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7篇 您的检索式:作者名="Francesco Amenta"
    题名 作者 年代 出处 被引量
1Treatment with acetyl-L-carnitine exerts a neuroprotective effect in the sciatic nerve following loose ligation:a functional and microanatomical study显示文摘Peripheral neuropathies are chronic painful syndromes characterized by allodynia,hyperalgesia and altered nerve functionality.Nerve tissue degeneration represents the microanatomical correlate of peripheral neuropathies.Aimed to improve the therapeutic possibilities,this study investigated the hypersensitivity and the neuromorphological alterations related to the loose ligation of the sciatic nerve in rats.Effects elicited by treatment with acetyl-L-carnitine(ALCAR) in comparison to gabapentin were assessed.Axonal injury,reduction of myelin deposition and accumulation of inflammatory cells were detected in damaged nerve.A decrease of phosphorylated 200-k Da neurofilament(NFP) immunoreactivity and a redistribution in small clusters of myelin basic like-protein(MBP) were observed in ipsilateral nerves.Treatment with ALCAR(100 mg/kg intraperitoneally-i.p.) and gabapentin(70 mg/kg i.p.) administered bis in die for 14 days induced a significant pain relieving effect.ALCAR,but not gabapentin,significantly countered neuromorphological changes and increased axonal NFP immunoreactivity.These findings indicate that both ALCAR and gabapentin significantly decreased the hypersensitivity related to neuropathic lesions.The observation of the positive ALCAR effect on axonal and myelin sheath alterations in damaged nerve supports its use as neurorestorative agent against neuropathies through mechanism(s) consistent to those focused in this study.Daniele Tomassoni Lorenzo Di Cesare Mannelli Vincenzo Bramanti Carla Ghelardini Francesco Amenta Alessandra Pacini 2018Neural Regeneration Research2018,13,4:1
2Protective effect of anti-hypertensive treatment on cognitive function in essential hypertension:Analysis of published clinical data显示文摘Francesco Amenta Fiorenzo Mignini Franco Rabbia 2002Journal of the Neurological Sciences2002,,:1
3Treatment of Alzheimer’s disease: From pharmacology to a better understanding of disease pathophysiology显示文摘Giorgio Silvestrelli Alessia Lanari Lucilla Parnetti Daniele Tomassoni Francesco Amenta 2005Mechanisms of Ageing and Development2005,,2:1
4Spontaneously hypertensive rat as a model of vascular brain disorder: Microanatomy, neurochemistry and behavior显示文摘Seyed Khosrow Tayebati Daniele Tomassoni Francesco Amenta 2012Journal of the Neurological Sciences (-)2012,,1:1
5Nimodipine and Its Use in Cerebrovascular Disease: Evidence from Recent Preclinical and Controlled Clinical Studies显示文摘Daniele Tomassoni Alessia Lanari Giorgio Silvestrelli Enea Traini Francesco Amenta 2008Clinical and Experimental Hypertension2008,,8:1
6The Cerebral Cortex of Spontaneously Hypertensive Rats: A Quantitative Microanatomical Study显示文摘Fiorenzo Mignini Lucia Vitaioli Maurizio Sabbatini Daniele Tomassoni Francesco Amenta 2004Clinical and Experimental Hypertension2004,,4:1
7Effect of Treatment with the Cholinesterase Inhibitor Rivastigmine on Vesicular Acetylcholine Transporter and Choline Acetyltransferase in Rat Brain显示文摘Seyed Khosrow Tayebati Maria Antonietta Di Tullio Francesco Amenta 2004Clinical and Experimental Hypertension2004,,4:1
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