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| 1 | Effect of rapamycin on hepatic osteodystrophy in rats with portasystemic shunting显示文摘瞄准:如果与推延的 portasystemic 有关的 T 房间激活通过 RANKL 依赖的小径引起调停骨破折的骨头损失,学习。如果用 rapamycin 的 T 房间抑制将在老鼠免于骨头损失,我们也调查了。方法:推延的 Portasystemic 在男 Sprague-Dawley 老鼠和 rapamycin 被执行 0.1 mg/kg 被管饲法为 15 wk 管理。老鼠收到了 powderized 食物并且补加喂在骨头作文上阻止营养不良的效果。重量获得和生长在推延的动物在外科以后被恢复。在结束,骨头周转和量的骨头组织学的生物化学的参数被估计。T 房间激活,煽动性的 cytokine 生产,和 RANKL 依赖的小径的标记被测量。另外, IGF-1 和性腺机能减退的角色被调查。结果:推延的 Portasystemic 引起了是 RANKL 独立人士的低周转骨质疏松症。包括 IL-1, IL-6 和 TNFalpha,骨头再吞 cytokine 层次没在浆液和 TNFalpha 被增加, RANKL 表示不起来在 PBMC 调整了。推延的 Portasystemic 增加了传播 CD8+T 房间人口。Rapamycin 减少了传播 CD8+T 房间人口,增加了 CD8+CD25+T 规章的房间人口并且改进了骨头周转的所有参数。结论:推延的 portasystemic 引起的骨质疏松症可以被 rapamycin 部分在肝的骨营养不良的老鼠模型改善。 | Schalk W van der Merwe Maria M Conradie Robert Bond Brenda J Olivier Elongo Fritz Martin Nieuwoudt Rhena Delport Tomas Slavik Gert Engelbrecht Del Kahn Enid G Shephard Maritha J Kotze Nico P de Villiers Stephen Hough | 2006 | World Journal of Gastroenterology2006，12，28： | 2 |
| 2 | The isotopic composition of secondary dolomites显示文摘 | Fritz P smith D G W | 1970 | Geochimica et Cosmochimica Acta1970，34，： | 1 |
| 3 | Photon counting multienergy x - ray imaging: effect of the characteristic x rays on detector performance 显示文摘 | Shikhaliev P M Fritz S G Chapman J W | 2009 | Medical Physics2009，36，11： | 1 |
| 4 | Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CP2C19 genotypes显示文摘 | Schroth W Antoniadou L Fritz P | 2007 | J Clin Oncol2007，25，33： | 1 |
| 5 | Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes显示文摘 | Schroth W Antoniadou L Fritz P | 2007 | J Clin Oncol2007，25，33： | 1 |
| 6 | Predictive models for the median and variability of building period and damping 显示文摘 | Fritz W P Jones N P | 2009 | Journal of Structural Engineering2009，135，5： | 1 |
| 7 | Assessment of ASCE 7 standard wind load factors for tall building response estimates 显示文摘 | Gabbai R D Fritz W P Wright A P | 2008 | Journal of Structural Engineering ASCE2008，134，5： | 1 |
| 8 | The isotopic composition of secondary dolomites 显示文摘 | Fritz P Smith D G W | 1970 | Geochimica et comochimica Acta1970，，34： | 1 |
| 9 | Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP'2C19 genotypes 显示文摘 | Sehroth W Antoniadou L Fritz P | 2007 | J Clin 0ncol2007，25，33： | 1 |
| 10 | Cylindrical block co-micelles with spatially selective functionalization by nanoparticles显示文摘 | Wang H Lin W Fritz K P | 2007 | J Am Chem Soc2007，129，12： | 1 |
| 11 | High-frequency jet venti- lation for complete target immobilization and reduction of plan- ning target volume in stereotactic high single-dose irradiation of stage I non-small cell lung cancer and lung metastases显示文摘 | Fritz P Kraus HJ Muhlnickel W | 2010 | Int J Radiat Oncol Biol Phys2010，78，1： | 1 |
| 12 | Breast cancer treatment outcome with adjuvanttamoxifen relative to patient CYP2D6 and CYP2C19 genotypes显示文摘 | Schroth W Antoniadou L Fritz P | 2007 | J Clin Oncol2007，25，33： | 1 |
| 13 | Extracranial stereotactic radiation therapy: set-up accuracy of patients treated for liver metastases显示文摘 | K.K Herfarth J Debus F Lohr M.L Bahner P Fritz A H?ss W Schlegel M.F Wannenmacher | 2000 | International Journal of Radiation Oncology Biology Physics2000，，2： | 1 |
| 14 | Late-Quaternary cli- matic trends and history of Lake Erie from stable isotope stud- ies显示文摘 | Fritz P Anderson T W Lewis C F M | 1975 | Science1975，190，： | 1 |
| 15 | Properties and morphology of polyester blends and of fibers made therefrom显示文摘 | Oppermann W Hirt P Fritz C | 1999 | Chemical Fibers International1999，49，1： | 1 |
| 16 | Tamoxifen attenuates the effects of exgenous glucocorticoids on bone formation and growth in piglets显示文摘 | Fritz P C Ward W E Atkinson S A | 1998 | Endocrinology1998，139，： | 1 |
| 17 | Laser-fabricated glass microlens arrays 显示文摘 | FRITZE M STERN M B WYATT P W | 1998 | Optics Letters1998，23，2： | 1 |
| 18 | Assessing meteoric water composition and ralative humidity from 18O and 2H in wood cellulose:paleoclimatic implications for southern Ontario, Canada 显示文摘 | Edwards T W D Fritz P | 1986 | Applied Geochemistry1986，1，： | 1 |
| 19 | The artesian thermal groundwater's of northern Jordan: Insights into their recharge history and age显示文摘 | Bajjali W Clark I D Fritz P | 1997 | Journal of Hydrology1997，19，3： | 1 |
| 20 | Breast cancer treatment out- come with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes 显示文摘 | Schroth W Antoniadou L Fritz P | 2007 | J Clin Oncol2007，25，33： | 1 |
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