|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of VEGF gene polymorphisms and proliferative diabetic retinopathy in Mexican population显示文摘● AIM: To assess if the included vascular endothelial growth factor(VEGF) polymorphisms rs3025035, rs3025021 and rs2010963 are associated to proliferative retinopathy in a Mexican population with type 2 diabetes mellitus(T2DM).● METHODS: A case-control study was conducted in adult individuals with T2 DM associated to proliferative retinopathy or non-proliferative retinopathy from Oct. 2014 to Jun. 2015 from the Retina Department of the Asociation to Prevent Blindness in Mexico. The selected patients were adults with a diagnosis of T2 DM ≥5y. All subjects had a comprehensive ocular examination and the classification of the retinopathy severity was made considering the Early Treatment Diabetic Retinopathy Study(ETDRS) standardization protocols. Genomic DNA was extracted from whole fresh blood. All samples were genotyped by q PCR for selected VEGF polymorphisms. Hardy-Weinberg equilibrium was calculated by comparing Chi-square values between the expected and the observed values for genotype counts.● RESULTS: In total 142 individuals were enrolled, 71 individuals with T2 DM and associated proliferative retinopathy and 71 individuals with non-proliferative retinopathy. One-sided Fisher's exact test was performed for rs3025021[OR(95% CI)=0.44(0.08-2.2); P=0.25] and rs2010963 [OR(95% CI)=0.63(0.25-1.6); P=0.23]. The minor allelic frequencies obtained were 26% for rs3025021, 10% for rs3025035 and 61% for rs2010963. The pairwise linkage disequilibrium between the three SNP was assessed, and was as follows: rs3025021 vs rs3025035: D'=1.0, r^2=0.1043, P≤0.0001; rs3025021 vs rs2010963: D'=0.442, r^2=0.0446, P=0.149; rs3025035 vs rs2010963: D'=0.505, r^2=0.0214, P=0.142.● CONCLUSION: This is the first analysis involving VEGFA polymorphisms and proliferative diabetic retinopathy in a Mexican population. A major finding of the present study is that none of the polymorphisms studied was significantly associated with proliferative retinopathy. Based on these results, we can infer that different populations have different associations for the same polymorphisms. | Roberto Gonzalez-Salinas Maria C Garcia-Gutierrez Gerardo Garcia-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Vidal R Soberon-Ventura Victoria Gonzalez Rodrigo Lechuga Pablo Garcia-Solis David G Garcia-Gutierrez Marco Vinicio Garcia-Solis Manuel Saenz de Viteri Juan C Solis-S | 2017 | International Journal of Ophthalmology(English edition)2017，10，1： | 12 |
| 2 | Closed reduction and iliosacral percutaneous fixation of unstable pelvic ring fractures显示文摘 | Daniel Schweitzer Alejandro Zylberberg Marcelo Córdova Jaime Gonzalez | 2008 | Injury2008，，8： | 3 |
| 3 | Impact of changes in the treatment of nasopharyngeal carcinoma: an experience of 30 years 显示文摘 | Santos JA Gonzalez C Cuesta P | 1995 | Radiotherapy and Oncology1995，36，2： | 2 |
| 4 | Occurrence of Organochlorine Insecticides, PCBs and PCB Congeners in waters and Sediments of the Ebro River (Spain) 显示文摘 | Fernandez M A Alonso C Gonzalez M J | 1999 | Chemosphere1999，38，： | 2 |
| 5 | Is cisplatin-induced cell death always produced by apoptosis?显示文摘 | Gonzalez VM Fuertes MA Alonso C | 2001 | Mol Pharmacol2001，59，： | 1 |
| 6 | Nitric-oxide-directed synaptie remodeling in the adult mamml CNS 显示文摘 | Sunieo C R Portillo F Gonzalez Forero D | 2005 | Neuroscience2005，25，6： | 1 |
| 7 | Interaction of surfactants with thickeners used in waterborne paints: A rheological study显示文摘 | Maestro A Gonzalez C Gutierrez J M | 2005 | J Colloid Interf Sci2005，288，： | 1 |
| 8 | Use of Kraft black liquors from a pulp mill for the production of soil conditioners 显示文摘 | Alvarez R Coca J | 1992 | Water Air and Soil Pollution1992，61，： | 1 |
| 9 | A phase Ⅱ study of multimodality treatment for locally advanced cervical cancer:necadjuvant carboplatin and paclitaxel followed by radical hysterectomy and adjuvant cisplatin chemoradiation显示文摘 | Lopez Graniel C Gonzalez Enciso A | 2003 | Ann Oncol2003，14，： | 1 |
| 10 | An improved algorithm for reaction path following显示文摘 | GONZALEZ C SCHLEGEL H B | 1989 | J Chem Phys1989，90，： | 1 |
| 11 | Is cisplatin-induced cell death always produced by apoptosis?显示文摘 | GONZALEZ V M FUERTES M A ALONSO C | 2001 | Mol Pharmaeol2001，59，4： | 1 |
| 12 | Pluripotency of mesenchymal stem cells derived from adult marrow显示文摘 | Jiang Y Jahagirdar B N Reinhardt R L Schwartz R E Keene C D Ortiz Gonzalez X R | 2002 | Nature2002，418，： | 1 |
| 13 | Normal human monocytes exposed to glioma cells acquire myeloid-derived suppressor cell-like properties显示文摘 | RODRIGUES J C GONZALEZ G C ZHANG L | 2010 | Neuro Oncol2010，12，4： | 1 |
| 14 | Confocal mi-croscopy study of phase morphology evolution in epoxy/polysiloxanethermosets显示文摘 | Cabanelas J C Serrano B Gonzalez M G | 2005 | Polymer2005，46，： | 1 |
| 15 | Inorganic calcite morphology: roles of fluid chemistry and fluid flow显示文摘 | Gonzalez L A Carpenter S J Lohann K C | 1992 | Journal of Sedimentary Petrology1992，62，： | 1 |
| 16 | Vasoconstrictive effect of bile acids on isolated human placental chorionic veins显示文摘 | Sepulveda WH Gonzalez C Cruz MA | 1991 | Eur J Obstet Gynecol Reprod Biol1991，42，： | 1 |
| 17 | A prospective analysis of the HOMA model显示文摘 | Haffner S M Gonzalez C Miettinen H | 1996 | The Mexic City Diabetes Staty Diabetes Care1996，19，10： | 1 |
| 18 | An improved algorithm for reaction path following显示文摘 | Gonzalez C Schlegel H B | 1989 | J Chem Phys1989，90，9： | 1 |
| 19 | Effects of coupoling agents on mechnical and morphological behaviour of the PP/HDPE blend with two different CaCO3 显示文摘 | GONZALEZ J ALBANO C ICHAZO M | 2002 | Eur Polym J2002，38，： | 1 |
| 20 | Comparison of ISSR and RAPD markers to characterize three Chilean Nothofagus species显示文摘 | MATTIONAI C CASASOLI M GONZALEZ M | 2002 | Theor Appl Genet2002，104，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员