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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Fractionation of sulfur and oxygen isotopes in sulfate by soil sorption 显示文摘 | van Stempvoort D R Reardon E J Fritz P | 1990 | Geochim Cosmochim Acta1990，54，10： | 1 |
| 3 | Reconnaissance of the July10,2000,Payatas Landfill Failure显示文摘 | Merry S M Jr E K Fritz W U | 2005 | Journal of Perfor-mance of Constructed Facilities ASCE2005，19，2： | 1 |
| 4 | Aerial application methods for increasing spray deposition on wheat heads 显示文摘 | Fritz B K Hoffmann W C Martin D E | 2007 | Applied Engineering in Agriculture2007，23，6： | 1 |
| 5 | Cell aggregation of Pseudomonas aeruginosa strain PAO1 as an energy- dependent stress response during growth with sodium dodecyl sulfate显示文摘 | Klebensberger J Rui O Fritz E | 2006 | Archives of microbiology2006，185，6： | 1 |
| 6 | Localization and toxic effects of cadmium, copper and uranium in AzoUa显示文摘 | Sela M Tel-Or E Fritz E | 1988 | Plant Physiology1988，88，1： | 1 |
| 7 | X-ray microanalysis of diffusible elements in plant cells after freeze-drying:pressure infiltration with ether and embedding in plastic显示文摘 | Fritz E | 1989 | Scanning Microsco1989，3，： | 1 |
| 8 | Seasonal chemical and isotopic variations of soil CO2 at Trout Creek,Outario显示文摘 | REARDON E J ALLISON G B FRITZ P | 1979 | Journal of Hydrology1979，43，1： | 1 |
| 9 | Anemia in cancer patients显示文摘 | Ludwig H Fritz E | 1998 | Semin Oncol1998，25，7： | 1 |
| 10 | Feasibility of intensive mobility training to improve gait, balance, and mobility in persons with chronic neurological conditions: a case series显示文摘 | FRITZ S MERLO-RAINS A RIVERS E | 2011 | J Neural Phys Ther2011，35，3： | 1 |
| 11 | Anemia of cancer patients election and patients tratifieation for epoetin treatment 显示文摘 | Ludwig H Fritz E | 1998 | Semin Oncol1998，25，7： | 1 |
| 12 | The prognostic significance of proliferating cell nuclear antigen,epidermal growth factor receptor,and mdr gene expression in colorectal cancer显示文摘 | Mayer A Takimoto M Fritz E | 1993 | Cancer1993，71，8： | 1 |
| 13 | The carbon isotope geochemistry of a small groundwater system in northeastern Ontario显示文摘 | FRITZ P REARDON E J BARKER J | 1987 | Water Resources Research1987，14，6： | 1 |
| 14 | Sodium and chloride distri-bution in roots and transport in three poplar genotypes un-der increasing NaCl stress显示文摘 | Chen S L Li J K Fritz E | 2002 | Forest Ecology and Manage-ment2002，168，： | 1 |
| 15 | Soluble interleukin-2 receptors are released from activated human lymphoid cells in vitro显示文摘 | Rubin L A Kurman C C Fritz M E | 1985 | J Immunol1985，135，5： | 1 |
| 16 | Binding of S100 pro- teins to RAGE: an update 显示文摘 | Leclerc E Fritz G Vetter SW | 2009 | Biochim Biophys Acta2009，1793，6： | 1 |
| 17 | Binding of S100 proteins to RAGE: an update 显示文摘 | Leclerc E Fritz G Vetter SW | 2009 | Biochim Biophys Acta2009，1793，6： | 1 |
| 18 | Mesoporous silicas modified with dioxomolybdenum (VI) complexes: synthesis and catalysis 显示文摘 | Paula Ferreira Isabel S Fritz E Ktihn | 2000 | European Journal of Inorganic Chemistry2000，，10： | 1 |
| 19 | Near field characteristics of landslide generated impulse waves显示文摘 | Fritz H M Hager W H Minor H E | 2004 | Journal of Waterway Port Coastal and Ocean Engineering2004，130，6： | 1 |
| 20 | Anemia in cancer patients显示文摘 | LLUDWIG H FRITZ E | 1998 | Semin Onol1998，，： | 1 |
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