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| 1 | Promising biological therapies for ulcerative colitis: A review of the literature显示文摘Ulcerative colitis(UC) is a chronic lifelong condition characterized by alternating flare-ups and remission. There is no single known unifying cause, and the pathogenesis is multifactorial, with genetics, environmental factors, microbiota, and the immune system all playing roles. Current treatment modalities for UC include 5-aminosalicylates, corticosteroids, immunosuppressants(including purine antimetabolites, cyclosporine, and tacrolimus), and surgery. Therapeutic goals for UC are evolving. Medical treatment aims to induce remission and prevent relapse of disease activity. Infliximab, an anti-tumor necrosis factor(TNF)-α monoclonal antibody, is the first biological agent for the treatment of UC. Over the last decade, infliximab and adalimumab(anti-TNF-α agents) have been used for moderate to severe UC, and have been shown to be effective in inducing and maintaining remission. Recent studies have indicated that golimumab(another anti-TNF-α agent), tofacitinib(a Janus kinase inhibitor), and vedolizumab and etrolizumab(integrin antagonists), achieved good clinical remission and response rates in UC. Recently, golimumab and vedolizumab have been approved for UC by the United States Food and Drug Administration. Vedolizumab may be used as a first-line alternative to anti-TNF-α therapy in patients with an inadequate response to corticosteroids and/or immunosuppressants. Here, we provide updated information on various biological agents in the treatment of UC. | Hirotada Akiho Azusa Yokoyama Shuichi Abe Yuichi Nakazono Masatoshi Murakami Yoshihiro Otsuka Kyoko Fukawa Mitsuru Esaki Yusuke Niina Haruei Ogino | 2015 | World Journal of Gastrointestinal Pathophysiology2015，6，4： | 8 |
| 2 | Recursive least squares adaptive algorithm maximum likelihood sequence estimation: RLS-MLSE-an application of maximum likelihood estimation theory to mobile radio显示文摘 | SUZUKI H | 1993 | Trans IEICE B1993，76，4： | 1 |
| 3 | Development of 500 kV XLPE cables and accessories for long distance underground transmission line-part Ⅲ: electrical properties of 500 kV cables显示文摘 | Fukawa M Kawai T Okano Y | 1996 | IEEE Trans on Power Delivery1996，11，2： | 1 |
| 4 | Genomic regions affecting backfat thickness and cannon bone circumference identified by genome‐wide association study in a D uroc pig population显示文摘 | Naohiko Okumura Toshimi Matsumoto Takeshi Hayashi Kensuke Hirose Kazuo Fukawa Tetsuya Itou Hirohide Uenishi Satoshi Mikawa Takashi Awata | 2013 | Anim Genet2013，，4： | 1 |
| 5 | A method for evaluating analgesic agents in rats 显示文摘 | Fukawa K Kawano O Hibi M | 1980 | J Pharmacol Methods1980，4，3： | 1 |
| 6 | 显示文摘 | Fukawa M | 2001 | Solar Energy Materials & Solar Cells2001，66，： | 1 |
| 7 | Production technology of large-area multicrystalline silicon solar cells显示文摘 | Fujii S Fukawa Y Takahashi H | 2001 | Solar Energy Mate- rials & Solar Cells2001，65，： | 1 |
| 8 | Clinical significance of Galectin - 3 in clear cell renal cell carcinoma 显示文摘 | Sakaki M Fukumori T Fukawa T | 2010 | J Med Invest2010，57，12： | 1 |
| 9 | Effects of IL-23 and IL-27 on osteoblasts and osteoclasts: inhibitory ef- fects on osteoclast differentiation 显示文摘 | Kamiya S Nakamura C Fukawa T | 2007 | J Bone Miner Metab2007，25，5： | 1 |
| 10 | Physical properties and cutting performance of silicon nitride ceramic显示文摘 | Fukuhara M Fukazawa K Fukawa A | 1985 | Wear1985，102，： | 1 |
| 11 | Surface OH group governing adsorption properties of metal oxide films 显示文摘 | Takeda S Fukawa M Mayashi Y | 1999 | Thin Solid Films1999，339，： | 1 |
| 12 | Surface OH groups governing surface chemical properties of SiO2 thin films deposited by RF magnetron sputtering 显示文摘 | Takeda S Fukawa M | 2003 | Thin Solid Films2003，444，12： | 1 |
| 13 | The genetic and non-genetic asepects of leg weakness and osteochondrosis in pigs显示文摘 | Fukawa F Kusuhara S | 2001 | Asian Australasian Journal of Animal Sciences2001，14，1： | 1 |
| 14 | Potentia tion by squalene of the cytotoxidty of anticancer agents a gainst cultured mammalian cells and murine tumor 显示文摘 | Nakagawa M Yamagucmi T Fukawa H | 1985 | JpnJ CancerRes (GANN)1985，76，4： | 1 |
| 15 | Suboptimal algorithm of MLD using gradient signal search in direction of noise enhancement for MIMO channels 显示文摘 | Khine T H Fukawa K and Suzuki H | 2007 | IEICE Transactions on Communications2007，90，6： | 1 |
| 16 | Domain structures and stress distributions due to ball-point scratching in 3% Si-Fe single crystals with orientation near (110)显示文摘 | FUKAWA K YAMAMOTO T | 1982 | IEEE Transactions on Magnetics1982，18，4： | 1 |
| 17 | High rate growth of microcrystalline silicon using a high-pressure depletion method with VHF plasma显示文摘 | Fukawa M Suzuki S Guo L | 2001 | Solar Energy Materials and Solar Cells2001，66，14： | 1 |
| 18 | High-rate deposition of microcrystalline silicon using conventional plasma-enhanced chemical vapor deposition显示文摘 | Guo L Kondo M Fukawa M | 1998 | Jpn J Appl Phys1998，37，： | 1 |
| 19 | 显示文摘 | Takeda S Fukawa M | 2003 | Thin Solid Films2003，444，12： | 1 |
| 20 | Clinical significance of galeetin-3 in clear cell renal cell carcinoma 显示文摘 | SAKAKI M FUKUMORI T FUKAWA T | 2010 | J Med Invest2010，57，12： | 1 |
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