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| 1 | Laparoscopic fundoplication for gastroesophageal reflux disease显示文摘Gastroesophageal reflux disease(GERD) is a condition that develops when the reflux of gastric contents into the esophagus leads to troublesome symptoms and/or complications. Heartburn is the cardinal symptom, often associated with regurgitation. In patients with endoscopy-negative heartburn refractory to proton pump inhibitor(PPI) therapy and when the diagnosis of GERD is in question, direct reflux testing by impedance-pH monitoring is warranted. Laparoscopic fundoplication is the standard surgical treatment for GERD. It is highly effective in curing GERD with a 80% success rate at 20-year follow-up. The Nissen fundoplication, consisting of a total(360°) wrap, is the most commonly performed antireflux operation. To reduce postoperative dysphagia and gas bloating, partial fundoplications are also used, including the posterior(Toupet) fundoplication, and the anterior(Dor) fundoplication. Currently, there is consensus to advise laparoscopic fundoplication in PPI-responsive GERD only for those patients who develop untoward side-effects or complications from PPI therapy. PPI resistance is the real challenge in GERD. There is consensus that carefully selected GERD patients refractory to PPI therapy are eligible for laparoscopic fundoplication, provided that objective evidence of reflux as the cause of ongoing symptoms has been obtained. For this purpose, impedance-pH monitoring is regarded as the diagnostic gold standard. | Marzio Frazzoni Micaela Piccoli Rita Conigliaro Leonardo Frazzoni Gianluigi Melotti | 2014 | World Journal of Gastroenterology2014，20，39： | 10 |
| 2 | Cholangiocarcinoma and malignant bile duct obstruction: A review of last decades advances in therapeutic endoscopy显示文摘In the last decades many advances have been achieved in endoscopy, in the diagnosis and therapy of cholangiocarcinoma, however blood test, magnetic resonance imaging, computed tomography scan may fail to detect neoplastic disease at early stage, thus the diagnosis of cholangiocarcinoma is achieved usually at unresectable stage. In the last decades the role of endoscopy has moved from a diagnostic role to an invaluable therapeutic tool for patients affected by malignant bile duct obstruction. One of the major issues for cholangiocarcinoma is bile ducts occlusion, leading to jaundice, cholangitis and hepatic failure. Currently, endoscopy has a key role in the work up of cholangiocarcinoma, both in patients amenable to surgical intervention as well as in those unfit for surgery or not amenable to immediate surgical curative resection owing to locally advanced or advanced disease, with palliative intention. Endoscopy allows successful biliary drainage and stenting in more than 90% of patients with malignant bile duct obstruction, and allows rapid reduction of jaundice decreasing the risk of biliary sepsis. When biliary drainage and stenting cannot be achieved with endoscopy alone, endoscopic ultrasound-guided biliary drainage represents an effective alternative method affording successful biliary drainage in more than 80% of cases. The purpose of this review is to focus on the currently available endoscopic management options in patients with cholangiocarcinoma. | Helga Bertani Marzio Frazzoni Santi Mangiafico Angelo Caruso Mauro Manno Vincenzo Giorgio Mirante Flavia Pigò Carmelo Barbera Raffaele Manta Rita Conigliaro | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，6： | 8 |
| 3 | Prevention of pelvic radiation disease显示文摘Pelvic cancers are among the most frequently diagnosed cancers worldwide. Treatment of patients requires a multidisciplinary approach that frequently includes radiotherapy. Gastrointestinal(GI) radiation-induced toxicity is a major complication and the transient or long-term problems, ranging from mild to very severe, arising in non-cancerous tissues resulting from radiation treatment to a tumor of pelvic origin, are actually called as pelvic radiation disease. The incidence of pelvic radiation disease changes according to the radiation technique, the length of follow up, the assessmentmethod, the type and stage of cancer and several other variables. Notably, even with the most recent radiation techniques, i.e., intensity-modulated radiotherapy, the incidence of radiation-induced GI side effects is overall reduced but still not negligible. In addition, radiation-induced GI side effects can develop even after several decades; therefore, the improvement of patient life expectancy will unavoidably increase the risk of developing radiation-induced complications. Once developed, the management of pelvic radiation disease may be challenging. Therefore, the prevention of radiation-induced toxicity represents a reasonable way to avoid a dramatic drop of the quality of life of these patients. In the current manuscript we provide an updated and practical review on the best available evidences in the field of the prevention of pelvic radiation disease. | Lorenzo Fuccio Leonardo Frazzoni Alessandra Guido | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，1： | 6 |
| 4 | Pre-operative clinical and instrumental factors as antireflux surgery outcome predictors显示文摘Gastroesophageal reflux disease(GERD) is nowadays a highly prevalent, chronic condition, with 10% to 30% of Western populations affected by weekly symptoms. Many patients with mild reflux symptoms are treated adequately with lifestyle modifications, dietary changes, and low-dose proton pump inhibitors(PPIs). For those with refractory GERD poorly controlled with daily PPIs, numerous treatment options exist. Fundoplication is currently the most commonly performed antireflux operation for management of GERD. Outcomes described in current literature following laparoscopic fundoplication indicate that it is highly effective for treatment of GERD; early clinical studies demonstrate relief of symptoms in approximately 85%-90% of patients. However it is still unclear which factors, clinical or instrumental, are able to predict a good outcome after surgery. Virtually all demographic, esophagogastric junction anatomic conditions, as well as instrumental(such as presence of esophagitis at endoscopy, or motility patterns determined by esophageal high resolution manometry or reflux patterns determined by means of pH /impedance-pH monitoring) and clinical features(such as typical or atypical symptoms presence) of patients undergoing laparoscopic fundoplication for GERD can be factors associated with symptomatic relief. With this in mind, we sought to review studies that identified the factors that predict outcome after laparoscopic total fundoplication. | Salvatore Tolone Giorgia Gualtieri Edoardo Savarino Marzio Frazzoni Nicola de Bortoli Manuele Furnari Giuseppina Casalino Simona Parisi Vincenzo Savarino Ludovico Docimo | 2016 | World Journal of Gastrointestinal Surgery2016，8，11： | 3 |
| 5 | Pelvic radiation disease:Updates on treatment options显示文摘Pelvic cancers are among the most frequently diagnosed neoplasms and radiotherapy represents one of the main treatment options. The irradiation field usually encompasses healthy intestinal tissue,especially of distal large bowel,thus inducing gastrointestinal(GI) radiation-induced toxicity. Indeed,up to half of radiationtreated patients say that their quality of life is affected by GI symptoms(e.g.,rectal bleeding,diarrhoea). The constellation of GI symptoms- from transient to longterm,from mild to very severe- experienced by patients who underwent radiation treatment for a pelvic tumor have been comprised in the definition of pelvic radiation disease(PRD). A correct and evidence-based therapeutic approach of patients experiencing GI radiation-induced toxicity is mandatory. Therapeutic non-surgical strategies for PRD can be summarized in two broad categories,i.e.,medical and endoscopic. Of note,most of the studies have investigated the management of radiation-induced rectal bleeding. Patients with clinically significant bleeding(i.e.,causing chronic anemia) should firstly be considered for medical management(i.e.,sucralfate enemas,metronidazole and hyperbaric oxygen); in case of failure,endoscopic treatment should be implemented. This latter should be considered the first choice in case of acute,transfusion requiring,bleeding. More well-performed,high quality studies should be performed,especially the role of medical treatments should be better investigated as well as the comparative studies between endoscopic and hyperbaric oxygen treatments. | Leonardo Frazzoni Marina La Marca Alessandra Guido Alessio Giuseppe Morganti Franco Bazzoli Lorenzo Fuccio | 2015 | World Journal of Clinical Oncology2015，6，6： | 3 |
| 6 | Esophageal chemical clearance is impaired in gastro‐esophageal reflux disease – a 24‐h impedance‐pH monitoring assessment显示文摘 | M. Frazzoni R. Manta V. G. Mirante R. Conigliaro L. Frazzoni G. Melotti | 2013 | Neurogastroenterol Motil2013，，5： | 2 |
| 7 | Pathophysiological characteristics of the various forms of gastro-oesophageal reflux disease显示文摘 | M. Frazzoni M. Manno E. De Micheli V. Savarino | 2006 | Digestive and Liver Disease2006，，9： | 2 |
| 8 | Fingerprint Ridge Distance Computation Methodologies显示文摘 | Kovacs ZM Frazzoni M | 2000 | Pattern Recognition2000，33，1： | 1 |
| 9 | Esophageal chemical clearance is impaired in gastro-esophageal reflux disease--a 24-h impedance-pH monitoring assessment显示文摘 | Frazzoni M Manta R Mirante VG | 2013 | Neurogastroenterol Motil2013，25，5： | 1 |
| 10 | Fingerprint ridge distance computation methodologies显示文摘 | Z M Kovacs-Vajna R Rovatti M Frazzoni | 2000 | Pattern Recognition2000，33，4： | 1 |
| 11 | Fingerprint ridge distance computation methodologies显示文摘 | Kovacs- Vajna Z M Rovatti R Frazzoni M | 2000 | Pattern Recognition2000，33，4： | 1 |
| 12 | Fingerprint ridge distance computation methodologies 显示文摘 | Kovacs-VajnaZs M Rovatti R Frazzoni M | 2000 | Pattern Recognition2000，，33： | 1 |
| 13 | Improved detection of inci- dent dysplasia by probe-based confocal laser endomicroscopy in a Barrett~ esophagus surveillance program显示文摘 | Bertani H Frazzoni M Dabizzi E | 2013 | Dig Dis Sci2013，58，1： | 1 |
| 14 | Fingerprint ridge distance computation methodologies显示文摘 | Kovacs-Vajna Zs M Rovatti R Frazzoni M | 2000 | Pattern Recognition2000，33，1： | 1 |
| 15 | Pancreatic duct stenting for the duration of ERCP only does not prevent pancreatitis after accidental pancreatic duct cannulation: a prospective randomized trial显示文摘 | Rita Conigliaro Raffaele Manta Helga Bertani Mauro Manno Carmelo Barbera Angelo Caruso Giampiero Olivetti Gianluigi Melotti Marzio Frazzoni | 2013 | Surgical Endoscopy2013，，2： | 1 |
| 16 | Development of a prediction model of adverse events after stent placement for esophageal cancer显示文摘 | Fuccio L Scagliarini M Frazzoni L | 2015 | Gastrointest Endose2015，83，4： | 1 |
| 17 | Impairment of chemical elearunee is relevant to the pathogenesis of refractory reflux oesophagi- tis显示文摘 | Frazzoni M Bertani H Manta R | 2014 | Dig Liver Dis2014，46，7： | 1 |
| 18 | Fingerprint ridge distance computation methodologies 显示文摘 | KOVACS-VAJNA Z M ROVATH R FRAZZONI M | 2000 | Pattern Recognition2000，33，4： | 1 |
| 19 | Improved Detection of Incident Dysplasia by Probe-Based Confocal Laser Endomicroscopy in a Barrett’s Esophagus Surveillance Program显示文摘 | Helga Bertani Marzio Frazzoni Emanuele Dabizzi Flavia Pigò Luisa Losi Mauro Manno Raffaele Manta Gabrio Bassotti Rita Conigliaro | 2013 | Digestive Diseases and Sciences2013，，1： | 1 |
| 20 | Fingerprint ridge distance computation method logies显示文摘 | Kovacs V Z Rovatti R Frazzoni M | 2000 | Pattern Recognition2000，33，4： | 1 |
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