2021	Cellular & Molecular Immunology2021，18，3：	2
	2	Stakeholder Perceptions of CO2 Capture and Storage in Europe: Results from a Survey 显示文摘	Simon Shackley Holly Waterman Per Godfroij David Reiner Jason Anderson	2007	Energy Policy2007，35，：	1

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