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| 1 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 2 | Urethroscopic realignment of ruptured bulbous urethra显示文摘 | Sun YH Xu CL Gao X | 2000 | J Urol2000，164，： | 1 |
| 3 | K (ATP) activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function 显示文摘 | Gao S Long CL Wang RH | 2009 | Cardiovase Res2009，83，3： | 1 |
| 4 | Serum cholesterol, APOE genotype, and the risk of Alzheimer′s disease: a population-based study of African Americans 显示文摘 | Evans RM Emsley CL Gao S | 2000 | Neurology2000，54，1： | 1 |
| 5 | K(ATP) activation prevents pro- gression of cardiac hypertrophy to failure induced by pressure o- verload via protecting endothelial function 显示文摘 | Gao S Long CL Wang RH | 2009 | Cardiovasc Res2009，83，3： | 1 |
| 6 | Simvastatin activates Akt/glycogen synthase kinase-3 beta signal and inhibits caspase-3 activation after experimental subarachnoid hemorrhage显示文摘 | Gao C Wang CL Wu P | 2010 | Vascul Pharmacol2010，52，2： | 1 |
| 7 | HLA-Cw*04 and hepatitis C virus persistence显示文摘 | Thio CL Gao X Goedert JJ | 2002 | J Virol2002，76，10： | 1 |
| 8 | Detection of circulating prostate specific antigen expressing prostatic cells in the bone marrow of radical prostatectomy patients by sensitive reverse transcriptase polymerase chain reaction显示文摘 | Dean RC Pinto A | 1999 | J Urol1999，161，4： | 1 |
| 9 | Control and function of the homeostatic sleep response by adenosine A1 receptors显示文摘 | Bjorness TE Kelly CL Gao T | 2009 | J Neurosci2009，29，5： | 1 |
| 10 | LYRM1, a novel gene promotes proliferation and inhibits apoptosis of preadipocytes显示文摘 | Qiu J Gao CL Zhang M | 2009 | Eur J Endocrinol2009，160，2： | 1 |
| 11 | Nitric oxide stimulatory and endothelial protective effects of idoxifene,a selective estrogen receptor modulator,in the splanchnic artery of the ovariectomized rat显示文摘 | Ma XL Gao F Yao CL | 2000 | Pharmacol Exp Ther2000，295，2： | 1 |
| 12 | A ligand exchange route to highly luminescent surface-functionalized ZoS nanoparticles and their transparent polymer nanocomposites显示文摘 | Lv CL Gao JF Fu YQ | | 0，，： | 1 |
| 13 | Ureteroscope realignment of ruptured bulbous urethra显示文摘 | Sun YH Xu CL Gao X | 2000 | J Urol2000，164，5： | 1 |
| 14 | Intraurethral brachytherapy for prevention of recurrent urethral stricture after internal urethrotomy or transurethral resection of scar 显示文摘 | Sun YH Xu CL Gao X | 2001 | J En- douro12001，15，： | 1 |
| 15 | Erythropoietin protects against cisplatin-induced nephrotoxicity by attenuating en- doplasmic retieulum stress-induced apoptosis显示文摘 | Kong DY Zhuo L Gao CL | 2013 | J Neph- rol2013，26，1： | 1 |
| 16 | STAT3 Activation in Acute Lung Injury显示文摘 | Guo RF Speyer CL | 2004 | J Immunol2004，172，1： | 1 |
| 17 | K(ATP) activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function显示文摘 | Gao S Long CL Wang RH | 2009 | Cardiovac Res2009，83，3： | 1 |
| 18 | Association of CDX1 bindingsite of periostin gene with bone mineral density and vertebral fracturerisk显示文摘 | Xiao SM Gao Y Cheung CL | 2012 | Osteoporos Int2012，23，7： | 1 |
| 19 | Vancomycin intermediate- resistant Staphylococcus aureus (VISA) isolated from a patient who never received vancomycin treatment显示文摘 | ZHU XH LIU CL GAO S | 2015 | Int J Infect Dis2015，33，14： | 1 |
| 20 | Immunochemical localization of the Batten disease (CLN3) protein in retina显示文摘 | Katz ML Gao CL Prabhakaram M | 1997 | Invest Ophthamol Vis Sci1997，38，： | 1 |
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