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| 1 | Rationale of the combined use of inspiratory and expiratory devices in improving maximal inspiratory pressure and maximal expiratory pressure of patients with chronic obstructive pulmonary disease显示文摘 | Battaglia E Fulgenzi A Ferrero ME | | 0，，： | 1 |
| 2 | Prediction of nodal metastasis and prognosis of breast cancer by ANN-based assessment of tumour size and p53,Ki-67and steroid receptor expression显示文摘 | Mojarad S Venturini B Fulgenzi P | 2013 | Anticancer Res2013，33，9： | 1 |
| 3 | The effect of chronic skeletal muscle stimulation on capillary growth in the rat: are sensory nerve fibres involved?显示文摘 | Hudlicka O Graciotti L Fulgenzi G | 2003 | J Physiol2003，546，3： | 1 |
| 4 | CD4+and CD8+T cell subset distribu-tion in the blood of small-bowel-grafted rats:modification during graft-ver-sus-host disease显示文摘 | Marni A Forti D Fulgenzi A | 1998 | Transpl Int1998，11，1： | 1 |
| 5 | Resveratrol, a natural stilbene in grapes and wine, enhances intraphagocytosisin human promonocytes: a co-factor in antiinflammatory and anticancerchemopreventive activity 显示文摘 | Bertelli A A Ferrara F Diana G Fulgenzi A Corsi M Ponti W Ferrero M E Bertelli A | 1999 | International Journal of Tissue Reactions1999，21，4： | 1 |
| 6 | Expcrimental validation of FastSLAM algorithm integrated with a linear feutures based map显示文摘 | Fulgenzi C Ippoliti G Longhi S | 2009 | Mechatronics2009，19，5： | 1 |
| 7 | The effect of chronic skeletal muscle stimulation on capillary growth in the rat: are sensory nerve fibres involved? 显示文摘 | HUDLICKA O GRACIOTTI L FULGENZI G | 2003 | J Physiol2003，546，： | 1 |
| 8 | Aluminium involvement in neurotoxicity显示文摘 | FULGENZI A VIETTI D FERRERO ME | 2014 | Biomed Res Int2014，2014，75： | 1 |
| 9 | Probabilistic Navigation in Dynamic Environment Using Rapidly-exploring Random Trees and Gaussian Processes 显示文摘 | Fulgenzi H C Tay C Spalanzani A | 2008 | Intelligent Robots and Systems2008，，9： | 1 |
| 10 | Synovial fluid levels of fluconazole in a patient with Candida parapsilosis prosthetic joint infection who had an excellent clinical response显示文摘 | Cushing R Fulgenzi W | | 0，，： | 1 |
| 11 | The ionic envi- ronment controls the contribution of the barley HvHAK1 transporter to potassium acquisition 显示文摘 | Fulgenzi F R Peralta M L Mangano S | 2008 | Plant Physiology2008，147，： | 1 |
| 12 | CellfoodTM improves re- spiratory metabolism of endothelial cells and inhibits hypoxia-in- duced reactive oxygen species ( ros ) generation 显示文摘 | Ferrero E Fulgenzi A Belloni D | 2011 | J Physiol Pharmacol2011，62，3： | 1 |
| 13 | RANTES and MCP-1 chemokine plasma levels in chronic renal transplant dysfunction and chronic renal failure显示文摘 | Corsi MM Leone G Fulgenzi A | 1999 | Clin Biochem1999，32，3： | 1 |
| 14 | Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium显示文摘 | Ferrero ME Bertelli AE Fulgenzi A Pellegatta F Corsi MM Bonfrate M | 1998 | Am J Clin Nutr1998，68，6： | 1 |
| 15 | Cellfood? improves re- spiratory metabolism of endothelial cells and inhibits hypoxia-in- duced reactive oxygen species ( ros ) generation 显示文摘 | Ferrero E Fulgenzi A Belloni D | 2011 | J Physiol Pharmacol2011，62，3： | 1 |
| 16 | Rationale of the combined use of inspiratory and expiratory devices in improving maximal inspiratory pressure and maximal expiratory pressure of patients with chronic obstructive pulmonary disease显示文摘 | Battaglia E Fulgenzi A Ferrero ME | 2009 | Arch Phys Med Rehabil2009，90，6： | 1 |
| 17 | Treatment and Follow-up of HIV-Negative Multi drug-Resistant Tuberculosis Patients in an Infectious Diseases Reference Hospital, Buenos Aires, Argentina显示文摘 | Palmero DJ Ambroggi M Brea A De Lueas M Fulgenzi A Martinez D Mosea C Musella R Natiello M Gonzalez C Abbate E | 2004 | Int J Tuberc Lung Dis2004，8，6： | 1 |
| 18 | Baseline neutrophil-lymphocyte ratio and platelet-lymphocyte ratio appear predictive of immune treatment related toxicity in hepatocellular carcinoma显示文摘BACKGROUND A well-recognized class effect of immune checkpoint inhibitors(ICI)is immune-related adverse events(IrAEs)ranging from low grade toxicities to life-threatening end organ damage requiring permanent discontinuation of ICI.Deaths are reported in<5%of patients treated with ICI.There are,however,no reliable markers to predict the onset and severity of IrAEs.We tested the association between neutrophil-lymphocyte ratio(NLR)and platelet-lymphocyte ratio(PLR)at baseline with development of clinically significant IrAEs(grade≥2)in hepatocellular carcinoma(HCC)patients treated with ICI.AIM To test the association between NLR and PLR at baseline with development of clinically significant IrAEs(grade≥2)in HCC patients treated with ICI.METHODS Data was extracted from an international database from a consortium of 11 tertiary-care referral centers.NLR=absolute neutrophil count/absolute lymphocyte count(ALC)and PLR=platelet count/ALC.Cutoff of 5 was used for NLR and 300 for PLR based on literature.We also tested the association between RESULTS Data was collected from 361 patients treated between 2016-2020 across the United States(67%),Asia(14%)and Europe(19%).Most patients received Nivolumab(n=255,71%).One hundred sixty-seven(46%)patients developed at least one IrAE,highest grade 1 in 80(48%),grade≥2 in 87(52%)patients.In a univariable regression model PLR>300 was significantly associated with a lower incidence of grade≥2 IrAEs(OR=0.40;P=0.044).Similarly,a trend was observed between NLR>5 and lower incidence of grade≥2 IrAEs(OR=0.58;P=0.097).Multivariate analyses confirmed PLR>300 as an independent predictive marker of grade≥2 IrAEs(OR=0.26;P=0.011),in addition to treatment with programmed cell death ligand 1(PD-1)/cytotoxic T lymphocyte-associated protein-4(OR=2.57;P=0.037)and PD-1/tyrosine kinase inhibitor(OR=3.39;P=0.01)combinations.Antibiotic use was not associated with IrAE incidence(OR=1.02;P=0.954).Patients treated with steroids had a>2-fold higher incidence of grade≥2 IrAEs(OR=2.74;P<0.001),although 74%were prescribed steroids for the treatment of IrAEs.CONCLUSION Given that high baseline NLR and PLR are associated with a decreased incidence of IrAEs,lower baseline NLR and PLR may be predictive biomarkers for the appearance of IrAEs in HCC treated with ICI.This finding is in keeping with several studies in solid tumors that have shown that baseline NLR and PLR appear predictive of IrAEs. | Sirish Dharmapuri UmutÖzbek Hiren Jethra Tomi Jun Thomas U Marron Anwaar Saeed Yi-Hsiang Huang Mahvish Muzaffar Matthias Pinter Lorenz Balcar Claudia Fulgenzi Suneetha Amara Arndt Weinmann Nicola Personeni Bernhard Scheiner Tiziana Pressiani Musharraf Navaid Bertram Bengsch Sonal Paul Uqba Khan Dominik Bettinger Naoshi Nishida Yehia Ibrahim Mohamed Arndt Vogel Anuhya Gampa James Korolewicz Antonella Cammarota Ahmed Kaseb Peter R Galle Anjana Pillai Ying-Hong Wan Alessio Cortellini Masatoshi Kudo Antonio D’Alessio Lorenza Rimassa David James Pinato Celina Ang | 2023 | World Journal of Gastrointestinal Oncology2023，15，11： | 0 |
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