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| 1 | Antidiabetic Effects of Gegen Qinlian Decoction via the Gut Microbiota Are Attributable to Its Key Ingredient Berberine显示文摘Gegen Qinlian Decoction(GQD),a traditional Chinese medicine(TCM)formula,has long been used for the treatment of common metabolic diseases,including type 2 diabetes mellitus.However,the main limitation of its wider application is ingredient complexity of this formula.Thus,it is critically important to identify the major active ingredients of GQD and to illustrate mechanisms underlying its action.Here,we compared the effects of GQD and berberine,a hypothetical key active pharmaceutical ingredient of GQD,on a diabetic rat model by comprehensive analyses of gut microbiota,short-chain fatty acids,proinflammatory cytokines,and ileum transcriptomics.Our results show that berberine and GQD had similar effects on lowering blood glucose levels,modulating gut microbiota,inducing ileal gene expression,as well as relieving systemic and local inflammation.As expected,both berberine and GQD treatment significantly altered the overall gut microbiota structure and enriched many butyrate-producing bacteria,including Faecalibacterium and Roseburia,thereby attenuating intestinal inflammation and lowering glucose.Levels of short-chain fatty acids in rat feces were also significantly elevated after treatment with berberine or GQD.Moreover,concentration of serum proinflammatory cytokines and expression of immune-related genes,including Nfkb1,Stat1,and Ifnrg1,in pancreatic islets were significantly reduced after treatment.Our study demonstrates that the main effects of GQD can be attributed to berberine via modulating gut microbiota.The strategy employed would facilitate further standardization and widespread application of TCM in many diseases. | Xizhan Xu Zezheng Gao Fuquan Yang Yingying Yang Liang Chen Lin Han Na Zhao Jiayue Xu Xinmiao Wang Yue Ma Lian Shu Xiaoxi Hu Na Lyu Yuanlong Pan Baoli Zhu Linhua Zhao Xiaolin Tong Jun Wang | 2020 | Genomics, Proteomics & Bioinformatics2020，18，6： | 29 |
| 2 | The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2显示文摘 | Changjun Wang Ming Li Youjun Feng Feng Zheng Yaqing Dong Xiuzhen Pan Gong Cheng Ruiping Dong Dan Hu Xiaodan Feng Junchao Ge Di Liu Jing Wang Min Cao Fuquan Hu Jiaqi Tang | 2008 | Archives of Microbiology2008，，1： | 1 |
| 3 | Impact of countdown signals on traffic safety and efficiency:a review and proposal显示文摘Countdown signals for motorized vehicles,which are intended to ensure safety on the road and regulate motor vehicle speed limits at road intersections,are still considered a relatively novel concept.These signals have been adopted by only a few countries,and the number of cities that use them is limited.This review aims to summarize the effects of countdown signals on traffic safety and efficiency and to determine the consistency and differences of existing research propositions on the matter.Based on the review,considerable research presents evidently different conclusions in the areas of driver red-light running and traffic safety.Particularly,some studies propose that countdown signals reinforce traffic safety,whereas others consider that such signals adversely affect traffic safety.Meanwhile,related literature provides varying conclusions on the aspect of traffic efficiency for vehicle headway.At present,the number of studies conducted regarding the driving behaviors of motorists toward countdown-signalized intersections is insufficient.Accordingly,such inadequate diversity in research causes difficulty in completely assessing the benefits and disadvantages of countdown signals.In this paper,an important future research direction on microcosmic driving psychological and physiological data combined with macro-driving behavior is proposed. | Fuquan Pan Jingzhou Yang Lixia Zhang Changxi Ma Jinshun Yang Pingxia Zhang | 2023 | Digital Transportation and Safety2023，2，3： | 0 |
| 4 | Design of hazardous materials transportation safety management system under the vehicle-infrastructure connected environment显示文摘Purpose–For the purpose of reducing the incidence of hazardous materials transport accident,eliminating the potential threats and ensuring their safety,aiming at the shortcomings in the process of current hazardous materials transportation management,this paper aims to construct the framework of hazardous materials transportation safety management system under the vehicle-infrastructure connected environment.Design/methodology/approach–The system takes the intelligent connected vehicle as the main supporter,integrating GIS,GPS,eye location,GSM,networks and database technology.Findings–By analyzing the transportation characteristics of hazardous materials,this system consists offive subsystems,which are vehicle and driver management subsystem,dangerous sources and hazardous materials management subsystem,route analysis and optimization subsystem,early warning and emergency rescue management subsystem,and basic information query subsystem.Originality/value–Hazardous materials transportation safety management system includes omnibearing real-time monitoring,timely updating of system database,real-time generation and optimization of emergency rescue route.The system can reduce the transportation cost and improve the ability of accident prevention and emergency rescue of hazardous materials. | Xueyan Yang Changxi Ma Changfeng Zhu Bo Qi Fuquan Pan Chengming Zhu | 2019 | Journal of Intelligent and Connected Vehicles2019，2，1： | 0 |
| 5 | Theoretical studies of the structures and spectroscopic properties of the photoelectrochemical cell ruthenium sensitizers,C101 and J13显示文摘A variety of heteroleptic ruthenium sensitizers have been engineered and synthesized because of their higher light-harvesting efficiency and lower charge-recombination possibility than the well known homoleptic N3 dye.As such,a great deal of attention has been focused on sensitizers with the general formula Ru(ancillary-ligand)(anchoring-ligand)(NCS) 2,among which important examples are Ru(4,4'-bis(5-hexylthiophen-2-yl)-2,2'-bipyridine)(4,4'-carboxylic acid-4'-2,2'-bipyridine)(NCS)2(C101) and Ru(N-(4-butoxyphenyl)-N-2-pyridinyl-2-pyridinamine)(4,4'-carboxylic acid-4'-2,2'-bipyridine)(NCS)2(J13).In order to simulate experimental conditions with different pH values,the photosensitizing processes of these sensitizers possessing different degrees of deprotonation (2H,1H to 0H) have been explored theoretically in this work.Their ground/excited state geometries,electronic structures and spectroscopic properties are first calculated using density functional theory (DFT) and time-dependent DFT (TDDFT).The absorption and emission spectra of all the complexes in acetonitrile solution are also predicted at the TDDFT (B3LYP) level.The calculated results show that the ancillary ligand contributes to the molecular orbital (MO) energy levels and absorption transitions.It is intriguing to observe that the introduction of a thiophene group into the ancillary ligand leads directly to the increased energy of the absorption transitions in the 380-450 nm region.The calculations reveal that although deprotonation destabilizes the overall frontier MOs of the chromophores,it tends to exert a greater influence on the unoccupied orbitals than on the occupied orbitals.Consequently,an obvious blue shift was observed for the absorptions and emissions in going from 2H,1H to 0H.Finally,the optimal degree of deprotonation for C101 and J13 has also been evaluated,which is expected to lead to further improvements in the performance of dye-sensitized solar cells (DSSCs) coated with such sensitizers. | CHEN Jie BAI FuQuan WANG Jian SUN Lei PAN QingJiang ZHANG HongXing | 2012 | Science China Chemistry2012，55，3： | 0 |
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